M. Kurtz

发表

1-Phenyl-8-azabicyclo[3.2.1]octane ethers: a novel series of neurokinin (NK1) antagonists.

Alan Wheeldon, Clare London, Piotr Raubo, 2006, Bioorganic & medicinal chemistry letters.

Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A.

M. Kurtz, V. Bansal, J. Bergstrom, 1998, Archives of biochemistry and biophysics.

Structural optimization affording 2-(R)-(1-(R)-3, 5-bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a potent, orally active, long-acting morpholine acetal human NK-1 receptor antagonist.

J. Metzger, M. Maccoss, D. Macintyre, 1998, Journal of medicinal chemistry.

Farnesol-derived Dicarboxylic Acids in the Urine of Animals Treated with Zaragozic Acid A or with Farnesol*

J. D. Karkas, B. Arison, J. Germershausen, 1997, The Journal of Biological Chemistry.

Isolation, structure determination and squalene synthase activity of L-731,120 and L-731,128, alkyl citrate analogs of zaragozic acids A and B

P. Salmon, K. Wilson, H. Joshua, 1995 .

3,4-Diesters of zaragozic acid A

M. Kurtz, J. Bergstrom, G. D. Berger, 1995 .

The isolation and structure elucidation of zaragozic acid C, a novel potent squalene synthase inhibitor.

K. Wilson, F. Peláez, G. Bills, 1992 .

Fused tricyclic pyrrolizinones that exhibit pseudo-irreversible blockade of the NK1 receptor.

S. Boyce, R. DeVita, J. Demartino, 2010, Bioorganic & medicinal chemistry letters.

Substituted fused bicyclic pyrrolizinones as potent, orally bioavailable hNK1 antagonists.

P. Davies, S. Boyce, M. Reibarkh, 2010, Bioorganic & medicinal chemistry letters.

Fused bicyclic pyrrolizinones as new scaffolds for human NK1 antagonists.

S. Boyce, R. DeVita, J. Demartino, 2008, Bioorganic & medicinal chemistry.

Pyrrolidine-carboxamides and oxadiazoles as potent hNK1 antagonists.

R. DeVita, K. Tsao, S. Mills, 2007, Bioorganic & medicinal chemistry letters.

The discovery of potent, selective, and orally bioavailable hNK1 antagonists derived from pyrrolidine.

R. DeVita, H. Burns, R. Hargreaves, 2007, Bioorganic & medicinal chemistry letters.

Comparison of the functional blockade of rat substance P (NK1) receptors by GR205171, RP67580, SR140333 and NKP-608

G. Bentley, K. Tsao, R. Kilburn, 2003, Neuropharmacology.

2-Aryl indole NK1 receptor antagonists: optimisation of indole substitution.

K. Tsao, C. Swain, G. Hollingworth, 2001, Bioorganic & medicinal chemistry letters.

Spirocyclic NK(1) antagonists I: [4.5] and [5.5]-spiroketals.

C. Swain, B. Williams, E. Carlson, 2002, Bioorganic & medicinal chemistry letters.

2-Aryl indole NK1 receptor antagonists: optimisation of the 2-aryl ring and the indole nitrogen substituent.

K. Tsao, C. Swain, G. Hollingworth, 2001, Bioorganic & medicinal chemistry letters.

Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs.

J. Metzger, M. Maccoss, D. Macintyre, 2000, Journal of medicinal chemistry.

1-Phenyl-8-azabicyclo[3.2.1]octane ethers: a novel series of neurokinin (NK1) antagonists.

Alan Wheeldon, Clare London, Piotr Raubo, 2006, Bioorganic & medicinal chemistry letters.

Heterocyclic core analogs of a direct thrombin inhibitor.

A. Crespo, J. Wiltsie, M. Kurtz, 2014, Bioorganic & medicinal chemistry letters.

Serine derived NK1 antagonists. 1: The effect of modifications to the serine substituents.

A. Macleod, G. Chicchi, M. Kurtz, 1998, Bioorganic & medicinal chemistry letters.

Tetrahydroindolizinone NK1 antagonists.

R. DeVita, K. Tsao, G. Morriello, 2010, Bioorganic & medicinal chemistry letters.

NK1 antagonists based on seven membered lactam scaffolds.

Alan Wheeldon, Maria Dominguez, U. Gerhard, 2006, Bioorganic & medicinal chemistry letters.

Novel lactam NK1 antagonists with anti-emetic activity.

K. Tsao, R. Kilburn, C. Swain, 2006, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of 8-azabicyclo[3.2.1]octane benzylamine NK1 antagonists.

Alan Wheeldon, K. Tsao, C. Swain, 2006, Bioorganic & medicinal chemistry letters.

4,4-Disubstituted cyclohexylamine NK(1) receptor antagonists II.

K. Tsao, C. Swain, G. Hollingworth, 2002, Bioorganic & medicinal chemistry letters.

2-Aryl indole NK(1) antagonists: optimisation of the amide substituent.

C. Swain, G. Chicchi, M. Kurtz, 2001, Bioorganic & medicinal chemistry letters.

Identification, localization and receptor characterization of novel mammalian substance P-like peptides.

C. Austin, G. Chicchi, M. Kurtz, 2002, Gene.

Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver

M. Erion, D. Kemp, S. Souza, 2019, PloS one.

Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.

J. D. Karkas, O. Hensens, M. Kurtz, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase.

D. Kemp, Gaochao Zhou, F. A. Romero, 2018, ACS medicinal chemistry letters.

Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists.

R. DeVita, R. Hargreaves, K. Tsao, 2009, Journal of medicinal chemistry.

Serine derived NK1 antagonists. 2: A pharmacophore model for arylsulfonamide binding.

H. Broughton, A. Macleod, I. Huscroft, 1998, Bioorganic & medicinal chemistry letters.

4,4-Disubstituted piperidine high-affinity NK1 antagonists: structure-activity relationships and in vivo activity.

J. Metzger, D. Macintyre, C. Swain, 1998, Journal of medicinal chemistry.

Selective protection and relative importance of the carboxylic acid groups of zaragozic acid A for squalene synthase inhibition.

K. Wilson, R. Marquis, W. Parsons, 1994, Journal of medicinal chemistry.

Selective Protection and Relative Importance of the Carboxylic Acid Groups of Zargozic Acid A for Squalene Synthase Inhibition.

K. Wilson, R. Marquis, W. Parsons, 1994 .

Diesters of zaragozic acid A: Synthesis and biological activity

R. Marquis, G. Doss, M. Kurtz, 1993 .