Xiaoqi Chen

发表

Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition.

M. Lindstrom, J. Jaén, K. Dai, 2012, Bioorganic & medicinal chemistry letters.

Sequential Metabolism of AMG 487, a Novel CXCR3 Antagonist, Results in Formation of Quinone Reactive Metabolites That Covalently Modify CYP3A4 Cys239 and Cause Time-Dependent Inhibition of the Enzyme

D. Rock, R. Subramanian, G. Tonn, 2012, Drug Metabolism and Disposition.

Discovery of potent and specific CXCR3 antagonists.

B. Lemon, S. Miao, T. Sullivan, 2012, Bioorganic & medicinal chemistry letters.

Evaluation of furofuran as a P2 ligand for symmetry-based HIV protease inhibitors

S. Vasavanonda, D. Norbeck, D. Kempf, 1996 .

Soluble epoxide hydrolase inhibition provides multi-target therapeutic effects in rats after spinal cord injury

M. Xie, Wei Wang, C. Qin, 2015, Molecular Neurobiology.

Discovery of a new class of ghrelin receptor antagonists.

M. Lindstrom, Liang Tang, M. Lizarzaburu, 2012, Bioorganic & medicinal chemistry letters.

Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.

K. Pattabiraman, Zhulun Wang, C. Quéva, 2014, Journal of medicinal chemistry.

Novel a- and b-Amino Acid Inhibitors of Influenza Virus Neuraminidase

V. Stoll, V. Giranda, D. Norbeck, 2001 .

Novel α- and β-Amino Acid Inhibitors of Influenza Virus Neuraminidase

V. Stoll, V. Giranda, D. Norbeck, 2001, Antimicrobial Agents and Chemotherapy.

Vitamin D3 Metabolic Enzymes in Plateau Zokor (Myospalax baileyi) and Plateau Pika (Ochotona curzoniae): Expression and Response to Hypoxia

Xiaoqi Chen, Z. An, Jimei Li, 2022, Animals : an open access journal from MDPI.

Quality evaluation and chemometric discrimination of Zanthoxylum bungeanum Maxim leaves based on flavonoids profiles, bioactivity and HPLC-fingerprint in a common garden experiment

Cheng Wang, Xiaoqi Chen, Wei Wang, 2019, Industrial Crops and Products.

Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.

J. Jaén, K. Dai, P. Fan, 2011, Bioorganic & medicinal chemistry letters.

Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2.

M. Lindstrom, J. Jaén, Q. Ye, 2012, Bioorganic & medicinal chemistry letters.

Chapter 32. The use of bioisosteric groups in lead optimization

Xiaoqi Chen, Weibo Wang, 2003 .

Design and optimization of imidazole derivatives as potent CXCR3 antagonists.

B. Lemon, S. Miao, T. Sullivan, 2008, Bioorganic & medicinal chemistry letters.

A Novel Tin-Mediated Indole Synthesis

T. Fukuyama, G. Peng, Xiaoqi Chen, 1994 .

Stereocontrolled Synthesis of (-)-Hapalindole G

T. Fukuyama, Xiaoqi Chen, 1994 .

Stereoselective synthesis of a MCHr1 antagonist.

M. Martinelli, R. Syed, J. Tedrow, 2007, The Journal of organic chemistry.

3-Alkyl-2-pyridyl Directing Group-Enabled C2 Selective C-H Silylation of Indoles and Pyrroles via an Iridium Catalyst.

Lei Yang, Xiaoqi Chen, Yu-Ming Cui, 2022, The Journal of organic chemistry.

Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction.

N. Walker, Zhulun Wang, Haoda Xu, 2012, Journal of medicinal chemistry.

Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.

Y. Wang, J. Canon, M. Peterson, 2014, Journal of medicinal chemistry.

ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease

Dale J. Kempf, John M. Leonard, Jacob J. Plattner, 1998, Antimicrobial Agents and Chemotherapy.

Optimization of the heterocyclic core of the quinazolinone-derived CXCR3 antagonists.

B. Lemon, T. Sullivan, G. Tonn, 2008, Bioorganic & medicinal chemistry letters.

Thermodynamic analysis of mRNA cap binding by the human initiation factor eIF4E via free energy perturbations.

N. Walker, S. Thibault, J. Mihalic, 2009, Journal of the American Chemical Society.

Synthesis of 2,3-Disubstituted Indoles by Palladium-Mediated Coupling of 2-Iodoindoles

H. Tokuyama, T. Fukuyama, Xiaoqi Chen, 2000 .

Evaluation of AMG 076, a potent and selective MCHR1 antagonist, in rodent and primate obesity models

J. Jaén, K. Dai, Leping Li, 2013, Pharmacology research & perspectives.

Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P2 ligands.

S. Vasavanonda, D. Norbeck, D. Kempf, 2003, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of a novel series of HIV-1 protease inhibitors encompassing ABT-378 (Lopinavir).

S. Vasavanonda, D. Norbeck, D. Kempf, 2002, Bioorganic & medicinal chemistry letters.

Characterization and abolishment of the cyclopiazonic acids produced by Aspergillus oryzae HMP-F28

Ting Cao, Jiang-chun Hu, Xiaoqi Chen, 2018, Bioscience, biotechnology, and biochemistry.

Soluble epoxide hydrolase inhibition provides multi-target therapeutic effects in rats after spinal cord injury

M. Xie, Wei Wang, C. Qin, 2016, Molecular Neurobiology.

Cyclic dipeptides produced by fungus Eupenicillium brefeldianum HMP-F96 induced extracellular alkalinization and H2O2 production in tobacco cell suspensions

Xiao Wang, Yan-hua Mou, Jiang-chun Hu, 2015, World journal of microbiology & biotechnology.

Imidazo-pyrazine derivatives as potent CXCR3 antagonists.

B. Lemon, Zhulun Wang, S. Miao, 2009, Bioorganic & medicinal chemistry letters.