A. Motani

发表

Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition.

M. Lindstrom, J. Jaén, K. Dai, 2012, Bioorganic & medicinal chemistry letters.

Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4.

P. Coward, N. Walker, Zhulun Wang, 2014, Bioorganic & medicinal chemistry letters.

Corrigendum to “Phenylalanine derivatives as GPR142 agonists for the treatment of Type II diabetes” [Bioorg. Med. Chem. Lett. 22 (2012) 6218–6223]

J. Reagan, W. Shen, M. Lizarzaburu, 2012 .

Insulin‐like growth factor‐I modulates monocyte adhesion to EAhy 926 endothelial cells

G. Ferns, E. Änggård, S. Tull, 1996, International journal of experimental pathology.

Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor.

Katherine A. Winters, R. Lindberg, M. Véniant, 2010, American journal of physiology. Endocrinology and metabolism.

INT131: a selective modulator of PPAR gamma.

M. Lindstrom, N. Walker, Zhulun Wang, 2009, Journal of molecular biology.

CCR8 Is Not Essential for the Development of Inflammation in a Mouse Model of Allergic Airway Disease

W. Henderson, J. Kumer, A. Motani, 2003, The Journal of Immunology.

Distinct Mechanisms for Increased Cardiac Contraction Through Selective Alteration of Either Myosin or Troponin Activity

S. Sadayappan, J. Hartman, A. Motani, 2022, JACC. Basic to translational science.

Phenylalanine derivatives as GPR142 agonists for the treatment of type II diabetes.

Ying Zhang, Wang Shen, Yumei Xiong, 2012, Bioorganic & medicinal chemistry letters.

Aminopyrazole-Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies.

J. Reagan, M. Lizarzaburu, M. Yamazaki, 2013, ACS medicinal chemistry letters.

Malonyl CoA Decarboxylase Inhibition Improves Cardiac Function Post-Myocardial Infarction

J. Reagan, G. Lopaschuk, J. Dyck, 2019, JACC. Basic to translational science.

Biochemical characterization of two angiotensin II receptor subtypes in the rat.

S. Whitebread, M. de Gasparo, H. Ramjoué, 1990, Journal of cardiovascular pharmacology.

Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes.

Yi Chen, J. Reagan, M. Lizarzaburu, 2013, ACS medicinal chemistry letters.

INT131: A Selective Modulator of PPARγ

M. Lindstrom, N. Walker, Zhulun Wang, 2009 .

Functional arrays of human pluripotent stem cell-derived cardiac microtissues

M. Radisic, P. Zandstra, G. Keller, 2019, bioRxiv.

Evaluation of AMG 076, a potent and selective MCHR1 antagonist, in rodent and primate obesity models

J. Jaén, K. Dai, Leping Li, 2013, Pharmacology research & perspectives.

Identification and Characterization of a Non-retinoid Ligand for Retinol-binding Protein 4 Which Lowers Serum Retinol-binding Protein 4 Levels in Vivo*

P. Coward, N. Walker, Zhulun Wang, 2009, Journal of Biological Chemistry.

Novel Small-Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics

J. Balschi, J. Reagan, Brooke M. Rock, 2021, Circulation. Heart failure.

Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity.

M. Lindstrom, N. Walker, P. Timmermans, 2013, Bioorganic & medicinal chemistry.

Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity.

M. Lindstrom, M. Lizarzaburu, Ji Ma, 2010, Bioorganic & medicinal chemistry letters.

Recombinant insulin-like growth factor-1 modulates aggregation in human platelets via extracellular calcium.

G. Ferns, E. Änggård, A. Motani, 1996, Life sciences.