Dong Liu

发表

The discovery of aminopyrazines as novel, potent Na(v)1.7 antagonists: hit-to-lead identification and SAR.

H. Bregman, S. McDonough, Liyue Huang, 2012, Bioorganic & Medicinal Chemistry Letters.

Discovery of EBI-907: A highly potent and orally active B-Raf(V600E) inhibitor for the treatment of melanoma and associated cancers.

Minsheng Zhang, Weikang Tao, Xiao-dong Shen, 2016, Bioorganic & medicinal chemistry letters.

Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V

J. B. Jordan, Kristin L. Andrews, R. Stöcklin, 2018, PloS one.

Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel.

L. Poppe, Kristin L. Andrews, R. Stöcklin, 2015, Journal of Medicinal Chemistry.

Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1.

L. Poppe, Kristin L. Andrews, S. Meng, 2015, Bioorganic & medicinal chemistry letters.

Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.

Xiao Mei Zheng, A. Malmberg, H. Bregman, 2011, Journal of medicinal chemistry.

Engineering Antibody Reactivity for Efficient Derivatization to Generate NaV1.7 Inhibitory GpTx-1 Peptide-Antibody Conjugates.

K. Gunasekaran, Hantao Liu, B. Herberich, 2017, ACS chemical biology.

Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Na(v)1.7 antagonists.

H. Bregman, S. McDonough, A. Zou, 2012, Bioorganic & medicinal chemistry letters.

Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists.

A. Malmberg, H. Bregman, S. McDonough, 2012, Bioorganic & medicinal chemistry letters.

Discovery of 2-(Ortho-Substituted Benzyl)-Indole Derivatives as Potent and Orally Bioavailable RORγ Agonists with Antitumor Activity.

Minsheng Zhang, Suxing Liu, B. Gui, 2021, Journal of medicinal chemistry.

Discovery of Isoindoline Amide Derivatives as Potent and Orally Bioavailable ADAMTS-4/5 Inhibitors for the Treatment of Osteoarthritis.

Suxing Liu, Weikang Tao, Chunying Song, 2022, ACS pharmacology & translational science.

Discovery of a novel RORγ antagonist with skin-restricted exposure for topical treatment of mild to moderate psoriasis

Suxing Liu, Weikang Tao, Rumin Zhang, 2021, Scientific Reports.

Discovery of EBI-2511: A Highly Potent and Orally Active EZH2 Inhibitor for the Treatment of Non-Hodgkin's Lymphoma.

Minsheng Zhang, Weikang Tao, Xiao-dong Shen, 2018, ACS medicinal chemistry letters.

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities.

R. Fremeau, H. Bregman, M. Chu-Moyer, 2017, Journal of Medicinal Chemistry.

Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7

Dong Liu, J. Luther, R. Fremeau, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Rat NaV1.7 loss-of-function genetic model: Deficient nociceptive and neuropathic pain behavior with retained olfactory function and intra-epidermal nerve fibers

S. Waxman, B. Moyer, Dong Liu, 2019, Molecular pain.

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement.

R. Fremeau, H. Bregman, M. Chu-Moyer, 2016, ACS medicinal chemistry letters.

Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7

J. Luther, R. Fremeau, B. Moyer, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel.

L. Poppe, R. Stöcklin, B. Moyer, 2015, Journal of medicinal chemistry.

The discovery of aminopyrazines as novel, potent Na(v)1.7 antagonists: hit-to-lead identification and SAR.

H. Bregman, S. McDonough, Liyue Huang, 2012, Bioorganic & medicinal chemistry letters.

Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis.

Dong Liu, Kristin L. Andrews, Zhulun Wang, 2018, Journal of medicinal chemistry.