J. Mcdermott

发表

The discovery of aminopyrazines as novel, potent Na(v)1.7 antagonists: hit-to-lead identification and SAR.

H. Bregman, S. McDonough, Liyue Huang, 2012, Bioorganic & Medicinal Chemistry Letters.

Block of hERG channel by ziprasidone: biophysical properties and molecular determinants.

G. Gintant, M. Gopalakrishnan, Ruth L. Martin, 2006, Biochemical pharmacology.

Tetrodotoxin-Resistant Sodium Channels in Sensory Neurons Generate Slow Resurgent Currents That Are Enhanced by Inflammatory Mediators

E. Nisenbaum, T. Cummins, B. Priest, 2014, The Journal of Neuroscience.

Importance of Species Selection in Arrythmogenic Models of Q-T Interval Prolongation

G. Gintant, B. Cox, J. Mcdermott, 2002, Antimicrobial Agents and Chemotherapy.

Cardiac ion channels

B. Priest, J. Mcdermott, J. McDermott, 2015, Channels.

Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.

Xiao Mei Zheng, A. Malmberg, H. Bregman, 2011, Journal of Medicinal Chemistry.

Extracellular signal-regulated kinases mediate the enhancing effects of inflammatory mediators on resurgent currents in dorsal root ganglion neurons

E. Nisenbaum, T. Cummins, J. Mcdermott, 2019, Molecular pain.

[125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding.

G. Gintant, C. Shieh, M. Gopalakrishnan, 2003, Molecular pharmacology.

Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Na(v)1.7 antagonists.

H. Bregman, S. McDonough, A. Zou, 2012, Bioorganic & medicinal chemistry letters.

Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists.

A. Malmberg, H. Bregman, S. McDonough, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and activity of substituted carbamates as potentiators of the alpha4beta2 nicotinic acetylcholine receptor.

A. Malmberg, K. Clarkin, S. McDonough, 2008, Bioorganic & medicinal chemistry letters.

Control of Neurotransmission by NaV1.7 in Human, Guinea Pig, and Mouse Airway Parasympathetic Nerves

E. Nisenbaum, M. Kollarik, S. Meeker, 2017, The Journal of Pharmacology and Experimental Therapeutics.

The Canine Purkinje Fiber: An In Vitro Model System for Acquired Long QT Syndrome and Drug-Induced Arrhythmogenesis

G. Gintant, C. Wegner, B. Cox, 2001, Journal of cardiovascular pharmacology.

The effects of plasma proteins on delayed repolarization in vitro with cisapride, risperidone, and D, L-sotalol.

G. Gintant, Ruth L. Martin, B. Cox, 2007, Journal of pharmacological and toxicological methods.

The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o.

Gary A Gintant, Zhi Su, G. Gintant, 2004, Journal of pharmacological and toxicological methods.

The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement.

R. Fremeau, H. Bregman, M. Chu-Moyer, 2017, Bioorganic & medicinal chemistry letters.

ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders.

D. Donnelly-roberts, G. Gintant, J. Sullivan, 2006, CNS drug reviews.

Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant alpha4beta2 nicotinic acetylcholine receptor potentiators.

A. Malmberg, K. Clarkin, S. McDonough, 2008, Bioorganic & Medicinal Chemistry Letters.