Raku Shinkyo

发表

A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes.

Yasunari Kanda, Takashi Yoshinaga, Kohei Sawada, 2017, Journal of pharmacological and toxicological methods.

Metabolism of vitamin D by human microsomal CYP2R1.

K. Inouye, T. Sakaki, Raku Shinkyo, 2004, Biochemical and biophysical research communications.

Conversion of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1.

K. Inouye, T. Sakaki, Tatsuya Kusudo, 2004, Biochemical and biophysical research communications.

Rat cytochrome P450-mediated transformation of dichlorodibenzo-p-dioxins by recombinant white-rot basidiomycete Coriolus hirsutus

K. Inouye, T. Sakaki, Raku Shinkyo, 2005, Applied Microbiology and Biotechnology.

Biodegradation of polychlorinated dibenzo-p-dioxins by recombinant yeast expressing rat CYP1A subfamily.

K. Inouye, T. Sakaki, Raku Shinkyo, 2002, Archives of biochemistry and biophysics.

Metabolism of polychlorinated dibenzo-p-dioxins by cytochrome P450 BM-3 and its mutant

K. Inouye, Qing-Shan Li, R. Schmid, 2004, Biotechnology Letters.

Metabolic pathways of dioxin by CYP1A1: species difference between rat and human CYP1A subfamily in the metabolism of dioxins.

K. Inouye, T. Sakaki, Raku Shinkyo, 2003, Archives of biochemistry and biophysics.

Metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) by human cytochrome P450-dependent monooxygenase systems.

K. Inouye, T. Sakaki, Raku Shinkyo, 2002, Journal of agricultural and food chemistry.

Crystal Structure of CYP105A1 (P450SU-1) in Complex with 1alpha,25-Dihydroxyvitamin D3

H. Sugimoto, S. Ikushiro, T. Sakaki, 2008 .

Enzymatic properties of human CYP2W1 expressed in Escherichia coli.

K. Inouye, S. Ikushiro, T. Sakaki, 2006, Biochemical and biophysical research communications.

METABOLISM OF 26,26,26,27,27,27-F 6 -1 (cid:1) ,23 S ,25-TRIHYDROXYVITAMIN D 3 BY HUMAN UDP-GLUCURONOSYLTRANSFERASE 1A3*

T. Iyanagi, K. Inouye, S. Ikushiro, 2004 .

Metabolism of mono- and dichloro-dibenzo-p-dioxins by Phanerochaete chrysosporium cytochromes P450

K. Yasuda, S. Ikushiro, H. Wariishi, 2010, Applied Microbiology and Biotechnology.

Generation of 2,3,7,8-TCDD-metabolizing enzyme by modifying rat CYP1A1 through site-directed mutagenesis.

K. Inouye, T. Sakaki, Raku Shinkyo, 2003, Biochemical and biophysical research communications.

Cytochrome P450 7A1 cholesterol 7alpha-hydroxylation: individual reaction steps in the catalytic cycle and rate-limiting ferric iron reduction.

F. Guengerich, Raku Shinkyo, 2011, The Journal of biological chemistry.

Crystal structure of CYP105A1 (P450SU-1) in complex with 1alpha,25-dihydroxyvitamin D3.

H. Sugimoto, S. Ikushiro, T. Sakaki, 2008, Biochemistry.

Eribulin penetrates brain tumor tissue and prolongs survival of mice harboring intracerebral glioblastoma xenografts

K. Tamura, K. Ichimura, A. Mukasa, 2019, Cancer science.

Structure-based design of a highly active vitamin D hydroxylase from Streptomyces griseolus CYP105A1.

H. Sugimoto, S. Ikushiro, T. Sakaki, 2008, Biochemistry.

cDNA cloning and characterization of feline CYP1A1 and CYP1A2.

T. Miyasho, T. Sakaki, H. Yokota, 2006, Life sciences.

Cytochrome P450 2E polymorphism in feline liver.

S. Imaoka, Y. Funae, T. Sakaki, 2005, Biochimica et biophysica acta.

Insight into functional diversity of cytochrome P450 in the white-rot basidiomycete Phanerochaete chrysosporium: involvement of versatile monooxygenase.

H. Wariishi, T. Sakaki, H. Tsunekawa, 2011, Biochemical and biophysical research communications.

Molecular Cloning and Characterization of CYP719, a Methylenedioxy Bridge-forming Enzyme That Belongs to a Novel P450 Family, from cultured Coptis japonica Cells*

F. Sato, K. Inouye, Nobuhiro Ikezawa, 2003, Journal of Biological Chemistry.

Inhibition of Human Cytochrome P450 3A4 by Cholesterol*

F. Guengerich, Raku Shinkyo, 2011, The Journal of Biological Chemistry.

Biodegradation of dioxins by recombinant Escherichia coli expressing rat CYP1A1 or its mutant

K. Inouye, S. Ikushiro, T. Sakaki, 2006, Applied Microbiology and Biotechnology.

Cytochrome P450 2S1 is Reduced by NADPH-Cytochrome P450 Reductase

F. Guengerich, Raku Shinkyo, Yi Xiao, 2011, Drug Metabolism and Disposition.

METABOLISM OF 26,26,26,27,27,27-F6-1α,23S,25-TRIHYDROXYVITAMIN D3 BY HUMAN UDP-GLUCURONOSYLTRANSFERASE 1A3*

T. Iyanagi, K. Inouye, S. Ikushiro, 2005, Drug Metabolism and Disposition.

Conversion of 7-Dehydrocholesterol to 7-Ketocholesterol Is Catalyzed by Human Cytochrome P450 7A1 and Occurs by Direct Oxidation without an Epoxide Intermediate

F. Guengerich, Libin Xu, N. Porter, 2011, The Journal of Biological Chemistry.

Requirements for human iPS cell-derived hepatocytes as an alternative to primary human hepatocytes for assessing absorption, distribution, metabolism, excretion and toxicity of pharmaceuticals

Keisuke Nagata, Tomoaki Inoue, Y. Iwase, 2016 .

A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Trial of AWZ1066S, an Anti-Wolbachia Candidate Macrofilaricide.

Raku Shinkyo, W. D. Hong, G. Devereux, 2024, Clinical pharmacology in drug development.