G. Hanton

发表

Preclinical Cardiac Safety Assessment of Drugs

G. Hanton, Gilles Hanton, 2007, Drugs in R&D.

Hepatotoxin-induced hypertyrosinemia and its toxicological significance

J. Lindon, J. Nicholson, J. Everett, 2007, Archives of Toxicology.

Improvement of QT analysis for Evaluating the Proarrhythmic Risk of Drug: The Importance of Spatial and Temporal Dispersion of Repolarization

G. Hanton, 2014 .

Impact of study design on proarrhythmia prediction in the SCREENIT rabbit isolated heart model.

A. Mcharg, R. Wallis, D. Leishman, 2008, Journal of pharmacological and toxicological methods.

Binding of drugs to eye melanin is not predictive of ocular toxicity.

S. Jezequel, G. Hanton, B. Leblanc, 1998, Regulatory toxicology and pharmacology : RTP.

Doppler tissue imaging in assessment of pulmonary hypertension-induced right ventricle dysfunction.

V. Eder, J. Boissière, G. Hanton, 2005, American journal of physiology. Heart and circulatory physiology.

Use of M-mode and Doppler echocardiography to investigate the cardiotoxicity of minoxidil in beagle dogs

G. Hanton, P. Bonnet, M. Gautier, 2004, Archives of Toxicology.

Dexfenfluramine discontinuous treatment does not worsen hypoxia-induced pulmonary vascular remodeling but activates RhoA/ROCK pathway: consequences on pulmonary hypertension.

Coralie Apfeldorfer, J. Hyvelin, E. Schenck, 2009, European journal of pharmacology.

Title : Continuous inhalation of carbon monoxide induces right ventricle ischemia and dysfunction in rat with hypoxic pulmonary hypertension

V. Eder, G. Hanton, P. Bonnet, 2007 .

Continuous inhalation of carbon monoxide induces right ventricle ischemia and dysfunction in rats with hypoxic pulmonary hypertension.

V. Eder, G. Hanton, P. Bonnet, 2007, American journal of physiology. Heart and circulatory physiology.

Echocardiography, a non-invasive method for the investigation of heart morphology and function in laboratory dogs: 1. Method and reference values for M-mode parameters

B. Geffray, A. Lodola, G. Hanton, 1998, Laboratory animals.

An hypothesis for a mechanism underlying hepatotoxin-induced hypercreatinuria

J. Lindon, J. Nicholson, J. Everett, 2003, Archives of Toxicology.

Investigation of the molecular mechanisms preceding PDE4 inhibitor-induced vasculopathy in rats: tissue inhibitor of metalloproteinase 1, a potential predictive biomarker.

G. Hanton, J. Freslon, V. Pawlowski, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

Altered gene expression in rat mesenteric tissue following in vivo exposure to a phosphodiesterase 4 inhibitor.

G. Guigon, D. Ledieu, G. Hanton, 2007, Toxicology and applied pharmacology.

THE QT INTERVAL IN THE DOG ECG: IMPORTANCE IN PRECLINICAL TOXICOLOGY AND RELATIONSHIP TO HEART RATE

G. Hanton, Y. Rabemampianina, K. Nahas, 2001 .

Dexfenfluramine does not worsen but moderates progression of chronic hypoxia-induced pulmonary hypertension.

V. Eder, J. Hyvelin, G. Rochefort, 2006, European journal of pharmacology.

Short communication Dexfenfluramine does not worsen but moderates progression of chronic hypoxia-induced pulmonary hypertension

V. Eder, J. Hyvelin, G. Rochefort, 2006 .

Cardiac safety strategies

G. Hanton, L. Tilbury, 2006, Expert opinion on drug safety.

Plasma triglycerides: an overlooked biomarker of hepatotoxicity in the rat

G. Hanton, J. L. Net, J. Provost, 2003, Comparative Clinical Pathology.

Pharmaco-metabonomic phenotyping and personalized drug treatment

J. Lindon, J. Nicholson, O. Cloarec, 2006, Nature.

Characterisation of the vascular and inflammatory lesions induced by the PDE4 inhibitor CI-1044 in the dog.

P. Comby, G. Hanton, J. Provost, 2008, Toxicology letters.

Characterization of the arteritis induced by infusion of rats with UK-61,260, an inodilator, for 24 h

B. Leblanc, G. Hanton, J. L. Net, 2009, Archives of Toxicology.

Preclinical safety profile of sildenafil

J. Stadler, P. Comby, A. Lodola, 2004, International Journal of Impotence Research.

Miscellaneous: P17: Lethal rhinitis/sinusitis in rodents by aspiration of formulation in gavage studies: Importance of evaluation of the nose

F. Broeckaert, L. Lammens, G. Hanton, 2009 .

The electrocardiogram of the Beagle dog: reference values and effect of sex, genetic strain, body position and heart rate

G. Hanton, Y. Rabemampianina, 2006, Laboratory animals.

Echocardiography, a non-invasive method for the assessment of cardiac function and morphology in preclinical drug toxicology and safety pharmacology

V. Eder, J. Hyvelin, G. Rochefort, 2008, Expert opinion on drug metabolism & toxicology.

An integrated metabonomic approach to describe temporal metabolic disregulation induced in the rat by the model hepatotoxin allyl formate.

John C Lindon, Jeremy K Nicholson, J. Lindon, 2006, Journal of proteome research.

Cardiovascular toxicity of minoxidil in the marmoset.

V. Eder, G. Rochefort, G. Hanton, 2008, Toxicology letters.

Echocardiography a Non-Invasive Method for Investigating Preclinical Drug Toxicity and Safety

G. Hanton, 2014 .

Effect of milrinone on echocardiographic parameters after single dose in Beagle dogs and relationship with drug-induced cardiotoxicity.

G. Hanton, P. Bonnet, M. Gautier, 2005, Toxicology letters.

Echocardiography, a non-invasive method for the investigation of heart morphology and function in laboratory dogs: 2. Effects of minoxidil and quinidine on the left ventricle function

A. Lodola, G. Hanton, 1998, Laboratory animals.

Quantitative relationship between plasma potassium levels and QT interval in beagle dogs

G. Hanton, M. Doubovetzky, A. Racaud, 2007, Laboratory animals.

Hepatotoxin-induced hypercreatinaemia and hypercreatinuria: their relationship to one another, to liver damage and to weakened nutritional status

John C. Lindon, Jeremy K. Nicholson, J. Lindon, 2004, Archives of Toxicology.

Time course toxicogenomic profiles in CD-1 mice after nontoxic and nonlethal hepatotoxic paracetamol administration.

D. Smith, R. Walsh, P. Brain, 2004, Chemical Research in Toxicology.

Temporal variability of QT interval and changes in T wave morphology in dogs as markers of the clinical risk of drug-induced proarrhythmia.

G. Hanton, A. Racaud, G Hanton, 2008, Journal of pharmacological and toxicological methods.