J. Polakowski

发表

Predictive, non-GLP models of secondary pharmacodynamics: putting the best compounds forward.

G. Gintant, R. Fryer, B. Cox, 2005, Current opinion in chemical biology.

Tumor selective antivascular effects of the novel antimitotic compound ABT-751: an in vivo rat regional hemodynamic study

J. Segreti, S. Rosenberg, H. Sham, 2004, Cancer Chemotherapy and Pharmacology.

Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs.

G. Gintant, Y. Koshman, S. Mittelstadt, 2020, Journal of pharmacological and toxicological methods.

Preischemic and Postischemic Administration of AEOL10113 Reduces Infarct Size in a Rat Model of Myocardial Ischemia and Reperfusion

J. Crapo, C. Wegner, B. Cox, 2003, Journal of cardiovascular pharmacology.

Discovery of a well-absorbed, efficacious renin inhibitor, A-74273.

P. Kovar, H. Kleinert, J. Polakowski, 1992, Hypertension.

Vitamin D Receptor Activation Mitigates the Impact of Uremia on Endothelial Function in the 5/6 Nephrectomized Rats

M. Nakane, J. Segreti, J. R. Wu-wong, 2010, International journal of endocrinology.

Hemodynamic effects of potent and selective JNK inhibitors in anesthetized rats: implication for targeting protein kinases in metabolic diseases.

H. Sham, D. Beno, J. Trevillyan, 2007, Bioorganic & medicinal chemistry letters.

Evoked Changes in Cardiovascular Function in Rats by Infusion of Levosimendan, OR-1896 [(R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide], OR-1855 [(R)-6-(4-Aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one], Dobutamine, and Milrinone: Comparative Effects on Peripheral R

J. Segreti, R. Fryer, K. Marsh, 2008, Journal of Pharmacology and Experimental Therapeutics.

Postischemic Administration of CGX-1051, a Peptide from Cone Snail Venom, Reduces Infarct Size in Both Rat and Dog Models of Myocardial Ischemia and Reperfusion

G. Gross, G. Bulaj, R. Layer, 2005, Journal of cardiovascular pharmacology.

Angiotensin II receptor blockade improves renal function in rats with reduced renal mass.

D. Pollock, J. Polakowski, T. Opgenorth, 1993, The Journal of pharmacology and experimental therapeutics.

Dobutamine , and Milrinone : Comparative Effects on Peripheral Resistance , Cardiac Output , dP / dt , Pulse Rate , and Blood Pressure

J. Segreti, R. Fryer, K. Marsh, 2008 .

ETA receptor blockade prevents hypertension associated with exogenous endothelin-1 but not renal mass reduction in the rat.

D. Pollock, J. Polakowski, 1997, Journal of the American Society of Nephrology : JASN.

Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.

K. Longenecker, J. Segreti, H. Sham, 2006, Journal of medicinal chemistry.

Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families.

K. Glaser, S. Davidsen, C. Tse, 2012, Bioorganic & medicinal chemistry letters.

Pharmacological properties and pro-cognitive effects of ABT-288, a potent and selective histamine H 3 receptor antagonist

K. Browman, J. Sullivan, J. Brioni, 2012 .

Differential effects of n-3 polyunsaturated fatty acids on metabolic control and vascular reactivity in the type 2 diabetic ob/ob mouse.

Yung-Sheng Huang, V. Mustad, J. Polakowski, 2006, Metabolism: clinical and experimental.

Comparative effects of levosimendan, OR-1896, OR-1855, dobutamine, and milrinone on vascular resistance, indexes of cardiac function, and O2 consumption in dogs.

R. Fryer, K. Marsh, B. Cox, 2008, American journal of physiology. Heart and circulatory physiology.

Role of endothelin ET(A) receptors in the hypertension produced by 4-day L-nitroarginine methyl ester and cyclosporine treatment.

J. Pollock, D. Pollock, J. Polakowski, 1998, European journal of pharmacology.

Pharmacological comparison of peristaltic effects in rats and mice.

J. Polakowski, R. L. Martin, K. Larson, 2013, Journal of pharmacological and toxicological methods.

Pharmacological Properties and Procognitive Effects of ABT-288, a Potent and Selective Histamine H3 Receptor Antagonist

Min Zhang, Min Zhang, K. Browman, 2012, Journal of Pharmacology and Experimental Therapeutics.

Structure-activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists.

A. Gomtsyan, Jill M. Wetter, J. Segreti, 2006, Bioorganic & Medicinal Chemistry.

A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat

T. Brennan, J. Sullivan, M. Williams, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists.

Chih-Hung Lee, Robert G. Schmidt, C. Surowy, 2008, Bioorganic & medicinal chemistry.

Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.

A. Gomtsyan, J. Segreti, A. King, 2014, Journal of medicinal chemistry.

Discovery of a peptide-based renin inhibitor with oral bioavailability and efficacy.

P. Kovar, S. Rosenberg, H. Kleinert, 1992, Science.

Analgesic and anti-inflammatory effects of A-286501, a novel orally active adenosine kinase inhibitor

Chih-Hung Lee, M. Jarvis, J. Mikusa, 2002, Pain.

Tumour‐selective antivascular effects of the novel anti‐mitotic compound A‐318315: An in vivo rat regional haemodynamic study

J. Segreti, S. Rosenberg, H. Sham, 2010, Clinical and experimental pharmacology & physiology.

Angiotensin blockade reverses hypertension during long-term nitric oxide synthase inhibition.

D. Pollock, J. Polakowski, T. Opgenorth, 1993, Hypertension.

α4β2 neuronal nicotinic receptor positive allosteric modulation: an approach for improving the therapeutic index of α4β2 nAChR agonists in pain.

Chih-Hung Lee, Murali Gopalakrishnan, John Malysz, 2011, Biochemical pharmacology.

PII: S0304-3959(01)00435-3

Chih-Hung Lee, M. Jarvis, J. Mikusa, 2002 .

ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat.

A. Gomtsyan, E. Schweitzer, M. Williams, 2000, The Journal of pharmacology and experimental therapeutics.

Studies directed toward the design of orally active renin inhibitors. 1. Some factors influencing the absorption of small peptides.

D. Egan, S. Rosenberg, J. Polakowski, 1993, Journal of medicinal chemistry.

Studies directed toward the design of orally active renin inhibitors. 2. Development of the efficacious, bioavailable renin inhibitor (2S)-2-benzyl-3- [[(1-methylpiperazin-4-yl)sulfonyl]propionyl]-3-thiazol-4-yl-L-alanine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane (A-7251

P. Kovar, S. Rosenberg, J. Polakowski, 1993, Journal of medicinal chemistry.

Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins.

G. Gintant, Y. Koshman, S. Mittelstadt, 2021, Journal of pharmacological and toxicological methods.

Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins.

G. Gintant, Y. Koshman, S. Mittelstadt, 2021, Journal of pharmacological and toxicological methods.

Automated Blood Sampling in a Canine Telemetry Cardiovascular Model.

Y. Koshman, S. Mittelstadt, J. Polakowski, 2021, Comparative medicine.

Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety.

G. Diaz, E. Bush, H. Sham, 2006, Journal of medicinal chemistry.

K-ATP opener-mediated attenuation of spontaneous bladder contractions in ligature-intact, partial bladder outlet obstructed rats.

J. Sullivan, J. Brioni, J. J. Lynch, 2003, Life sciences.

Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats.

D. Donnelly-roberts, J. Sullivan, M. Nakane, 2004, Proceedings of the National Academy of Sciences of the United States of America.

The evaluation of drug-induced changes in left ventricular function in pentobarbital-anesthetized dogs.

Y. Koshman, S. Mittelstadt, T. Seifert, 2018, Journal of pharmacological and toxicological methods.

Cardiovascular Effects of Torcetrapib in Conscious and Pentobarbital-anesthetized Dogs

G. Gintant, A. King, K. Marsh, 2009, Journal of Cardiovascular Pharmacology.

Effects of selective dopamine receptor subtype agonists on cardiac contractility and regional haemodynamics in rats

J. Segreti, J. Brioni, R. Moreland, 2004, Clinical and experimental pharmacology & physiology.

Pharmacological antagonism of α‐adrenergic agonist induced increases in canine intraurethral pressure in vivo

A. Hancock, M. Brune, S. Buckner, 1995 .

Beneficial effect of ETA receptor blockade in a rat model of radiocontrast-induced nephropathy.

C. Wegner, D. Pollock, D M Pollock, 1997, Renal failure.

Simultaneous measurement of arterial and left ventricular pressure in conscious freely moving rats by telemetry.

J. Segreti, A. King, E. Blomme, 2011, Journal of pharmacological and toxicological methods.

Bimoclomol elevates heat shock protein 70 and cytoprotects rat neonatal cardiomyocytes.

C. Wegner, B. Cox, J. Polakowski, 2002, European journal of pharmacology.

Oral bimoclomol elevates heat shock protein 70 and reduces myocardial infarct size in rats.

G. Diaz, C. Wegner, B. Cox, 2002, European journal of pharmacology.

Negative inotropic effect of a CB2 agonist A-955840 in isolated rabbit ventricular myocytes is independent of CB1 and CB2 receptors.

G. Gintant, G. Diaz, Ruth L. Martin, 2011, Current Drug Safety.

Effect of the Endothelin ETA Receptor Antagonist, BQ-123, on Pressor Responses to Endothelin Family Peptides

D. Pollock, J. Polakowski, T. Opgenorth, 1993 .

Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension.

V. Stoll, G. Gintant, Eric F. Johnson, 2007, Journal of medicinal chemistry.

Suppression of superoxide/hydrogen peroxide production at mitochondrial site IQ decreases fat accumulation, improves glucose tolerance and normalizes fasting insulin concentration in mice fed a high-fat diet.

J. Segreti, M. Brand, T. Vortherms, 2023, Free radical biology & medicine.

Screening for cardiovascular safety: a structure-activity approach for guiding lead selection of melanin concentrating hormone receptor 1 antagonists.

Ju Gao, Anil Vasudevan, John K Lynch, 2006, Journal of medicinal chemistry.

Pharmacological Properties and Procognitive Effects of ABT-288, a Potent and Selective Histamine H3 Receptor Antagonist

Min Zhang, K. Browman, J. Sullivan, 2012, Journal of Pharmacology and Experimental Therapeutics.

(Metabolism, 55:1365-1374)Differential effects of n-3 polyunsaturated fatty acids on metabolic control and vascular reactivity in the type diabetic ob/ob mouse

Yung-Sheng Huang, V. Mustad, J. Polakowski, 2006 .