Lei Yang

发表

Physagulide Q suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells by regulating the ROS-JAK2/Src-STAT3 signaling pathway

Lingyi Kong, Yanwei Yang, Lei Yang, 2017 .

Flavonostilbenes from Sophora alopecuroides L. as multidrug resistance associated protein 1 (MRP1) inhibitors

Lingyi Kong, Yuan-zheng Xia, Lei Yang, 2014, Natural product research.

Discovery of an Orally Selective Inhibitor of Signal Transducer and Activator of Transcription 3 Using Advanced Multiple Ligand Simultaneous Docking.

K. Yu, Jiayuh Lin, Hongbin Sun, 2017, Journal of medicinal chemistry.

Tomentodione M sensitizes multidrug resistant cancer cells by decreasing P-glycoprotein via inhibition of p38 MAPK signaling

Lingyi Kong, Chao Han, Jianguang Luo, 2017, Oncotarget.

Polyphyllin I induced-apoptosis is enhanced by inhibition of autophagy in human hepatocellular carcinoma cells.

Lingyi Kong, Lei Yang, Chao Zhang, 2015, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Ginkgolide B Targets and Inhibits Creatine Kinase B to Regulate the CCT/TRiC-SK1 Axis and Exerts Pro-Angiogenic Activity in Middle Cerebral Artery Occlusion Mice.

L. Kong, Jun Luo, Lei Yang, 2022, Pharmacological research.

Diverse tritepenoids from the fruits of Walsura robusta and their reversal of multidrug resistance phenotype in human breast cancer cells.

Yucheng Gu, Jun Luo, Lingyi Kong, 2017, Phytochemistry.

Icariside II-induced mitochondrion and lysosome mediated apoptosis is counterbalanced by an autophagic salvage response in hepatoblastoma.

Lingyi Kong, Yuan-zheng Xia, Lei Yang, 2015, Cancer letters.

ATF4 destabilizes RET through nonclassical GRP78 inhibition to enhance chemosensitivity to bortezomib in human osteosarcoma

Hao Zhang, Jun Luo, Lingyi Kong, 2019, Theranostics.

Anti-proliferation of triple-negative breast cancer cells with physagulide P: ROS/JNK signaling pathway induces apoptosis and autophagic cell death

Lingyi Kong, Hao Zhang, Yanwei Yang, 2017, Oncotarget.

Cloning, enzyme characterization of recombinant human Eg5 and the development of a new inhibitor.

Q. You, Cheng Jiang, Lei Yang, 2008, Biological & pharmaceutical bulletin.

Icariin enhances cytotoxicity of doxorubicin in human multidrug-resistant osteosarcoma cells by inhibition of ABCB1 and down-regulation of the PI3K/Akt pathway.

Lingyi Kong, Yuan-zheng Xia, Lei Yang, 2015, Biological & pharmaceutical bulletin.

C-Phycocyanin inhibits hepatic gluconeogenesis and increases glycogen synthesis via activating Akt and AMPK in insulin resistance hepatocytes.

Lei Yang, Y. Ou, Mu-Yun Gong, 2018, Food & function.

Investigation on the substitution effects of the flavonoids as potent anticancer agents: a structure–activity relationships study

Wei Liu, Q. Guo, Xiaobing Wang, 2012, Medicinal Chemistry Research.

GRP78 inhibition enhances ATF4-induced cell death by the deubiquitination and stabilization of CHOP in human osteosarcoma.

Jun Luo, Lingyi Kong, Jie Luo, 2017, Cancer letters.

CPUYJ039, a newly synthesized benzimidazole‐based compound, is proved to be a novel inducer of apoptosis in HCT116 cells with potent KSP inhibitory activity

Q. You, Q. Guo, Cheng Jiang, 2011, The Journal of pharmacy and pharmacology.

Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents.

Q. You, Cheng Jiang, Lei Yang, 2010, Bioorganic & medicinal chemistry.

Design, synthesis and evaluation of tetrahydroisoquinolines as new kinesin spindle protein inhibitors.

J. Chern, Q. You, Q. Guo, 2009, Chemical & pharmaceutical bulletin.

Quercitrin alleviates cartilage extracellular matrix degradation and delays ACLT rat osteoarthritis development: An in vivo and in vitro study

Lingyi Kong, Lei Yang, Chao Zhang, 2020, Journal of advanced research.

Alopecurone B reverses doxorubicin-resistant human osteosarcoma cell line by inhibiting P-glycoprotein and NF-kappa B signaling.

Lingyi Kong, Yuan-zheng Xia, Lei Yang, 2015, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Reversal effects of traditional Chinese herbs on multidrug resistance in cancer cells

L. Kong, Junsong Wang, D. Wei, 2011, Natural product research.

Polyphyllin I promotes cell death via suppressing UPR-mediated CHOP ubiquitination and degradation in non-small cell lung cancer.

Lingyi Kong, Mingming Liu, Rui-Fang Dong, 2021, Chinese journal of natural medicines.

Tooniliatone A sensitizes multidrug resistant cancer cells by decreasing Bcl-xL via activation of JNK MAPK signaling.

Lingyi Kong, Yuan-zheng Xia, Lei Yang, 2019, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Quantitative Evaluation of 4-Coumarate: CoA Ligase (4CL) Activity and Correlated Chemical Constituents in Four Plant Materials by Chromatographic Analysis

Xiaobing Wang, L. Kong, Lei Yang, 2010 .

Calyxin Y sensitizes cisplatin-sensitive and resistant hepatocellular carcinoma cells to cisplatin through apoptotic and autophagic cell death via SCF βTrCP-mediated eEF2K degradation

Lingyi Kong, Jian-Li Lei, Yuan-zheng Xia, 2017, Oncotarget.

Simple and Efficient Synthesis of Belinostat

Yihua Zhang, Xiaowen Xue, Lei Yang, 2010 .

Sophoraflavanone G from Sophora alopecuroides inhibits lipopolysaccharide-induced inflammation in RAW264.7 cells by targeting PI3K/Akt, JAK/STAT and Nrf2/HO-1 pathways.

Jun Luo, Lingyi Kong, Yuan-zheng Xia, 2016, International immunopharmacology.

(±)-Melicolones A and B, rearranged prenylated acetophenone stereoisomers with an unusual 9-oxatricyclo[3.2.1.1(3,8)]nonane core from the leaves of Melicope ptelefolia.

Hequan Yao, Xiaobing Wang, L. Kong, 2015, Organic letters.

Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.

Sai-Sai Xie, Xiaobing Wang, Lingyi Kong, 2013, European journal of medicinal chemistry.

De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors.

Q. You, Q. Guo, Cheng Jiang, 2011, Bioorganic & medicinal chemistry.

Protective effect of trans-δ-viniferin against high glucose-induced oxidative stress in human umbilical vein endothelial cells through the SIRT1 pathway

L. Kong, Chao Han, Jianguang Luo, 2016, Free radical research.

Sarglaperoxides A and B, Sesquiterpene-Normonoterpene Conjugates with a Peroxide Bridge from the Seeds of Sarcandra glabra.

L. Kong, Ming-Hua Yang, Rui-Huan Liu, 2016, Organic letters.

Exploration of possible biosynthetic origin of 1/8/9-orthoester moiety in phragmalins

L. Kong, Jun Luo, Lei Yang, 2014 .

Physakengose G induces apoptosis via EGFR/mTOR signaling and inhibits autophagic flux in human osteosarcoma cells.

Lingyi Kong, Jie Luo, Yuan-zheng Xia, 2018, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Spirotrichilins A and B: Two Rearranged Spirocyclic Limonoids from Trichilia connaroides.

Xiaobing Wang, L. Kong, Ming-Hua Yang, 2016, Organic letters.

Anti-neuroinflammatory effect of Sophoraflavanone G from Sophora alopecuroides in LPS-activated BV2 microglia by MAPK, JAK/STAT and Nrf2/HO-1 signaling pathways.

Meng Chen, Lingyi Kong, Yuan-zheng Xia, 2016, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Reversal of multidrug resistance by icaritin in doxorubicin-resistant human osteosarcoma cells.

Lingyi Kong, Yuan-zheng Xia, Lei Yang, 2018, Chinese journal of natural medicines.

Combining GRP78 suppression and MK2206-induced Akt inhibition decreases doxorubicin-induced P-glycoprotein expression and mitigates chemoresistance in human osteosarcoma

Q. Guo, Lingyi Kong, Yuan-zheng Xia, 2016, Oncotarget.

Diverse chemosensitizing 8,9-secolindenane-type sesquiterpenoid oligomers and monomers from Sarcandra glabra.

L. Kong, Ding-qiao Xu, Jun Luo, 2019, The Journal of organic chemistry.

Schisandrin A enhances the cytotoxicity of doxorubicin by the inhibition of nuclear factor-kappa B signaling in a doxorubicin-resistant human osteosarcoma cell line

Lingyi Kong, Yuan-zheng Xia, Lei Yang, 2015 .

Calyxin Y induces hydrogen peroxide-dependent autophagy and apoptosis via JNK activation in human non-small cell lung cancer NCI-H460 cells.

Xiaobing Wang, Junsong Wang, Lingyi Kong, 2013, Cancer letters.

The mitochondrial genome of the brown citrus aphid Aphis (Toxoptera) citricidus: Insights into the repeat regions in aphids and phylogenetic implications.

N. Lang, Jinjun Wang, Y. Tao, 2019, International journal of biological macromolecules.

Chrysanthemulide A induces apoptosis through DR5 upregulation via JNK‐mediated autophagosome accumulation in human osteosarcoma cells

Lingyi Kong, Yuan-zheng Xia, Hao Zhang, 2019, Journal of cellular physiology.

Avicularin suppresses cartilage extracellular matrix degradation and inflammation via TRAF6/MAPK activation.

Ming-Hui Sun, Lingyi Kong, Lei Yang, 2021, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Walsuronoid B induces mitochondrial and lysosomal dysfunction leading to apoptotic rather than autophagic cell death via ROS/p53 signaling pathways in liver cancer

Lingyi Kong, Jian-Li Lei, Yuan-zheng Xia, 2017, Biochemical pharmacology.

Eucalrobusone C suppresses cell proliferation and induces ROS-dependent mitochondrial apoptosis via the p38 MAPK pathway in hepatocellular carcinoma cells.

Lingyi Kong, Lei Yang, Chao Zhang, 2017, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Glycyrrhetinic Acid Functionalized Graphene Oxide for Mitochondria Targeting and Cancer Treatment In Vivo.

Zunfeng Liu, Q. Guo, Hongbin Sun, 2018, Small.

Icariside II, a natural mTOR inhibitor, disrupts aberrant energy homeostasis via suppressing mTORC1-4E-BP1 axis in sarcoma cells

Q. Guo, Lingyi Kong, Jianguang Luo, 2016, Oncotarget.

Cytotoxic withanolides from Physalis angulata var. villosa and the apoptosis-inducing effect via ROS generation and the activation of MAPK in human osteosarcoma cells

Lingyi Kong, Jianguang Luo, Lei Yang, 2016 .

The Chk2-PKM2 axis promotes metabolic control of vasculogenic mimicry formation in p53-mutated triple-negative breast cancer

Lingyi Kong, Yuan-zheng Xia, Hao Zhang, 2021, Oncogene.

Meso‐Hannokinol inhibits breast cancer bone metastasis via the ROS/JNK/ZEB1 axis

Lingyi Kong, Lei Yang, Chao Zhang, 2023, Phytotherapy research : PTR.

A rapid and sensitive LC-MS/MS assay for the determination of berbamine in rat plasma with application to preclinical pharmacokinetic study.

Junsong Wang, Lingyi Kong, Lei Yang, 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Vielanin K enhances doxorubicin-induced apoptosis via activation of IRE1α- TRAF2 - JNK pathway and increases mitochondrial Ca2 + influx in MCF-7 and MCF-7/MDR cells.

Lingyi Kong, Jianguang Luo, Yuan-zheng Xia, 2020, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Quantitative Evaluation of 4-Coumarate: CoA Ligase (4CL) Activity and Correlated Chemical Constituen

Xiaobing Wang, L. Kong, Lei Yang, 2010 .

Type B polycyclic polyprenylated acylphloroglucinols from the roots of Hypericum beanii.

Jun Luo, Lingyi Kong, Lei Yang, 2021, Chinese journal of natural medicines.

Vielanin P enhances the cytotoxicity of doxorubicin via the inhibition of PI3K/Nrf2-stimulated MRP1 expression in MCF-7 and K562 DOX-resistant cell lines.

Lingyi Kong, Yuan-zheng Xia, Lei Yang, 2019, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Cassane-type diterpenoids from the seed kernels of Caesalpinia bonduc.

Xiaobing Wang, Jun Luo, Lingyi Kong, 2014, Fitoterapia.

Trichiconlides CF, four new limonoids with 1,2-seco phragmalin-type carbon skeleton from the fruits of Trichilia connaroides.

Xiaobing Wang, Jun Luo, Lingyi Kong, 2018, Fitoterapia.

Relationship of chemical structure to in vitro anti-inflammatory activity of tirucallane triterpenoids from the stem barks of Aphanamixis grandifolia.

L. Kong, Junsong Wang, Lei Yang, 2012, Chemical & pharmaceutical bulletin.

Oral multivalent epitope vaccine, based on UreB, HpaA, CAT, and LTB, for prevention and treatment of Helicobacter pylori infection in C57BL / 6 mice

L. Kong, Lei Yang, W. Xie, 2021, Helicobacter.

How Long Will It Take to Launch an Effective Helicobacter pylori Vaccine for Humans?

Lei Yang, Wenfeng Zhao, Songhui Li, 2023, Infection and drug resistance.

Investigation on the substitution effects of the flavonoids as potent anticancer agents: a structure–activity relationships study

Wei Liu, Q. Guo, Xiaobing Wang, 2012, Medicinal Chemistry Research.

Toonasindiynes A-F, new polyacetylenes from Toona sinensis with cytotoxic and anti-inflammatory activities.

Jun Luo, Lingyi Kong, Yuan-zheng Xia, 2020, Fitoterapia.

Blockade of epidermal growth factor receptor/mammalian target of rapamycin pathway by Icariside II results in reduced cell proliferation of osteosarcoma cells.

Lingyi Kong, Lei Yang, Chao Zhang, 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Reversal of multidrug resistance in human breast cancer cells by Curcuma wenyujin and Chrysanthemum indicum.

Zhimin Chen, L. Kong, Junsong Wang, 2011, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Icariside II-induced mitochondrion and lysosome mediated apoptosis is counterbalanced by an autophagic salvage response in hepatoblastoma.

Lingyi Kong, Yuan-zheng Xia, Lei Yang, 2015, Cancer letters.

Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP.

Q. You, Cheng Jiang, Lei Yang, 2010, Bioorganic & medicinal chemistry.