Hilda H. Brown

发表

Enhanced Neurite Outgrowth and Regeneration in ALS Resistant Motor Neurons from SOD1 Mutant Mouse Models

Jacob I. Ayers, Eric A. Vitriol, D. Borchelt, 2018 .

ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons

Jacob I. Ayers, Eric A. Vitriol, D. Borchelt, 2018, iScience.

ALS-linked SOD1 Mutants Enhance Outgrowth, Branching, and the Formation of Actin-Based Structures in Adult Motor Neurons

Jacob I. Ayers, Eric A. Vitriol, D. Borchelt, 2018, bioRxiv.

Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy

D. Borchelt, M. Swanson, Jada Lewis, 2018, Scientific Reports.

Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice.

D. Borchelt, Guilian M. Xu, S. Fromholt, 2015, Human molecular genetics.

An Analysis of Interactions between Fluorescently-Tagged Mutant and Wild-Type SOD1 in Intracellular Inclusions

D. Borchelt, Keith W Crosby, Hilda H. Brown, 2013, PloS one.

Features of wild-type human SOD1 limit interactions with misfolded aggregates of mouse G86R Sod1

D. Borchelt, Keith W Crosby, M. Prudencio, 2013, Molecular Neurodegeneration.

Substantially elevating the levels of αB‐crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation

D. Borchelt, Zoe B Siemienski, Keith W Crosby, 2015, Journal of neurochemistry.

Generation of a new transgenic mouse model for assessment of tau gene silencing therapies

D. Borchelt, Jada Lewis, S. Fromholt, 2016, Alzheimer's Research & Therapy.

Metal-deficient aggregates and diminished copper found in cells expressing SOD1 mutations that cause ALS

D. Borchelt, S. Vogt, L. Miller, 2014, Front. Aging Neurosci..

Distinctive features of the D101N and D101G variants of superoxide dismutase 1; two mutations that produce rapidly progressing motor neuron disease

Jacob I. Ayers, D. Borchelt, J. Valentine, 2014, Journal of neurochemistry.

Role of Disulfide Cross-Linking of Mutant SOD1 in the Formation of Inclusion-Body-Like Structures

D. Borchelt, Hilda H. Brown, Brittany L. Roberts, 2012, PloS one.

Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3

D. Borchelt, Jada Lewis, Zoe B Siemienski, 2018, Acta Neuropathologica Communications.

Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype

D. Borchelt, M. Swanson, L. Notterpek, 2017, Acta Neuropathologica Communications.

Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype

D. Borchelt, M. Swanson, L. Notterpek, 2016, Acta Neuropathologica Communications.

A novel variant of human superoxide dismutase 1 harboring amyotrophic lateral sclerosis‐associated and experimental mutations in metal‐binding residues and free cysteines lacks toxicity in vivo

D. Borchelt, J. Valentine, J. Whitelegge, 2012, Journal of neurochemistry.

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

Jacob I. Ayers, D. Borchelt, N. Cashman, 2020, PloS one.

Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis

Jacob I. Ayers, D. Borchelt, P. Hart, 2019, G3: Genes, Genomes, Genetics.

Analysis of Mutant SOD1 Electrophoretic Mobility by Blue Native Gel Electrophoresis; Evidence for Soluble Multimeric Assemblies

D. Borchelt, Hilda H. Brown, 2014, PloS one.

N-terminal sequences in Matrin 3 mediate phase separation into droplet-like structures that recruit TDP43 variants lacking RNA binding elements

D. Borchelt, Hilda H. Brown, E. Rodríguez-Lebrón, 2019, Laboratory Investigation.

Subcellular Localization of Matrin 3 Containing Mutations Associated with ALS and Distal Myopathy

D. Borchelt, Jada Lewis, C. Janus, 2015, PloS one.

Experimental mutagenesis of huntingtin to map cleavage sites: different outcomes in cell and mouse models.

D. Borchelt, Andrew T. N. Tebbenkamp, L. Tessarollo, 2014, Journal of Huntington's disease.

ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons

Eric A. Vitriol, D. Borchelt, T. Golde, 2019, iScience.

Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3

D. Borchelt, Jada Lewis, S. Fromholt, 2018, Acta neuropathologica communications.

Vulnerability of newly synthesized proteins to proteostasis stress

D. Borchelt, Amrutha Pattamatta, Hilda H. Brown, 2016, Journal of Cell Science.

Correction: Identification of Proteins Sensitive to Thermal Stress in Human Neuroblastoma and Glioma Cell Lines

D. Borchelt, M. Gold, S. Stevens, 2012, PLoS ONE.

Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative.

D. Borchelt, Andrew T. N. Tebbenkamp, R. Mandel, 2011, Human molecular genetics.

Identification of Proteins Sensitive to Thermal Stress in Human Neuroblastoma and Glioma Cell Lines

D. Borchelt, M. Gold, S. Stevens, 2012, PloS one.

Analysis of Proteolytic Processes and Enzymatic Activities in the Generation of Huntingtin N-Terminal Fragments in an HEK293 Cell Model

D. Borchelt, Andrew T. N. Tebbenkamp, T. Golde, 2012, PloS one.

Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype

D. Borchelt, M. Swanson, L. Notterpek, 2016, Acta neuropathologica communications.

Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype

D. Borchelt, M. Swanson, L. Notterpek, 2016, Acta neuropathologica communications.

Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models

Jacob I. Ayers, D. Borchelt, J. Ayers, 2018, PloS one.

Loss of charge at solvent exposed Lys residues does not induce the aggregation of superoxide dismutase 1

Jacob I. Ayers, D. Borchelt, J. Ayers, 2018, bioRxiv.

Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models

Jacob I. Ayers, D. Borchelt, J. Valentine, 2017, Journal of neurochemistry.

Generation of a new transgenic mouse model for assessment of tau gene silencing therapies

D. Borchelt, Jada Lewis, S. Fromholt, 2016, Alzheimer's Research & Therapy.