J. Tikkanen

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VEGFR-1 and -2 Regulate Inflammation, Myocardial Angiogenesis, and Arteriosclerosis in Chronically Rejecting Cardiac Allografts

K. Alitalo, D. Hicklin, L. Alhonen, 2007, Arteriosclerosis, thrombosis, and vascular biology.

Eosinophils in transbronchial biopsies: a predictor of chronic lung allograft dysfunction and reduced survival after lung transplantation — a retrospective single‐center cohort study

G. Tomlinson, S. Keshavjee, D. Hwang, 2020, Transplant international : official journal of the European Society for Organ Transplantation.

Extending cytomegalovirus prophylaxis in high‐risk (D+/R−) lung transplant recipients from 6 to 9 months reduces cytomegalovirus disease: A retrospective study

G. Tomlinson, S. Keshavjee, M. Binnie, 2020, Transplant infectious disease : an official journal of the Transplantation Society.

Upregulation of activin-B and follistatin in pulmonary fibrosis – a translational study using human biopsies and a specific inhibitor in mouse fibrosis models

M. Rönty, M. Myllärniemi, O. Leppäranta, 2014, BMC Pulmonary Medicine.

Bone morphogenetic protein-inducer tilorone identified by high-throughput screening is antifibrotic in vivo.

M. Myllärniemi, O. Leppäranta, K. Koli, 2013, American journal of respiratory cell and molecular biology.

Natural course and risk factors for impaired renal function during the first year after heart transplantation.

J. Lommi, J. Jokinen, K. Lemström, 2010, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Postoperative Management of Lung Transplant Recipients in the Intensive Care Unit

S. Keshavjee, N. Ferguson, L. Del Sorbo, 2021, Anesthesiology.

Intragraft donor-specific antibodies and lung transplantation

K. Tinckam, J. Tikkanen, 2019, European Respiratory Journal.

Donor Simvastatin Treatment Abolishes Rat Cardiac Allograft Ischemia/Reperfusion Injury and Chronic Rejection Through Microvascular Protection

P. Neuvonen, S. Syrjälä, M. Keränen, 2011, Circulation.

Role of platelet-derived growth factor and vascular endothelial growth factor in obliterative airway disease.

J. Wood, A. Nykänen, K. Lemström, 2006, American journal of respiratory and critical care medicine.

CMV infection and allograft rejection.

K. Lemström, P. Koskinen, J. Tikkanen, 1998, Transplantation proceedings.

Inhibition of tumor necrosis factor-alpha attenuates myocardial remodeling in rat cardiac allografts.

V. Pulkkinen, K. Lemström, P. Koskinen, 2006, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Role of Endogenous Endothelin‐1 in Transplant Obliterative Airway Disease in the Rat

K. Lemström, P. Koskinen, J. Tikkanen, 2004, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Identification and inhibition of specific pathways leading to transplant obliterative bronchiolitis : an experimental approach in the rat

J. Tikkanen, 2003 .

Tacrolimus treatment effectively inhibits progression of obliterative airway disease even at later stages of disease development.

A. Nykänen, K. Lemström, P. Koskinen, 2008, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Dual role of vascular endothelial growth factor in experimental obliterative bronchiolitis.

M. Jeltsch, R. Krebs, A. Nykänen, 2005, American journal of respiratory and critical care medicine.

Platelet-derived growth factor regulates cytomegalovirus infection-enhanced obliterative bronchiolitis in rat tracheal allografts

R. Krebs, K. Lemström, C. Bruggeman, 2004, Transplantation.

DUAL ROLE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN EXPERIMENTAL OBLITERATIVE BRONCHIOLITIS

R. Krebs, A. Nykänen, K. Lemström, 2004, American journal of respiratory and critical care medicine.

Inhibition of tumor necrosis factor-alpha attenuates myocardial remodeling in rat cardiac allografts.

V. Pulkkinen, K. Lemström, P. Koskinen, 2006, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Effect of simvastatin on development of obliterative airway disease: an experimental study.

S. Syrjälä, M. Keränen, R. Krebs, 2012, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

α1-Anti-trypsin improves function of porcine donor lungs during ex-vivo lung perfusion.

S. Keshavjee, D. Hwang, M. Cypel, 2017, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Alpha-1 Antitrypsin Improves Function of Porcine Donor Lungs during Ex Vivo Lung PerfusionA 1 AT treatment of donor lungs during EVLP

S. Keshavjee, D. Hwang, M. Cypel, 2017 .

The Association Between Extravascular Lung Water and Critical Care Outcomes Following Bilateral Lung Transplantation

S. Keshavjee, J. Granton, D. Scales, 2022, Transplantation direct.

Lung transplantation for cystic fibrosis.

S. Keshavjee, T. Waddell, M. Cypel, 2020, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Prevention of viral transmission during lung transplantation with hepatitis C-viraemic donors: an open-label, single-centre, pilot trial.

Arthur S Slutsky, V. Bagnato, C. Kurachi, 2020, The Lancet. Respiratory medicine.

Long-term Outcomes of Lung Transplant With Ex Vivo Lung Perfusion.

S. Keshavjee, T. Waddell, M. Cypel, 2019, JAMA surgery.

Functional outcomes and quality of life after normothermic ex vivo lung perfusion lung transplantation.

S. Keshavjee, T. Waddell, M. Cypel, 2015, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Cytological monitoring of peripheral blood, bronchoalveolar lavage fluid, and transbronchial biopsy specimens during acute rejection and cytomegalovirus infection in lung and heart–lung allograft recipients

K. Lemström, E. Taskinen, S. Pakkala, 2001, Clinical transplantation.

Pig lung transplant survival model

S. Keshavjee, M. Cypel, Mingyao Liu, 2018, Nature Protocols.

Vascular endothelial growth factor plays a major role in development of experimental obliterative bronchiolitis.

D. Hicklin, R. Krebs, K. Lemström, 2006, Transplantation proceedings.

Combined Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor Inhibition in Rat Cardiac Allografts: Beneficial Effects on Inflammation and Smooth Muscle Cell Proliferation

J. Wood, R. Krebs, A. Nykänen, 2005, Transplantation.

Lung Transplantation With Donation After Circulatory Determination of Death Donors and the Impact of Ex Vivo Lung Perfusion

S. Keshavjee, T. Waddell, M. Cypel, 2015, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

De Novo DQ Donor-Specific Antibodies Are Associated with Chronic Lung Allograft Dysfunction after Lung Transplantation.

S. Keshavjee, S. Kim, M. Binnie, 2016, American journal of respiratory and critical care medicine.

PDGF receptor inhibition prevents cardiac allograft arteriosclerosis in cholesterol-fed rabbits.

E. Buchdunger, K. Lemström, P. Koskinen, 2001, Transplantation proceedings.

Blockade of CD28/B7-2 costimulation inhibits experimental obliterative bronchiolitis in rat tracheal allografts: suppression of helper T cell type1-dominated immune response.

K. Lemström, P. Koskinen, J. Tikkanen, 2002, American journal of respiratory and critical care medicine.

Cytomegalovirus infection accelerates experimental obliterative bronchiolitis via platelet-derived growth factor upregulation.

K. Lemström, C. Bruggeman, P. Koskinen, 1997, Transplantation Proceedings.

Epithelial cell death markers in bronchoalveolar lavage correlate with chronic lung allograft dysfunction subtypes and survival in lung transplant recipients—a single‐center retrospective cohort study

N. Mitsakakis, S. Keshavjee, E. Huszti, 2019, Transplant international : official journal of the European Society for Organ Transplantation.

The fraction of sensitization among lung transplant recipients in a transplant center in Japan

H. Niikawa, Y. Okada, H. Oishi, 2020, BMC Pulmonary Medicine.

CD28-B7-2 but not CD28-B7-1 interaction is required for T cell costimulation in experimental obliterative bronchiolitis in the rat.

K. Lemström, P. Koskinen, J. Tikkanen, 2001, Transplantation proceedings.

Late Onset Invasive Pulmonary Aspergillosis in Lung Transplant Recipients in the Setting of a Targeted Prophylaxis/Preemptive Antifungal Therapy Strategy

Deepali Kumar, A. Humar, S. Keshavjee, 2020, Transplantation.

Airway Oscillometry Detects Spirometric-Silent Episodes of Acute Cellular Rejection.

M. Cypel, C. Ryan, C. Chow, 2020, American journal of respiratory and critical care medicine.

The impact of first untreated subclinical minimal acute rejection on risk for chronic lung allograft dysfunction or death after lung transplantation

S. Keshavjee, D. Hwang, E. Huszti, 2020, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Drug-resistant cytomegalovirus infection after lung transplantation: Incidence, characteristics, and clinical outcomes.

A. Humar, S. Keshavjee, M. Cypel, 2019, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Detailed analysis of cell profiles in peripheral blood, bronchoalveolar lavage fluid, and transbronchial biopsy specimens during acute rejection and CMV infection in lung and heart-lung allograft recipients.

K. Lemström, E. Taskinen, S. Pakkala, 1999, Transplantation proceedings.

Letermovir as Salvage Therapy for CMV Infection in Transplant Recipients.

Deepali Kumar, A. Humar, A. Viswabandya, 2020, Transplantation.

Immunobiology of Chronic Cardiac Allograft Rejection

K. Lemström, P. Koskinen, J. Tikkanen, 2001 .

Cytomegalovirus infection and cardiac allograft vasculopathy

K. Lemström, P. Koskinen, J. Tikkanen, 1999, Transplant infectious disease : an official journal of the Transplantation Society.

Epstein‐Barr virus‐associated smooth muscle tumors after lung transplantation

M. Binnie, S. Cleary, J. Tikkanen, 2019, Transplant infectious disease : an official journal of the Transplantation Society.

Innate and adaptive immune responses in obliterative airway disease in rat tracheal allografts.

S. Syrjälä, R. Krebs, A. Nykänen, 2011, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Prevention of cytomegalovirus infection-enhanced experimental obliterative bronchiolitis by antiviral prophylaxis or immunosuppression in rat tracheal allografts.

K. Lemström, C. Bruggeman, P. Koskinen, 2001, American journal of respiratory and critical care medicine.

Bronchoalveolar lavage cytokine-based risk stratification of minimal acute rejection in clinically stable lung transplant recipients.

S. Keshavjee, E. Huszti, S. Juvet, 2021, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Strongyloides hyper-infection in a lung transplant recipient: Case report and review of the literature.

Ian A. Brasg, C. Rotstein, C. Chaparro, 2022, Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada.

Inhibition of VEGF-receptors 1 and 2 attenuates NK cell and innate immune responses in an experimental model for obliterative bronchiolitis.

A. Raissadati, R. Krebs, K. Lemström, 2021, The American journal of pathology.

Identification of risk epitope mismatches associated with de novo donor‐specific HLA antibody development in cardiothoracic transplantation

S. Keshavjee, H. Ross, Y. Moayedi, 2018, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Ureaplasma spp. and Mycoplasma hominis PCR in Respiratory Samples from Lung Transplant Recipients with Hyperammonemia Syndrome and Cerebral Edema

Deepali Kumar, A. Humar, S. Keshavjee, 2018 .

Risk assessment of chronic lung allograft dysfunction phenotypes: Validation and proposed refinement of the 2019 International Society for Heart and Lung Transplantation classification system.

S. Keshavjee, E. Huszti, S. Moshkelgosha, 2020, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Phenotyping CLAD after single lung transplant: Limits and prognostic assessment of the 2019 ISHLT classification system.

E. Huszti, L. Singer, J. Tikkanen, 2022, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

The accuracy of forced vital capacity for diagnosing restrictive allograft syndrome and mixed phenotype of chronic lung allograft dysfunction

S. Keshavjee, E. Huszti, S. Moshkelgosha, 2021, European Respiratory Journal.

Role of angiogenic growth factors in transplant coronary artery disease

R. Krebs, A. Nykänen, K. Lemström, 2004, Annals of medicine.

Vascular Endothelial Growth Factor Enhances Cardiac Allograft Arteriosclerosis

J. Wood, K. Alitalo, S. Ylä-Herttuala, 2002, Circulation.

Endothelin-1 is biologically active in experimental rat obliterative bronchiolitis.

V. Pulkkinen, K. Lemström, P. Koskinen, 2001, Transplantation proceedings.

Increased myeloid cell hypoxia-inducible factor-1 delays obliterative airway disease in the mouse.

A. Raissadati, M. Keränen, R. Krebs, 2016, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Critical role of VEGF-C/VEGFR-3 signaling in innate and adaptive immune responses in experimental obliterative bronchiolitis.

S. Ylä-Herttuala, M. Jeltsch, J. Jokinen, 2012, The American journal of pathology.

Pulmonary epithelial markers in phenotypes of chronic lung allograft dysfunction.

S. Keshavjee, E. Huszti, S. Moshkelgosha, 2023, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Donor and recipient human leukocyte antigen-G polymorphisms modulate the risk of adverse immunologic events following lung transplantation.

V. Rao, S. Keshavjee, D. Delgado, 2023, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Significance of phenotype change after chronic lung allograft dysfunction onset

S. Keshavjee, E. Huszti, C. Chow, 2021, Transplant international : official journal of the European Society for Organ Transplantation.

Risk Assessment of Chronic Lung Allograft Dysfunction Phenotypes: Validation and Proposed Refinement of the 2019 ISHLT Classification System.

S. Keshavjee, E. Huszti, S. Moshkelgosha, 2020, The Journal of Heart and Lung Transplantation.

Donor human leukocyte antigen-G single nucleotide polymorphisms are associated with post-lung transplant mortality

G. Tomlinson, V. Rao, S. Keshavjee, 2019, European Respiratory Journal.

The Impact of Inadequate ('AX') Transbronchial Biopsies on Post-lung Transplant CLAD or Death.

S. Keshavjee, E. Huszti, L. Singer, 2020, Transplantation.

Feasibility of Avoiding Higher Risk Epitope and Allele HLA Mismatch to Reduce de novo Donor Specific Antibody (dnDSA) in Lung Transplantation

S. Keshavjee, M. Cypel, K. Tinckam, 2018 .

(955) - Automating the Diagnosis of Potential CLAD and Its Subtypes in Lung Transplant Recipients

S. Keshavjee, J. Belperio, S. Juvet, 2017 .

Connective-Tissue Growth Factor (CTGF/CCN2) Contributes to TGF-β1-Induced Lung Fibrosis

S. Keshavjee, M. Kolb, K. Ask, 2020, bioRxiv.

Platelet-derived growth factor receptor inhibition reduces allograft arteriosclerosis of heart and aorta in cholesterol-fed rabbits

E. Buchdunger, R. Krebs, K. Lemström, 2003, Transplantation.

Cytomegalovirus-induced allograft vascular disease

V. Pulkkinen, K. Lemström, P. Koskinen, 2000 .

Effect of Cytomegalovirus on Cardiac Allograft Arteriosclerosis—Indirect or Direct?

K. Lemström, P. Koskinen, J. Tikkanen, 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

MONOTHERAPY WITH EVEROLIMUS OR FTY720 AMELIORATES CHRONIC ALLOGRAFT NEPHROPATHY (CAN) AT LATE STAGES, WHILE THE COMBINATION WITH CYCLOSPORINE DOES NOT TREAT CAN

D. Hicklin, Yan Wu, U. Heemann, 2006 .

Intra-subject variability in oscillometry correlates with acute rejection and CLAD post-lung transplant

S. Keshavjee, E. Huszti, M. Cypel, 2023, Frontiers in Medicine.

Connective-Tissue Growth Factor (CTGF/CCN2) Contributes to TGF-β1-Induced Lung Fibrosis.

S. Keshavjee, M. Kolb, K. Tsubouchi, 2021, American journal of respiratory cell and molecular biology.

De Novo DQ Donor-Specific Antibodies Are Associated With Chronic Lung Allograft Dysfunction

S. Keshavjee, T. Waddell, M. Cypel, 2014 .

Letermovir as Salvage Therapy for Cytomegalovirus Infection in Transplant Recipients.

Deepali Kumar, A. Humar, A. Viswabandya, 2020 .

Pig lung transplant survival model

S. Keshavjee, M. Cypel, Mingyao Liu, 2018, Nature Protocols.