J. Jacobson

发表

Activated Protein C Mediates Novel Lung Endothelial Barrier Enhancement

J. Garcia, S. Dudek, S. Camp, 2005, Journal of Biological Chemistry.

Role of migratory inhibition factor in age-related susceptibility to radiation lung injury via NF-E2-related factor-2 and antioxidant regulation.

R. Weichselbaum, G. Fingerle-Rowson, R. Bucala, 2013, American journal of respiratory cell and molecular biology.

Simvastatin-induced sphingosine 1−phosphate receptor 1 expression is KLF2-dependent in human lung endothelial cells

J. Garcia, Xiaoguang Sun, B. Mathew, 2017, Pulmonary circulation.

Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury.

R. Weichselbaum, J. Garcia, S. Dudek, 2013, American journal of respiratory cell and molecular biology.

Novel therapies for microvascular permeability in sepsis.

J. Jacobson, J. G. Garcia, Joe G.N. Garcia, 2007, Current drug targets.

by the small GTPase Rac and cortactin Endothelial cell barrier enhancement by ATP is mediated

J. Garcia, S. Dudek, A. Verin, 2016 .

Endothelial cell barrier enhancement by ATP is mediated by the small GTPase Rac and cortactin.

J. Garcia, S. Dudek, A. Verin, 2006, American journal of physiology. Lung cellular and molecular physiology.

Cigarette Smoke and Nicotine-Containing E-cigarette Vapor Downregulate Lung WWOX Expression Which is Associated with Increased Severity of Murine ARDS

S. Dudek, R. Machado, V. Natarajan, 2020, bioRxiv.

Cigarette Smoke and Nicotine-Containing E-cigarette Vapor Downregulate Lung WWOX Expression Which is Associated with Increased Severity of Murine ARDS.

S. Dudek, R. Machado, V. Natarajan, 2020, American journal of respiratory cell and molecular biology.

Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta

J. Garcia, Prasad Kanteti, S. Dudek, 2016, PloS one.

MicroRNA regulation of integrins.

Wei Zhang, M. Harbeck, J. Jacobson, 2013, Translational research : the journal of laboratory and clinical medicine.

EVL is a novel focal adhesion protein involved in the regulation of cytoskeletal dynamics and vascular permeability

S. Novak, C. Gregorio, J. Garcia, 2021, Pulmonary circulation.

Imatinib attenuates inflammation and vascular leak in a clinically relevant two-hit model of acute lung injury.

E. Letsiou, J. Garcia, S. Dudek, 2015, American journal of physiology. Lung cellular and molecular physiology.

Imatinib attenuates inflammation and vascular leak in a clinically relevant two-hit model of acute lung injury.

E. Letsiou, J. Garcia, S. Dudek, 2015, American journal of physiology. Lung cellular and molecular physiology.

Temporal gene expression analysis of human coronary artery endothelial cells treated with Simvastatin.

R. Setterquist, D. Grigoryev, Shwu-Fan Ma, 2008, Gene expression.

Pulmonary Vascular Barrier Regulation by Thrombin and Edg Receptors

J. Garcia, Joe G. N. Garcia, J. Jacobson, 2005 .

Differential regulation of endothelial cell barrier function

J. Garcia, S. Dudek, Joe G. N. Garcia, 2005 .

Integrin β4 attenuates SHP‐2 and MAPK signaling and reduces human lung endothelial inflammatory responses

J. Garcia, Joe G. N. Garcia, J. Jacobson, 2010, Journal of cellular biochemistry.

Forum Statins in Endothelial Signaling and Activation

J. Jacobson, 2009 .

eNAMPT Neutralization Preserves Lung Fluid Balance and Reduces Acute Renal Injury in Porcine Sepsis/VILI-Induced Inflammatory Lung Injury

C. Karmonik, J. Garcia, C. Bime, 2022, Frontiers in Physiology.

Cigarette Smoke and Nicotine-Containing Electronic-Cigarette Vapor Downregulate Lung WWOX Expression, Which Is Associated with Increased Severity of Murine Acute Respiratory Distress Syndrome

S. Dudek, V. Natarajan, L. Ware, 2020 .

Role Played by Paxillin and Paxillin Tyrosine Phosphorylation in Hepatocyte Growth Factor/Sphingosine-1-Phosphate-Mediated Reactive Oxygen Species Generation, Lamellipodia Formation, and Endothelial Barrier Function

R. Salgia, J. Garcia, A. Cress, 2015, Pulmonary Circulation.

Genomics made functional in ventilator-associated lung injury.

J. Garcia, Joe G. N. Garcia, J. Jacobson, 2003, American journal of respiratory and critical care medicine.

eNAMPT neutralization reduces preclinical ARDS severity via rectified NFkB and Akt/mTORC2 signaling

L. Cancio, J. Garcia, C. Bime, 2022, Scientific Reports.

Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung.

J. Garcia, Xiaoguang Sun, S. Dudek, 2010, American journal of respiratory cell and molecular biology.

Use of consomic rats for genomic insights into ventilator-associated lung injury.

Lee T. Sam, Y. Lussier, D. Grigoryev, 2007, American journal of physiology. Lung cellular and molecular physiology.

Nonmuscle Myosin Light Chain Kinase Activity Modulates Radiation-Induced Lung Injury

R. Weichselbaum, J. Garcia, S. Dudek, 2016, Pulmonary circulation.

Attenuation of Rodent Lung Ischemia Reperfusion Injury by Sphingosine 1 Phosphate

J. Garcia, P. Bonde, W. Vigneswaran, 2008 .

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19

Christopher M. Horvat, David T. Huang, R. Hyzy, 2021, The New England journal of medicine.

Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody

Zhonglin Liu, J. Garcia, C. Bime, 2020, European Respiratory Journal.

Bigger is Betterin ARDS.

J. Jacobson, M. Anis, 2019, The American journal of the medical sciences.

Critical Role of S1PR1 and Integrin β4 in HGF/c-Met-mediated Increases in Vascular Integrity

R. Salgia, J. Garcia, Prasad Kanteti, 2012, The Journal of Biological Chemistry.

Endothelial cell barrier enhancement by HGF 1 Critical Role of S 1 PR 1 and Integrin β 4 in HGF / c-Met-Mediated Increases in Vascular Integrity

R. Salgia, J. Garcia, Prasad Kanteti, 2012 .

Statins and thrombin.

G. Shen, F. Ofosu, J. Fenton, 2005, Current drug targets. Cardiovascular & haematological disorders.

Endothelial cell barrier protection by simvastatin: GTPase regulation and NADPH oxidase inhibition.

J. Garcia, V. Natarajan, Joe G. N. Garcia, 2008, American journal of physiology. Lung cellular and molecular physiology.

Reply to “Generic Statins and Angiotensin Receptor Blockers: Are They Really Useful in Ebola?”

S. Opal, D. Fedson, J. Jacobson, 2016, mBio.

Pharmacologic Therapies on the Horizon for Acute Lung Injury/Acute Respiratory Distress Syndrome

J. Jacobson, 2009, Journal of Investigative Medicine.

Interaction of Integrin β4 With S1P Receptors in S1P‐ and HGF‐Induced Endothelial Barrier Enhancement

J. Garcia, Joe G. N. Garcia, Y. Epshtein, 2014, Journal of cellular biochemistry.

Haloperidol Attenuates Lung Endothelial Cell Permeability In Vitro and In Vivo

Y. Epshtein, J. Jacobson, Weiguo Chen, 2021, Cells.

Attenuation of murine acute lung injury by PF-573,228, an inhibitor of focal adhesion kinase.

B. Mathew, Y. Epshtein, J. Jacobson, 2018, Vascular pharmacology.

Non-Muscle MLCK Contributes to Endothelial Cell Hyper-Proliferation through the ERK Pathway as a Mechanism for Vascular Remodeling in Pulmonary Hypertension

D. Fraidenburg, Y. Epshtein, J. Jacobson, 2022, International journal of molecular sciences.

Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19

Christopher M. Horvat, David T. Huang, R. Hyzy, 2021, The New England journal of medicine.

Conflicting Physiological andGenomic Cardiopulmonary Effects of Recruitment Maneuvers in Murine Acute Lung Injury

L. Brochard, J. Garcia, S. Dudek, 2012 .

Role of Integrin β4 in Lung Endothelial Cell Inflammatory Responses to Mechanical Stress

J. Garcia, A. Cress, Joe G. N. Garcia, 2015, Scientific Reports.

Essential role for paxillin tyrosine phosphorylation in LPS-induced mitochondrial fission, ROS generation and lung endothelial barrier loss

J. Garcia, A. Cress, V. Natarajan, 2021, Scientific Reports.

Krüppel Like Factor 4 Promoter Undergoes Active Demethylation during Monocyte/Macrophage Differentiation

J. Christman, R. Ranjan, M. Karpurapu, 2014, PloS one.

A practical treatment for COVID‐19 and the next pandemic

A. Casadevall, I. Hung, D. Musher, 2022, Pharmacology research & perspectives.

Role of claudin-5 in the attenuation of murine acute lung injury by simvastatin.

J. Siegler, Joe G. N. Garcia, J. Jacobson, 2013, American journal of respiratory cell and molecular biology.

Critical role for integrin-β4 in the attenuation of murine acute lung injury by simvastatin.

Shwu-Fan Ma, S. Sammani, Joe G. N. Garcia, 2012, American journal of physiology. Lung cellular and molecular physiology.

acute lung injury by simvastatin 4 in the attenuation of murine β Critical role for integrin

Shwu-Fan Ma, S. Sammani, Joe G. N. Garcia, 2012 .

Magnitude-dependent regulation of pulmonary endothelial cell barrier function by cyclic stretch.

S. Ye, A. Verin, A. Birukova, 2003, American journal of physiology. Lung cellular and molecular physiology.

Statins as a novel therapeutic strategy in acute lung injury

J. Jacobson, S. Singla, 2012, Pulmonary circulation.

Activation of NFkB and coagulation in lung injury by hyperoxia and excessive mechanical ventilation: one more reason "low and slow" is the way to go?

K. Birukov, J. Jacobson, 2009, Translational research : the journal of laboratory and clinical medicine.

Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation.

Elena Alekseeva, A. Birukova, K. Birukov, 2007, Experimental cell research.

Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets.

J. Yuan, S. Black, A. Desai, 2017, American journal of physiology. Lung cellular and molecular physiology.

Regulation of Hyperoxia-induced NADPH Oxidase Activation in Human Lung Endothelial Cells by the Actin Cytoskeleton and Cortactin*

S. Dudek, L. Romer, N. Parinandi, 2007, Journal of Biological Chemistry.

Sphingolipids as a Novel Therapeutic Target in Radiation-Induced Lung Injury

J. Jacobson, 2021, Cell Biochemistry and Biophysics.

Role of c-Met/Phosphatidylinositol 3-Kinase (PI3k)/Akt Signaling in Hepatocyte Growth Factor (HGF)-mediated Lamellipodia Formation, Reactive Oxygen Species (ROS) Generation, and Motility of Lung Endothelial Cells*

R. Salgia, S. Dudek, V. Natarajan, 2014, The Journal of Biological Chemistry.

LPS‐induced Acute Lung Injury Involves NF‐&kgr;B‐mediated Downregulation of SOX18

M. Gonzalez-Garay, J. Catravas, A. Verin, 2017, American journal of respiratory cell and molecular biology.

Differential and Opposing Effects of Imatinib on LPS-and Ventilator-Induced 1 Lung Injury

E. Letsiou, S. Dudek, S. Sammani, 2014 .

Role of sphingolipids in murine radiation‐induced lung injury: protection by sphingosine 1‐phosphate analogs

R. Weichselbaum, Xiaoguang Sun, S. Dudek, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Treating the Host Response to Ebola Virus Disease with Generic Statins and Angiotensin Receptor Blockers

Steven M. Opal, S. Opal, D. Fedson, 2015, mBio.

Endothelial FAK as a therapeutic target in disease.

J. Jacobson, Giovanni Infusino, 2012, Microvascular research.

GADD45a Promoter Regulation by a Functional Genetic Variant Associated with Acute Lung Injury

Wei Zhang, Xiaoguang Sun, C. Flores, 2014, PloS one.

Role of GADD45a in murine models of radiation- and bleomycin-induced lung injury.

R. Weichselbaum, B. Mathew, S. Sammani, 2015, American Journal of Physiology - Lung cellular and Molecular Physiology.

Translational Research in Acute Lung Injury and Pulmonary Fibrosis Role of GADD 45 a in murine models of radiation-and bleomycin-induced lung injury

R. Weichselbaum, B. Mathew, S. Sammani, 2015 .

Signaling Pathways Involved in Adenosine Triphosphate-Induced Endothelial Cell Barrier Enhancement

A. Verin, L. Romer, V. Natarajan, 2005, Circulation research.

Statins in endothelial signaling and activation.

J. Jacobson, 2009, Antioxidants & redox signaling.

Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression.

R. Weichselbaum, Y. Lussier, S. Dudek, 2011, American journal of respiratory cell and molecular biology.

Sphingosine-1-phosphate receptor-3 is a novel biomarker in acute lung injury.

J. Zhao, E. Letsiou, Xiaoguang Sun, 2012, American journal of respiratory cell and molecular biology.

Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury.

D. Grigoryev, R. Tuder, Joe G. N. Garcia, 2005, American journal of physiology. Lung cellular and molecular physiology.

Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin.

D. Grigoryev, S. Ye, S. Dudek, 2004, American journal of respiratory cell and molecular biology.

Integrin Beta 4E Promotes Endothelial Phenotypic Changes and Attenuates Lung Endothelial Cell Inflammatory Responses

A. Cress, S. Camp, Joe G. N. Garcia, 2022, Frontiers in Physiology.

GADD45a is a novel candidate gene in inflammatory lung injury via influences on Akt signaling

Y. Lussier, A. Husain, N. Meyer, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Enhanced interaction between focal adhesion and adherens junction proteins: involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement.

Jun Wada, Hirofumi Makino, Xiaoguang Sun, 2009, Microvascular research.

Nuclear factor, erythroid 2-like 2-associated molecular signature predicts lung cancer survival

Z. Qian, A. Cress, Christopher I. Gurguis, 2015, Scientific Reports.

Sphingolipids Signaling in Lamellipodia Formation and Enhancement of Endothelial Barrier Function.

A. Karginov, V. Natarajan, P. Fu, 2018, Current topics in membranes.

Role of growth arrest and DNA damage-inducible α in Akt phosphorylation and ubiquitination after mechanical stress-induced vascular injury.

S. Dudek, N. Meyer, S. Sammani, 2011, American journal of respiratory and critical care medicine.

murine inflammatory lung injury Simvastatin attenuates vascular leak and inflammation in

D. Grigoryev, Joe G. N. Garcia, J. Barnard, 2016 .

Statins and Acute Lung Injury

A. Mahajan, J. Jacobson, 2011 .

Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression[S]

R. Weichselbaum, T. Zhou, V. Natarajan, 2012, Journal of Lipid Research.

DNA damage and mismatch repair pathway in lung ischemia and reperfusion injury

P. Bonde, Joe G. N. Garcia, Chiming Wei, 2006 .

Therapeutic Strategies to Limit Lung Endothelial Cell Permeability

Joe G. N. Garcia, J. Jacobson, Gabriel D Lang, 2009 .

Conflicting physiological and genomic cardiopulmonary effects of recruitment maneuvers in murine acute lung injury.

L. Brochard, S. Dudek, T. Zhou, 2012, American journal of respiratory cell and molecular biology.

Pulmonary Endothelial Cell Barrier Enhancement by Sphingosine 1-Phosphate

S. Dudek, K. Birukov, Peiyi Wang, 2004, Journal of Biological Chemistry.

Translational Research in Acute Lung Injury and Pulmonary Fibrosis Differential and opposing effects of imatinib on LPS-and ventilator-induced lung injury

E. Letsiou, S. Dudek, S. Sammani, 2014 .

Essential role of pre-B-cell colony enhancing factor in ventilator-induced lung injury.

Y. Lussier, S. Ye, S. Dudek, 2008, American journal of respiratory and critical care medicine.

Critical Role Of Sphingolipid Pathway Components In Murine Radiation-Induced Lung Injury: Protection By Sphingosine 1 Phosphate Analogues

R. Weichselbaum, Y. Lussier, Xiaoguang Sun, 2011, Asian Test Symposium.

Type 2 deiodinase and host responses of sepsis and acute lung injury.

M. Pino-Yanes, R. Kittles, E. Letsiou, 2011, American journal of respiratory cell and molecular biology.

eNAMPT neutralization reduces preclinical ARDS severity via rectified NFkB and Akt/mTORC2 signaling

L. Cancio, C. Bime, A. Cress, 2022, Scientific Reports.

Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome.

I. Noth, M. Pino-Yanes, Xiaoguang Sun, 2013, American journal of physiology. Lung cellular and molecular physiology.

Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome.

I. Noth, M. Pino-Yanes, Xiaoguang Sun, 2013, American journal of physiology. Lung cellular and molecular physiology.

UCHL1, a Deubiquitinating Enzyme, Regulates Lung Endothelial Cell Permeability In Vitro and In Vivo.

S. Sammani, A. Desai, H. Quijada, 2021, American journal of physiology. Lung cellular and molecular physiology.

Cardiopulmonary Effects Of Recruitment Maneuvers In Murine Acute Lung Injury Highlight Conflicting Physiological And Genomic Indices

L. Brochard, S. Dudek, T. Zhou, 2011, ATS 2011.

An Actin-, Cortactin- and Ena-VASP-Linked Complex Contributes to Endothelial Cell Focal Adhesion and Vascular Barrier Regulation

A. Cress, S. Dudek, S. Camp, 2022, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells.

R. Rafikov, J. Yuan, S. Black, 2016, American journal of respiratory cell and molecular biology.

ASYMMETRIC DIMETHYLARGININE STIMULATES AKT1 PHOSPHORYLATION VIA HSP70-FACILITATED CTMP DEGRADATION IN PULMONARY ARTERIAL ENDOTHELIAL CELLS

R. Rafikov, J. Yuan, S. Black, 2016 .

endothelial cell barrier function by cyclic stretch Magnitude-dependent regulation of pulmonary

S. Ye, A. Verin, K. Birukov, 2016 .

Endothelial Knockdown of the Tumor Suppressor, WWOX, Increases Inflammation in Ventilator-Induced Lung Injury

S. Dudek, V. Natarajan, J. Jacobson, 2023, bioRxiv.

Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung.

Xiaoguang Sun, S. Dudek, V. Natarajan, 2010, American journal of respiratory cell and molecular biology.

UCHL1 Regulates Radiation Lung Injury via Sphingosine Kinase-1

B. Mathew, Y. Epshtein, J. Jacobson, 2023, Cells.