Gang Wu

发表

Binding kinetics of calmodulin with target peptides of three nitric oxide synthase isozymes.

A. Tsai, Gang Wu, V. Berka, 2011, Journal of inorganic biochemistry.

Development and preclinical studies of broad-spectrum anti-HIV agent (3'R,4'R)-3-cyanomethyl-4-methyl-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (3-cyanomethyl-4-methyl-DCK).

Hong Lu, Shibo Jiang, Keduo Qian, 2008, Journal of medicinal chemistry.

Synthesis, in vitro and in vivo biological evaluation, docking studies, and structure--activity relationship (SAR) discussion of dipeptidyl boronic acid proteasome inhibitors composed of beta-amino acids.

L. Zhang, Zhen-ming Liu, Xinrong Zhu, 2010, Journal of medicinal chemistry.

Cysteine racemization during the Fmoc solid phase peptide synthesis of the Nav1.7‐selective peptide – protoxin II

K. Carlin, Gang Wu, D. Kyle, 2012, Journal of peptide science : an official publication of the European Peptide Society.

Kinetic Isotope Effect of Prostaglandin H Synthase Exhibits Inverted Temperature Dependence

A. Tsai, Gang Wu, R. Kulmacz, 2014 .

Design, synthesis, biological evaluation, and structure-activity relationship (SAR) discussion of dipeptidyl boronate proteasome inhibitors, part I: comprehensive understanding of the SAR of alpha-amino acid boronates.

Xinrong Zhu, Qingzhi Gao, Gang Wu, 2009, Journal of medicinal chemistry.

Synthesis, in vitro and in vivo biological evaluation, and comprehensive understanding of structure-activity relationships of dipeptidyl boronic acid proteasome inhibitors constructed from β-amino acids.

Xinrong Zhu, Gang Wu, Meng Lei, 2010, Journal of medicinal chemistry.

Critical Comparison of the Superoxide Dismutase-Like Activity of Carbon Anti-Oxidant Nanozymes by Direct Superoxide Consumption Kinetic Measurements.

T. Kent, J. Tour, A. Tsai, 2019, ACS nano.

Fluorescent Determination of Calcium Ion Using a Coumarinyl Pyrazoline Scaffold and Its Application in Living Cells

Ya-jing Shang, Gang Wu, Yunzhi Hua, 2020, Analytical Letters.

Aglycone exploration of C-arylglucoside inhibitors of renal sodium-dependent glucose transporter SGLT2.

W. Humphreys, T. Waldron, Songping Han, 2008, Bioorganic & medicinal chemistry letters.

The selectivity of Vibrio cholerae H-NOX for gaseous ligands follows the "sliding scale rule" hypothesis. Ligand interactions with both ferrous and ferric Vc H-NOX.

A. Tsai, Gang Wu, V. Berka, 2013, Biochemistry.

Carboxyl-promoted enhancement of selectivity for the β3 adrenergic receptor. Negative charge of the sulfonic acid BMS-187413 introduces-β3 binding selectivity

A. Mathur, K. Dickinson, Gang Wu, 1997 .

α-Hemoglobin Stabilizing Protein (AHSP) Markedly Decreases the Redox Potential and Reactivity of α-Subunits of Human HbA with Hydrogen Peroxide*

M. Weiss, J. Olson, A. Alayash, 2012, The Journal of Biological Chemistry.

Structural Characterization of Arachidonyl Radicals Formed by Aspirin-treated Prostaglandin H Synthase-2*

W. A. van der Donk, N. Okeley, A. Tsai, 2002, The Journal of Biological Chemistry.

A new paradigm for gaseous ligand selectivity of hemoproteins highlighted by soluble guanylate cyclase.

A. Tsai, E. Martin, Gang Wu, 2020, Journal of inorganic biochemistry.

Design, synthesis and docking studies on benzamide derivatives as histone deacetylase inhibitors.

Jian Liu, Gang Wu, H. Luo, 2011, Bioorganic & medicinal chemistry letters.

Ligand-Dependent Colloidal Stability Controls the Growth of Aluminum Nanocrystals.

Michael J. McClain, P. Nordlander, N. Halas, 2019, Journal of the American Chemical Society.

Peroxidase Self-inactivation in Prostaglandin H Synthase-1 Pretreated with Cyclooxygenase Inhibitors or Substituted with Mangano Protoporphyrin IX*

A. Tsai, Gang Wu, R. Kulmacz, 2001, The Journal of Biological Chemistry.

Functional and structural roles of residues in the third extramembrane segment of adrenal cytochrome b561.

A. Tsai, Gang Wu, G. Palmer, 2011, Biochemistry.

Structure and mechanism of a unique diiron center in mammalian stearoyl-CoA desaturase.

Jiemin Shen, Ming Zhou, A. Tsai, 2020, Journal of molecular biology.

Plasmon-Generated Solvated Electrons for Chemical Transformations.

P. Nordlander, N. Halas, A. Tsai, 2022, Journal of the American Chemical Society.

Transmembrane helices mediate the formation of a stable ternary complex of b5R, cyt b5, and SCD1

Jiemin Shen, Ming Zhou, A. Tsai, 2022, Communications Biology.

A Mechanistic Study of Self-inactivation of the Peroxidase Activity in Prostaglandin H Synthase-1*

A. Tsai, Gang Wu, R. Kulmacz, 1999, The Journal of Biological Chemistry.

Rapid Kinetics of Tyrosyl Radical Formation and Heme Redox State Changes in Prostaglandin H Synthase-1 and -2*

J. Koehn, A. Tsai, Gang Wu, 1999, The Journal of Biological Chemistry.

Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.

W. Humphreys, O. Flint, E. Janovitz, 2008, Journal of medicinal chemistry.

Perylene Diimide as a Precise Graphene-like Superoxide Dismutase Mimetic

T. Kent, J. Tour, Chenhao Zhang, 2017, ACS nano.

Structural comparisons of arachidonic acid-induced radicals formed by prostaglandin H synthase-1 and -2.

G. Gerfen, W. A. van der Donk, A. Tsai, 2011, Journal of inorganic biochemistry.

Six-Transmembrane Epithelial Antigen of Prostate 1 (STEAP1) Has a Single b Heme and Is Capable of Reducing Metal Ion Complexes and Oxygen.

Da-Neng Wang, Jinmei Song, S. Poget, 2016, Biochemistry.

Cyclooxygenase competitive inhibitors alter tyrosyl radical dynamics in prostaglandin H synthase-2.

A. Tsai, Gang Wu, R. Kulmacz, 2009, Biochemistry.

Reductions in log P improved protein binding and clearance predictions enabling the prospective design of cannabinoid receptor (CB1) antagonists with desired pharmacokinetic properties.

K. Behnia, N. Murugesan, Z. Gu, 2013, Journal of medicinal chemistry.

Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy

K. Nilsson, C. Soto, Xiangan Liu, 2020, Nature.

Mechanism of stepwise electron transfer in six-transmembrane epithelial antigen of the prostate (STEAP) 1 and 2

M. Zhou, Jiemin Shen, Ming Zhou, 2021, bioRxiv.

Gaseous ligand selectivity of the H-NOX sensor protein from Shewanella oneidensis and comparison to those of other bacterial H-NOXs and soluble guanylyl cyclase.

A. Tsai, Gang Wu, V. Berka, 2017, Biochimie.

H-NOX from Clostridium botulinum, like H-NOX from Thermoanaerobacter tengcongensis, Binds Oxygen but with a Less Stable Oxyferrous Heme Intermediate.

A. Tsai, Gang Wu, V. Berka, 2015, Biochemistry.

Bindings of NO, CO, and O2 to multifunctional globin type dehaloperoxidase follow the 'sliding scale rule'.

Jing Zhao, S. Franzen, A. Tsai, 2017, The Biochemical journal.

Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin.

J. Olson, A. Alayash, Todd L. Mollan, 2014, Free radical biology & medicine.

Synthesis and biological evaluation of novel 7-substituted 3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amines as potent Bruton's tyrosine kinase (BTK) inhibitors.

Wei Huang, Wei Huang, H. Xiang, 2015, Bioorganic & medicinal chemistry.

Discovery of thieno[3,2-c]pyridin-4-amines as novel Bruton's tyrosine kinase (BTK) inhibitors.

Wei Huang, Wei Huang, H. Xiang, 2015, Bioorganic & medicinal chemistry.

Structure-activity relationship studies and discovery of a potent transient receptor potential vanilloid (TRPV1) antagonist 4-[3-chloro-5-[(1S)-1,2-dihydroxyethyl]-2-pyridyl]-N-[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxamide (V116517) as a clinical candidate for pain management

Y. Yamaguchi, Gang Wu, D. Kyle, 2014, Journal of medicinal chemistry.

A-317491, a selective P2X3/P2X2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats.

Gary Lee, M. Niosi, Gang Wu, 2004, European journal of pharmacology.

Experimental evolution of adenylate kinase reveals contrasting strategies toward protein thermostability.

J. C. Myers, R. Couñago, Y. Shamoo, 2010, Biophysical journal.

N-(4-Tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a Novel, Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties: I. In Vitro Characterization and Pharmacokinetic Properties

Qun Sun, M. Hachicha, E. R. Whittemore, 2003, Journal of Pharmacology and Experimental Therapeutics.

Synthesis and identification of artificial antigen for imidacloprid

Wenjun Gui, Guonian Zhu, Jing-li Cheng, 2006 .

Transmembrane helices mediate the formation of a stable ternary complex of cyt b5 reductase, cyt b5, and SCD1

Jiemin Shen, Ming Zhou, A. Tsai, 2021, bioRxiv.

Cysteine mutants of human apolipoprotein A-I: a study of secondary structural and functional properties Published, JLR Papers in Press, April 1, 2005. DOI 10.1194/jlr.M400401-JLR200

Xuewei Zhu, Bao-sheng Chen, Gang Wu, 2005, Journal of Lipid Research.

Identification of Tyr504 as an alternative tyrosyl radical site in human prostaglandin H synthase-2.

A. Tsai, Gang Wu, Wen Liu, 2004, Biochemistry.

Cyclooxygenase inactivation kinetics during reaction of prostaglandin H synthase-1 with peroxide.

A. Tsai, Gang Wu, R. Kulmacz, 2003, Biochemistry.

Cyclooxygenase reaction mechanism of PGHS--evidence for a reversible transition between a pentadienyl radical and a new tyrosyl radical by nitric oxide trapping.

W. A. van der Donk, A. Tsai, Gang Wu, 2011, Journal of inorganic biochemistry.

Oxyferryl heme and not tyrosyl radical is the likely culprit in prostaglandin H synthase-1 peroxidase inactivation.

J. Wang, A. Tsai, Gang Wu, 2007, Biochemistry.

Dynamics of Radical Intermediates in Prostaglandin H Synthase-1 Cyclooxygenase Reactions is Modulated by Multiple Factors.

A. Tsai, Gang Wu, 2016, Protein and peptide letters.

Synthesis of isotopically labeled arachidonic acids to probe the reaction mechanism of prostaglandin H synthase.

W. A. van der Donk, N. Okeley, A. Tsai, 2002, Journal of the American Chemical Society.

In Vitro Activity of a Purified Natural Anion Channelrhodopsin*

J. Spudich, O. Sineshchekov, Gang Wu, 2016, The Journal of Biological Chemistry.

Cyclooxygenase reaction mechanism of prostaglandin H synthase from deuterium kinetic isotope effects.

W. A. van der Donk, A. Tsai, Gang Wu, 2011, Journal of inorganic biochemistry.

Determination of the structural environment of the tyrosyl radical in prostaglandin H2 synthase-1: a high frequency ENDOR/EPR study.

G. Gerfen, A. Tsai, Gang Wu, 2005, Journal of the American Chemical Society.

Comparison of oxygen-induced radical intermediates in iNOS oxygenase domain with those from nNOS and eNOS.

A. Tsai, Gang Wu, V. Berka, 2014, Journal of inorganic biochemistry.

Titanium oxide improves boron nitride photocatalytic degradation of perfluorooctanoic acid

P. Westerhoff, A. Mohite, T. Senftle, 2022, Chemical Engineering Journal.

Synthesis of unsymmetrical biphenyls as potent cytotoxic agents.

K. Lee, S. Morris-Natschke, Lan Xie, 2008, Bioorganic & medicinal chemistry letters.

Electron relay via diffusible and protein-bound flavin cofactor in human six-transmembrane epithelial antigen of the prostate (STEAP)

Jiemin Shen, Ming Zhou, A. Tsai, 2021 .

Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels.

K. Carlin, P. Blake, Gang Wu, 2014, Journal of medicinal chemistry.

High-yield production, purification and characterization of functional human duodenal cytochrome b in an Escherichia coli system.

A. Tsai, Gang Wu, Wen Liu, 2011, Protein expression and purification.

Characterization of cDNAs encoding potential Drosophila acetylcholine receptors

Gang Wu, 2020 .