N. Hughes-Jones

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S. Wickramasinghe, N. Hughes-Jones, 1970 .

Risk assessment and factor VIII concentrates

N. Hughes-Jones, 1995, The Lancet.

Optimal Conditions for Detecting Blood Group Antibodies by the Antiglobulin Test

M. Polley, N. Hughes-Jones, B. Gardner, 1964, Vox sanguinis.

Prolongation of cell cycle transit time and the presence of non‐cycling cells in human lymphoblastoid cells cultured under adverse conditions

N. Miller, C. Villiers, N. Hughes-Jones, 1987, Cell and tissue kinetics.

Soluble factor requirements for the autostimulatory growth of B lymphoblasts immortalized by Epstein-Barr virus

P. Åman, S. Ley, N. Hughes-Jones, 1984, The Journal of experimental medicine.

Immortalized B lymphocytes produce B-cell growth factor

J. Gordon, S. Ley, N. Hughes-Jones, 1984, Nature.

Comparison of Low‐Molecular‐Weight Products Following Reaction of C3‐C3b with C3b Inactivator and with Trypsin 1

J. Freedman, C. Johnson, H. Chaplin, 1977, Vox sanguinis.

STUDIES ON THE REACTION BETWEEN THE BLOOD-GROUP ANTIBODY ANTI-D AND ERYTHROCYTES.

N. Hughes-Jones, B. Gardner, R. Telford, 1963, The Biochemical journal.

Quantitation and the Rh blood group system *

N. Hughes-Jones, 1991, Transfusion medicine.

Assay of Anti‐D Activity by Two Radioimmunoassay Techniques Using Purified 125I‐Labelled Anti‐D

N. Hughes-Jones, B. Gardner, I. Norley, 1971 .

Reaction between the isolated globular sub-units of the complement component C1q and IgG-complexes.

N. Hughes-Jones, B. Gardner, 1979, Molecular immunology.

An antiglobulin reagent labelled with colloidal gold for use in electron microscopy.

N. Hughes-Jones, E. Romano, C. Stolinski, 1974, Immunochemistry.

The efficient production of stable, human monoclonal antibody-secreting hybridomas from EBV-transformed lymphocytes using the mouse myeloma X63-Ag8.653 as a fusion partner.

D. Hough, P. Maddison, K. Thompson, 1986, Journal of immunological methods.

Multiple Epitopes Recognised by Human Monoclonal IgM Anti‐D Antibodies

D. Beale, B. Gorick, N. Hughes-Jones, 1990, Vox sanguinis.

Comparison of the Reactions of the Rh‐Related Murine Monoclonal Antibodies BS58 and R6A

B. Gorick, N. Hughes-Jones, C. Lomas, 1990, Vox sanguinis.

Three Epitopes on the Human Rh Antigen D Recognized by 125I‐Labelled Human Monoclonal IgG Antibodies

B. Gorick, K. Thompson, N. Hughes-Jones, 1988, Vox sanguinis.

Evidence that the c, D and E epitopes of the human Rh blood group system are on separate polypeptide molecules.

P. Rouger, J. Cartron, B. Gorick, 1988, Molecular immunology.

Reactivity of anti-D Immunoglobulin G Subunits

N. Hughes-Jones, 1970, Nature.

The reaction between the complement subcomponent C1q, IgG complexes and polyionic molecules.

N. Hughes-Jones, B. Gardner, 1978, Immunology.

Characterization of human blood group scFv antibodies derived from a V gene phage‐display library

W. Ouwehand, J. Bye, J. Marks, 1994, British journal of haematology.

Cloning and sequencing of human λ immunoglobulin genes by the polymerase chain reaction

J. Bye, J. Marks, N. Hughes-Jones, 1990 .

Cloning and sequencing of human lambda immunoglobulin genes by the polymerase chain reaction.

J. Bye, J. Marks, N. Hughes-Jones, 1990, European journal of immunology.

Functional affinity constants of subfragments of immunoglobulin G for Clq.

N. Hughes-Jones, B. Gardner, R. H. Painter, 1982, Molecular immunology.

The mechanism of synergistic complement‐mediated lysis of rat red cells by monoclonal IgG antibodies

B. Gorick, J. Howard, N. Hughes-Jones, 1983, European journal of immunology.

Differences between the activities of human monoclonal IgG1 and IgG3 anti-D antibodies of the Rh blood group system in their abilities to mediate effector functions of monocytes.

H. C. Scott, V. Jolliffe, B. Kumpel, 1988, Immunology.

Clearance of Rh-positive red cells by low concentrations of Rh antibody.

P. Mollison, N. Hughes-Jones, 1967, Immunology.

Rate of Removal from the Circulation of Red Cells Sensitized with Different Amounts of Antibody

P. Mollison, N. Hughes-Jones, Patricia Crome, 1965, British journal of haematology.

The Classical Pathway

N. Hughes-Jones, 1986 .

Observations of the Number of Available c, D, and E Antigen Sites on Red Cells

P. Lincoln, N. Hughes-Jones, B. Gardner, 1971, Vox sanguinis.

Formation and Destruction of Blood Cells

N. Hughes-Jones, 1972 .

International conference to ban landmines

Nevin Hughes‐Jones, N. Hughes-Jones, 1995 .

Invertebrate Blood Cells, Vols 1 and 2

N. Hughes-Jones, 1982 .

Inter‐group aggression: The multi‐individual organism and the survival instinct

N. Hughes-Jones, 2000, Medicine, conflict, and survival.

Intergroup aggression: multi-individual organisms and the survival instinct

N. Hughes-Jones, 2000 .

Loss of Rh Antigen Activity Following the Action of Phospholipase A2 on Red Cell Stroma

N. Hughes-Jones, V. Hunt, Elizabeth J. Green, 1975, Vox sanguinis.

Human anti‐self antibodies with high specificity from phage display libraries.

J. Bye, G. Winter, A. Griffiths, 1993, The EMBO journal.

Quantitative Measurments Concerning A and B Antigen Sites

N. Hughes-Jones, B. Gardner, J. Economidou, 1967, Vox sanguinis.

The Use of Purified 125I‐Labelled Anti‐γ Globulin in the Determination of the Number of D Antigen Sites on Red Cells of Different Phenotypes

N. Hughes-Jones, E. Rochna, Erna Rochna, 1965, Vox sanguinis.

A molecular size determination of Rh(D) antigen by radiation inactivation.

J. Ellory, E. Folkerd, N. Hughes-Jones, 1977, Immunochemistry.

Molecular and Cellular Aspects of Allergy: Transaction of the Collegium Internationale Allergologicum —10th Symposium, Copenhagen, August 1974

N. Hughes-Jones, 1976 .

Distribution and Mobility of the A, D and c Antigens on Human Red Cell Membranes: Studies with a Gold‐labelled Antiglobulin Reagent

N. Hughes-Jones, E. Romano, C. Stolinski, 1975, British journal of haematology.

The Anti‐D Content of IgG Preparations for Use in the Prevention of Rh Haemolytic Disease

N. Hughes-Jones, MaryM. Stevenson, N. C. Hughes-Jones, 1968, Vox sanguinis.

V. Pascual, O. Førre, I. Randen, 1992, Journal of immunology.

Suppression of Primary Rh Immunization by Passively‐Administered Antibody. Experiments in Volunteers

P. Mollison, N. Hughes-Jones, Margaret Lindsay, 1969, Vox sanguinis.

Human Antibody Fragments Specific for Human Blood Group Antigens from a Phage Display Library

W. Ouwehand, J. Bye, G. Winter, 1993, Bio/Technology.

Quantitation of D Sites on Selected ‘Weak D’ and ‘Partial D’ Red Cells

W. Ouwehand, M. Overbeeke, D. Rhenen, 1993, Vox sanguinis.

Ruth Ann Sanger. 6 June 1918 – 4 June 2001

N. Hughes-Jones, P. Tippett, 2003, Biographical Memoirs of Fellows of the Royal Society.

Activation of human complement by glutaraldehyde-treated red cells

N. Hughes-Jones, B. Gardner, J. Rowlands, 1977, Nature.

Intensive plasmapheresis as a therapeutic measure in Rhesus-immunised women.

C. Clarke, C. Elson, N. Hughes-Jones, 1970, Lancet.

The relationship between the binding ability and the rate of activation of the complement component C1.

E. Folkerd, N. Hughes-Jones, B. Gardner, 1980, Immunology.

Clearance of Rh D-positive red cells with monoclonal anti-D

B. Gorick, P. Mollison, B. Kumpel, 1990, The Lancet.

Relative Functional Binding Activity of IgGl and IgG3 Anti‐D in IgG Preparations

B. Gorick, N. Hughes-Jones, 1991, Vox sanguinis.

Failure of a Relatively Small Dose of Passively Administered Anti-Rh to Suppress Primary Immunization by a Relatively Large Dose of Rh-positive Red Cells

P. Mollison, N. Hughes-Jones, 1968 .

Initiation of complement activation

P. Lachmann, N. Hughes-Jones, 2005, Springer Seminars in Immunopathology.

Monoclonal antibodies to red cell alloantigens with particular reference to anti-D.

N. Hughes-Jones, S. Parsons, 1992, Transfusion medicine reviews.

Synthesis of Rh Fv phage‐antibodies using VH and VL germline genes

W. Ouwehand, J. Bye, B. Gorick, 1999, British journal of haematology.

Differential exposure of epitopes on the human red cell antigen D (Rh).

B. Gorick, N. Hughes-Jones, D. Brown, 1991, Immunology letters.

Demonstration of Seven Epitopes on the Rh Antigen D Using Human Monoclonal Anti‐D Antibodies and Red Cells from D Categories

K. Thompson, N. Hughes-Jones, P. Tippett, 1989, Vox sanguinis.

Requirements for the establishment of heterohybridomas secreting monoclonal human antibody to rhesus (D) blood group antigen.

K. Thompson, N. Hughes-Jones, M. Melamed, 1987, Journal of immunological methods.

Senescence of a human lymphoblastoid clone producing anti‐Rhesus(D)

N. Hughes-Jones, D. Edgar, M. Melamed, 1985, European journal of immunology.

Production of Human IgM Anti‐D in Tissue Culture by EB‐Virus‐transformed Lymphocytes

R. Anderson, N. Hughes-Jones, B. Gardner, 1980, Scandinavian journal of immunology.

Observations on the Number of Available C Antigen Sites on Red Cells

N. Hughes-Jones, F. Skov, 1977, Vox sanguinis.

Direct Antiglobulin Reaction in ABO-Haemolytic Disease of the Newborn

P. Mollison, N. Hughes-Jones, E. Romano, 1973, British medical journal.

Critical dependence on antibody for defence against mycoplasmas.

P. Furr, D. Taylor-Robinson, B. Gorick, 1988, Clinical and experimental immunology.

The functional activities of IgG and IgM anti-A and anti-B.

N. Hughes-Jones, B. Gardner, J. Economidou, 1967, Immunology.

THE HUMORAL IMMUNE RESPONSE AGAINST BLOOD GROUP ANTIGENS AT THE MOLECULAR LEVEL

J. Bye, J. Marks, B. Gorick, 1994, Vox sanguinis.

Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies. Evidence for affinity maturation by somatic hypermutation and repertoire shift.

J. Bye, G. Winter, J. Marks, 1992, The Journal of clinical investigation.

Nucleotide sequences and three-dimensional modelling of the VH and VL domains of two human monoclonal antibodies specific for the D antigen of the human Rh-blood-group system.

J. Bye, J. Coadwell, D. Beale, 1990, Biochemical Journal.

Differences between the activities of human monoclonal IgG1 and IgG3 subclasses of anti-D(Rh) antibody in their ability to mediate red cell-binding to macrophages.

B. Gorick, E. Wiener, K. Thompson, 1987, Immunology.

Heterogeneity in the ability of IgG1 monoclonal anti‐D to promote lymphocyte‐mediated red cell lysis

A. Blancher, B. Kumpel, A. Hadley, 1989, European journal of immunology.

The binding and activation of the Clr-Cls subunit of the first component of human complement.

B. Gorick, N. Hughes-Jones, 1982, Molecular immunology.

Functional affinity constants of the reaction between 125I-labelled C1q and C1q binders and their use in the measurement of plasma C1q concentrations.

N. Hughes-Jones, 1977, Immunology.

THE EFFECT OF PH AND IONIC STRENGTH ON THE REACTION BETWEEN ANTI-D AND ERYTHROCYTES.

N. Hughes-Jones, B. Gardner, R. Telford, 1964, Immunology.

The estimation of the concentration and equilibrium constant of anti-D.

N. Hughes-Jones, 1967, Immunology.

Quantification of antibodies to the C3d subcomponent of human C3.

H. Chaplin, N. Hughes-Jones, J. Freedman, 1977, Immunology.

NATURE OF THE REACTION BETWEEN ANTIGEN AND ANTIBODY.

N. Hughes-Jones, 1963, British medical bulletin.

Production of human monoclonal IgG and IgM antibodies with anti-D (rhesus) specificity using heterohybridomas.

A. Holburn, B. Gorick, K. Thompson, 1986, Immunology.

Monoclonal antibodies as potential blood typing reagents.

N. Hughes-Jones, 1988, Immunology today.

Red cell agglutination: the first description by creite (1869) and further observations made by landois (1875) and landsteiner (1901)

N. Hughes-Jones, B. Gardner, 2002, British journal of haematology.

Comparison of Various Methods of Dissociation of Anti‐D, using 131I‐labelled Antibody

N. Hughes-Jones, B. Gardner, R. Telford, 1963, Vox sanguinis.

Some biological effects of IgM anti-Rh (D).

A. Holburn, P. Mollison, N. Hughes-Jones, 1971, Immunology.

The equilibrium constants of anti-D immunoglobulin preparations made from pools of donor plasma.

N. Hughes-Jones, B. Gardner, 1970, Immunology.

Anti-immunoglobulin inhibits DNA synthesis in Epstein-Barr virus-transformed lymphoblastoid cell lines.

S. Ley, J. Gordon, N. Hughes-Jones, 1984, Immunology.

Immunoglobulin M Conformational Change is a Signal for Complement Activation

B. Gorick, N. Hughes-Jones, N. Richardson, 1983 .

Synergistic complement lysis by monoclonal antibodies to the human leukocyte common antigen requires both the classical and alternative pathways.

G. Hale, H. Waldmann, B. Gorick, 1987, Molecular immunology.

Anti‐D‐coated Rh‐positive red cells will bind the first component of the complement pathway, C1q

N. Hughes-Jones, Sunit Ghosh, 1981, FEBS letters.

Complement and solubilization of immune complexes.

N. Hughes-Jones, 1982, Immunology today.

Anti‐D Concentration in Mother and Child in Haemolytic Disease of the Newborn

N. Hughes-Jones, W. Walker, M. I. Ellis, 1971, Vox sanguinis.

Complement-mediated lysis with monoclonal antibodies.

N. Hughes-Jones, J. Howard, 1988, Progress in allergy.

Elution of antispectrin antibodies from red cells in homozygous beta-thalassaemia.

E. Wiener, S. Wickramasinghe, N. Hughes-Jones, 1986, Clinical and experimental immunology.

Controlled trial of various anti-D dosages in suppression of Rh sensitization following pregnancy. Report to the Medical Research Council by the working party on the use of anti-D-immunoglobulin for the prevention of isoimmunization of Rh-negative women during pregnancy.

R. Doll, S. L. Barron, P. Mollison, 1974, British medical journal.

The Kell System Studied with Radioactively‐Labelled Anti‐K

N. Hughes-Jones, B. Gardner, N. C. Hughes‐Jones, 1971, Vox sanguinis.

The Amount of Anti‐D on Red Cells in Haemolytic Disease of the Newborn

N. Hughes-Jones, M. Hughes, W. Walker, 1967 .

HUMAN MONOCLONAL ANTIBODIES AND HAEMOLYTIC DISEASE OF THE NEWBORN

N. Hughes-Jones, 1988, British journal of haematology.

Prediction of the Severity of Haemolytic Disease of the Newborn: Quantitative IgG Anti‐D Subclass Determinations Explain the Correlation with Functional Assay Results

S. Garner, B. Gorick, M. Contreras, 1995, Vox sanguinis.

The Effect of Ficin on the Reaction Between Anti‐D and Red Cells

N. Hughes-Jones, B. Gardner, R. Telford, 1964, Vox sanguinis.

International Collaborative Study of Assay of Anti‐D (Anti‐Rho) Immunoglobulin

D. Bangham, H. Gunson, N. Hughes-Jones, 1978 .

Antibody density on rat red cells determines the rate of activation of the complement component Cl

B. Gorick, J. Howard, N. Hughes-Jones, 1985, European journal of immunology.

2 Production and characterization of monoclonal anti-Rh

K. Thompson, N. Hughes-Jones, 1990 .

Ability of Monoclonal Anti‐D Antibodies to Promote the Binding of Red Cells to Lymphocytes, Granulocytes and Monocytes

B. Kumpel, A. Hadley, N. Hughes-Jones, 1989, Vox sanguinis.

Radio‐Immunoassay of the Functional Activity of Anti‐D (Rh) Preparations using a Human Monoclonal 125I‐Labelled Anti‐D

B. Gorick, K. Thompson, N. Hughes-Jones, 1987, Vox sanguinis.

IgG pair formation on one antigenic molecule is the main mechanism of synergy between antibodies in complement‐mediated lysis

N. Miller, B. Gorick, J. Howard, 1984, European journal of immunology.

A simple method for the detection and assay of C1.

E. Folkerd, N. Hughes-Jones, 1979, Journal of immunological methods.

Antibody-independent activation of the classical pathway of complement by Epstein-Barr virus.

B. Gorick, I. Mcconnell, N. Hughes-Jones, 1987, Clinical and experimental immunology.

Failure of a Relatively Small Dose of Passively Administered Anti-Rh to Suppress Primary Immunization by a Relatively Large Dose of Rh-positive Red Cells.

P. Mollison, N. Hughes-Jones, 1968, British medical journal.

The measurement of the concentration and equilibrium constant of anti-D.

N. Hughes-Jones, 1968, Bibliotheca haematologica.

Iodine-125-labelled L Chains of Human Blood Group Antibodies

N. Hughes-Jones, 1965, Nature.

The kinetics of the reaction between the blood-group antibody anti-c and erythrocytes.

N. Hughes-Jones, B. Gardner, R. Telford, 1962, The Biochemical journal.