N. Miyata

发表

Ozoralizumab, a Humanized Anti-TNFα NANOBODY® Compound, Exhibits Efficacy Not Only at the Onset of Arthritis in a Human TNF Transgenic Mouse but Also During Secondary Failure of Administration of an Anti-TNFα IgG

Masanao Kyuuma, Chihiro Ishiwatari-Ogata, Hitoshi Ogata, 2022, Frontiers in Immunology.

DMOG, a Prolyl Hydroxylase Inhibitor, Increases Hemoglobin Levels without Exacerbating Hypertension and Renal Injury in Salt-Sensitive Hypertensive Rats

R. Roman, Sota Kato, N. Miyata, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors.

Toshio Nakamura, H. Kakinuma, N. Miyata, 2004, Bioorganic & medicinal chemistry letters.

Effect of 20-HETE Inhibition on Infarct Volume and Cerebral Blood Flow after Transient Middle Cerebral Artery Occlusion

R. Koehler, R. Roman, D. Harder, 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Beneficial Effects of a new 20-HETE Synthesis Inhibitor, TS-011, on Hemorrhagic and Ischemic Stroke

S. Okuyama, D. Harder, N. Miyata, 2005 .

Beneficial Effects of a New 20-Hydroxyeicosatetraenoic Acid Synthesis Inhibitor, TS-011 [N-(3-Chloro-4-morpholin-4-yl) Phenyl-N′-hydroxyimido Formamide], on Hemorrhagic and Ischemic Stroke

S. Okuyama, R. Roman, D. Harder, 2005, Journal of Pharmacology and Experimental Therapeutics.

Effects of a 20-HETE antagonist and agonists on cerebral vascular tone.

J. Falck, R. Roman, K. Takeuchi, 2004, European journal of pharmacology.

Effect of a New Inhibitor of the Synthesis of 20-HETE on Cerebral Ischemia Reperfusion Injury

S. Okuyama, S. Nakaike, R. Roman, 2006, Stroke.

20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat.

M. L. Schulte, A. Hudetz, R. Roman, 2002, American journal of physiology. Heart and circulatory physiology.

Suppression of Renal α‐Dicarbonyl Compounds Generated following Ureteral Obstruction by Kidney‐Specific α‐Dicarbonyl/l‐Xylulose Reductase

K. Maeda, H. Odani, A. Nakamura, 2008 .

Reversal of delayed vasospasm by TS-011 in the dual hemorrhage dog model of subarachnoid hemorrhage.

J. Cusick, R. Roman, L. Hacein-Bey, 2006, AJNR. American journal of neuroradiology.

Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE.

R. Roman, K. Takeuchi, D. Harder, 2005, American journal of physiology. Heart and circulatory physiology.

Effects of a New SGLT 2 Inhibitor , Luseogliflozin , on Diabetic Nephropathy in T 2 DN Rats

R. Roman, J. Williams, N. Miyata, 2013 .

Effects of a New SGLT2 Inhibitor, Luseogliflozin, on Diabetic Nephropathy in T2DN Rats

R. Roman, J. Williams, N. Miyata, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Suppression of AGE Precursor Formation Following Unilateral Ureteral Obstruction in Mouse Kidneys by Transgenic Expression of α-Dicarbonyl/L-Xylulose Reductase

K. Maeda, H. Odani, A. Nakamura, 2006, Bioscience, biotechnology, and biochemistry.

(1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment.

H. Kakinuma, F. Io, Saeko Uchida, 2010, Journal of medicinal chemistry.

Impairment of endothelium‐dependent relaxation and changes in levels of cyclic GMP in aorta from streptozotocin‐induced diabetic rats

K. Kamata, Y. Kasuya, N. Miyata, 1989, British journal of pharmacology.

Functional changes in vascular smooth muscle and endothelium of arteries during diabetes mellitus.

K. Kamata, Y. Kasuya, N. Miyata, 1992, Life sciences.

Effects of endothelin on the portal vein from spontaneously hypertensive and Wistar Kyoto rats.

K. Kamata, Y. Kasuya, N. Miyata, 1990, General pharmacology.

Involvement of endothelial cells in relaxation and contraction responses of the aorta to isoproterenol in naive and streptozotocin-induced diabetic rats.

K. Kamata, Y. Kasuya, N. Miyata, 1989, The Journal of pharmacology and experimental therapeutics.

Decrease in endothelium-dependent relaxation and levels of cyclic nucleotides in aorta from rabbits with alloxan-induced diabetes.

Y. Watanabe, K. Kamata, Y. Kasuya, 1990, Research communications in chemical pathology and pharmacology.

Hemoglobin, NO, and 20-HETE interactions in mediating cerebral vasoconstriction following SAH.

R. Roman, K. Takeuchi, D. Harder, 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

Cardiovascular-Kidney Interactions in Health and Disease Hemoglobin , NO , and 20-HETE interactions in mediating cerebral vasoconstriction following

R. Roman, K. Takeuchi, D. Harder, 2005 .

Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor.

T. Ishii, M. Sato, N. Miyata, 2001, Bioorganic & medicinal chemistry letters.

Functional changes in potassium channels in aortas from rats with streptozotocin-induced diabetes.

K. Kamata, Y. Kasuya, N. Miyata, 1989, European journal of pharmacology.

Continuous inhibition of 20-HETE synthesis by TS-011 improves neurological and functional outcomes after transient focal cerebral ischemia in rats

S. Nakaike, S. Yoshida, N. Miyata, 2007, Neuroscience Research.

Role of cyclic GMP in inhibitory effects of CD-349 in isolated blood vessels.

N. Miyata, S. Otomo, K. Tsuchida, 1994, General pharmacology.

CD-832, a new dihydropyridine derivative with both nitrate-like and Ca2+ channel antagonist vasodilator activities.

K. Takahashi, N. Miyata, S. Otomo, 1993, European journal of pharmacology.

Changes in responsiveness of the canine basilar artery to endothelin-1 after subarachnoid hemorrhage.

K. Kamata, Y. Kasuya, N. Miyata, 1991, Life sciences.

Renal medullary interstitial infusion ofl-arginine prevents hypertension in Dahl salt-sensitive rats.

A. Cowley, D. Mattson, A. Zou, 1998, American journal of physiology. Regulatory, integrative and comparative physiology.

Increased Levels of Renal Lysophosphatidic Acid in Rodent Models with Renal Disease

R. Roman, N. Miyata, Teisuke Takahashi, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Effects of CD-832, a dihydropyridine derivative with a nitrate ester moiety on rabbit femoral artery and vein.

K. Takahashi, N. Miyata, S. Otomo, 1994, European journal of pharmacology.

Cytochrome P450 4A isoform inhibitory profile of N-hydroxy-N'-(4-butyl-2-methylphenyl)-formamidine (HET0016), a selective inhibitor of 20-HETE synthesis.

N. Miyata, M. Laniado-Schwartzman, M. Wang, 2005, Biological & pharmaceutical bulletin.

Effects of taurine and enalapril on kidney function of the hypertensive glucose-intolerant rat.

M. Mozaffari, N. Miyata, S. Schaffer, 2003, American journal of hypertension.

S. Okuyama, K. Kamata, Y. Kasuya, 1992, The American journal of physiology.

Pyrazole and isoxazole derivatives as new, potent, and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors.

Toshio Nakamura, H. Kakinuma, N. Miyata, 2003, Journal of medicinal chemistry.

Distribution of angiotensin AT1 and AT2 receptor subtypes in the rat kidney.

F. Park, A. Cowley, N. Miyata, 1999, American journal of physiology. Renal physiology.

Distribution of angiotensin AT1 and AT2 receptor subtypes in the rat kidney.

F. Park, A. Cowley, N. Miyata, 1999, American journal of physiology. Renal physiology.

HET0016, a potent and selective inhibitor of 20‐HETE synthesizing enzyme

N. Miyata, Masakazu Sato, K. Taniguchi, 2001, British journal of pharmacology.

Renoprotective effects of combined SGLT2 and ACE inhibitor therapy in diabetic Dahl S rats

R. Roman, J. Williams, Sota Kato, 2015, Physiological reports.

Renal intramedullary infusion of L-arginine prevents reduction of medullary blood flow and hypertension in Dahl salt-sensitive rats.

A. Cowley, N. Miyata, 1999, Hypertension.

Renal medullary interstitial infusion of L-arginine prevents hypertension in Dahl salt-sensitive rats.

A. Cowley, D. Mattson, A. Zou, 1998, The American journal of physiology.

Role of 20-hydroxyeicosatetraenoic acid (20-HETE) in vascular system.

R. Roman, N. Miyata, 2005, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Increased excretion of urinary 20-HETE in rats with cyclosporine-induced nephrotoxicity.

R. Roman, N. Miyata, K. Taniguchi, 2005, Journal of pharmacological sciences.

Enhanced contractile effect of phorbol dibutyrate in portal veins from hypertensive rats.

N. Miyata, S. Otomo, K. Tsuchida, 1991, Biochemical and biophysical research communications.

Impairment of Endothelium‐dependent Relaxation and Changes in Levels of cyclic GMP in Carotid Arteries from Stroke‐prone Spontaneously Hypertensive Rats

N. Miyata, S. Otomo, K. Tsuchida, 1990, The Journal of pharmacy and pharmacology.

Multidirectional contraction of human hypertrophied prostate.

K. Kawabe, N. Moriyama, N. Miyata, 1994, General pharmacology.

Mechanisms of increased responses of the aorta to alpha-adrenoceptor agonists in streptozotocin-induced diabetic rats.

K. Kamata, Y. Kasuya, N. Miyata, 1988, Journal of pharmacobio-dynamics.

Changes in responsiveness of the aorta to vasorelaxant agents in genetically diabetic rats: a study in WBN/Kob rats.

K. Kamata, Y. Kasuya, N. Miyata, 1992, Life Science.

Differences in vascular responses to vasoactive agents of basilar artery and aorta from rabbits with alloxan-induced diabetes.

K. Kamata, Y. Kasuya, N. Miyata, 1990, Canadian journal of physiology and pharmacology.

Functional changes in potassium channels in carotid arteries from stroke-prone spontaneously hypertensive rats.

N. Miyata, S. Otomo, K. Tsuchida, 1990, European journal of pharmacology.

Pyrazole derivatives as new potent and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors.

Toshio Nakamura, H. Kakinuma, N. Miyata, 2004, Bioorganic & medicinal chemistry.

Design and synthesis of 1-(4-benzoylphenyl)imidazole derivatives as new potent 20-HETE synthase inhibitors.

T. Ishii, Toshio Nakamura, N. Miyata, 2004, Bioorganic & medicinal chemistry letters.

Design and Synthesis of 1‐(4‐Benzoylphenyl)imidazole Derivatives as New Potent 20‐HETE Synthase Inhibitors.

T. Ishii, Toshio Nakamura, N. Miyata, 2005 .

Effects of CD-349 and 8-BrcGMP on isoproterenol-induced relaxation in rabbit aorta precontracted with endothelin-1.

N. Miyata, S. Otomo, K. Tsuchida, 1992, The American journal of physiology.