J. Reckless

发表

Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease

S. Clare, L. Maggiore, K. Ray, 2018, Scientific Reports.

Tamoxifen decreases cholesterol sevenfold and abolishes lipid lesion development in apolipoprotein E knockout mice.

D. Grainger, J. Metcalfe, J. Reckless, 1997, Circulation.

Anaesthetic Impairment of Immune Function Is Mediated via GABAA Receptors

J. Trowsdale, D. Menon, A. J. Thompson, 2011, PloS one.

Neuroprotection in Ischemia–Reperfusion Injury: An Antiinflammatory Approach Using a Novel Broad-Spectrum Chemokine Inhibitor

Steven C. R. Williams, D. Menon, D. Grainger, 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Feedback Mechanism of Focal Vascular Lesion Formation in Transgenic Apolipoprotein(a) Mice*

E. Rubin, A. Pearle, R. Lawn, 1996, The Journal of Biological Chemistry.

Broad-Spectrum Chemokine Inhibition Reduces Vascular Macrophage Accumulation and Collagenolysis Consistent with Plaque Stabilization in Mice

D. Grainger, E. McKilligin, J. Reckless, 2005, Journal of Vascular Research.

Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms

N. Morrell, Jingxu Guo, D. Grainger, 2020, Nature Communications.

Identification of 3-(acylamino)azepan-2-ones as stable broad-spectrum chemokine inhibitors resistant to metabolism in vivo.

D. Grainger, I. Greig, D. Fox, 2005, Journal of medicinal chemistry.

Highly potent, orally available anti-inflammatory broad-spectrum chemokine inhibitors.

D. Grainger, Hannah Lingard, D. Fox, 2009, Journal of medicinal chemistry.

The pan‐chemokine inhibitor NR58‐3.14.3 abolishes tumour necrosis factor‐α accumulation and leucocyte recruitment induced by lipopolysaccharide in vivo

D. Grainger, J. Reckless, Lauren M. Tatalick, 2001, Immunology.

Oral Anti-Tumour Necrosis Factor Domain Antibody V565 Provides High Intestinal Concentrations, and Reduces Markers of Inflammation in Ulcerative Colitis Patients

L. Maggiore, P. Irving, K. Ray, 2019, Scientific Reports.

Design, synthesis, and preliminary pharmacological evaluation of N-acyl-3-aminoglutarimides as broad-spectrum chemokine inhibitors in vitro and anti-inflammatory agents in vivo.

D. Grainger, D. Fox, J. Reckless, 2002, Journal of medicinal chemistry.

Broad-spectrum chemokine inhibitors (BSCIs) and their anti-inflammatory effects in vivo.

D. Grainger, J. Reckless, 2003, Biochemical pharmacology.

Monocyte chemoattractant protein-1 but not tumor necrosis factor-alpha is correlated with monocyte infiltration in mouse lipid lesions.

E. Rubin, D. Grainger, J. Metcalfe, 1999, Circulation.

The MHP36 line of murine neural stem cells expresses functional CXCR1 chemokine receptors that initiate chemotaxis in vitro

D. Menon, D. Grainger, P. Mastroeni, 2007, Journal of Neuroimmunology.

Apolipoprotein E Modulates Clearance of Apoptotic Bodies In Vitro and In Vivo, Resulting in a Systemic Proinflammatory State in Apolipoprotein E-Deficient Mice1

D. Grainger, E. McKilligin, Elaine McKilligin, 2004, The Journal of Immunology.

State in Apolipoprotein E-Deficient Mice Resulting in a Systemic Proinflammatory Apoptotic Bodies In Vitro and In Vivo, Apolipoprotein E Modulates Clearance of

D. Grainger, E. McKilligin, J. Reckless, 2004 .

Tools for anti‐inflammatory drug design: In vitro models of leukocyte migration

D. Grainger, E. Frow, J. Reckless, 2004, Medicinal research reviews.

A Common Phenotype Associated with Atherogenesis in Diverse Mouse Models of Vascular Lipid Lesions

E. Rubin, D. Grainger, J. Metcalfe, 2001, Journal of Vascular Research.

Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms

N. Morrell, Jingxu Guo, D. Grainger, 2020, Nature Communications.

Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease

S. Clare, L. Maggiore, K. Ray, 2018, Scientific Reports.

Molecular activation-deactivation of xanthine oxidase in human milk.

M. Benboubetra, J. Reckless, R. Harrison, 1995, Biochimica et biophysica acta.

Identification of oligopeptide sequences which inhibit migration induced by a wide range of chemokines.

D. Grainger, J. Reckless, 1999, Biochemical Journal.

Tools for Antiinflammatory Drug Design: In vitro Models of Leukocyte Migration

D. Grainger, E. Frow, J. Reckless, 2004 .