M. Johnstone

发表

Resistance the Binding Pocket , and Implications for Mechanism of Inhibition , Conservation of-Lactamases : β Avibactam and Class C

P. Ross, R. Alm, R. Mclaughlin, 2014 .

In Vitro Antibacterial Activity of AZD0914, a New Spiropyrimidinetrione DNA Gyrase/Topoisomerase Inhibitor with Potent Activity against Gram-Positive, Fastidious Gram-Negative, and Atypical Bacteria

G. Basarab, M. Huband, P. Miller, 2014, Antimicrobial Agents and Chemotherapy.

Avibactam and Class C β-Lactamases: Mechanism of Inhibition, Conservation of the Binding Pocket, and Implications for Resistance

P. Ross, R. Alm, R. Mclaughlin, 2014, Antimicrobial Agents and Chemotherapy.

Characterization of Escherichia coli NDM isolates with decreased susceptibility to aztreonam/avibactam: role of a novel insertion in PBP3.

R. Alm, M. Johnstone, S. Lahiri, 2015, The Journal of antimicrobial chemotherapy.

Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC.

R. Alm, R. Mclaughlin, James D. Whiteaker, 2015, The Journal of antimicrobial chemotherapy.

Exploring the UDP pocket of LpxC through amino acid analogs.

Matthew D. Miller, Wei Yang, P. Ross, 2013, Bioorganic & medicinal chemistry letters.

NBTI 5463 Is a Novel Bacterial Type II Topoisomerase Inhibitor with Activity against Gram-Negative Bacteria and In Vivo Efficacy

T. Dougherty, D. Ehmann, M. Cronin, 2014, Antimicrobial Agents and Chemotherapy.

NBTI 5463 Is a Novel Bacterial Type II Topoisomerase Inhibitor with Activity against Gram-Negative Bacteria and In Vivo Efficacy

T. Dougherty, D. Ehmann, M. Cronin, 2014, Antimicrobial Agents and Chemotherapy.

Antibacterial Therapy (PPAT) To Validate PPAT as a Target for -Phosphopantetheine Adenylyltransferase ' Discovery of Inhibitors of 4

M. Johnstone, Ning Gao, Jason Thresher, 2014 .

Discovery of Inhibitors of 4′-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy

H. Ni, M. Johnstone, S. Lahiri, 2013, Antimicrobial Agents and Chemotherapy.

Translating slow-binding inhibition kinetics into cellular and in vivo effects.

Peter J Tonge, Virna J A Schuck, Zhiping You, 2015, Nature chemical biology.

Negishi cross-coupling enabled synthesis of novel NAD(+)-dependent DNA ligase inhibitors and SAR development.

Matthew D. Miller, M. Gowravaram, C. Eyermann, 2015, Bioorganic & medicinal chemistry letters.

Activity of avibactam against Enterobacter cloacae producing an extended-spectrum class C β-lactamase enzyme.

R. Alm, R. Giacobbe, M. Johnstone, 2014, The Journal of antimicrobial chemotherapy.

Efficacy In Vivo against Gram-Negative Bacteria and Topoisomerase Inhibitor with Activity NBTI 5463 Is a Novel Bacterial Type II

T. Dougherty, M. Cronin, F. Reck, 2014 .

NBTI 5463 is a novel bacterial type II topoisomerase inhibitor with Gram-6 negative antibacterial activity and in vivo efficacy

T. Dougherty, D. Ehmann, M. Cronin, 2014 .

Frequency and Mechanism of Spontaneous Resistance to Sulbactam Combined with the Novel β-Lactamase Inhibitor ETX2514 in Clinical Isolates of Acinetobacter baumannii

S. McLeod, R. Mclaughlin, M. Johnstone, 2017, Antimicrobial Agents and Chemotherapy.