Mayland Chang

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Discovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity

M. Suckow, Malika Kumarasiri, Hualiang Pi, 2014, Journal of the American Chemical Society.

Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials

S. Mobashery, Choonkeun Kim, S. Ceballos, 2019, Antimicrobial Agents and Chemotherapy.

Acceleration of diabetic wound healing using a novel protease–anti-protease combination therapy

M. Suckow, S. Mobashery, W. Wolter, 2015, Proceedings of the National Academy of Sciences.

Synthesis, Kinetic Characterization and Metabolism of Diastereomeric 2‐(1‐(4‐Phenoxyphenylsulfonyl)ethyl)thiiranes as Potent Gelatinase and MT1‐MMP Inhibitors

R. Fridman, A. Oliver, S. Mobashery, 2009, Chemical biology & drug design.

Targeting Extracellular Matrix Remodeling Restores BRAF Inhibitor Sensitivity in BRAFi-resistant Melanoma

G. Mills, R. Sullivan, K. Flaherty, 2020, Clinical Cancer Research.

Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds.

S. Franzblau, H. Boshoff, Marvin J. Miller, 2012, Bioorganic & medicinal chemistry.

Conformational Dynamics in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus, Allosteric Communication Network and Enablement of Catalysis.

R. Molina, J. Hermoso, Kiran V. Mahasenan, 2017, Journal of the American Chemical Society.

Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials.

Malika Kumarasiri, Kiran V. Mahasenan, S. Mobashery, 2016, Bioorganic & medicinal chemistry letters.

Pharmacological Stabilization of Intracranial Aneurysms in Mice

S. Mobashery, T. Hashimoto, Kosuke Wada, 2012 .

Pharmacological Stabilization of Intracranial Aneurysms in Mice: A Feasibility Study

S. Mobashery, H. Makino, T. Hashimoto, 2012, Stroke.

Role of Matrix Metalloproteinases and Therapeutic Benefits of Their Inhibition in Spinal Cord Injury

D. Basso, L. Noble-Haeusslein, Christopher N. Hansen, 2011, Neurotherapeutics.

Allosteric Inhibition of Bacterial Targets: An Opportunity for Discovery of Novel Antibacterial Classes

S. Mobashery, J. Fisher, Mayland Chang, 2017 .

Roles of Matrix Metalloproteinases in Flow-Induced Outward Vascular Remodeling

W. Young, A. Sakamoto, S. Mobashery, 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus

J. Hermoso, Kiran V. Mahasenan, S. Mobashery, 2019, Antimicrobial Agents and Chemotherapy.

Metabolism of the Selective Matrix Metalloproteinase-9 Inhibitor (R)-ND-336.

S. Mobashery, J. Fisher, Mayland Chang, 2021, ACS pharmacology & translational science.

The haustorium and the chemistry of host recognition in parasitic angiosperms

D. Lynn, Mayland Chang, 1986, Journal of Chemical Ecology.

Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy.

T. Bui, R. Balsara, F. Castellino, 2020, ACS pharmacology & translational science.

MMP-1 and ADAM10 as Targets for Therapeutic Intervention in Idiopathic Pulmonary Fibrosis.

S. Mobashery, Mayland Chang, Man Wang, 2022, ACS pharmacology & translational science.

Selective MMP-9 Inhibitor (R)-ND-336 Alone or in Combination with Linezolid Accelerates Wound Healing in Infected Diabetic Mice.

S. Mobashery, Mijoon Lee, D. Hesek, 2020, ACS pharmacology & translational science.

Endogenous matrix metalloproteinases 2 and 9 regulate activation of CD4+ and CD8+ T cells.

Gerald N. Smith, S. Mobashery, F. Kheradmand, 2011, American journal of respiratory cell and molecular biology.

Targeting extracellular matrix remodeling sensitizes glioblastoma to ionizing radiation

S. Welford, B. Bedogni, V. Thakur, 2022, Neuro-oncology advances.

Exploration of the structure-activity relationship of 1,2,4-oxadiazole antibiotics.

S. Mobashery, E. Lastochkin, Peter I. O’Daniel, 2015, Bioorganic & medicinal chemistry letters.

A chemical biological strategy to facilitate diabetic wound healing.

M. Suckow, Hualiang Pi, S. Mobashery, 2014, ACS chemical biology.

Control ofGermination inStriga asiatica: Chemistry of Spatial Definition1

Mayland Chang, G. Fate, 1990 .

Limitations of Knockout Mice and Other Tools in Assessment of the Involvement of Matrix Metalloproteinases in Wound Healing and the Means to Overcome Them.

M. Suckow, Valerie A. Schroeder, W. Wolter, 2020, ACS pharmacology & translational science.

Proteomics Identification of Targets for Intervention in Pressure Ulcers.

S. Mobashery, Valerie A. Schroeder, W. Wolter, 2022, ACS chemical biology.

Chemical Regulation of Distance: Characterization of the First Natural Host Germination Stimulant for Striga asiatica.

L. Butler, D. Lynn, Mayland Chang, 1987 .

Water-soluble mmp-9 inhibitor prodrug generates active metabolites that cross the blood-brain barrier.

Jiankun Cui, M. Suckow, Z. Gu, 2013, ACS chemical neuroscience.

Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinases.

S. Mobashery, J. Fisher, R. Bouley, 2011, Bioorganic & medicinal chemistry letters.

Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery after Spinal Cord Injury.

M. Suckow, Kiran V. Mahasenan, S. Mobashery, 2016, ACS chemical neuroscience.

Conformational analyses of thiirane-based gelatinase inhibitors.

S. Mobashery, J. Fisher, Mijoon Lee, 2008, Bioorganic & medicinal chemistry letters.

Unconventional Antibacterials and Adjuvants.

J. Hermoso, Kiran V. Mahasenan, S. Mobashery, 2021, Accounts of chemical research.

Structure−activity Relationship for the Oxadiazole Class of Antibiotics Scheme 1. Structure of the Lead Oxadiazole 1

M. Suckow, Hualiang Pi, S. Mobashery, 2022 .

PHENOLIC SIGNALS IN COHABITATION: IMPLICATIONS FOR PLANT DEVELOPMENT

D. Lynn, Mayland Chang, 1990 .

Structure–Activity Relationship for the 4(3H)-Quinazolinone Antibacterials

Wei Song, Mark A. Suckow, M. Suckow, 2016, Journal of medicinal chemistry.

The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity.

A. Oliver, S. Mobashery, Mijoon Lee, 2016, Journal of natural products.

Ferric chloride, an anomerization catalyst for the preparation of alkyl α-glycopyranosides

K. Nakanishi, L. Lo, Mayland Chang, 1992 .

Combined Scaffold Evaluation and Systems‐Level Transcriptome‐Based Analysis for Accelerated Lead Optimization Reveals Ribosomal Targeting Spirooxindole Cyclopropanes

P. Schnepp, B. Ashfeld, M. Burnette, 2019, ChemMedChem.

Synthesis and evaluation of 1,2,4-triazolo[1,5-a]pyrimidines as antibacterial agents against Enterococcus faecium.

Malika Kumarasiri, S. Mobashery, Mijoon Lee, 2015, Journal of medicinal chemistry.

Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one.

M. Suckow, J. Hermoso, Malika Kumarasiri, 2015, Journal of the American Chemical Society.

Structure-activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters.

S. Franzblau, U. Möllmann, Marvin J. Miller, 2010, European journal of medicinal chemistry.

O-phenyl carbamate and phenyl urea thiiranes as selective matrix metalloproteinase-2 inhibitors that cross the blood-brain barrier.

M. Suckow, Kiran V. Mahasenan, S. Mobashery, 2013, Journal of medicinal chemistry.

Design, synthesis, and evaluation of a mechanism-based inhibitor for gelatinase A.

S. Meroueh, M. Bernardo, R. Fridman, 2005, The Journal of organic chemistry.

A Potent Gelatinase Inhibitor with Anti‐Tumor‐Invasive Activity and its Metabolic Disposition

M. Suckow, M. Bernardo, R. Fridman, 2009, Chemical biology & drug design.

Roles of Matrix Metalloproteinases in Cutaneous Wound Healing

S. Mobashery, Mayland Chang, Trung T. Nguyen, 2016 .

Strategy for Treatment of Infected Diabetic Foot Ulcers.

Mayland Chang, Trung T. Nguyen, 2021, Accounts of chemical research.

Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus, an essential component of the divisome machinery

I. Muñoz, R. Molina, J. Hermoso, 2021, Computational and structural biotechnology journal.

Exploration of the Structural Space in 4(3H)-Quinazolinone Antibacterials.

Kiran V. Mahasenan, S. Mobashery, E. Lastochkin, 2020, Journal of medicinal chemistry.

Structural basis for carbapenemase activity of the OXA-23 β-lactamase from Acinetobacter baumannii.

Malika Kumarasiri, S. Mobashery, M. Tóth, 2013, Chemistry & biology.

Regular and irregular sesquiterpenes containing a halogenated hydropyran from Laurencia caespitosa

K. Nakanishi, J. T. Vázquez, Mayland Chang, 1989 .

A CD‐Spectroscopic Alternative to Methylation Analysis of Oligosaccharides: Reference Spectra for Identification of Chromophoric Glycopyranoside Derivatives

K. Nakanishi, N. Berova, M. Ojika, 1990 .

A CD-Spectroscopic Alternative to Methylation Analysis of Oligosaccharides: Reference Spectra for Identification of Chromophoric Glycopyranoside Derivatives.

K. Nakanishi, N. Berova, M. Ojika, 1990 .

Microscale glycosidic cleavage of oligosaccharide bromobenzoates for circular dichroism analysis

K. Nakanishi, M. Ojika, Mayland Chang, 1989 .

Microscale structure determination of oligosaccharides by the exciton chirality method

J. H. Park, K. Nakanishi, M. Ojika, 1989 .

In Search of Selectivity in Inhibition of ADAM10.

M. Suckow, Kiran V. Mahasenan, S. Mobashery, 2018, ACS medicinal chemistry letters.

Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis.

Yihai Cao, R. Beyaert, Qi Li, 2018, JCI insight.

Testosterone-Induced Matrix Metalloproteinase Activation Is a Checkpoint for Neuronal Addition to the Adult Songbird Brain

S. Goldman, Zhuoxun Chen, S. Mobashery, 2008, The Journal of Neuroscience.

Structure of hydroazulenoid diterpenes from a marine alga and their absolute configuration based on circular dichroism

K. Nakanishi, J. T. Vázquez, Mayland Chang, 1988 .

How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function

J. Hermoso, Malika Kumarasiri, C. Carrasco-López, 2013, Proceedings of the National Academy of Sciences.

Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing.

M. Suckow, Kiran V. Mahasenan, S. Mobashery, 2018, Journal of medicinal chemistry.

Structure-Activity Relationship for the Picolinamide Antibacterials that Selectively Target Clostridioides difficile.

A. Oliver, S. Mobashery, J. Fisher, 2021, ACS medicinal chemistry letters.

Matrix metalloproteinase profiling and their roles in disease

Mayland Chang, 2023, RSC advances.

In Vitro and In Vivo Synergy of the Oxadiazole Class of Antibacterials with β-Lactams

S. Mobashery, Jeshina Janardhanan, Derong Ding, 2016, Antimicrobial Agents and Chemotherapy.

Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases.

M. Suckow, Kiran V. Mahasenan, S. Mobashery, 2017, ACS medicinal chemistry letters.

Antimetastatic activity of a novel mechanism-based gelatinase inhibitor.

A. Krüger, M. Bernardo, R. Fridman, 2005, Cancer research.

Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background.

B. Fingleton, L. Matrisian, S. Mobashery, 2008, Cancer research.

Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism‐based selective gelatinase inhibitor

M. Bernardo, R. Fridman, S. Mobashery, 2006, International journal of cancer.

Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA

Brent A. Biddy, G. Dantas, M. Suckow, 2015, Nature chemical biology.

Selective water-soluble gelatinase inhibitor prodrugs.

M. Suckow, S. Mobashery, Mijoon Lee, 2011, Journal of medicinal chemistry.

Metabolism of (4‐Phenoxyphenylsulfonyl)methylthiirane, a Selective Gelatinase Inhibitor

M. Suckow, S. Mobashery, Mijoon Lee, 2008 .

Metabolism of a Highly Selective Gelatinase Inhibitor Generates Active Metabolite

R. Fridman, S. Mobashery, M. Tóth, 2007, Chemical biology & drug design.

The oxadiazole antibacterials.

S. Mobashery, Jeshina Janardhanan, Mayland Chang, 2016, Current opinion in microbiology.

Structure-Activity Relationship for the Oxadiazole Class of Antibacterials.

M. Suckow, S. Mobashery, E. Lastochkin, 2019, ACS medicinal chemistry letters.

Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia

Jiankun Cui, Z. Gu, Fanjun Meng, 2012, Molecular Neurodegeneration.

Production of Proteins of the SARS-CoV-2 Proteome for Drug Discovery

A. Bhardwaj, O. Wiest, Kiran V. Mahasenan, 2021, ACS omega.

Selective Inhibition of Matrix Metalloproteinase-9 Attenuates Secondary Damage Resulting from Severe Traumatic Brain Injury

B. N. Tomlinson, Jiankun Cui, Dmitriy Shin, 2013, PloS one.

Targeting MMP-9 in Diabetic Foot Ulcers

Mayland Chang, Trung T. Nguyen, Zhihong Peng, 2019, Pharmaceuticals.

Mutations in mmpL and in the Cell Wall Stress Stimulon Contribute to Resistance to Oxadiazole Antibiotics in Methicillin-Resistant Staphylococcus aureus

S. Mobashery, S. Vakulenko, Mayland Chang, 2014, Antimicrobial Agents and Chemotherapy.

aureusstant Staphylococcus to Oxadiazole Antibiotics in Stress Stimulon Contribute to Resistance and in the Cell Wall mmpL Mutations in

S. Mobashery, S. Vakulenko, Mayland Chang, 2014 .

Restructuring of the extracellular matrix in diabetic wounds and healing: A perspective.

Mayland Chang, 2016, Pharmacological research.

Selective small-molecule inhibitors as chemical tools to define the roles of matrix metalloproteinases in disease.

Mayland Chang, J. Meisel, 2017, Biochimica et biophysica acta. Molecular cell research.

The Allosteric Site for the Nascent Cell Wall in Penicillin-Binding Protein 2a: An Achilles' Heel of Methicillin-Resistant Staphylococcus aureus.

J. Hermoso, S. Mobashery, Mayland Chang, 2015, Current medicinal chemistry.

Penicillin‐binding protein 2a of methicillin‐resistant Staphylococcus aureus

J. Hermoso, S. Mobashery, Mayland Chang, 2014, IUBMB life.

The Tipper-Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA).

S. Mobashery, J. Fisher, Mayland Chang, 2015, Journal of the American Chemical Society.

Synthesis and PreliminaryIn VitroandIn VivoEvaluation of Thiirane‐Based Slow‐Binding MMP Inhibitors as Potential Radiotracers for PET Imaging

M. Schäfers, S. Hermann, H. Breyholz, 2018, ChemistrySelect.

Early Abrogation of Gelatinase Activity Extends the Time Window for tPA Thrombolysis after Embolic Focal Cerebral Ischemia in Mice

Jiankun Cui, Hailong Song, Z. Gu, 2018, eNeuro.

Blood-brain barrier resealing in neuromyelitis optica occurs independently of astrocyte regeneration.

M. Haberl, W. Möbius, C. Stadelmann, 2021, The Journal of clinical investigation.

Discovery of a potent picolinamide antibacterial active against Clostridioides difficile.

S. Mobashery, J. Fisher, E. Lastochkin, 2020, ACS infectious diseases.

Sulfonate-containing thiiranes as selective gelatinase inhibitors.

S. Mobashery, M. Tóth, Mijoon Lee, 2011, ACS medicinal chemistry letters.

Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier.

M. Suckow, S. Mobashery, Valerie A. Schroeder, 2012, ACS chemical neuroscience.

The thiirane-based selective MT1-MMP/MMP2 inhibitor ND-322 reduces melanoma tumor growth and delays metastatic dissemination.

B. Bedogni, Ian M. Bayles, Mayland Chang, 2016, Pharmacological research.

Water-Soluble MMP-9 Inhibitor Reduces Lesion Volume after Severe Traumatic Brain Injury.

B. N. Tomlinson, M. Suckow, Z. Gu, 2015, ACS chemical neuroscience.

Potent Mechanism-based Inhibitors for Matrix Metalloproteinases*

M. Bernardo, R. Fridman, S. Mobashery, 2005, Journal of Biological Chemistry.

Structure-Activity Relationship for Thiirane-Based Gelatinase Inhibitors.

Malika Kumarasiri, S. Mobashery, M. Tóth, 2012, ACS medicinal chemistry letters.

Chapter 10:Thiirane Class of Gelatinase Inhibitors as a Privileged Template that Crosses the Blood–Brain Barrier

S. Mobashery, Mayland Chang, Major Gooyit, 2015 .

Characterization of a selective inhibitor for matrix metalloproteinase-8 (MMP-8)

Hualiang Pi, S. Mobashery, Derong Ding, 2014 .

Early Gelatinase Activity Is Not a Determinant of Long-Term Recovery after Traumatic Brain Injury in the Immature Mouse

J. Raber, M. Suckow, Bridgette D. Semple, 2015, PloS one.

Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics

J. Hermoso, C. Carrasco-López, S. Mobashery, 2014, Journal of the American Chemical Society.

MMP-9 inhibitors impair learning in spontaneously hypertensive rats

Jeffrey F. Thompson, S. Mobashery, G. Rosenberg, 2018, PloS one.

Expression of active matrix metalloproteinase‐9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers

M. Suckow, S. Mobashery, Mijoon Lee, 2018, European journal of pharmacology.

Synthesis of Muramyl‐δ‐Lactam in Spore Peptidoglycan of Clostridioides difficile

S. Mobashery, Choonkeun Kim, Mijoon Lee, 2023, Chembiochem : a European journal of chemical biology.

Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA

Brent A. Biddy, G. Dantas, M. Suckow, 2015, Nature chemical biology.

Matrix Metalloproteinase-14 as an Instigator of Fibrosis in Human Pterygium and Its Pharmacological Intervention.

J. Hovanesian, S. Mobashery, Mayland Chang, 2022, ACS pharmacology & translational science.

Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria

S. Mobashery, Choonkeun Kim, S. Ceballos, 2018, Antimicrobial Agents and Chemotherapy.

Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinases.

S. Mobashery, J. Fisher, R. Bouley, 2011, Bioorganic & medicinal chemistry letters.

Hyperbaric oxygen therapy accelerates wound healing in diabetic mice by decreasing active matrix metalloproteinase‐9

M. Suckow, S. Mobashery, Mijoon Lee, 2019, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

Metabolism of (4‐Phenoxyphenylsulfonyl)methylthiirane, a Selective Gelatinase Inhibitor

M. Suckow, S. Mobashery, Mijoon Lee, 2008, Chemical Biology and Drug Design.

A Potent and Narrow-Spectrum Antibacterial against Clostridioides difficile Infection.

S. Mobashery, Jeshina Janardhanan, Derong Ding, 2023, Journal of medicinal chemistry.

Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials.

Malika Kumarasiri, Kiran V. Mahasenan, S. Mobashery, 2016, Bioorganic & medicinal chemistry letters.

A dual-action antibiotic that kills Clostridioides difficile vegetative cells and inhibits spore germination

S. Mobashery, Choonkeun Kim, Jeshina Janardhanan, 2023, Proceedings of the National Academy of Sciences of the United States of America.