Hong Wu

发表

Efg1, a Morphogenetic Regulator in Candida albicans, Is a Sequence-Specific DNA Binding Protein

Alistair J. P. Brown, Philip R. Lee, P. Leng, 2001, Journal of bacteriology.

Structural Biology of Human H3K9 Methyltransferases

Valérie Campagna-Slater, Matthieu Schapira, Abdellah Allali-Hassani, 2010, PloS one.

Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1).

G. Poda, C. Arrowsmith, M. Schapira, 2016, Journal of medicinal chemistry.

A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

L. Qin, L. Mazutis, J. Min, 2019, eLife.

Separation of the DNA Replication, Segregation, and Transcriptional Activation Functions of Epstein-Barr Nuclear Antigen 1

L. Frappier, Hong Wu, P. Kapoor, 2002, Journal of Virology.

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.

Kyle V. Butler, C. Arrowsmith, M. Schapira, 2016, ACS chemical biology.

Selective, small molecule co-factor binding site inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax (SET) domain containing lysine methyltransferase.

C. Arrowsmith, M. Schapira, R. Ferreira de Freitas, 2019, Journal of medicinal chemistry.

Revealing the Protein Propionylation Activity of the Histone Acetyltransferase Males absent on the first (MOF)

C. Arrowsmith, Yingming Zhao, Y. G. Zheng, 2018 .

Global Profiling of Acetyltransferase Feedback Regulation.

M. Vedadi, Julie M. Garlick, J. Meier, 2016, Journal of the American Chemical Society.

An unprecedented Ag–pipemidic acid complex with helical structure: Synthesis, structure and interaction with CT-DNA

Hong Wu, Jingquan Sha, Jingwen Sun, 2013 .

A Basic Post-SET Extension of NSDs Is Essential for Nucleosome Binding In Vitro

C. Arrowsmith, M. Schapira, S. Gräslund, 2014, Journal of biomolecular screening.

The DNA segregation mechanism of Epstein–Barr virus nuclear antigen 1

L. Frappier, D. Ceccarelli, Hong Wu, 2000, EMBO reports.

A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

L. Qin, L. Mazutis, J. Min, 2019, bioRxiv.

Structural basis of arginine asymmetrical dimethylation by PRMT6.

J. Min, M. Vedadi, A. Frankel, 2016, The Biochemical journal.

(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells

Amber L. Couzens, A. Gingras, M. Bunnage, 2014, Proceedings of the National Academy of Sciences.

TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma

K. Saikatendu, C. Arrowsmith, M. Schapira, 2018, Oncotarget.

Structural basis of allele variation of human thiopurine‐S‐methyltransferase

Xiaodong Cheng, M. Vedadi, A. Bochkarev, 2007, Proteins.

Structure and mechanism of spermidine synthases.

J. Min, A. Pegg, A. Plotnikov, 2007, Biochemistry.

Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase.

J. Min, D. V. van Aalten, A. Plotnikov, 2008, The Biochemical journal.

Molecular basis for the regulation of the H3K4 methyltransferase activity of PRDM9.

Jan Kadlec, S. Cusack, J. Kadlec, 2013, Cell reports.

Trimethylation of Histone H3 Lysine 36 by Human Methyltransferase PRDM9 Protein

C. Arrowsmith, M. Schapira, M. Vedadi, 2014, The Journal of Biological Chemistry.

Structure-activity relationship studies of G9a-like protein (GLP) inhibitors.

C. Arrowsmith, M. Vedadi, Jian Jin, 2017, Bioorganic & medicinal chemistry.

Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.

C. Arrowsmith, M. Vedadi, Jian Jin, 2017, Journal of medicinal chemistry.

Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations

C. Arrowsmith, M. Schapira, M. Vedadi, 2013, PloS one.

Structural and Histone Binding Ability Characterizations of Human PWWP Domains

Chao Xu, Wei Qiu, J. Min, 2011, PloS one.

The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions

R. Aebersold, Yun-Xing Wang, C. Arrowsmith, 2019, Nucleic acids research.

MLL1 minimal catalytic complex is a dynamic conformational ensemble susceptible to pharmacological allosteric disruption

R. Aebersold, Yun-Xing Wang, C. Arrowsmith, 2018, bioRxiv.

H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1

R. Reinhardt, J. Min, Sara Weirich, 2017, Nature Communications.

H 3 K 14 ac is linked to methylation of H 3 K 9 by the triple Tudor domain of SETDB 1

R. Reinhardt, J. Min, Sara Weirich, 2017 .

Structural Basis of Substrate-binding Specificity of Human Arylamine N-Acetyltransferases*

Ludmila Dombrovsky, Wolfram Tempel, Peter Loppnau, 2007, Journal of Biological Chemistry.

Protein Profiling with Epstein-Barr Nuclear Antigen-1 Reveals an Interaction with the Herpesvirus-associated Ubiquitin-specific Protease HAUSP/USP7*

J. Greenblatt, M. Zeghouf, L. Frappier, 2003, Journal of Biological Chemistry.

Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction.

G. Poda, C. Arrowsmith, M. Schapira, 2013, ACS medicinal chemistry letters.

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

G. Poda, C. Arrowsmith, M. Schapira, 2012, The Biochemical journal.

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

G. Poda, G. Superti-Furga, K. Bennett, 2015, Nature chemical biology.

Revealing the protein propionylation activity of the histone acetyltransferase MOF (males absent on the first)

C. Arrowsmith, Yingming Zhao, Xiang-Jiao Yang, 2018, The Journal of Biological Chemistry.

Biochemical and Structural Studies of Conserved Maf Proteins Revealed Nucleotide Pyrophosphatases with a Preference for Modified Nucleotides

A. Caudy, A. Murzin, J. Min, 2013, Chemistry & biology.

Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome

J. Min, R. Lam, W. Tempel, 2015, Acta crystallographica. Section F, Structural biology communications.

Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2

J. Min, M. Schapira, Xian-Hui Wu, 2013, FEBS letters.

An allosteric inhibitor of protein arginine methyltransferase 3.

Jian Jin, Matthieu Schapira, Alena Siarheyeva, 2012, Structure.

Solution NMR Structure and Histone Binding of the PHD Domain of Human MLL5

S. Aparicio, C. Arrowsmith, S. Houliston, 2013, PloS one.

Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation.

Jayme L. Dahlin, M. Walters, D. Lafontaine, 2020, ACS medicinal chemistry letters.

The human pseudouridine synthase PUS7 recognizes RNA with an extended multi-domain binding surface

C. Arrowsmith, A. Dong, Julia Guéguéniat, 2021, Nucleic acids research.

An intact SAM‐dependent methyltransferase fold is encoded by the human endothelin‐converting enzyme‐2 gene

A. Bochkarev, A. Plotnikov, P. Loppnau, 2009, Proteins.

Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A

A. Bochkarev, A. Plotnikov, A. Schuetz, 2007, Proteins.

Structural basis for substrate specificity and catalysis of human histone acetyltransferase 1

J. Min, Ming-Ming Zhou, Natasha Moshkina, 2012, Proceedings of the National Academy of Sciences.

Crystal Structure of Human Spermine Synthase

Peter Loppnau, Jinrong Min, J. Min, 2008, Journal of Biological Chemistry.

H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1

R. Reinhardt, J. Min, Sara Weirich, 2017, Nature Communications.

Design of a fluorescent ligand targeting the S-adenosylmethionine binding site of the histone methyltransferase MLL1.

C. Arrowsmith, S. Houliston, M. Vedadi, 2016, Organic & biomolecular chemistry.

Identification and characterization of the first fragment hits for SETDB1 Tudor domain.

J. Min, C. Arrowsmith, S. Houliston, 2019, Bioorganic & medicinal chemistry.

Identification and Characterization of the First Fragment Hits for SETDB1 Tudor Domain

J. Min, C. Arrowsmith, S. Houliston, 2019, bioRxiv.

Crystal structures of human CDY proteins reveal a crotonase‐like fold

J. Min, A. Plotnikov, Hong Wu, 2009, Proteins.

Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase

C. Arrowsmith, M. Vedadi, Jian Jin, 2017 .

Defining efficient enzyme–cofactor pairs for bioorthogonal profiling of protein methylation

J. Min, Yuling Chen, M. Luo, 2013, Proceedings of the National Academy of Sciences.

Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.

C. Arrowsmith, M. Schapira, M. Vedadi, 2016, Journal of medicinal chemistry.

Cortactin Localization in Actin-containing Adult and Fetal tissues

K. Montone, Hong Wu, 1998, Journal of Histochemistry and Cytochemistry.

Crystal structure of the methyltransferase domain of human TARBP1

A. Plotnikov, Hong Wu, H. Zeng, 2008, Proteins.