D. J. Little

发表

Characterization of the Pseudomonas aeruginosa Glycoside Hydrolase PslG Reveals That Its Levels Are Critical for Psl Polysaccharide Biosynthesis and Biofilm Formation*

P. Howell, H. Robinson, Perrin Baker, 2015, The Journal of Biological Chemistry.

In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA)

P. Howell, H. Robinson, C. Dowson, 2017, PLoS pathogens.

PilN Binding Modulates the Structure and Binding Partners of the Pseudomonas aeruginosa Type IVa Pilus Protein PilM*

J. Koo, S. Tammam, L. Burrows, 2016, The Journal of Biological Chemistry.

The TPR domain of PgaA is a multifunctional scaffold that binds PNAG and modulates PgaB-dependent polymer processing

R. Pomès, P. Howell, J. Klassen, 2022, PLoS pathogens.

Combining in situ proteolysis and mass spectrometry to crystallize Escherichia coli PgaB.

P. Howell, P. Yip, J. Whitney, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Synthesis and evaluation of inhibitors of E. coli PgaB, a polysaccharide de-N-acetylase involved in biofilm formation.

P. Howell, M. Nitz, D. J. Little, 2012, Organic & biomolecular chemistry.

Direct Staudinger–Phosphonite Reaction Provides Methylphosphonamidates as Inhibitors of CE4 De‐N‐acetylases

P. Howell, M. Nitz, D. J. Little, 2015, Chembiochem : a European journal of chemical biology.

The Structure- and Metal-dependent Activity of Escherichia coli PgaB Provides Insight into the Partial De-N-acetylation of Poly-β-1,6-N-acetyl-d-glucosamine*

P. Howell, J. Whitney, H. Robinson, 2012, The Journal of Biological Chemistry.

P. aeruginosa SGNH Hydrolase-Like Proteins AlgJ and AlgX Have Similar Topology but Separate and Distinct Roles in Alginate Acetylation

P. Howell, J. Whitney, H. Robinson, 2014, PLoS pathogens.

PatB1 is an O-acetyltransferase that decorates secondary cell wall polysaccharides.

P. Howell, H. Robinson, G. Boons, 2018, Nature chemical biology.

Functional diversification of the NleG effector family in enterohemorrhagic Escherichia coli

C. Arrowsmith, S. Houliston, A. Lemak, 2018, Proceedings of the National Academy of Sciences.

Identification of Poly-N-acetylglucosamine as a Major Polysaccharide Component of the Bacillus subtilis Biofilm Matrix*

P. Howell, G. Pier, D. Skurnik, 2015, The Journal of Biological Chemistry.

Molecular basis for CesT recognition of type III secretion effectors in enteropathogenic Escherichia coli

B. Coombes, D. J. Little, 2018, PLoS pathogens.

Sph3 Is a Glycoside Hydrolase Required for the Biosynthesis of Galactosaminogalactan in Aspergillus fumigatus*♦

P. Howell, H. Robinson, Perrin Baker, 2015, The Journal of Biological Chemistry.

The Protein BpsB Is a Poly-β-1,6-N-acetyl-d-glucosamine Deacetylase Required for Biofilm Formation in Bordetella bronchiseptica*

P. Howell, R. Deora, M. Nitz, 2015, The Journal of Biological Chemistry.

Functional characterization of Staphylococcus epidermidis IcaB, a de-N-acetylase important for biofilm formation.

P. Howell, M. Nitz, D. J. Little, 2013, Biochemistry.

Structural Basis for the De-N-acetylation of Poly-β-1,6-N-acetyl-d-glucosamine in Gram-positive Bacteria*

P. Howell, H. Robinson, M. Nitz, 2014, The Journal of Biological Chemistry.

PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms

P. Howell, G. Pier, H. Robinson, 2018, PLoS pathogens.

Distinct Molecular Features of NleG Type 3 Secreted Effectors Allow for Different Roles during Citrobacter rodentium Infection in Mice

P. Stogios, T. Skarina, A. Savchenko, 2022, Infection and immunity.

Modification and periplasmic translocation of the biofilm exopolysaccharide poly-β-1,6-N-acetyl-d-glucosamine

R. Pomès, P. Howell, H. Robinson, 2014, Proceedings of the National Academy of Sciences.

Metal-Dependent Polysaccharide Deacetylase PgaB

P. Howell, M. Nitz, N. Bamford, 2014 .

Regulatory Evolution Drives Evasion of Host Inflammasomes by Salmonella Typhimurium.

Wael Elhenawy, Caressa N. Tsai, B. Coombes, 2018, Cell reports.