R. Tjalkens

发表

Optical nanosensors for chemical analysis inside single living cells. 2. Sensors for pH and calcium and the intracellular application of PEBBLE sensors.

H. Clark, M. Philbert, R. Kopelman, 1999, Analytical chemistry.

Modulation of intercellular calcium signaling by melatonin in avian and mammalian astrocytes is brain region‐specific

V. Cassone, M. Zoran, J. Peters, 2005, The Journal of comparative neurology.

CI-1010 induced opening of the mitochondrial permeability transition pore precedes oxidative stress and apoptosis in SY5Y neuroblastoma cells

M. Philbert, L. Dethloff, R. Tjalkens, 2003, Brain Research.

The effects of genetic variation in N-acetyltransferases on 4-aminobiphenyl genotoxicity in mouse liver.

R. Erickson, M. Philbert, C. Mcqueen, 2003, Chemico-biological interactions.

The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes.

J. Lupton, Naisyin Wang, R. Chapkin, 2005, Carcinogenesis.

The peroxisome proliferator‐activated receptor‐γ agonist 1,1‐bis(3′‐indolyl)‐1‐(p‐trifluoromethylphenyl)methane suppresses manganese‐induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells

S. Safe, J. Moreno, B. Mohl, 2008, Journal of neuroscience research.

Pebble Nanosensors for Real Time Intracellular Chemical Imaging

H. Clark, J. Aylott, M. Philbert, 2002 .

Compensatory Expression of Nur77 and Nurr1 Regulates NF-κB–Dependent Inflammatory Signaling in Astrocytes

J. Moreno, D. Backos, Donald S. Backos, 2018, Molecular Pharmacology.

SARS-CoV-2 infection, neuropathogenesis and transmission among deer mice: Implications for spillback to New World rodents

G. Ebel, B. Geiss, O. Peersen, 2021, PLoS pathogens.

Domoic acid-induced seizures in California sea lions (Zalophus californianus) are associated with neuroinflammatory brain injury.

C. Duncan, F. Gulland, R. Tjalkens, 2014, Aquatic toxicology.

SARS-CoV-2 infection, neuropathogenesis and transmission among deer mice: Implications for reverse zoonosis to New World rodents

G. Ebel, B. Geiss, O. Peersen, 2020, bioRxiv.

Alpha, beta-unsaturated aldehydes mediate inducible expression of glutathione S-transferase in hepatoma cells through activation of the antioxidant response element (ARE).

D. Petersen, D. Kroll, R. Tjalkens, 1999, Advances in experimental medicine and biology.

α,β-Unsaturated Aldehydes Increase GlutathioneS-Transferase mRNA and Protein: Correlation with Activation of the Antioxidant Response Element

D. Petersen, D. Kroll, R. Tjalkens, 1998 .

Manganese-induced NF-kappaB activation and nitrosative stress is decreased by estrogen in juvenile mice.

W. Hanneman, J. Moreno, R. Tjalkens, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Manganese potentiates nuclear factor‐κB‐dependent expression of nitric oxide synthase 2 in astrocytes by activating soluble guanylate cyclase and extracellular responsive kinase signaling pathways

W. Hanneman, J. Moreno, R. Tjalkens, 2008, Journal of neuroscience research.

Manganese potentiates lipopolysaccharide-induced expression of NOS2 in C6 glioma cells through mitochondrial-dependent activation of nuclear factor kappaB.

R. Barhoumi, R. Tjalkens, Jennifer B. Faske, 2004, Brain research. Molecular brain research.

Structure‐dependent activation of gene expression by bis‐indole and quinoline‐derived activators of nuclear receptor 4A2

S. Safe, R. Shrestha, R. Tjalkens, 2019, Chemical biology & drug design.

Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes.

W. Hanneman, J. Moreno, R. Tjalkens, 2009, Toxicology letters.

Rotenone induces regionally distinct α-synuclein protein aggregation and activation of glia prior to loss of dopaminergic neurons in C57Bl/6 mice

Richard J Smeyne, R. Tjalkens, T. Aboellail, 2022, Neurobiology of Disease.

Glial-neuronal signaling mechanisms underlying the neuroinflammatory effects of manganese

R. Tjalkens, Maryam F. Afzali, Katriana A. Popichak, 2018, Journal of Neuroinflammation.

The Nurr1 Ligand,1,1-bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism

Pranav U. Damale, Edwin K. P. Chong, D. Backos, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Neurotoxicology of Metals

Louis W. Chang, R. Tjalkens, 2010 .

Role of oxidative stress and the mitochondrial permeability transition in methylmercury cytotoxicity.

K. Reuhl, M. Philbert, A. Halladay, 2011, Neurotoxicology.

NF- j B Signaling in Astrocytes Modulates Brain Inflammation and Neuronal Injury Following Sequential Exposure to Manganese and MPTP During Development and Aging

Pranav U. Damale, Edwin K. P. Chong, R. Tjalkens, 2020 .

A novel diindolylmethane analog, 1,1‐bis(3′‐indolyl)‐1‐(p‐chlorophenyl) methane, inhibits the tumor necrosis factor‐induced inflammatory response in primary murine synovial fibroblasts through a Nurr1‐dependent mechanism

R. Tjalkens, S. Safe, L. H. Burton, 2018, Molecular immunology.

NF-kappaB-dependent production of nitric oxide by astrocytes mediates apoptosis in differentiated PC12 neurons following exposure to manganese and cytokines.

R. Tjalkens, Xuhong Liu, Julie A Buffington, 2005, Brain research. Molecular brain research.

Formation and export of the glutathione conjugate of 4-hydroxy-2, 3-E-nonenal (4-HNE) in hepatoma cells.

D. Petersen, R. Tjalkens, L. W. Cook, 1999, Archives of biochemistry and biophysics.

Proteomic analysis of diaminochlorotriazine adducts in wistar rat pituitary glands and LbetaT2 rat pituitary cells.

C. Foradori, K. Reardon, W. Hanneman, 2008, Chemical research in toxicology.

Mechanism of inhibition of rat liver class 2 ALDH by 4-hydroxynonenal.

D. Petersen, R. Tjalkens, S. Luckey, 1999, Advances in experimental medicine and biology.

CO Can We Panelize Seizure?

Jennifer B Pierson, Ruth Roberts, I. Suzuki, 2020 .

Repeated exposure to low doses of kainic acid activates nuclear factor kappa B (NF-κB) prior to seizure in transgenic NF-κB/EGFP reporter mice.

Manisha N. Patel, J. Miller, Y. H. Raol, 2014, Neurotoxicology.

Production, characteristics and applications of fluorescent PEBBLE nanosensors : Potassium, oxygen, calcium and pH imaging inside live cells : Biomedical applications

H. Clark, J. Aylott, M. Philbert, 2002 .

Irradiation of mitochondria initiates apoptosis in a cell free system

A. Rehemtulla, M. Philbert, N. Taneja, 2001, Oncogene.

Differential cellular regulation of the mitochondrial permeability transition in an in vitro model of 1,3-dinitrobenzene-induced encephalopathy

M. Philbert, R. Tjalkens, Megan M Ewing, 2000, Brain Research.

Spontaneous Development of Cutaneous Squamous Cell Carcinoma in Mice with Cell-specific Deletion of Inhibitor of κB Kinase 2.

C. Duncan, R. Tjalkens, Kelly S. Kirkley, 2017, Comparative medicine.

Regional variation in the activation threshold for 1,3-DNB-induced mitochondrial permeability transition in brainstem and cortical astrocytes.

M. Philbert, R. Tjalkens, A. Phelka, 2003, Neurotoxicology.

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability.

K. J. Reddy, R. Tjalkens, K. Krueger, 2015, Journal of visualized experiments : JoVE.

The Nurr1 Activator 1,1-Bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB

B. D. De Miranda, R. Tjalkens, S. Safe, 2015, Molecular Pharmacology.

The Nurr1 activator 1,1-bis(3'-indolyl)-1-( p -chlorophenyl)methane blocks inflammatory gene expression in BV-2 microglial cells by inhibiting NF-κ

S. Safe, R. Tjalkens, Sean L. Hammond, 2015 .

Prenatal expression of N-acetyltransferases in C57Bl/6 mice.

M. Philbert, C. Mcqueen, R. Tjalkens, 2003, Chemico-biological interactions.

Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

M. Aschner, K. Erikson, Keith M Erikson, 2009, NeuroMolecular Medicine.

A Potent SARS-CoV-2 Neutralizing Human Monoclonal Antibody That Reduces Viral Burden and Disease Severity in Syrian Hamsters

A. Corper, T. Schountz, R. Tjalkens, 2020, Frontiers in Immunology.

A potent SARS-CoV-2 neutralizing human monoclonal antibody that reduces viral burden and disease severity in Syrian hamsters

A. Corper, T. Schountz, R. Tjalkens, 2020, bioRxiv.

In Vitro Studies of Neurotoxicant Effects on Cellular Homeostasis

G. Audesirk, R. Tjalkens, 2004 .

Angiotensin Ii Regulates Brain (pro)renin Receptor Expression through Activation of Camp Response Element-binding Protein Running Title: Angiotensin Ii and (pro)renin Receptor Regulation

Jiao Liu, Z. Saifudeen, Yumei Feng, 2022 .

Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

M. Aschner, K. Erikson, R. Tjalkens, 2009, NeuroMolecular Medicine.

Manganese-induced neurotoxicity: the role of astroglial-derived nitric oxide in striatal interneuron degeneration.

R. Tjalkens, M. Légaré, Xuhong Liu, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation

Richard J Smeyne, K. Olson, R. Tjalkens, 2019, npj Parkinson's Disease.

Manganese exposure in juvenile C57BL/6 mice increases glial inflammatory responses in the substantia nigra following infection with H1N1 influenza virus

Richard J Smeyne, R. Slayden, J. Cummings, 2021, PloS one.

Venezuelan and western equine encephalitis virus E1 liposome antigen nucleic acid complexes protect mice from lethal challenge with multiple alphaviruses.

A. Powers, D. Jarvis, K. Olson, 2016, Virology.

Entry Sites of Venezuelan and Western Equine Encephalitis Viruses in the Mouse Central Nervous System following Peripheral Infection

K. Olson, Charles B. Stauft, R. Tjalkens, 2016, Journal of Virology.

Neuroprotective Efficacy and Pharmacokinetic Behavior of Novel Anti-Inflammatory Para-Phenyl Substituted Diindolylmethanes in a Mouse Model of Parkinson’s Disease

D. Colagiovanni, R. Hansen, D. Gustafson, 2013, The Journal of Pharmacology and Experimental Therapeutics.

1,3-Dinitrobenzene-induced metabolic impairment through selective inactivation of the pyruvate dehydrogenase complex.

M. Philbert, J. Miller, R. Tjalkens, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Toxicological and pathophysiological roles of reactive oxygen and nitrogen species.

Robert A. Smith, S. Safe, F. Robertson, 2010, Toxicology.

Nuclear factor kappa-B mediates selective induction of neuronal nitric oxide synthase in astrocytes during low-level inflammatory stimulation with MPTP

J. Moreno, R. Tjalkens, D. Carbone, 2008, Brain Research.

Nuclear receptor 4A2 (NR4A2) is a druggable target for glioblastomas

S. Safe, S. Mittal, K. Mohankumar, 2019, Journal of Neuro-Oncology.

Association of glutathione S-transferase isozyme-specific induction and lipid peroxidation in two inbred strains of mice subjected to chronic dietary iron overload.

D. Petersen, Y. Awasthi, R. Tjalkens, 1998, Toxicology and applied pharmacology.

Nuclear receptor 4A (NR4A) family – orphans no more

S. Safe, Mandip Singh, U. Jin, 2016, The Journal of Steroid Biochemistry and Molecular Biology.

Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity

R. Tjalkens, M. Légaré, Maryam F. Afzali, 2017, Journal of Neuroinflammation.

Can We Panelize Seizure?

Jennifer B Pierson, Ruth Roberts, I. Suzuki, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Experimental Zika virus infection of Jamaican fruit bats (Artibeus jamaicensis) and possible entry of virus into brain via activated microglial cells

R. Perera, C. Campbell, T. Schountz, 2019, PLoS neglected tropical diseases.

Regulatory T cell-like response to SARS-CoV-2 in Jamaican fruit bats (Artibeus jamaicensis) transduced with human ACE2

D. Veesler, J. Richt, S. Weiss, 2023, bioRxiv.

Inflammatory Activation of Microglia and Astrocytes in Manganese Neurotoxicity.

R. Tjalkens, Katriana A. Popichak, Kelly A Kirkley, 2017, Advances in neurobiology.

Subunit composition and domain structure of the Spo0A sporulation transcription factor of Bacillus subtilis.

J. Hoch, M. Strauch, G. Spiegelman, 1994, The Journal of biological chemistry.

Detection of nitric oxide formation in primary neural cells and tissues.

Guoyao Wu, R. Tjalkens, D. Carbone, 2011, Methods in molecular biology.

Fluorescent nanosensors for intracellular chemical analysis: decyl methacrylate liquid polymer matrix and ion-exchange-based potassium PEBBLE sensors with real-time application to viable rat C6 glioma cells.

M. Philbert, R. Kopelman, R Kopelman, 2001, Analytical chemistry.

A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro

S. Safe, R. Tjalkens, Sean L. Hammond, 2015, Neuroscience Letters.

Astrocyte inflammatory signaling mediates α-synuclein aggregation and dopaminergic neuronal loss following viral encephalitis

Richard J Smeyne, K. Olson, C. T. French, 2021, Experimental Neurology.

A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflammatory Responses in the Syrian Hamster Model of SARS-CoV-2 Infection

R. Slayden, N. Theise, T. Schountz, 2022, Frontiers in Immunology.

Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity

R. Tjalkens, M. Légaré, Maryam F. Afzali, 2017, Journal of Neuroinflammation.

Developmental exposure to manganese increases adult susceptibility to inflammatory activation of glia and neuronal protein nitration.

J. Moreno, R. Tjalkens, Karin M. Streifel, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Age-dependent susceptibility to manganese-induced neurological dysfunction.

J. Moreno, R. Tjalkens, Karin M. Streifel, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells.

S. Safe, Qiao Wu, D. Backos, 2014, Molecular endocrinology.

Genetic suppression of IKK2/NF-κB in astrocytes inhibits neuroinflammation and reduces neuronal loss in the MPTP-Probenecid model of Parkinson's disease

R. Tjalkens, Sean L. Hammond, Katriana A. Popichak, 2019, Neurobiology of Disease.

Cellular selectivity of AAV serotypes for gene delivery in neurons and astrocytes by neonatal intracerebroventricular injection

R. Tjalkens, Evan H. Richman, Sean L. Hammond, 2017, PloS one.

A Low-Cost, Autonomous Gait Detection and Estimation System for Analyzing Gait Impairments in Mice

Pranav U. Damale, Edwin K. P. Chong, R. Tjalkens, 2021, Journal of Healthcare Engineering.

Immune Modulation as an Effective Adjunct Post-exposure Therapeutic for B. pseudomallei

W. Hanneman, R. Slayden, J. Cummings, 2016, PLoS neglected tropical diseases.

Regulatory T Cell-like Response to SARS-CoV-2 in Jamaican Fruit Bats Transduced with Human ACE2

D. Veesler, J. Richt, S. Weiss, 2023 .

Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease.

J. Miller, B. D. De Miranda, R. Tjalkens, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Suppression of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Nitric-Oxide Synthase 2 Expression in Astrocytes by a Novel Diindolylmethane Analog Protects Striatal Neurons against Apoptosis

J. Moreno, R. Tjalkens, S. Safe, 2009, Molecular Pharmacology.

DJ-1 mutation decreases astroglial release of inflammatory mediators.

W. Hanneman, R. Tjalkens, M. Légaré, 2016, Neurotoxicology.

Dopaminergic Neurotoxicants Cause Biphasic Inhibition of Purinergic Calcium Signaling in Astrocytes

S. Earley, B. D. De Miranda, R. Tjalkens, 2014, PloS one.

Manganese suppresses ATP-dependent intercellular calcium waves in astrocyte networks through alteration of mitochondrial and endoplasmic reticulum calcium dynamics

Mark J. Zoran, M. Zoran, B. Mohl, 2006, Brain Research.

Low‐dose 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine causes inflammatory activation of astrocytes in nuclear factor‐κB reporter mice prior to loss of dopaminergic neurons

R. Roberts, J. Miller, R. Bialecki, 2011, Journal of neuroscience research.

Microglia‐specific knock‐out of NF‐κB/IKK2 increases the accumulation of misfolded α‐synuclein through the inhibition of p62/sequestosome‐1‐dependent autophagy in the rotenone model of Parkinson's disease

Richard J Smeyne, R. Tjalkens, T. Aboellail, 2023, Glia.

Manganese inhibits ATP-induced calcium entry through the transient receptor potential channel TRPC3 in astrocytes.

James R. Miller, R. Tjalkens, Karin M. Streifel, 2013, Neurotoxicology.

Gene deletion of nos2 protects against manganese-induced neurological dysfunction in juvenile mice.

W. Hanneman, J. Moreno, R. Tjalkens, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

NF-κB signaling in astrocytes modulates brain inflammation and neuronal injury following sequential exposure to manganese and MPTP during development and aging.

Pranav U. Damale, Edwin K. P. Chong, R. Tjalkens, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Glial-neuronal signaling mechanisms underlying the neuroinflammatory effects of manganese

R. Tjalkens, Maryam F. Afzali, Katriana A. Popichak, 2018, Journal of Neuroinflammation.

Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation

Richard J Smeyne, K. Olson, R. Tjalkens, 2019, npj Parkinson's Disease.

A novel glucocorticoid and androgen receptor modulator reduces viral entry and innate immune inflammatory responses in the Syrian Hamster model of SARS-CoV-2

R. Slayden, N. Theise, T. Schountz, 2021, bioRxiv.

Structure–Activity Relationship of Lower Chlorinated Biphenyls and Their Human-Relevant Metabolites for Astrocyte Toxicity

Andres Martinez, N. Paranjape, H. Lehmler, 2023, Chemical research in toxicology.

Role of oxidative stress and the mitochondrial permeability transition in methylmercury cytotoxicity.

K. Reuhl, M. Philbert, A. Halladay, 2011, Neurotoxicology.

Angiotensin II regulates brain (pro)renin receptor expression through activation of cAMP response element-binding protein.

Jiao Liu, Z. Saifudeen, Yumei Feng, 2015, American journal of physiology. Regulatory, integrative and comparative physiology.

Manganese-induced neurotoxicity: the role of astroglial-derived nitric oxide in striatal interneuron degeneration.

R. Tjalkens, M. Légaré, Xuhong Liu, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

W. Hanneman, J. Moreno, R. Tjalkens, 2008, Journal of neuroscience research.

A novel meningioma with tyrosine‐rich crystals in a 6‐year‐old Great Dane

R. Tjalkens, T. Aboellail, Savannah M Rocha, 2023, Journal of veterinary internal medicine.