Peter F Leadlay

发表

Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation.

Marie-France Carlier, Fabrice Chrétien, Anne Danckaert, 2013, The Journal of clinical investigation.

Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases.

Frank Schulz, Hui Hong, P. Leadlay, 2008, Chemistry & biology.

Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338

Markiyan Samborskyy, P. Leadlay, T. Mironenko, 2007, Nature Biotechnology.

Evaluating Ketoreductase Exchanges as a Means of Rationally Altering Polyketide Stereochemistry

Kira J Weissman, Thibault Annaval, P. Leadlay, 2015, Chembiochem : a European journal of chemical biology.

Accumulation of an E,E,E-triene by the monensin-producing polyketide synthase when oxidative cyclization is blocked.

James Staunton, P. Leadlay, J. Staunton, 2005, Angewandte Chemie.

Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272.

Sabine Gaisser, James Staunton, Barrie Wilkinson, 2003, Organic & biomolecular chemistry.

Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase.

Rolf Müller, Barrie Wilkinson, H. Petković, 2008, Organic & biomolecular chemistry.

A novel erythromycin, 6-desmethyl erythromycin D, made by substituting an acyltransferase domain of the erythromycin polyketide synthase.

James Staunton, Ellen L McCormick, Barrie Wilkinson, 2003, The Journal of antibiotics.

Evidence that a Novel Thioesterase is Responsible for Polyketide Chain Release during Biosynthesis of the Polyether Ionophore Monensin

Wolfgang Kroutil, James Staunton, Hui Hong, 2006, Chembiochem : a European journal of chemical biology.

Engineering specificity of starter unit selection by the erythromycin‐producing polyketide synthase

James Staunton, P. Leadlay, P. Long, 2002, Molecular microbiology.

Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin.

Markiyan Samborskyy, Hui Hong, P. Leadlay, 2006, Microbiology.

Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues.

Mohammad Nur-E-Alam, Carlos Olano, Barrie Wilkinson, 2006, Chemical communications.

A Polylinker Approach to Reductive Loop Swaps in Modular Polyketide Synthases

Guido Sauter, James Staunton, P. Leadlay, 2008, Chembiochem : a European journal of chemical biology.

Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization

James Staunton, P. Leadlay, J. Staunton, 2003, Molecular microbiology.

Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase.

P. Leadlay, N. Campillo, A. Baerga-Ortiz, 2006, Chemistry & biology.

Mutagenesis of a modular polyketide synthase enoylreductase domain reveals insights into catalysis and stereospecificity.

P. Leadlay, D. Kwan, Peter F Leadlay, 2010, ACS chemical biology.

Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.

Sarojini Adusumilli, Thierry Garnier, P. Leadlay, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Engineering of the spinosyn PKS: directing starter unit incorporation.

Thomas C Sparks, Christine J. Martin, William A. Vousden, 2006, Journal of natural products.

Engineered Biosynthesis of Phenyl‐Substituted Polyketides

Bradley S Moore, Hui Hong, P. Leadlay, 2004, Chembiochem : a European journal of chemical biology.

New Rapamycin Derivatives by Precursor‐Directed Biosynthesis

James Staunton, P. Leadlay, J. Staunton, 2004, Chembiochem : a European journal of chemical biology.

The structure of docking domains in modular polyketide synthases.

Kira J Weissman, Daniel Nietlispach, P. Leadlay, 2003, Chemistry & biology.

Biosynthesis of the putative siderophore erythrochelin requires unprecedented crosstalk between separate nonribosomal peptide gene clusters.

P. Leadlay, A. Slusarczyk, J. Cortés, 2010, Chemistry & biology.