M. Gadd

发表

Solution Structure of the LIM-Homeodomain Transcription Factor Complex Lhx3/Ldb1 and the Effects of a Pituitary Mutation on Key Lhx3 Interactions

J. Trewhella, J. Mackay, J. Matthews, 2012, PloS one.

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrroli

K. Read, S. Rocha, Julianty Frost, 2017, Journal of medicinal chemistry.

3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation

A. Ciulli, X. Lucas, A. Runcie, 2018, Journal of the American Chemical Society.

Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex

A. Ciulli, M. Gadd, T. A. Cardote, 2017, Structure.

Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases

A. Ciulli, M. Gadd, E. Bulatov, 2015, PloS one.

Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities

Pedro Soares, Sarah Hewitt, Alessio Ciulli, 2014, Journal of medicinal chemistry.

Selective Wee1 degradation by PROTAC degraders recruiting VHL and CRBN E3 ubiquitin ligases.

T. Harrison, M. Gadd, Marine C. Aublette, 2022, Bioorganic & medicinal chemistry letters.

Crystallization and diffraction of an Lhx4-Isl2 complex.

J. Matthews, J. Guss, D. Langley, 2009, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structural basis of PROTAC cooperative recognition for selective protein degradation

D. Lamont, A. Ciulli, X. Lucas, 2017, Nature chemical biology.

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

P. Grandi, K. Read, M. Bantscheff, 2016, Nature Communications.

A Structural Basis for the Regulation of the LIM-Homeodomain Protein Islet 1 (Isl1) by Intra- and Intermolecular Interactions*

J. Matthews, A. Kwan, D. Jacques, 2013, The Journal of Biological Chemistry.

Intermolecular Interactions byLIM-Homeodomain Protein Islet 1 ( Isl 1 ) A Structural Basis for the Regulation of the Protein Structure and Folding :

J. Matthews, A. Kwan, D. Jacques, 2013 .

Crystallization and diffraction of an Isl1-Ldb1 complex.

J. Matthews, D. Jacques, J. Guss, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

The PROTAC MZ1 in complex with the second bromodomain of Brd4 and pVHL:ElonginC:ElonginB

A. Ciulli, M. Gadd, M. Zengerle, 2017 .

Structural Basis for Partial Redundancy in a Class of Transcription Factors, the LIM Homeodomain Proteins, in Neural Cell Type Specification*

Jill Trewhella, J Mitchell Guss, Cy M Jeffries, 2011, The Journal of Biological Chemistry.

1 Title : Structural basis of PROTAC cooperative recognition for selective protein 1 degradation 2

D. Lamont, A. Ciulli, X. Lucas, 2017 .

Biochemical and biophysical characterisation of haloalkane dehalogenases DmrA and DmrB in Mycobacterium strain JS60 and their role in growth on haloalkanes

J. Matthews, J. Guss, S. Cheung, 2015, Molecular microbiology.