Hatasu Kobayashi

发表

Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes SCA36, a type of spinocerebellar ataxia accompanied by motor neuron involvement.

Koji Abe, Akio Koizumi, Hiroko Okuda, 2011, American journal of human genetics.

Nitrative DNA damage in lung epithelial cells exposed to indium nanoparticles and indium ions

S. Oikawa, Y. Hiraku, N. Ma, 2020, Scientific Reports.

The moyamoya disease susceptibility variant RNF213 R4810K (rs112735431) induces genomic instability by mitotic abnormality.

K. Nakao, D. Taura, M. Sone, 2013, Biochemical and biophysical research communications.

Biological Monitoring of Human Exposure to Neonicotinoids Using Urine Samples, and Neonicotinoid Excretion Kinetics

H. Okuda, A. Koizumi, Tamon Niisoe, 2016, PloS one.

RNF213 as a Susceptibility Gene for Moyamoya Disease has Multifunctional Roles in Biological Processes

A. Koizumi, Kouji H. Harada, T. Habu, 2021 .

Dysregulation of RNF213 promotes cerebral hypoperfusion

H. Iida, S. Miyamoto, H. Okuda, 2018, Scientific Reports.

Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease

S. Miyamoto, Takeshi Kimura, H. Izawa, 2017, PloS one.

Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease

S. Miyamoto, Takeshi Kimura, H. Izawa, 2017, PloS one.

The mechanisms of oxidative DNA damage and apoptosis induced by norsalsolinol, an endogenous tetrahydroisoquinoline derivative associated with Parkinson’s disease

Y. Yada, S. Oikawa, Y. Hiraku, 2009, Journal of neurochemistry.

Temporal trend and age-dependent serum concentration of phenolic organohalogen contaminants in Japanese men during 1989-2010.

A. Koizumi, Kouji H. Harada, Y. Fujii, 2014, Environmental pollution.

Importance of molecular diagnosis in the accurate diagnosis of systemic carnitine deficiency

A. Koizumi, Kouji H. Harada, Toshiaki Hitomi, 2015, Journal of Genetics.

Rare variants in RNF213, a susceptibility gene for moyamoya disease, are found in patients with pulmonary hypertension and aggravate hypoxia-induced pulmonary hypertension in mice

Takeshi Kimura, H. Okuda, K. Ono, 2018, Pulmonary circulation.

Moyamoya disease: diagnosis and interventions

G. Steinberg, A. Koizumi, E. Tournier-Lasserve, 2022, The Lancet Neurology.

Lactational Transfer of Long-Chain Perfluorinated Carboxylic Acids in Mice: A Method to Directly Collect Milk and Evaluate Chemical Transferability

A. Koizumi, Kouji H. Harada, Y. Fujii, 2020, Toxics.

Suppression of RNF213, a susceptibility gene for moyamoya disease, inhibits endoplasmic reticulum stress through SEL1L upregulation.

H. Okuda, A. Koizumi, S. Oikawa, 2022, Biochemical and biophysical research communications.

Moyamoya disease patient mutations in the RING domain of RNF213 reduce its ubiquitin ligase activity and enhance NFκB activation and apoptosis in an AAA+ domain-dependent manner.

T. Mizushima, S. Taketani, A. Koizumi, 2020, Biochemical and biophysical research communications.

RNF213 Rare Variants in Slovakian and Czech Moyamoya Disease Patients

M. Brozman, A. Koizumi, Kouji H. Harada, 2016, PloS one.

Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G>A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients.

K. Nakao, D. Taura, M. Sone, 2013, Biochemical and biophysical research communications.

Ablation of Rnf213 retards progression of diabetes in the Akita mouse.

S. Takashima, H. Okuda, A. Koizumi, 2013, Biochemical and biophysical research communications.

A new horizon of moyamoya disease and associated health risks explored through RNF213

A. Koizumi, Kouji H. Harada, Toshiaki Hitomi, 2015, Environmental Health and Preventive Medicine.

Frequency of RNF213 p.R4810K, a susceptibility variant for moyamoya disease, and health characteristics of carriers in the Japanese population

A. Koizumi, Kouji H. Harada, Hatasu Kobayashi, 2016, Environmental Health and Preventive Medicine.

Distribution of moyamoya disease susceptibility polymorphism p.R4810K in RNF213 in East and Southeast Asian populations.

A. Koizumi, Kouji H. Harada, Toshiaki Hitomi, 2012, Neurologia medico-chirurgica.

An Integrative Study of the Genetic, Social and Environmental Determinants of Chronic Kidney Disease Characterized by Tubulointerstitial Damages in the North Central Region of Sri Lanka

R. Yamada, R. Chandrajith, S. Nanayakkara, 2014, Journal of occupational health.

RNF213 Is Associated with Intracranial Aneurysms in the French-Canadian Population.

G. Rouleau, A. Dionne‐Laporte, D. Spiegelman, 2016, American journal of human genetics.

A rare Asian founder polymorphism of Raptor may explain the high prevalence of Moyamoya disease among East Asians and its low prevalence among Caucasians

D. Tregouet, N. Hashimoto, K. Kikuta, 2010, Environmental health and preventive medicine.

Genomewide association study identifies no major founder variant in Caucasian moyamoya disease

A. Koizumi, Toshiaki Hitomi, C. Roder, 2013, Journal of Genetics.

Characterization of Moyamoya and Middle Cerebral Artery Diseases by Carotid Canal Diameter and RNF213 p.R4810K Genotype.

Kazumichi Yoshida, A. Koizumi, Toshiaki Hitomi, 2022, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

Prevalence of RNF213 p.R4810K Variant in Early-Onset Stroke With Intracranial Arterial Stenosis.

H. Maruyama, A. Koizumi, Kouji H. Harada, 2019, Stroke.

Rapid contralateral progression of focal cerebral arteriopathy distinguished from RNF213-related moyamoya disease and fibromuscular dysplasia

S. Miyamoto, T. Wakabayashi, Y. Mineharu, 2017, Child's Nervous System.

Significant Association of the RNF213 p.R4810K Polymorphism with Quasi-Moyamoya Disease.

S. Miyamoto, A. Koizumi, Kouji H. Harada, 2016, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

Rapid Progression of Unilateral Moyamoya Disease in a Patient with a Family History and an RNF213 Risk Variant

S. Miyamoto, A. Koizumi, Toshiaki Hitomi, 2013, Cerebrovascular Diseases.

Letter to the Editor Regarding, "Thyroid Cancer "Epidemic": A Socio-Environmental Health Problem Needs Collaborative Efforts".

Kouji H. Harada, Hatasu Kobayashi, T. Fujitani, 2020, Environmental science & technology.

Damage to cellular and isolated DNA induced by a metabolite of aspirin.

S. Oikawa, S. Kawanishi, S. Tada-Oikawa, 2009, Mutation research.

β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice

H. Okuda, A. Koizumi, Kouji H. Harada, 2018, PloS one.

Pathological Investigation on RNF213: Animal Models Knockout and Transgenic Mice in Diabetes and Signal Transduction

Hatasu Kobayashi, 2017 .

Mechanism of DNA Damage and Apoptosis Induced by Tetrahydropapaveroline, a Metabolite of Dopamine

S. Oikawa, S. Kawanishi, Hatasu Kobayashi, 2006, Neurochemical Research.

Proteomic analysis of the monkey hippocampus for elucidating ischemic resistance

T. Yamashima, Y. Kitamura, S. Oikawa, 2020, Journal of clinical biochemistry and nutrition.

Mechanism of metal-mediated DNA damage and apoptosis induced by 6-hydroxydopamine in neuroblastoma SH-SY5Y cells

S. Oikawa, S. Kawanishi, Hatasu Kobayashi, 2008, Free radical research.

RNF213 p.R4810K Variant and Intracranial Arterial Stenosis or Occlusion in Relatives of Patients with Moyamoya Disease.

S. Miyamoto, A. Koizumi, Kouji H. Harada, 2017, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

Early onset of moyamoya syndrome in a Down syndrome patient with the genetic variant RNF213 p.R4810K

A. Koizumi, R. Kira, Reina Ogata, 2015, Brain and Development.

Moyamoya Disease Susceptibility Variant RNF213 p.R4810K Increases the Risk of Ischemic Stroke Attributable to Large-Artery Atherosclerosis.

Y. Kamatani, K. Matsuda, M. O’Donnell, 2019, Circulation.

Deletion of 2 amino acids in IHH in a Japanese family with brachydactyly type A1

H. Okuda, A. Koizumi, Kouji H. Harada, 2021, BMC Medical Genomics.

Copper-mediated DNA damage caused by purpurin, a natural anthraquinone

S. Oikawa, S. Kawanishi, M. Murata, 2022, Genes and environment : the official journal of the Japanese Environmental Mutagen Society.

Use of Nonprescription and Prescription Drugs and Drug Information Sources among Breastfeeding Women in Japan: A Cross-Sectional Study

T. Kubota, Kouji H. Harada, Y. Fujii, 2022, International journal of environmental research and public health.

Metal-mediated oxidative damage to cellular and isolated DNA by gallic acid, a metabolite of antioxidant propyl gallate.

S. Oikawa, S. Kawanishi, Hatasu Kobayashi, 2004, Mutation research.

Targeting fructose metabolism by glucose transporter 5 regulation in human cholangiocarcinoma

Raynoo Thanan, S. Oikawa, S. Kawanishi, 2021, Genes & diseases.

Polyphenols with Anti-Amyloid β Aggregation Show Potential Risk of Toxicity Via Pro-Oxidant Properties

S. Oikawa, S. Kawanishi, M. Murata, 2020, International journal of molecular sciences.

Clinical features of SCA36

K. Okamoto, K. Abe, A. Koizumi, 2012, Neurology.

Identification of RNF213 as a Susceptibility Gene for Moyamoya Disease and Its Possible Role in Vascular Development

A. Fujiyama, A. Toyoda, N. Hashimoto, 2011, PloS one.

Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models

K. Nakao, T. Ichisaka, S. Yamanaka, 2016, Scientific Reports.

Mechanism of reactive oxygen species generation and oxidative DNA damage induced by acrylohydroxamic acid, a putative metabolite of acrylamide.

Y. Fujita, S. Oikawa, S. Kawanishi, 2021, Mutation research. Genetic toxicology and environmental mutagenesis.

C. Wongkham, C. Pairojkul, K. Vaeteewoottacharn, 2013, Free radical biology & medicine.

Nitrative DNA damage and Oct3/4 expression in urinary bladder cancer with Schistosoma haematobium infection.

O. Hammam, Raynoo Thanan, S. Oikawa, 2011, Biochemical and biophysical research communications.

Preliminary assessment of ecological exposure of adult residents in Fukushima Prefecture to radioactive cesium through ingestion and inhalation

Akio Koizumi, Hirohiko Ishikawa, A. Koizumi, 2011, Environmental Health and Preventive Medicine.

Combined linkage analysis and exome sequencing identifies novel genes for familial goiter

H. Okuda, A. Koizumi, Kouji H. Harada, 2013, Journal of Human Genetics.

Genomewide association study identifies no major founder variant in Caucasian moyamoya disease

A. Koizumi, Toshiaki Hitomi, C. Roder, 2013, Journal of Genetics.

P.R4810K, a polymorphism of RNF213, the susceptibility gene for moyamoya disease, is associated with blood pressure

S. Nanayakkara, H. Okuda, A. Koizumi, 2013, Environmental Health and Preventive Medicine.

E44Q mutation in NaV1.7 in a patient with infantile paroxysmal knee pain: electrophysiological analysis of voltage-dependent sodium current

H. Okuda, T. Ohba, A. Koizumi, 2021, Heliyon.

Genetic Study of Intracranial Aneurysms

H. Okuda, A. Koizumi, Kouji H. Harada, 2015, Stroke.

CD44v9 Induces Stem Cell-Like Phenotypes in Human Cholangiocarcinoma

S. Oikawa, N. Ma, S. Kawanishi, 2020, Frontiers in Cell and Developmental Biology.

Biochemical and Functional Characterization of RNF213 (Mysterin) R4810K, a Susceptibility Mutation of Moyamoya Disease, in Angiogenesis In Vitro and In Vivo

D. Taura, M. Sone, S. Miyamoto, 2015, Journal of the American Heart Association.

Infantile Pain Episodes Associated with Novel Nav1.9 Mutations in Familial Episodic Pain Syndrome in Japanese Families

M. Tominaga, H. Okuda, A. Koizumi, 2016, PloS one.

Methods Study Population

H. Okuda, A. Koizumi, Kouji H. Harada, 2022 .

Proteomic analysis of carbonylated proteins in the monkey substantia nigra after ischemia-reperfusion

T. Yamashima, Y. Kitamura, Y. Minabe, 2014, Free radical research.

Proteomic identification of carbonylated proteins in the monkey hippocampus after ischemia-reperfusion

T. Yamashima, S. Oikawa, Hatasu Kobayashi, 2009, Neuroscience Research.

Proteomic identification of carbonylated proteins in the monkey hippocampus after ischemia-reperfusion.

T. Yamashima, A. Furukawa, S. Oikawa, 2009, Free radical biology & medicine.

Influence of Epstein–Barr virus and human papillomavirus infection on macrophage migration inhibitory factor and macrophage polarization in nasopharyngeal carcinoma

H. Ishinaga, K. Takeuchi, Yifei Xu, 2021, BMC cancer.

Whole-exome sequencing reveals genetic variants associated with chronic kidney disease characterized by tubulointerstitial damages in North Central Region, Sri Lanka

R. Chandrajith, S. Nanayakkara, A. Koizumi, 2015, Environmental Health and Preventive Medicine.

Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation

K. Kawakami, I. Komuro, M. Horie, 2019, Circulation.

Taurine induces upregulation of p53 and Beclin1 and has antitumor effect in human nasopharyngeal carcinoma cells in vitro and in vivo.

S. Oikawa, M. Murata, I. Tawara, 2022, Acta histochemica.

Taurine Attenuates Carcinogenicity in Ulcerative Colitis-Colorectal Cancer Mouse Model

S. Oikawa, N. Ma, S. Kawanishi, 2020, Oxidative medicine and cellular longevity.

Combination of RERG and ZNF671 methylation rates in circulating cell‐free DNA: A novel biomarker for screening of nasopharyngeal carcinoma

Yingxi Mo, K. Takeuchi, Yifei Xu, 2020, Cancer science.

Vegetable Oil-Peroxidation Product ‘Hydroxynonenal’ Causes Hepatocyte Injury and Steatosis via Hsp70.1 and BHMT Disorders in the Monkey Liver

T. Yamashima, S. Oikawa, E. Mizukoshi, 2023, Nutrients.

Hsp70.1 carbonylation induces lysosomal cell death for lifestyle-related diseases

T. Yamashima, S. Oikawa, E. Mizukoshi, 2023, Frontiers in Molecular Biosciences.

Dysregulation of RNF213 promotes cerebral hypoperfusion

H. Iida, S. Miyamoto, H. Okuda, 2018, Scientific Reports.

Suppressed phosphorylation of collapsin response mediator protein-2 in the hippocampus of HCNP precursor transgenic mice

N. Matsukawa, S. Oikawa, K. Ojika, 2010, Brain Research.

Oxidative DNA Damage by N4-hydroxycytidine, a Metabolite of the SARS-CoV-2 Antiviral Molnupiravir

S. Oikawa, S. Kawanishi, M. Murata, 2022, The Journal of infectious diseases.

Cognitive and affective impairments of a novel SCA/MND crossroad mutation Asidan

M. Shoji, K. Abe, A. Koizumi, 2012, European journal of neurology.

Importance of molecular diagnosis in the accurate diagnosis of systemic carnitine deficiency

A. Koizumi, Kouji H. Harada, Toshiaki Hitomi, 2015, Journal of Genetics.

Familial episodic limb pain in kindreds with novel Nav1.9 mutations

Takeshi Yoshida, H. Okuda, Y. Kato, 2018, PloS one.

Paroxysmal limb intolerable pain (infantile pain episodes associated with novel Nav1.9 mutations in familial episodic pain syndrome).

H. Okuda, A. Koizumi, A. Noguchi, 2017, Nihon rinsho. Japanese journal of clinical medicine.

Knockdown of TFRC suppressed the progression of nasopharyngeal carcinoma by downregulating the PI3K/Akt/mTOR pathway

Zhe Zhang, K. Takeuchi, S. Oikawa, 2023, Cancer Cell International.

Perfluorinated carboxylic acids discharged from the Yodo River Basin, Japan.

A. Koizumi, Tamon Niisoe, Kouji H. Harada, 2015, Chemosphere.

Myricetin causes site-specific DNA damage via reactive oxygen species generation by redox interactions with copper ions.

S. Oikawa, S. Kawanishi, M. Murata, 2023, Mutation research. Genetic toxicology and environmental mutagenesis.