S. Ripp

发表

DHEA metabolites activate estrogen receptors alpha and beta

C. Klinge, M. Ivanova, R. Prough, 2013, Steroids.

Tissue distribution of anidulafungin in neonatal rats.

D. Cross, G. Chmielewski, C. Bowman, 2012, Birth defects research. Part B, Developmental and reproductive toxicology.

Modulation of Receptor Phosphorylation Contributes to Activation of Peroxisome Proliferator Activated Receptor α by Dehydroepiandrosterone and Other Peroxisome Proliferators

R. Prough, K. Miller, S. Ripp, 2008, Molecular Pharmacology.

Induction of Drug-Metabolizing Enzymes: Contrasting Roles in Detoxification and Bioactivation of Drugs and Xenobiotics

S. Ripp, 2008 .

Induction of CYP3A expression by dehydroepiandrosterone: involvement of the pregnane X receptor.

J. Peters, R. Prough, S. Ripp, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Species and sex differences in expression of flavin-containing monooxygenase form 3 in liver and kidney microsomes.

K. Itagaki, A. Elfarra, R. Philpot, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections.

Bryan M. Li, T. Dougherty, R. Obach, 2009, Journal of medicinal chemistry.

Characterization of the methionine S-oxidase activity of rat liver and kidney microsomes: immunochemical and kinetic evidence for FMO3 being the major catalyst.

A. Elfarra, R. Philpot, S. Ripp, 1996, Archives of biochemistry and biophysics.

Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11beta-hydroxysteroid dehydrogenases?

R. Prough, B. Robinzon, S. Winters, 2003, Archives of biochemistry and biophysics.

Metabolism of DHEA by cytochromes P450 in rat and human liver microsomal fractions.

W. Pierce, R. Prough, N. Smith, 2001, Archives of biochemistry and biophysics.

Oxidative metabolism of seleno-L-methionine to L-methionine selenoxide by flavin-containing monooxygenases.

A. Elfarra, S. Ripp, R. J. Krause, 2006, Chemical research in toxicology.

In Vitro and In Vivo Investigation of Potential for Complex CYP3A Interaction for PF‐00251802 (Dagrocorat), a Novel Dissociated Agonist of the Glucocorticoid Receptor

T. Stock, H. Eng, D. Fleishaker, 2017, Clinical pharmacology in drug development.

Stereo- and regioselectivity account for the diversity of dehydroepiandrosterone (DHEA) metabolites produced by liver microsomal cytochromes P450.

W. Pierce, T. Rushmore, R. Prough, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Deuterium Isotope Effects on Drug Pharmacokinetics. I. System-Dependent Effects of Specific Deuteration with Aldehyde Oxidase Cleared Drugs

Klaas Schildknegt, Douglas K Spracklin, Hongying Gao, 2012, Drug Metabolism and Disposition.

Non-clinical safety assessment and toxicokinetics of voriconazole and anidulafungin in the juvenile rat: a combination study design in support of a Paediatric Investigation Plan.

D. Cross, G. Chmielewski, C. Bowman, 2012, Regulatory toxicology and pharmacology : RTP.

Transcriptional suppression of cytochrome P450 genes by endogenous and exogenous chemicals.

J. Chiang, P. Cheng, R. Prough, 2004, Drug metabolism and disposition: the biological fate of chemicals.

In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective

Vikram Sinha, Heidi J Einolf, Michael Sinz, 2009, Drug Metabolism and Disposition.

Dehydroepiandrosterone affects the expression of multiple genes in rat liver including 11 beta-hydroxysteroid dehydrogenase type 1: a cDNA array analysis.

R. Prough, S. Ripp, T. Geoghegan, 2003, Molecular pharmacology.

A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif.

G. S. Walker, A. Kalgutkar, A. Mutlib, 2007, Chemical research in toxicology.

Structure-activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor.

M. Munchhof, T. Harris, J. Driscoll, 2010, Bioorganic & medicinal chemistry letters.

The identification of orally bioavailable thrombopoietin agonists.

A. Marfat, M. Munchhof, T. Harris, 2009, Bioorganic & medicinal chemistry letters.

Pyrimidine benzamide-based thrombopoietin receptor agonists.

M. Munchhof, J. Driscoll, Jonathan L. Doty, 2007, Bioorganic & medicinal chemistry letters.

Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks.

Hao Sun, A. Kalgutkar, R. Obach, 2012, Journal of medicinal chemistry.

Oxidation of cysteine S-conjugates by rabbit liver microsomes and cDNA-expressed flavin-containing mono-oxygenases: studies with S-(1,2-dichlorovinyl)-L-cysteine, S-(1,2,2-trichlorovinyl)-L-cysteine, S-allyl-L-cysteine, and S-benzyl-L-cysteine.

A. Elfarra, R. Philpot, S. Ripp, 1997, Molecular pharmacology.

Regulation of CYP2C11 by dehydroepiandrosterone and peroxisome proliferators: identification of the negative regulatory region of the gene.

R. Prough, K. Falkner, S. Ripp, 2003, Molecular pharmacology.

Effect of moxidectin on CYP3A4 activity as evaluated by oral midazolam pharmacokinetics in healthy subjects

Kyle T. Matschke, S. Chalon, S. Ripp, 2014, Clinical pharmacology in drug development.

In Vitro and In Vivo Induction of Cytochrome P 450 : A Survey of the Current Practices and Recommendations : A Pharmaceutical Research and Manufacturers of America ( PhRMA ) Perspective

R. Evers, V. Sinha, D. Moore, 2009 .

Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: mechanisms involving endogenous factors.

Z. Luo, C. Elferink, R. Hines, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Evaluation of models for predicting drug–drug interactions due to induction

Sharon L Ripp, O. Fahmi, S. Ripp, 2010, Expert opinion on drug metabolism & toxicology.

Methionine S-oxidation in human and rabbit liver microsomes: evidence for a high-affinity methionine S-oxidase activity that is distinct from flavin-containing monooxygenase 3.

K. Itagaki, A. Elfarra, R. Philpot, 1999, Archives of biochemistry and biophysics.

Comparative nonclinical assessments of the biosimilar PF-06410293 and originator adalimumab.

M. Leach, Z. Radi, A. Shoieb, 2020, Regulatory toxicology and pharmacology : RTP.

Use of Immortalized Human Hepatocytes to Predict the Magnitude of Clinical Drug-Drug Interactions Caused by CYP3A4 Induction

T. Maurer, S. D. de Morais, O. Fahmi, 2006, Drug Metabolism and Disposition.

Juvenile toxicity assessment of anidulafungin in rats: an example of navigating case-by-case study design through scientific and regulatory challenges.

D. Cross, G. Chmielewski, C. Bowman, 2011, Birth defects research. Part B, Developmental and reproductive toxicology.