W. Ripka

发表

Computer Graphics and Molecular Modeling in the Analysis of Synthetic Targets

J. Blaney, W. Ripka, Jeffrey M. Blaney, 2007 .

Novel and general method for the preparation of peptidyl argininals

R. Nutt, S. Tamura, W. Ripka, 1996 .

Rational design and synthesis of a novel, selective class of thrombin inhibitors: P1-argininal derivatives incorporating P3P4 quaternary lactam dipeptide surrogates

R. Nutt, S. Tamura, W. Ripka, 1997 .

Structure-based Design of a Low Molecular Weight, Nonphosphorus, Nonpeptide, and Highly Selective Inhibitor of Protein-tyrosine Phosphatase 1B*

Ole Hvilsted Olsen, Sven Branner, O. Olsen, 2000, The Journal of Biological Chemistry.

Protein β-turn mimetics I. Design, synthesis, and evaluation in model cyclic peptides.

W. C. Ripka, J. Blaney, A. Bach, 1993 .

Design, synthesis, and evolution of a novel, selective, and orally bioavailable class of thrombin inhibitors: P1-argininal derivatives incorporating P3-P4 lactam sulfonamide moieties.

R. Nutt, S. Tamura, A. Tulinsky, 1996, Journal of medicinal chemistry.

Chapter 8. Antithrombotics/Serine Proteases

W. Ripka, G. Vlasuk, 1997 .

Synthesis and NMR conformational analysis of a β-turn mimic incorporated into gramicidin S : a general approach to evaluate β-turn peptidomimetics

A. Bach, J. Markwalder, W. Ripka, 2009 .

Computer Graphics and Molecular Modeling in the Analysis of Synthetic Targets

J. Blaney, W. Ripka, 2007 .

Development of potent non-carbohydrate imidazole-based small molecule selectin inhibitors with antiinflammatory activity.

D. Slee, W. Ripka, J. Yu, 2001, Journal of medicinal chemistry.

Characterisation of a Novel Series of Aprotinin-Derived Anticoagulants

J. Vermylen, J. Sixma, A. Lambeir, 1995, Thrombosis and Haemostasis.

Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.

M. J. Newman, O. Olsen, L. Iversen, 2002, Journal of medicinal chemistry.

Novel Synthesis of Potent Site-Specific Phospholipase A2 Inhibitors

R. Magolda, W. Ripka, M. Rudnick, 1985 .

RATIONAL DESIGN, SYNTHESIS, AND SERINE PROTEASE INHIBITORY ACTIVITY OF NOVEL P1-ARGININOYL HETEROCYCLES

S. Tamura, W. Ripka, B. Shamblin, 1997 .

Design and synthesis of a novel class of thrombin inhibitors incorporating heterocyclic dipeptide surrogates

R. Nutt, S. Tamura, M. Lim-Wilby, 1997 .

Rational design, synthesis, and serine protease inhibitory activity of a novel P1-argininal derivative featuring a conformationally constrained P2–P3 bicyclic lactam moiety

S. Tamura, W. Ripka, J. E. Semple, 1997 .

Design and Synthesis of a Novel Class of Thrombin Inhibitors Incorporating Heterocyclic Dipeptide Surrogates.

R. Nutt, S. Tamura, W. Ripka, 1997 .

Potent and selective thrombin inhibitors incorporating the constrained arginine mimic l-3-piperidyl(N-guanidino)alanine at P1.

R. Nutt, A. Tulinsky, E. Dempsey, 1996, Journal of medicinal chemistry.

PAVINAN AND ISOPAVINAN ALKALOIDS. SYNTHESIS OF RACEMIC AND NATURAL THALIDINE, BISNORARGEMONINE, AND CONGENERS FROM N-NORRETICULINE

A. Brossi, K. Rice, W. Ripka, 1980 .

Decyanation of tertiary nitriles by alkyllithium reagents observed during the synthesis of imidazoles pendant to a quaternary carbon center

W. Ripka, A. L. Johnson, G. B. Gregory, 1990 .

Fluorination by Sulfur Tetrafluoride

W. Ripka, R. Scribner, G. A. Boswell, 2011 .

Dependence of hyperconjugative spin-spin coupling upon electron demand

W. Ripka, D. E. Applequist, 1967 .

Study of the shape of the binding site of bovine opsin using 10-substituted retinal isomers.

F. Crescitelli, T. Mirzadegan, W. Ripka, 1986, Biochemistry.

MODELING RHODOPSIN, A MEMBER OF G‐PROTEIN COUPLED RECEPTORS, BY COMPUTER GRAPHICS. INTERPRETATION OF CHEMICAL SHIFTS OF FLUORINATED RHODOPSINS

C. Humblet, T. Mirzadegan, Robert S. H. Liu, 1992, Photochemistry and photobiology.

Chapter 21. Protein tyrosine phosphatase inhibition

W. Ripka, 2000 .

Inhibition of Fructose-1,6-bisphosphatase by a New Class of Allosteric Effectors*

M. J. Newman, H. Fromm, D. Slee, 2003, Journal of Biological Chemistry.

New thrombin inhibitors in cardiovascular disease.

W. Ripka, 1997, Current opinion in chemical biology.

Synthetic route to P 1 -argininals suitable for radiolabeling studies

R. Nutt, S. Tamura, D. Rowley, 2002 .

A short and stereospecific synthesis of (±)-α-lycorane

P. Confalone, W. Ripka, C. Wang, 1984 .

Strategies in the Design of Inhibitors of Serine Proteases of the Coagulation Cascade - Factor Xa

I. Lasters, S. Tamura, P. Stanssens, 1995, European Journal of Medicinal Chemistry.

Computer modelling of the NAD binding site of ADP‐ribosylating toxins: active‐site structure and mechanism of NAD binding

R. Rappuoli, C. Montecucco, W. Ripka, 1991, Molecular microbiology.

Molecular modeling in the design of phospholipase A2 inhibitors

W. Ripka, W C Ripka, W J Sipio, 1989, Journal of cellular biochemistry.

Synthesis and biological activity of P2–P4 azapeptidomimetic P1-argininal and P1-ketoargininamide derivatives: a novel class of serine protease inhibitors

D. Rowley, W. Ripka, J. E. Semple, 1997 .

Computer-assisted model building

W. C. Ripka, W. Ripka, 1986, Nature.

Design, synthesis, and evolution of a novel, selective, and orally bioavailable class of thrombin inhibitors: P1-argininal derivatives incorporating P3-P4 lactam sulfonamide moieties.

R. Nutt, S. Tamura, A. Tulinsky, 1996, Journal of medicinal chemistry.

High-throughput purification of compound libraries.

J. Krakover, W. Ripka, W C. Ripka, 2001, Drug discovery today.

Total synthesis of (.+-.)-justicidin P. A new lignan lactone from Justicia extensa

W. Ripka, C. Wang, 1983 .

Synthesis, structure, and structure‐activity relationships of divalent thrombin inhibitors containing an α‐keto‐amide transition‐state mimetic

A. Tulinsky, W. Ripka, T. Brunck, 1996, Protein science : a publication of the Protein Society.

Protein β-Turn Mimetics. Part 1. Design, Synthesis, and Evaluation in Model Cyclic Peptides.

J. Blaney, A. Bach, W. Ripka, 1993 .

Gramicidin S: A general model for β-turn mimics?

J. Blaney, A. Bach, W. Ripka, 1994 .