R. Cosstick

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Incorporation of a complete set of deoxyadenosine and thymidine analogues suitable for the study of protein nucleic acid interactions into oligodeoxynucleotides. Application to the EcoRV restriction endonuclease and modification methylase.

D. Williams, F. Seela, David M Williams, 1990, Biochemistry.

Interaction of the EcoRV restriction endonuclease with the deoxyadenosine and thymidine bases in its recognition hexamer d(GATATC).

D. Williams, F. Seela, B. Connolly, 1990, Biochemistry.

Stabilization of a Bimolecular Triplex by 3'-S-Phosphorothiolate Modifications: An NMR and UV Thermal Melting Investigation.

J. Arnold, R. Wheelhouse, J. Fisher, 2015, Chemistry.

Probing the Run-On Oligomer of Activated SgrAI Bound to DNA

N. Horton, J. Bitinaite, V. Wysocki, 2015, PLoS ONE.

Site-specific ligation of DNA-modified gold nanoparticles activated by the restriction enzyme StyI.

A. G. Kanaras, M. Brust, I. Hussain, 2007, Small.

Duplex stability of DNA.DNA and DNA.RNA duplexes containing 3'-S-phosphorothiolate linkages.

J. Fisher, R. Cosstick, J. Bentley, 2007, Organic & biomolecular chemistry.

Foldamers Derived From Nucleoside β-Amino Acids: Pna Or Dna? Can We Have Both In One Place?

N. Howarth, R. Cosstick, A. Davies, 2007, Nucleosides, nucleotides & nucleic acids.

Hydrolytic Reactions of the cis-Methyl Ester of 3′-Deoxy-3′-thiothymidine 3′,5′-Cyclic(phosphorothiolate)

H. Lönnberg, R. Cosstick, M. Elzagheid, 2000 .

SERS and SERRS Detection of the DNA Lesion 8-Nitroguanine: A Self-Labeling Modification.

S. Bell, I. O'neil, R. Cosstick, 2017, Chemistry.

Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells.

B. K. Park, James Chadwick, P. O’Neill, 2009, Bioorganic & medicinal chemistry.

Reverse-direction (5'-->3') synthesis of oligonucleotides containing a 3'-S-phosphorothiolate linkage and 3'-terminal 3'-thionucleosides.

J. Fisher, R. Cosstick, J. Gaynor, 2010, Organic & biomolecular chemistry.

Syntheses of 2′-C-amidoalkyl and 2′-C-cyanoalkyl containing oligodeoxyribonucleotides and assessment of their hybridisation affinity for complementary DNA and RNA

A. Aerschot, I. O'neil, R. Cosstick, 2007 .

Probing the effect of a 3'-S-phosphorothiolate link on the conformation of a DNA:RNA hybrid; implications for antisense drug design.

J. Arnold, J. Fisher, S. Roberts, 2002, Chemical communications.

Dinucleotides containing 3'-S-phosphorothiolate linkages.

R. Cosstick, J. Gaynor, 2011, Methods in molecular biology.

Inhibition of the Herpes Simplex Virus Thymidine Kinase by 5 Substituted Thymidine Analogues. Comparison of the Types 1 and 2 Enzymes

R. T. Walker, R. Cosstick, I. Sim, 1988 .

Artemisinin–Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation

Amy E. Chadwick, Nuna C. P. Araújo, P. Stocks, 2013, ChemMedChem.

Chemistry of the 8-Nitroguanine DNA Lesion: Reactivity, Labelling and Repair.

K. Williams, I. O'neil, R. Cosstick, 2018, Chemistry.

Antitumour and antimalarial activity of artemisinin-acridine hybrids.

J. Baird, I. Piantanida, B. K. Park, 2009, Bioorganic & medicinal chemistry letters.

An approach to the stereoselective synthesis of Sp-dinucleoside phosphorothioates using phosphotriester chemistry.

D. Williams, R. Cosstick, 1987, Nucleic acids research.

Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity.

Michal Hocek, R. Kuchta, J. Engels, 2006, Biochemistry.

Studies on 2'-alpha-C-carboxyalkyl nucleosides and their application to a stereocontrolled nucleobase exchange process.

I. O'neil, R. Cosstick, V. Fehring, 2003, Organic & biomolecular chemistry.

A novel stereo-controlled nucleobase exchange process for the synthesis of 2′-C-branched nucleosides

I. O'neil, R. Cosstick, V. Fehring, 2000 .

Synthesis of a dinucleoside monophosphate analogue containing 6-N-(2-aminoethyl)-2'-deoxyadenosine. A novel approach to sequence specific cross-linking in synthetic oligonucleotides

R. Cosstick, M. Douglas, 1991 .

Synthesis and Characterization of an RNA Dinucleotide Containing a 3‘-S-Phosphorothiolate Linkage

L. B. Weinstein, T. Cech, R. Cosstick, 1996 .

Solid phase synthesis of oligonucleotides containing 3′-thiothymidine

R. Cosstick, J. S. Vyle, 1989 .

Dinucleoside Monophosphate Analogues Containing Disulfide Linkages

R. Cosstick, Emma M. Witch, 1997 .

Peptides derived from nucleoside beta-amino acids form an unusual 8-helix.

N. Howarth, J. Fisher, R. Cosstick, 2008, Chemical communications.

Synthesis and structure of S-nucleosidyl S-aryl disulfides and their reaction with phosphites

A. Higson, R. Cosstick, A. Baxter, 1996 .

Synthesis and Properties of 2‘-Deoxy-2‘-α-C-branched Nucleosides and Nucleotides

A. Lawrence, I. O'neil, R. Cosstick, 1996 .

Synthesis and properties of dithymidine phosphate analogues containing 3'-thiothymidine.

R. Cosstick, J. S. Vyle, 1990, Nucleic acids research.

The Biochemical and Physiological Genesis of Alliin in Garlic

B. Thomas, J. H. Hughes, R. Cosstick, 2007 .

Synthesis of the flavour precursor, alliin, in garlic tissue cultures.

M. G. Jones, H. Collin, R. Cosstick, 2005, Phytochemistry.

Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin.

Dominic P. Williams, B. K. Park, James Chadwick, 2004, Journal of medicinal chemistry.

Synthesis, Properties and Application of Nucleic Acids Containing Phosphorothiolate Linkages

R. Cosstick, J. Gaynor, Richard Cosstick and James W. Gaynor, 2008 .

Synthesis of phosphorothioamidites derived from 3'-thio-3'-deoxythymidine and 3'-thio-2',3'-dideoxycytidine and the automated synthesis of oligodeoxynucleotides containing a 3'-S-phosphorothiolate linkage.

I. O'neil, R. Cosstick, R. Gosain, 2004, Nucleic acids research.

Effect of Low Storage Temperature on Some of the Flavour Precursors in Garlic (Allium Sativum)

H. Collin, Meriel G. Jones, R. Cosstick, 2006, Plant foods for human nutrition.

Synthesis and transcription studies on 5'-triphosphates derived from 2'-C-branched-uridines: 2'-homouridine-5'-triphosphate is a substrate for T7 RNA polymerase.

A. Lawrence, I. O'neil, R. Cosstick, 2004, Organic & biomolecular chemistry.

Synthesis and duplex stability of oligodeoxyribonucleotides containing a 2′→5′-amide linkage

J. Arnold, J. Fisher, I. O'neil, 1999 .

THE SYNTHESIS OF 2'-HOMOURIDINE, ITS INCORPORATION INTO A DINUCLEOSIDE MONOPHOSPHATE AND HYDROLYTIC BEHAVIOUR OF THE DIMER

A. Lawrence, Andrew Potter, I. O'neil, 1998 .

Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors

P. Eyers, D. Byrne, D. Fernig, 2019, RSC advances.

NOVEL MACROCYCLES DERIVED FROM NUCLEOSIDES

I. O'neil, R. Cosstick, Noelia Calcerrada‐Munoz, 2001, Nucleosides, Nucleotides & Nucleic Acids.

Sequence- and strand-specific cleavage in oligodeoxyribonucleotides and DNA containing 3'-thiothymidine.

D. Kemp, B. Connolly, R. Cosstick, 1992, Biochemistry.

New methods for the synthesis of 3′-S-phosphorothiolate internucleoside linkages

R. Cosstick, Xiaoguang Li, J. S. Vyle, 1992 .

Synthesis of the 3′-thio-nucleosides and subsequent automated synthesis of oligodeoxynucleotides containing a 3′-S-phosphorothiolate linkage

R. Cosstick, J. Gaynor, J. Bentley, 2007, Nature Protocols.

SOLID-PHASE SYNTHESIS OF OLIGODEOXYNUCLEOTIDES CONTAINING 3′-S-PHOSPHOROTHIOLATE LINKAGES

S. Roberts, I. O'neil, R. Cosstick, 2001, Nucleosides, nucleotides & nucleic acids.

Conformational analysis of 3′‐S‐PO3‐linked ribo‐ and deoxyribodinucleoside monophosphates

J. Arnold, J. Fisher, R. Cosstick, 1999 .

Application of the Michaelis–Arbusov reaction to the synthesis of internucleoside 3′-S-phosphorothiolate inkages

R. Cosstick, A. Baxter, Xiang Li, 1994 .

Application of an intramolecular Michaelis-Arbusov reaction to the synthesis of nucleoside 3'-S,5'-O-cyclic phosphorothiolate triesters

R. Cosstick, Xiang Li, 1993 .

New Methods for the Synthesis of 3′‐S‐Phosphorothiolate Internucleoside Linkages.

R. Cosstick, Xiaoguang Li, J. S. Vyle, 1992 .

Synthesis of a dinucleoside 3′-S-phosphorothiolate containing 2′-deoxy-3′-thioadenosine

D. M. Andrews, R. Cosstick, Xiaoguang Li, 1992 .

Site-specific Disulfide Bridges in Oligodeoxyribonucleotide Duplexes containing 6-Mercaptopurine and 4-Thiothymine bases.

B. Connolly, R. Cosstick, John Milton, 1993 .

A novel approach to sequence-specific cross-linking in oligonucleotides.

R. Cosstick, M. Douglas, 1991 .

Synthesis of bridged dinucleosides

A. McLennan, M. Prescott, P. C. Page, 1990 .

NMR and UV studies of 3'-S-phosphorothiolate modified DNA in a DNA : RNA hybrid dodecamer duplex; implications for antisense drug design.

J. Arnold, J. Fisher, R. Cosstick, 2004, Organic & biomolecular chemistry.

Incorporation of a S-glycosidic linkage into a glyconucleoside changes the conformational preference of both furanose sugars.

J. Fisher, R. Cosstick, J. Brazier, 2007, Carbohydrate research.

Synthesis, structure and reactions of uridine2′-C,3′-O-γ-butyrolactone:versatile intermediate for the synthesis of 2′-C-branchednucleosides

A. Lawrence, J. Fisher, I. O'neil, 1997 .

Sunthesis of functionalised 2′-C-branched nucleosides via their γ-butyrolactones

A. Lawrence, I. O'neil, R. Cosstick, 1995 .

Application of an Intramolecular Michaelis-Arbusov Reaction to the Synthesis of Nucleoside 3′-S,5′-O-Cyclic Phosphorothiolate Triesters.

R. Cosstick, Xiaoguang Li, 1993 .

Synthesis and phosphorus–sulphur bond cleavage of 3′-thiothymidylyl(3′-5′)thymidine

R. Cosstick, J. S. Vyle, 1988 .

Hydrolytic Reactions of 3′-Deoxy-3′-thioinosylyl-(3′→ >5′)-uridine; An RNA Dinucleotide Containing a 3′-S-Phosphorothiolate Linkage

H. Lönnberg, K. Klika, R. Cosstick, 1999 .

Application of the Michaelis‐Arbusov Reaction to the Synthesis of Internucleoside 3′‐S‐Phosphorothiolate Linkages.

A. Baxter, R. Cosstick, Xiang Li, 1995 .

Thermal stabilisation of RNA·RNA duplexes and G-quadruplexes by phosphorothiolate linkages.

J. Fisher, R. Cosstick, J. Gaynor, 2013, Organic & biomolecular chemistry.

Synthesis of 3′- S-Phosphorothiolate Oligonucleotides for their Potential Use in RNA Interference

R. Cosstick, J. Gaynor, J. Brazier, 2007, Nucleosides, nucleotides & nucleic acids.

NMR studies of the conformational effect of single and double 3′‐S‐phosphorothiolate substitutions within deoxythymidine trinucleotides

J. Fisher, N. Berry, R. Cosstick, 2007, Magnetic resonance in chemistry : MRC.

CONTROL OF DNA CONFORMATION USING 3′-S-PHOSPHOROTHIOLATE-MODIFIED LINKAGES

J. Fisher, R. Cosstick, J. Brazier, 2005, Nucleosides, nucleotides & nucleic acids.

A second catalytic metal ion in a group I ribozyme

L. B. Weinstein, T. Cech, R. Cosstick, 1997, Nature.

Nicked-site substrates for a serine recombinase reveal enzyme–DNA communications and an essential tethering role of covalent enzyme–DNA linkages

F. J. Olorunniji, W. Stark, Hania J. Pavlou, 2015, Nucleic acids research.

A novel mechanism for the scission of double-stranded DNA: BfiI cuts both 3′–5′ and 5′–3′ strands by rotating a single active site

Virginijus Siksnys, Stephen E. Halford, S. Halford, 2010, Nucleic acids research.

A novel mechanism for the scission of double-stranded DNA : BfiI cuts both 3 0 – 5 0 and 5 0 – 3 0 strands by rotating a single active site

Virginijus Siksnys, Stephen E. Halford, S. Halford, 2009 .

Mechanism of the Escherichia coli DNA T:G-mismatch endonuclease (Vsr protein) probed with thiophosphate-containing oligodeoxynucleotides.

B. Connolly, R. Cosstick, S. Elliott, 2005, Journal of molecular biology.

Stabilization of the DNA I-motif structure by incorporation of 3'-S-phosphorothiolate linkages.

J. Fisher, R. Cosstick, J. Brazier, 2005, Angewandte Chemie.

The RuvC protein dimer resolves Holliday junctions by a dual incision mechanism that involves base‐specific contacts

S. West, R. Cosstick, R. Shah, 1997, The EMBO journal.

Synthesis of a Dinucleoside 3′-S-Phosphorothiolate Containing 2′-Deoxy- 3′-thioadenosine.

D. M. Andrews, R. Cosstick, Xiaoguang Li, 1992 .

The Synthesis of 2′-Homouridine, Its Incorporation into a Dinucleoside Monophosphate and Hydrolytic Behavior of the Dimer.

A. Lawrence, Andrew Potter, I. O'neil, 1998 .

The synthesis of a novel 2′,3′-cyclic phosphate derived from 2′-homouridine

I. O'neil, R. Cosstick, J. Pavey, 1998 .

THE SYNTHESIS OF, AND STUDIES ON, 2′-C-MODIFIED NUCLEOTIDES

I. O'neil, R. Cosstick, L. Brennan, 2001, Nucleosides, nucleotides & nucleic acids.

THE SYNTHESIS OF 2'-C-FUNCTIONALISED NUCLEOSIDES FOR INCORPORATION INTO CATALYTIC RNA

A. Lawrence, I. O'neil, R. Cosstick, 1997 .

Synthesis of d(GC) and d(CG) octamers containing alternating phosphorothioate linkages: effect of the phosphorothioate group on the B-Z transition.

F. Eckstein, R. Cosstick, 1985, Biochemistry.

The use of phosphorothioate-modified DNA in restriction enzyme reactions to prepare nicked DNA.

F. Eckstein, F Eckstein, J W Taylor, 1985, Nucleic acids research.

Fluorescent labelling of tRNA and oligodeoxynucleotides using T4 RNA ligase.

F. Eckstein, L. McLaughlin, F Eckstein, 1984, Nucleic acids research.

Base-pairing preferences, physicochemical properties and mutational behaviour of the DNA lesion 8-nitroguanine†

P. Compagnone-Post, I. O'neil, R. Cosstick, 2012, Nucleic acids research.

RNA interference: a chemist's perspective.

B. Campbell, R. Cosstick, J. Gaynor, 2010, Chemical Society reviews.

Tautomerism in 8-Nitroguanosine Studied by NMR and Theoretical Calculations

R. J. Abraham, R. Cosstick, R. Rittner, 2016, Nucleosides, nucleotides & nucleic acids.

The Inhibition of Adenosine Kinase by α,ω-Di (Adenosin - N 6- YL) Alkanes1

A. McLennan, M. Prescott, R. Cosstick, 1989 .

The specific binding of Escherichia coli integration host factor involves both major and minor grooves of DNA.

R. Gumport, J. Gardner, R. Cosstick, 1995, Biochemistry.

Phosphorothioate Analogues : Probes for Studying DNA Conformation

S. A. Salisbury, F. Eckstein, R. Cosstick, 1987 .

Chiral phosphorothioate analogues of B-DNA: The crystal structure of Rp-d¦Gp(S)CpGp(S)CpGp(S)C¦☆

Fritz Eckstein, Olga Kennard, Tom Brown, 1993 .

Enzymatic disassembly of DNA-gold nanostructures.

Zhenxin Wang, Mathias Brust, Andrew D Bates, 2007, Small.

A combined top-down bottom-up approach for introducing nanoparticle networks into nanoelectrode gaps

J. Cooper, D. Cumming, A. Glidle, 2006, Nanotechnology.

Chiral phosphorothioate analogues of B-DNA. The crystal structure of Rp-d[Gp(S)CpGp(S)CpGp(S)C].

S. A. Salisbury, O Kennard, S A Salisbury, 1986, Journal of molecular biology.

SULFUR BIOCHEMISTRY OF GARLIC: THE BIOSYNTHESIS OF FLAVOR PRECURSORS

B. Thomas, H. Collin, Meriel G. Jones, 2005 .

STUDIES ON THE ATTACHMENT OF DNA TO SILICA-COATED NANOPARTICLES THROUGH A DIELS-ALDER REACTION

L. Liz‐Marzán, M. Brust, V. Salgueiriño-Maceira, 2005, Nucleosides, Nucleotides & Nucleic Acids.

Towards multistep nanostructure synthesis: programmed enzymatic self-assembly of DNA/gold systems.

Zhenxin Wang, Mathias Brust, Andrew D Bates, 2003, Angewandte Chemie.

Thermodynamic stability and drug-binding properties of oligodeoxyribonucleotide duplexes containing 3-deazaadenine:thymine base pairs.

T. Brown, X. Li, S. Ebel, 1993, Nucleic Acids Research.

Gold nanoparticle wires made using RNA-based self-assembly

Cody W. Geary, J. Cooper, D. Cumming, 2006 .

Properties of the diadenosine tetraphosphate nucleoside analogue, bis (N6-adenosyl)dodecane, and its possible use in the treatment of disorders of purine metabolism.

A. McLennan, R. Cosstick, H. Chen, 1991, Biochemical Society transactions.

RNA Interference: A Chemist′s Perspective

B. Campbell, R. Cosstick, J. Gaynor, 2011 .

Construction and characterization of a gold nanoparticle wire assembled using Mg2+-dependent RNA-RNA interactions.

Luc Jaeger, Jonathan M Cooper, Andrew Glidle, 2006, Nano letters.

Artemisinin–Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation

Amy E. Chadwick, Raman Sharma, N. Berry, 2013, ChemMedChem.

Peptides derived from nucleoside beta-amino acids form an unusual 8-helix.

N. Howarth, J. Fisher, R. Cosstick, 2008, Chemical communications.

A combined top-down bottom-up approach for introducing nanoparticle networks into nanoelectrode gaps

J. Cooper, D. Cumming, A. Glidle, 2006, Nanotechnology.