D. Dinh

发表

PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models.

Shibing Deng, Hui Wang, Shinji Yamazaki, 2015, Cancer cell.

Screening for inhibitors of the HMG‐CoA reductase promoter in HepG2 cells: Identification of four non‐oxysterol inhibitors

G. F. Hess, Y. Yagi, B. J. Keiser, 1997 .

Sterol and bile acid metabolism during development: 2. Identification of 3β-hydroxy-5-cholenoic acid (an intermediate in alternate pathway of bile acid synthesis) in newborn and fetal guinea pig

L. Marai, M. Subbiah, D. Dinh, 1977, Steroids.

Apolipoprotein A-I as a marker of angiographically assessed coronary-artery disease.

A. Zinsmeister, D. Holmes, S. Mao, 1983, The New England journal of medicine.

Effect of PF-04217329 a prodrug of a selective prostaglandin EP(2) agonist on intraocular pressure in preclinical models of glaucoma.

P. Wells, C. Toris, Chau Almaden, 2011, Experimental eye research.

Pioglitazone hydrochloride inhibits cholesterol absorption and lowers plasma cholesterol concentrations in cholesterol-fed rats

J. Colca, C. Dailey, D. Dinh, 1991, Diabetes.

Lifibrol increases hepatic cholesterol 7α‐hydroxylase activity in sprague‐dawley rats

T. Vidmar, D. Dinh, C. Spilman, 1994 .

Apolipoprotein A-I in coronary-artery disease.

A. Zinsmeister, D. Holmes, S. Mao, 1984, The New England journal of medicine.

Apolipoprotein A-I metabolism in cholesteryl ester transfer protein transgenic mice. Insights into the mechanisms responsible for low plasma high density lipoprotein levels.

K. Marotti, R. Murray, W. L. Blake, 1994, The Journal of biological chemistry.

Spontaneous hypercholesterolemia in cynomolgus monkeys: evidence for defective low-density lipoprotein catabolism.

T. Vidmar, D. Dinh, K. L. Hart, 1992, Biochimica et biophysica acta.

Alteration of biliary ursodeoxycholic acid in guinea pig during early stages of cholestyramine feeding

B. Kottke, D. Dinh, Job R. Li, 1979, Steroids.

The characteristics and metabolism of a genetically hypercholesterolemic strain of rats (RICO).

M. Subbiah, D. Dinh, K. Müller, 1979, Biochimica et biophysica acta.

Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain expos

Wei Liu, Huichun Zhu, Dac Dinh, 2014, Journal of medicinal chemistry.

Sterol and bile acid metabolism during development. 3. Occurrence of neonatal hypercholesterolemia in guinea pig and its possible relation to bile acid pool.

R. Ellefson, M. Subbiah, D. Dinh, 1979, Metabolism: clinical and experimental.

Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant

Huichun Zhu, Benjamin J. Burke, John Charles Kath, 2014 .

Regression of naturally occurring atherosclerotic lesions in pigeon aorta by intestinal bypass surgery. Early changes in arterial cholesteryl ester metabolism.

M. Subbiah, B. Kottke, D. Dinh, 1978, Atherosclerosis.

Conformationally-restricted cyclic sulfones as potent and selective mTOR kinase inhibitors.

K. Liu, M. Yin, P. A. Wells, 2012, Bioorganic & medicinal chemistry letters.

Dopamine D(3) receptor antagonists. 1. Synthesis and structure-activity relationships of 5,6-dimethoxy-N-alkyl- and N-alkylaryl-substituted 2-aminoindans.

A. Carlsson, N. F. Nichols, K. Svensson, 2001, Journal of medicinal chemistry.

Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation.

S. Greasley, E. Reyner, R. Ferre, 2010, Bioorganic & medicinal chemistry.

Arterial and metabolic changes during the critical period of spontaneous sterol accumulation in pigeon aorta.

K. Unni, M. Subbiah, B. Kottke, 1976, Experimental and molecular pathology.

Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.

Paolo Vicini, Deepak Dalvie, Chengyi Zhang, 2017, Journal of medicinal chemistry.

Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib.

N. Sach, Hong Shen, M. McTigue, 2014, Journal of medicinal chemistry.

Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquin

K. Gajiwala, N. Sach, P. Kung, 2017, Journal of medicinal chemistry.

Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.

P. Kung, S. Yamazaki, M. Edwards, 2016, Journal of medicinal chemistry.

Design and Synthesis of Pyridone-Containing 3 , 4-Dihydroisoquinoline-1 ( 2 H ) ‐ ones as a Novel Class of Enhancer of Zeste Homolog 2 ( EZH 2 ) Inhibitors

P. Kung, S. Yamazaki, M. Edwards, 2016 .

Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.

Deepak Dalvie, Michael Zientek, Rose Ann Ferre, 2016, Journal of medicinal chemistry.

Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors.

E. Wong, R. Hurst, M. Hajós, 2005, Journal of medicinal chemistry.

Regional aortic differences in atherosclerosis-susceptibility: Changes in prostaglandin biosynthesis and cholesterol accumulation in response to desoxycorticosterone (DOCA)-salt induced hypertension

L. Bale, M. Subbiah, B. Kottke, 1981, Virchows Archiv. B, Cell pathology including molecular pathology.

Synthesis and hypocholesterolemic activity of 6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-diones, novel inhibitors of acylCoA:cholesterol O-acyltransferase.

S. Larsen, D. Dinh, C. Spilman, 1991, Journal of medicinal chemistry.

Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors.

E. Wong, R. Hurst, M. Hajós, 2005, Journal of medicinal chemistry.

Design, synthesis, and evaluation of NO-donor containing carbonic anhydrase inhibitors to lower intraocular pressure.

M. Edwards, E. Rui, P. Richardson, 2015, Journal of medicinal chemistry.

Substituted 4-aminopiperidines having high in vitro affinity and selectivity for the cloned human dopamine D4 receptor.

M. Smith, T. Poel, D. Dinh, 1997, European journal of pharmacology.

2,3,4,5-Tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: new templates for 5-HT2C agonists

R. Mccall, N. F. Nichols, K. Svensson, 2003 .

Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.

P. Kung, S. Yamazaki, M. Edwards, 2016, Journal of Medicinal Chemistry.

Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility

Zhou Zhu, S. Murphy, Sergei L Timofeevski, 2015, PloS one.

Discovery of a novel class of targeted kinase inhibitors that blocks protein kinase C signaling and ameliorates retinal vascular leakage in a diabetic rat model.

K. Liu, P. Tran, P. Wells, 2010, European journal of pharmacology.

Positive allosteric modulator of the human 5-HT2C receptor.

D. Dinh, W. Im, C. Chio, 2003, Molecular pharmacology.

Abstract C253: PF-06463922, a novel brain-penetrating small molecule inhibitor of ALK/ROS1 with potent activity against a broad spectrum of ALK resistant mutations in preclinical models in vitro and in vivo.

Sergei L Timofeevski, S. Yamazaki, Qiuhua Li, 2013 .

K. Gajiwala, N. Sach, Sherry L. Niessen, 2016, Journal of medicinal chemistry.

Sterol and bile acid metabolism during development. 1. Studies on the gallbladder and intestinal bile acids of newborn and fetal rabbit

L. Marai, M. Subbiah, D. Dinh, 1977, Steroids.

N. Sach, H. Zou, R. Kania, 2014 .