E. Lansdon

发表

Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation.

S. Viatchenko‐Karpinski, J. Sudhamsu, Xiaowu Chen, 2019, ACS medicinal chemistry letters.

New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action

Xiaohong Liu, R. Geleziunas, Wayne Huang, 2012, The Journal of Biological Chemistry.

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.

R. Neve, R. Mackman, Xiaowu Chen, 2019, Bioorganic & Medicinal Chemistry.

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.

R. Neve, R. Mackman, Xiaowu Chen, 2019, Bioorganic & medicinal chemistry.

Novel (2,6-difluorophenyl)(2-(phenylamino)pyrimidin-4-yl)methanones with restricted conformation as potent non-nucleoside reverse transcriptase inhibitors against HIV-1.

G. Stepan, P. Jansa, E. Lansdon, 2016, European journal of medicinal chemistry.

N1-Heterocyclic pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.

James M. Chen, R. Geleziunas, Chong-kyo Lee, 2010, Bioorganic & medicinal chemistry letters.

Ligand-induced structural changes in adenosine 5'-phosphosulfate kinase from Penicillium chrysogenum.

I. H. Segel, A. Fisher, E. Lansdon, 2002, Biochemistry.

N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.

James M. Chen, R. Geleziunas, E. Cho, 2010, Bioorganic & medicinal chemistry letters.

Mechanism of Resistance to GS-9148 Conferred by the Q151L Mutation in HIV-1 Reverse Transcriptase

S. Swaminathan, K. White, S. Swaminathan, 2011, Antimicrobial Agents and Chemotherapy.

Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase--structure-activity relationships and crystallographic analysis.

Wei Huang, M. Balakrishnan, T. Kirschberg, 2008, Bioorganic & medicinal chemistry letters.

Crystal structures of HIV-1 reverse transcriptase with etravirine (TMC125) and rilpivirine (TMC278): implications for drug design.

Xiaohong Liu, S. Mukund, D. Jin, 2010, Journal of medicinal chemistry.

Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors

Xiaohong Liu, S. Leavitt, M. Balakrishnan, 2011, Antimicrobial Agents and Chemotherapy.

RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information.

Xiaohong Liu, S. Leavitt, J. Mak, 2009, Journal of medicinal chemistry.

Elucidating molecular interactions of L-nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistance

Z. Suo, E. Lansdon, Lijun Zhang, 2019, Communications Biology.

Elucidating molecular interactions of L-nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistance.

Z. Suo, E. Lansdon, Lijun Zhang, 2019 .

Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex.

K. White, Xiaohong Liu, M. Mcgrath, 2010, Journal of molecular biology.

The HIV-1 Reverse Transcriptase M184I Mutation Enhances the E138K-Associated Resistance to Rilpivirine and Decreases Viral Fitness

K. White, V. van Eygen, K. Babaoglu, 2012, Journal of acquired immune deficiency syndromes.

Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase.

H. Rong, K. Currie, J. Kropf, 2014, Journal of medicinal chemistry.

ASK1 contributes to fibrosis and dysfunction in models of kidney disease

Melanie H. Wong, S. Wise, D. French, 2018, The Journal of clinical investigation.

Affinities between the Binding Partners of the HIV-1 Integrase Dimer-Lens Epithelium-derived Growth Factor (IN Dimer-LEDGF) Complex

Kerim Babaoglu, Xiaohong Liu, R. Geleziunas, 2009, The Journal of Biological Chemistry.

Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains.

I. H. Segel, A. Fisher, E. Lansdon, 2004, Biochemistry.

Crystal structure of the bifunctional ATP sulfurylase-APS kinase from the chemolithotrophic thermophile Aquifex aeolicus.

I. H. Segel, A. Fisher, E. Lansdon, 2007, Journal of molecular biology.

Optimizing an enzyme for its physiological role: Structural and functional comparisons of ATP sulfurylases from three different organisms

I. MacRae, I. H. Segel, A. Fisher, 2005 .

Mutations in the thumb–connection and RNase H domain of HIV type-1 reverse transcriptase of antiretroviral treatment-experienced patients

K. White, K. Borroto-Esoda, E. Svarovskaia, 2009, Antiviral therapy.

Synthesis and biological evaluation of phosphonate analogues of nevirapine.

M. Desai, Xiaowu Chen, Xubin Zheng, 2013, Bioorganic & medicinal chemistry letters.

Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases.

J. Chandrasekhar, Helen Yu, S. Wise, 2020, ACS medicinal chemistry letters.

Design and Synthesis of Novel HIV-1 NNRTIs with Bicyclic Cores and with Improved Physicochemical Properties

Helen Yu, G. Stepan, P. Jansa, 2023, Journal of medicinal chemistry.

HIV-1 M184V reverse transcriptase-DNA complex

E. Lansdon, 2019 .

Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase.

H. Rong, K. Currie, J. Kropf, 2014, Journal of medicinal chemistry.

N-terminal bromodomain of human BRD2 with N-((4-(3-(N-cyclopentylsulfamoyl)-4-methylphenyl)-3-methylisoxazol-5-yl)methyl)acetamide inhibitor

R. Neve, R. Mackman, K. Babaoglu, 2019 .