P. Hornby

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The pharmacology and therapeutic applications of monoclonal antibodies

P. Mcgonigle, María Sofía Castelli, P. Hornby, 2019, Pharmacology research & perspectives.

Central neurocircuitry associated with emesis.

P J Hornby, P. Hornby, 2001, The American journal of medicine.

Small Intestinal Cannabinoid Receptor Changes Following a Single Colonic Insult with Oil of Mustard in Mice

M. D'Andrea, C. Schneider, E. S. Kimball, 2010, Front. Pharmacol..

Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium.

C. Schneider, E. S. Kimball, P. Hornby, 2006, American journal of physiology. Gastrointestinal and liver physiology.

Contribution of FcRn binding to intestinal uptake of IgG in suckling rat pups and human FcRn-transgenic mice.

B. Scallon, P. Cooper, G. Powers, 2013, American journal of physiology. Gastrointestinal and liver physiology.

Synthesis and SAR of pyridazinone-substituted phenylalanine amide alpha4 integrin antagonists.

E. S. Kimball, P. Hornby, Y. Gong, 2008, Bioorganic & medicinal chemistry letters.

Aza-bicyclic amino acid carboxamides as α4β1/α4β7 integrin receptor antagonists

B. Maryanoff, C. Schneider, B. Damiano, 2005 .

Altered tricarboxylic acid cycle flux in primary myotubes from severely obese humans

D. Zheng, G. Dohm, W. Pories, 2018, International Journal of Obesity.

Localization of immunoreactive tyrosine hydroxylase in the goldfish brain

L. S. Demski, P. Hornby, D. Piekut, 1987, The Journal of comparative neurology.

Hormonal Control of Fish Reproductive Behavior: Brain–Gonadal Steroid Interactions

L. S. Demski, P. Hornby, 1982 .

Impaired Glucose Partitioning in Primary Myotubes from Severely Obese Women with Type 2 Diabetes.

D. Zheng, G. Dohm, W. Pories, 2020, American journal of physiology. Cell physiology.

Intestinal SGLT 1 in metabolic health and disease

P. Hornby, A. Lehmann, 2016 .

Intestinal SGLT1 in metabolic health and disease.

P. Hornby, A. Lehmann, 2016, American journal of physiology. Gastrointestinal and liver physiology.

Immunocytochemical localization of the neuropeptide-synthesizing enzyme PC1 in AtT-20 cells.

I. Lindberg, S. Rosenthal, P. Hornby, 1993, Neuroendocrinology.

Design, synthesis and preclinical evaluation of bio-conjugated amylinomimetic peptides as long-acting amylin receptor agonists.

R. Patch, O. Libiger, S. Edavettal, 2022, European journal of medicinal chemistry.

Opposite Gastric Motor Effects of PACAP38 and VIP When Microinjected into the Nucleus Raphe Obscurus of Rats a

A. Arimura, P. Hornby, Z. Krowicki, 1996, Annals of the New York Academy of Sciences.

Cannabinoid1 Receptor in the Dorsal Vagal Complex Modulates Lower Oesophageal Sphincter Relaxation in Ferrets

P. Hornby, J. M. Moerschbaecher, R. Scullion, 2003, The Journal of physiology.

Drug discovery approaches to irritable bowel syndrome

P. Hornby, 2015, Expert opinion on drug discovery.

The contribution of cell surface FcRn in monoclonal antibody serum uptake from the intestine in suckling rat pups

P. Cooper, G. Powers, H. Dorai, 2014, Front. Pharmacol..

Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn

P. Cooper, P. Hornby, Yiqing Feng, 2013, Brain Research.

Human and Non-Human Primate Intestinal FcRn Expression and Immunoglobulin G Transcytosis

P. Cooper, G. Powers, Zhengyin Yan, 2013, Pharmaceutical Research.

The therapeutic potential of targeting the glucagon-like peptide-2 receptor in gastrointestinal disease

B. Moore, P. Hornby, 2011, Expert opinion on therapeutic targets.

The nucleus raphe obscurus controls pancreatic hormone secretion in the rat.

P. Hornby, Z. Krowicki, 1995, The American journal of physiology.

FcRn binding is not sufficient for achieving systemic therapeutic levels of immunoglobulin G after oral delivery of enteric‐coated capsules in cynomolgus macaques

P. Cooper, S. Muzammil, P. Hornby, 2016, Pharmacology research & perspectives.

Gastric motor effects of endothelins in the lower brainstem of the rat

P. Hornby, Z. Krowicki, 1996, InflammoPharmacology.

Excitatory gastric motor and cardiovascular effects of endothelins in the dorsal vagal complex are mediated through ET(A) receptors.

P. Hornby, Z. Krowicki, N. A. Nathan, 1997, The Journal of pharmacology and experimental therapeutics.

TLR3 activation stimulates cytokine secretion without altering agonist-induced human small airway contraction or relaxation.

P. Cooper, R. Panettieri, R. Lamb, 2009, American journal of physiology. Lung cellular and molecular physiology.

Electrical stimulation of the isolated rat intestine in the presence of nutrient stimulus enhances glucagon-like peptide-1 release

P. Wade, T. Ort, P. Hornby, 2010, Physiological measurement.

The Effect of Glucagon-Like Peptide-2 Receptor Agonists on Colonic Anastomotic Wound Healing

J. Holst, D. Hart, L. Wallace, 2010, Gastroenterology research and practice.

Designing Spiegelmers to antagonise ghrelin

P. Hornby, 2006, Gut.

Orexins in rat dorsal motor nucleus of the vagus potently stimulate gastric motor function.

H. Berthoud, P. Hornby, M. Burmeister, 2002, American journal of physiology. Gastrointestinal and liver physiology.

Lower oesophageal sphincter relaxation evoked by stimulation of the dorsal motor nucleus of the vagus in ferrets

P. Hornby, P. Hornby, T. Abrahams, 2002, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Orexin-A in the dorsal motor nucleus of the vagus potently increases gastric motor function via orexin 1 receptor in rats

H. Berthoud, P. Hornby, M. Burmeister, 2001 .

Orexin-A in rat hindbrain stimulates gastric motor function

H. Berthoud, P. Hornby, Z. Krowicki, 2000, Regulatory Peptides.

GLP-2 Receptor Agonism Ameliorates Inflammation and Gastrointestinal Stasis in Murine Postoperative Ileus

Dana L. Johnson, B. Moore, N. Peffer, 2010, Journal of Pharmacology and Experimental Therapeutics.

Synthesis and biological evaluation of benzocyclobutane-C-glycosides as potent and orally active SGLT1/SGLT2 dual inhibitors.

F. Du, S. Lee, E. Grant, 2018, Bioorganic & medicinal chemistry letters.

Delta9-tetrahydrocannabinol inhibits gastric motility in the rat through cannabinoid CB1 receptors.

P. Hornby, J. M. Moerschbaecher, P. Winsauer, 1999, European journal of pharmacology.

Opiocortin and catecholamine input to CRF-immunoreactive neurons in rat forebrain

P. Hornby, D. Piekut, 1989, Peptides.

Partial characterization of a neurotransmitter pathway regulating the in vivo release of prolactin.

K. Kellar, C. M. Flores, B. Hulihan-Giblin, 1992, Neuroendocrinology.

Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists.

D. Hlasta, B. Maryanoff, C. Schneider, 2006, Journal of medicinal chemistry.

Central mechanisms of lower esophageal sphincter control.

P. Hornby, T. Abrahams, E. Partosoedarso, 2002, Gastroenterology clinics of North America.

Involvement of cannabinoid receptors in gut motility and visceral perception

P. Hornby, S. Prouty, Pamela J Hornby, 2004, British journal of pharmacology.

Acute colitis induction by oil of mustard results in later development of an IBS-like accelerated upper GI transit in mice.

P. Wade, M. D'Andrea, E. S. Kimball, 2005, American journal of physiology. Gastrointestinal and liver physiology.

Substance P in the dorsal motor nucleus of the vagus evokes gastric motor inhibition via neurokinin 1 receptor in rat.

P. Hornby, Z. Krowicki, 2000, The Journal of pharmacology and experimental therapeutics.

Site of action of GABA(B) receptor for vagal motor control of the lower esophageal sphincter in ferrets and rats.

N. Hyland, P. Hornby, C. M. McDermott, 2001, Gastroenterology.

Distribution of catecholamine-synthesizing enzymes in goldfish brains: presumptive dopamine and norepinephrine neuronal organization.

P. Hornby, D. Piekut, 1990, Brain, behavior and evolution.

Emerging effects of tryptophan pathway metabolites and intestinal microbiota on metabolism and intestinal function

N. Hyland, P. Hornby, C. Cavanaugh, 2022, Amino Acids.

The non-NMDA subtype of excitatory amino acid receptor plays the major role in control of cardiovascular function by the subretrofacial nucleus in cats.

A. Dasilva, R. Gillis, P. Hornby, 1994, The Journal of pharmacology and experimental therapeutics.

Bicuculline blocks the inhibitory effects of substance p but not vasoactive intestinal polypeptide on gastric motor function in the nucleus raphe obscurus of the rat

P. Hornby, Z. Krowicki, 1997, InflammoPharmacology.

Opposing effects of vasoactive intestinal polypeptide on gastric motor function in the dorsal vagal complex and the nucleus raphe obscurus of the rat.

P. Hornby, Z. Krowicki, N. A. Nathan, 1997, The Journal of pharmacology and experimental therapeutics.

Anatomical evidence for interaction of ACTH1–39 immunostained fibers and hypothalamic paraventricular neurons that project to the dorsal vagal complex

P. Hornby, D. Piekut, 2004, Histochemistry.

The inhibitory effect of substance P on gastric motor function in the nucleus raphe obscurus is mediated via nitric oxide in the dorsal vagal complex.

P. Hornby, Z. Krowicki, 1996, Journal of the autonomic nervous system.

Serotonin and thyrotropin-releasing hormone do not augment their effects on gastric motility on their microinjection into the nucleus raphe obscurus of the rat.

P. Hornby, Z. Krowicki, 1995, The Journal of pharmacology and experimental therapeutics.

Opposing gastric motor responses to TRH and substance P on their microinjection into nucleus raphe obscurus of rats.

P. Hornby, Z. Krowicki, 1993, The American journal of physiology.

Serotonin microinjected into the nucleus raphe obscurus increases intragastric pressure in the rat via a vagally mediated pathway.

P. Hornby, Z. Krowicki, 1993, The Journal of pharmacology and experimental therapeutics.

Excitation of neurons in the medullary raphe increases gastric acid and pepsin production in cats.

J. Harmon, R. Gillis, P. Hornby, 1991, The American journal of physiology.

Identification of potent phenyl imidazoles as opioid receptor agonists.

Sui-Po Zhang, H. Breslin, P. Hornby, 2006, Bioorganic & medicinal chemistry letters.

Nitric oxide modulates ventilatory responses to hypoxia in the developing rat.

D. Gozal, E. Gozal, T. Nuckton, 1997, American journal of respiratory and critical care medicine.

Orphanin FQ/nociceptin and [Phe1Ψ(CH2‐NH)Gly2] nociceptin(1‐13)‐NH2 stimulate gastric motor function in anaesthetized rats

D. Kapusta, P. Hornby, Z. Krowicki, 2000 .

Stimulation of neuronal receptors, neuropeptides and cytokines during experimental oil of mustard colitis

C. Schneider, K. Pavlick, E. S. Kimball, 2007, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Catecholamine distribution and relationship to magnocellular neurons in the paraventricular nucleus of the rat

P. Hornby, D. Piekut, Diane. T. Piekut, 1987, Cell and Tissue Research.

Immunoreactive Dopamine β-Hydroxylase in Neuronal Groups in the Goldfish Brain

P. Hornby, D. Piekut, 1988 .

Functional-anatomical studies of neural control of heart rate in goldfish.

L. S. Demski, P. Hornby, 1988, Brain, Behavior and Evolution.

Central control of lower esophageal sphincter relaxation.

P. Hornby, T. Abrahams, 2000, The American journal of medicine.

Control of lower esophageal sphincter pressure by two sites in dorsal motor nucleus of the vagus.

R. Gillis, P. Hornby, C. D. Rossiter, 1990, The American journal of physiology.

Vagally-regulated gastric motor activity: evidence for kainate and NMDA receptor mediation.

P. Hornby, D. V. Sivarao, T. Abrahams, 1999, European journal of pharmacology.

Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice.

J. Lenhard, P. Hornby, Bhanu Singh, 2019, American journal of physiology. Gastrointestinal and liver physiology.

1104 - Intestinal Serine Protease Inhibition Increases Liver FGF21 Secretion in Diabetic Obese Mice

J. Lenhard, P. Hornby, J. Lanter, 2018 .

Distribution of nitric oxide synthase in rat dorsal vagal complex and effects of microinjection of nitric oxide compounds upon gastric motor function

P. Hornby, S. C. Serron, Z. Krowicki, 1997, The Journal of comparative neurology.

Pulmonary pharmacology.

P. Hornby, T. Abrahams, 1996, Clinical obstetrics and gynecology.

Emerging effects of tryptophan pathway metabolites and intestinal microbiota on metabolism and intestinal function

N. Hyland, P. Hornby, C. Cavanaugh, 2022, Amino Acids.

Pancreatic polypeptide, microinjected into the dorsal vagal complex, potentiates glucose-stimulated insulin secretion in the rat

P. Hornby, Z. Krowicki, 1995, Regulatory Peptides.

Intracisternal antisense oligonucleotides to TRH receptor abolish TRH-evoked gastric motor excitation.

P. Hornby, D. V. Sivarao, T. Abrahams, 1997, The American journal of physiology.

Microbiota‐derived tryptophan indoles increase after gastric bypass surgery and reduce intestinal permeability in vitro and in vivo

G. Leo, J. Lenhard, P. Hornby, 2018, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Hindbrain effects of PACAP on gastric motor function in the rat.

A. Arimura, P. Hornby, Z. Krowicki, 1997, The American journal of physiology.

Contribution of acetylcholine, vasoactive intestinal polypeptide and nitric oxide to CNS‐evoked vagal gastric relaxation in the rat

P. Hornby, Z. Krowicki, 1996, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Triazinediones as prokineticin 1 receptor antagonists. Part 1: SAR, synthesis and biological evaluation.

P. Hornby, J. Palmer, Wei He, 2009, Bioorganic & medicinal chemistry letters.

Organization and neurochemistry of vagal preganglionic neurons innervating the lower esophageal sphincter in ferrets

N. Hyland, P. Hornby, M. Burmeister, 2001, The Journal of comparative neurology.

Medullary raphe: a new site for vagally mediated stimulation of gastric motility in cats.

R. Gillis, P. Hornby, C. D. Rossiter, 1990, The American journal of physiology.

Potentiation of intrathecal DAMGO antinociception, but not gastrointestinal transit inhibition, by 5-hydroxytryptamine and norepinephrine uptake blockade.

P. Hornby, D. Paul, 1994, Life sciences.

Directed differentiation protocols for successful human intestinal organoids derived from multiple induced pluripotent stem cell lines

J. Ekert, P. Hornby, Jason E. Ekert, 2015 .

Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d).

P. Wade, R. Kavash, Sui-Po Zhang, 2012, Bioorganic & medicinal chemistry letters.

Potent Sodium/Glucose Cotransporter SGLT1/2 Dual Inhibition Improves Glycemic Control Without Marked Gastrointestinal Adaptation or Colonic Microbiota Changes in Rodents

N. Ajami, T. Kirchner, F. Du, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Distribution of neuropeptide Y-like immunoreactive perikarya and processes in the medulla of the cat

T. Milner, P. Hornby, V. Massari, 1990, Neuroscience Letters.

Human and Non-Human Primate Intestinal FcRn Expression and Immunoglobulin G Transcytosis

P. Cooper, G. Powers, Zhengyin Yan, 2013, Pharmaceutical Research.

FcRn Expression and Antibody Transcytosis in Adult Human and Non‐Human Primate Intestine

P. R. Cooper, H. Dorai, P. Hornby, 2013 .

Gastric motor and cardiovascular effects of insulin in dorsal vagal complex of the rat.

P. Hornby, Z. Krowicki, N. A. Nathan, 1998, American journal of physiology. Gastrointestinal and liver physiology.

Identification of potent phenyl imidazoles as opioid receptor agonists.

Sui-Po Zhang, H. Breslin, P. Hornby, 2006, Bioorganic & medicinal chemistry letters.

Immunocytochemical Distribution of Neurokinin 1 Receptor in Rat Dorsal Vagal Complex

P. Hornby, N. A. Nathan, M. Dixon, 1998, Peptides.

Nitric Oxide Modulates Anoxia-Induced Gasping in the Developing Rat

D. Gozal, E. Gozal, T. Nuckton, 1998, Neonatology.

Alternative functional in vitro models of human intestinal epithelia

Zhengyin Yan, Zhengyin Yan, P. Hornby, 2013, Front. Pharmacol..

Modulation of Gastrointestinal Function by MuDelta, a mixed Mu Opioid Receptor Agonist/Delta Opioid Receptor Antagonist

P. Hornby, 2012 .

Vanilloid receptor 1 antagonists attenuate disease severity in dextran sulphate sodium‐induced colitis in mice

M. D'Andrea, C. Schneider, E. S. Kimball, 2004, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Receptors and transmission in the brain-gut axis. II. Excitatory amino acid receptors in the brain-gut axis.

P J Hornby, P. Hornby, 2001, American journal of physiology. Gastrointestinal and liver physiology.

Functional effects and characteristics of cecum-projecting neurons in the dorsal motor nucleus of the vagus of rats

P. Hornby, A. J. Ball, M. Burmeister, 2007, Autonomic Neuroscience.

Striatal glutamic acid decarboxylase immunoreactivity is increased after dopaminergic deafferentation: densitometric analysis

W. Benzing, D. Armstrong, J. Segovia, 1991, Neuroscience Letters.

Excitation of dorsal motor vagal neurons evokes non-nicotinic receptor-mediated gastric relaxation.

P. Hornby, D. V. Sivarao, T. Abrahams, 1999, Journal of the autonomic nervous system.

TRH and substance P independently affect gastric motility in nucleus raphe obscurus of the rat.

P. Hornby, Z. Krowicki, 1994, The American journal of physiology.

An excitatory amino acid(s) in the ventrolateral medulla is (are) required for breathing to occur in the anesthetized cat.

R. Gillis, P. Hornby, T. Abrahams, 1991, The Journal of pharmacology and experimental therapeutics.

TRH: immunocytochemical distribution in vagal nuclei of the cat and physiological effects of microinjection.

R. Gillis, P. Hornby, C. D. Rossiter, 1989, The American journal of physiology.

Central Control of Gastrointestinal Function

P. Wade, P. Hornby, 2011 .

Contribution of FcRn binding to intestinal uptake of IgG in suckling rat pups and human FcRn-transgenic mice.

B. Scallon, P. Cooper, G. Powers, 2013, American journal of physiology. Gastrointestinal and liver physiology.

Design and optimization of aniline-substituted tetrahydroquinoline C5a receptor antagonists.

J. Li, M. Buntinx, P. Hornby, 2008, Bioorganic & Medicinal Chemistry Letters.

Synthesis and characterization of 5,6,7,8-tetrahydroquinoline C5a receptor antagonists.

J. Li, M. Buntinx, G. Van Lommen, 2008, Bioorganic & medicinal chemistry letters.