G. O'young

发表

Antitumor Activity of TGF-β, Inhibitor is Dependent on the Microenvironment

Lingyun Li, G. Schreiner, S. Medicherla, 2007 .

A Selective p 38 Mitogen-Activated Protein Kinase Inhibitor Reverses Cartilage and Bone Destruction in Mice with Collagen-Induced Arthritis

H. Genant, Yebin Jiang, S. Medicherla, 2006 .

Inhibition of p38α MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-XL, Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo

T. Hideshima, K. Anderson, G. Schreiner, 2006, Leukemia.

Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo.

T. Hideshima, K. Anderson, G. Schreiner, 2006, Leukemia.

B-Type Natriuretic Peptide Exerts Broad Functional Opposition to Transforming Growth Factor-&bgr; in Primary Human Cardiac Fibroblasts: Fibrosis, Myofibroblast Conversion, Proliferation, and Inflammation

G. Schreiner, A. Protter, A. Kapoun, 2004, Circulation research.

Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations.

M. Fischer, J. Lewicki, A. Gurney, 2011, Cancer research.

p38α Mitogen-Activated Protein Kinase Inhibition Improves Cardiac Function and Reduces Myocardial Damage in Isoproterenol-Induced Acute Myocardial Injury in Rats

G. Schreiner, A. Protter, A. Kapoun, 2004, Journal of cardiovascular pharmacology.

Transforming growth factor-beta receptor type 1 (TGFbetaRI) kinase activity but not p38 activation is required for TGFbetaRI-induced myofibroblast differentiation and profibrotic gene expression.

S. Rennard, Ying Wang, F. Wen, 2006, Molecular Pharmacology.

A Selective p38α Mitogen-Activated Protein Kinase Inhibitor Reverses Cartilage and Bone Destruction in Mice with Collagen-Induced Arthritis

H. Genant, Yebin Jiang, S. Medicherla, 2006, Journal of Pharmacology and Experimental Therapeutics.

A selective p38 alpha mitogen-activated protein kinase inhibitor reverses cartilage and bone destruction in mice with collagen-induced arthritis.

H. Genant, Yebin Jiang, S. Medicherla, 2006, The Journal of pharmacology and experimental therapeutics.

p38 Inhibition attenuates the pro-inflammatory response to C-reactive protein by human peripheral blood mononuclear cells.

Hui Wang, A. Protter, A. Kapoun, 2004, Journal of molecular and cellular cardiology.

Satyanarayana Medicherla, Jing Ying Ma, Ruban Mangadu, Yebin

H. Genant, A. Protter, A. Kapoun, 2006 .

Transforming Growth Factor-β Receptor Type 1 (TGFβRI) Kinase Activity but Not p38 Activation Is Required for TGFβRI-Induced Myofibroblast Differentiation and Profibrotic Gene Expression

S. Rennard, Ying Wang, F. Wen, 2006, Molecular Pharmacology.

Intratumoral heterogeneity generated by Notch signaling promotes small cell lung cancer

K. Garcia, M. Fischer, J. Sage, 2017, Nature.

RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations

M. Fischer, T. Hoey, F. Cattaruzza, 2017, Scientific Reports.

Abstract A030: Biomarker study of vantictumab plus paclitaxel in HER2- breast cancer patients

J. Lewicki, F. Cattaruzza, G. Argast, 2018 .

WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death

M. Fischer, J. Lewicki, A. Gurney, 2017, Science Advances.

Abstract 4367: Discovery and evaluation of pharmacodynamic and predictive biomarkers for anti-RSPO3, a treatment that reduces tumor growth and cancer stem cell frequency in patient derived xenograft tumor models

M. Fischer, J. Lewicki, A. Gurney, 2015 .

Recombinant Vascular Endothelial Growth Factor 121 Attenuates Hypertension and Improves Kidney Damage in a Rat Model of Preeclampsia

N Stephen Pollitt, Ying Zhang, Frederick Sannajust, 2007, Hypertension.

Abstract 4652: Effects of anti-DLL4 treatment on non-small cell lung cancer (NSCLC) human xenograft tumors

M. Fischer, J. Lewicki, A. Gurney, 2016 .

Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation.

G. Roodman, N. Kurihara, G. Schreiner, 2006, Experimental cell research.

Inhibition of Transforming Growth Factor β Signaling Reduces Pancreatic Adenocarcinoma Growth and Invasiveness

Alison Murphy, Lingyun Li, S. Medicherla, 2007, Molecular Pharmacology.

Antitumor activity of TGF-beta inhibitor is dependent on the microenvironment.

Lingyun Li, G. Schreiner, S. Medicherla, 2007, Anticancer research.

Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types.

M. Fischer, J. Lewicki, A. Gurney, 2016, Cancer research.

Transforming Growth Factor-β Receptor Type 1 (TGFβRI) Kinase Activity but Not p38 Activation Is Required for TGFβRI-Induced Myofibroblast Differentiation and Profibrotic Gene Expression

S. Rennard, Ying Wang, F. Wen, 2006, Molecular Pharmacology.

induced myofibroblast differentiation and pro-fibrotic gene expression

S. Rennard, Ying Wang, F. Wen, 2006 .

Abstract 404: Development of a RSPO3 CLIA-validated assay as a predictive biomarker for response to anti-RSPO3 antibody treatment in patients with solid tumors

M. Fischer, J. Lewicki, A. Gurney, 2016 .

A Selective p38α MAPK Inhibitor Reverses Cartilage and Bone Destruction in Mice with Collagen-Induced Arthritis

H. Genant, S. Medicherla, R. Mangadu, 2006 .

Therapeutic targeting of tumor-derived R-spondin attenuates β-catenin signaling and tumorigenesis in multiple cancer types

J. Lewicki, A. Gurney, T. Hoey, 2015 .

p38α Mitogen-Activated Protein Kinase Inhibition Improves Cardiac Function and Reduces Myocardial Damage in Isoproterenol-Induced Acute Myocardial Injury in Rats

A. Protter, A. Kapoun, S. Chakravarty, 2004, Journal of cardiovascular pharmacology.

Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations.

M. Fischer, J. Lewicki, A. Gurney, 2011, Cancer research.