S. Yokoshima

发表

Morphological Evaluation of Nonlabeled Cells to Detect Stimulation of Nerve Growth Factor Expression by Lyconadin B

Hiroto Sasaki, Hiroyuki Honda, Ryuji Kato, 2016, Journal of biomolecular screening.

Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: insight into substrate recognition.

T. Iwatsubo, T. Tomita, Nobuki Kato, 2013, Journal of medicinal chemistry.

Total synthesis of (±)-morphine

T. Kan, T. Fukuyama, S. Yokoshima, 2009 .

Total synthesis of (-)-histrionicotoxin.

T. Fukuyama, S. Yokoshima, Yohei Adachi, 2011, Organic letters.

Oseltamivir enhances hippocampal network synchronization.

N. Matsuki, Y. Ikegaya, Takuya Sasaki, 2008, Journal of pharmacological sciences.

Conversion of Ester Moieties to 4-Bromophenyl Groups via Electrocyclic Reaction of Dibromocyclopropanes.

T. Fukuyama, S. Yokoshima, Kyosuke Ueda, 2015, Organic letters.

New photocleavable linker: α-thioacetophenone-type linker.

T. Iwatsubo, T. Tomita, T. Fukuyama, 2014, Bioorganic & medicinal chemistry letters.

A novel ketone synthesis by a palladium-catalyzed reaction of thiol esters and organozinc reagents

H. Tokuyama, T. Fukuyama, S. Yokoshima, 1998 .

Total synthesis of (-)-mersicarpine.

T. Fukuyama, Tsuyoshi Ogino, S. Yokoshima, 2010, Journal of the American Chemical Society.

Total Synthesis of Tetrodotoxin.

T. Fukuyama, S. Yokoshima, Keigo Murakami, 2020, Angewandte Chemie.

Total synthesis of gelsemoxonine

T. Harada, T. Fukuyama, S. Yokoshima, 2011, Journal of the American Chemical Society.

Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors.

Shinji Tanaka, T. Adachi, S. Yuki, 2017, Bioorganic & medicinal chemistry letters.

Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker.

T. Iwatsubo, Yoichi Kita, T. Kan, 2009, Bioorganic & medicinal chemistry letters.

Total Synthesis of (-)-Cardiopetaline.

T. Fukuyama, S. Yokoshima, Y. Nishiyama, 2016, Organic letters.

Total synthesis of (-)-lepistine.

T. Fukuyama, S. Yokoshima, Yusuke Kitabayashi, 2014, Organic letters.

Synthetic studies on chartelline C: stereoselective construction of the core skeleton.

T. Fukuyama, S. Yokoshima, Kotaro Iwasaki, 2012, Angewandte Chemie.

2-Pyridone synthesis using 2-(phenylsulfinyl)acetamide.

T. Fukuyama, S. Yokoshima, M. Fujii, 2013, Organic letters.

Synthesis of Polycyclic Natural Products through Skeletal Rearrangement

S. Yokoshima, 2020, Synlett.

Total Synthesis of Lycoposerramine-R

T. Fukuyama, S. Yokoshima, Shinya Watanabe, 2018, Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry.

2‐Pyridone Synthesis Using 2‐(Phenylsulfinyl)acetamide.

T. Fukuyama, S. Yokoshima, M. Fujii, 2013 .

Concise total synthesis of (+)-lyconadin A.

T. Fukuyama, S. Yokoshima, Aditya K. Unni, 2011, Journal of the American Chemical Society.

A practical synthesis of (−)-oseltamivir

T. Fukuyama, S. Yokoshima, Nobuhiro Satoh, 2009 .

A practical synthesis of (-)-oseltamivir.

T. Fukuyama, S. Yokoshima, Nobuhiro Satoh, 2007, Angewandte Chemie.

Synthesis of Cardiopetaline via a Wagner-Meerwein Rearrangement without Preactivation of the Pivotal Hydroxy Group.

T. Fukuyama, S. Yokoshima, Y. Nishiyama, 2017, Organic letters.

Total synthesis of (-)-lepenine.

T. Fukuyama, S. Yokoshima, Y. Nishiyama, 2014, Journal of the American Chemical Society.

Total syntheses of lyconadins A-C.

T. Fukuyama, S. Yokoshima, Aditya K. Unni, 2013, Journal of the American Chemical Society.

Semipinacol Rearrangement Induced by Cleavage of Dibromocyclopropane

S. Yokoshima, Y. Nishiyama, Daisuke Nakajima, 2020 .

Synthesis of the [7-5-5] tricyclic core of Daphniphyllum alkaloids.

T. Fukuyama, S. Yokoshima, Yusuke Kitabayashi, 2018, Organic & biomolecular chemistry.

Total Syntheses of Aurachins A and B.

T. Fukuyama, S. Yokoshima, Haruhiko Hattori, 2017, Angewandte Chemie.

Total synthesis of (-)-morphine.

T. Fukuyama, S. Yokoshima, H. Koizumi, 2009, Chemistry, an Asian journal.

Total synthesis of (+/-)-morphine.

T. Kan, T. Fukuyama, S. Yokoshima, 2006, Organic letters.

Total synthesis of (-)-lemonomycin.

Y. Hamashima, T. Asakawa, T. Kan, 2012, Chemistry.

Total synthesis of (-)-anisatin.

A. Ogura, T. Fukuyama, S. Yokoshima, 2012, Organic letters.

Reduction of ethanethiol esters to aldehydes

H. Tokuyama, T. Fukuyama, Leping Li, 2002 .

Stereocontrolled total synthesis of (+)-vinblastine.

T. Ueda, H. Tokuyama, T. Fukuyama, 2002, Journal of the American Chemical Society.

Facile Palladium-Mediated Conversion of Ethanethiol Esters to Aldehydes and Ketones

H. Tokuyama, T. Fukuyama, S. Yokoshima, 1998 .

A practical preparation of highly versatile N-acylpyrroles from 2,4,4-trimethoxybutan-1-amine.

T. Fukuyama, S. Yokoshima, Rentaro Kanno, 2012, Organic letters.

Total synthesis of (-)-salinosporamide A.

T. Fukuyama, S. Yokoshima, Nobuhiro Satoh, 2011, Organic letters.

Total Synthesis of (-)-Morphine.

M. Inoue, T. Fukuyama, S. Yokoshima, 2017, Chemistry.

A Unified Strategy for Kainoid Synthesis

T. Fukuyama, S. Yokoshima, M. Fujii, 2014 .

Total synthesis of lysergic acid.

T. Fukuyama, S. Yokoshima, S. Umezaki, 2013, Organic letters.

A practical synthesis of (-)-kainic acid.

T. Fukuyama, Satoshi Takita, S. Yokoshima, 2011, Organic letters.

Stereocontrolled total synthesis of (+)-vinblastine

H. Tokuyama, T. Fukuyama, S. Yokoshima, 2003 .

(1-nosyl-5-nitroindol-3-yl)methyl ester: a novel protective group for carboxylic acids.

T. Fukuyama, S. Yokoshima, Kouhei Yamada, 2008, Organic letters.

Total synthesis of (+)‐vinblastine: Control of the stereochemistry at C18′

H. Tokuyama, T. Fukuyama, S. Yokoshima, 2010 .

Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates.

Yasuko Takahashi, Takeshi Iwatsubo, Makoto Sasaki, 2006, Bioorganic & medicinal chemistry letters.

Substitution of α-Azido Sulfones with Thiolates to Form α-Azido Sulfides.

T. Hosoya, S. Yokoshima, Y. Nishiyama, 2022, Organic letters.

Total Synthesis of (-)-Daphenylline.

T. Fukuyama, S. Yokoshima, Yohei Adachi, 2016, Angewandte Chemie.

A Practical Synthesis of (-)-KainicAcid

T. Fukuyama, Satoshi Takita, S. Yokoshima, 2011 .

Synthesis of (-)-oxycodone.

T. Fukuyama, S. Yokoshima, Atsushi Kimishima, 2014, Organic letters.

Enantioselective Total Synthesis of (+)-Gelsemine: Determination of Its Absolute Configuration

H. Tokuyama, T. Fukuyama, S. Yokoshima, 2000 .

Total Synthesis of (-)-Tetrodotoxin and 11-norTTX-6(R)-ol.

T. Fukuyama, S. Yokoshima, Keisuke Motoyama, 2017, Angewandte Chemie.

Conversion of Vindoline into 11-Mesyloxytabersonine.

H. Tokuyama, T. Fukuyama, S. Yokoshima, 2016, Chemical & pharmaceutical bulletin.

Total synthesis of (-)-isoschizogamine.

Yusuke Miura, T. Fukuyama, S. Yokoshima, 2012, Journal of the American Chemical Society.

Chemical Transformation of an Intermediate in the Synthesis of Huperzine A, Leading to a Diverse Array of Molecules.

T. Fukuyama, S. Yokoshima, Masatsugu Ishikawa, 2016, Chemical & pharmaceutical bulletin.

Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation

T. Iwatsubo, T. Tomita, T. Fukuyama, 2014, Molecular Neurodegeneration.

Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors

Yasuko Takahashi, Takeshi Iwatsubo, Tohru Fukuyama, 2006 .

Synthesis of Majusculamides A and B

S. Yokoshima, Kosuke Sueyoshi, T. Teruya, 2019, Synlett.

Synthetic Studies of the Daphniphyllum Alkaloids: A Cooperative Reaction of Proximal Functional Groups Forming a Tetracyclic System.

T. Fukuyama, S. Yokoshima, Ryosuke Yamada, 2018, Organic letters.

An artificial metalloenzyme biosensor can detect ethylene gas in fruits and Arabidopsis leaves

Katsunori Tanaka, K. Shirasu, Kenward Vong, 2019, Nature Communications.

Total synthesis of (+)-lysergic acid

M. Kanai, T. Fukuyama, S. Yokoshima, 2017, The Journal of Antibiotics.

SYNTHETIC STUDIES TOWARD (+)-LYSERGIC ACID : CONSTRUCTION OF THE TETRACYCLIC ERGOLINE SKELETON

Tohru Inoue, T. Fukuyama, S. Yokoshima, 2009 .

Synthetic Studies toward Ecteinascidin 743 (Trabectedin)

T. Fukuyama, S. Yokoshima, Takahiro Imai, 2012 .

Diastereoselective synthesis of atropisomeric 3-(2-substituted aryl)quinazolin-4-ones and their stereochemical properties

Hideyo Takahashi, Tohru Inoue, S. Yokoshima, 2006 .

A Practical Synthesis of (‐)‐Oseltamivir.

T. Fukuyama, S. Yokoshima, Nobuhiro Satoh, 2007 .

Synthesis of (-)-Oseltamivir

T. Fukuyama, S. Yokoshima, Nobuhiro Satoh, 2007 .

Synthetic Approach toward (–)-Tetrodotoxin via Construction of the Bicyclo[2.2.2]octane Skeleton

T. Fukuyama, S. Yokoshima, Tatsuya Toma, 2022, Synlett.

Total Synthesis of Lycoposerramine-R

T. Fukuyama, S. Yokoshima, Shinya Watanabe, 2012, Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry.

Total Synthesis of Haliclonin A.

T. Fukuyama, S. Yokoshima, Yuan Jin, 2021, Angewandte Chemie.

Synthesis of (+)-vinblastine and its analogues.

T. Miyazaki, H. Osada, H. Tokuyama, 2007, Organic letters.

Stereocontrolled total synthesis of (+)-vincristine.

H. Tokuyama, T. Fukuyama, S. Yokoshima, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Stereocontrolled Total Synthesis of (+)‐Vinblastine.

T. Ueda, H. Tokuyama, T. Fukuyama, 2002 .

A novel translation inhibitor, mersicarpine, inhibits S-phase progression and induces apoptosis in HL60 cells.

T. Usui, T. Fukuyama, S. Yokoshima, 2021, Bioscience, biotechnology, and biochemistry.

Total Synthesis of Huperzine Q.

T. Fukuyama, S. Yokoshima, S. Tanimura, 2009, Organic letters.

Structure-Activity Relationship Study of Majusculamides A and B and Their Analogues on Osteogenic Activity.

S. Yokoshima, T. Teruya, Noriyuki Natsume, 2020, Journal of natural products.

BIN1 regulates BACE1 intracellular trafficking and amyloid-β production.

S. Tsuji, G. Prendergast, T. Iwatsubo, 2016, Human molecular genetics.

Activity-Dependent Proteolytic Cleavage of Neuroligin-1

N. Matsuki, K. Horiuchi, T. Iwatsubo, 2012, Neuron.

Formal Synthesis of Sarain A: Intramolecular Cycloaddition of an Eight-Membered Cyclic Nitrone to Construct the 2-Azabicyclo[3.3.1]nonane Framework.

T. Fukuyama, S. Yokoshima, Takuya Higo, 2015, Angewandte Chemie.

Phenylpiperidine‐type γ‐secretase modulators target the transmembrane domain 1 of presenilin 1

T. Iwatsubo, O. Berezovska, T. Tomita, 2011, The EMBO journal.

BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

J. Trojanowski, T. Iwatsubo, T. Tomita, 2011, The Journal of Neuroscience.

Identification of novel deoxyribofuranosyl indole antimicrobial agents

K. Sekimizu, H. Hamamoto, Yoshihisa Kobayashi, 2011, Journal of antibiotics (Tokyo. 1968).

Photo-oxygenation by a biocompatible catalyst reduces amyloid-β levels in Alzheimer's disease mice.

Y. Hori, M. Kanai, T. Tomita, 2021, Brain : a journal of neurology.

Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator

Takeshi Iwatsubo, Satoko Osawa, Shigeyuki Yokoyama, 2014, Proceedings of the National Academy of Sciences.

Formal Synthesis of Ecteinascidin 743 via an Intramolecular Cascade Heck Reaction to Construct the Diazabicyclo[3.3.1]nonane Framework.

T. Fukuyama, S. Yokoshima, Y. Nishiyama, 2022, Organic letters.

Dogger Bank Itch revisited: isolation of (2-hydroxyethyl) dimethylsulfoxonium chloride as a cytotoxic constituent from the marine sponge Theonella aff. mirabilis.

S. Matsunaga, N. Fusetani, Y. Nakao, 2001, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

Title A small-molecule inhibitor of SOD 1-Derlin-1 interactionameliorates pathology in an ALS mouse model

H. Ichijo, M. Shibuya, H. Inoue, 2019 .

A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model

H. Ichijo, M. Shibuya, H. Inoue, 2018, Nature Communications.

High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway

K. Fukui, T. Nagano, H. Kojima, 2017, Scientific Reports.

Total synthesis of ecteinascidin 743.

T. Fukuyama, S. Yokoshima, Tatsuya Toma, 2002, Journal of the American Chemical Society.

Total synthesis of gelsemoxonine

T. Harada, T. Fukuyama, S. Yokoshima, 2012 .

Eudistomin C, an Antitumor and Antiviral Natural Product, Targets 40S Ribosome and Inhibits Protein Translation

H. Masumoto, Yuh Shiwa, H. Yoshikawa, 2016, Chembiochem : a European journal of chemical biology.

Synthetic Studies on Plakinidines

T. Fukuyama, S. Yokoshima, T. Komori, 2015, Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry.

A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model

H. Ichijo, M. Shibuya, H. Inoue, 2018, Nature Communications.

Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors.

T. Iwatsubo, T. Kan, T. Tomita, 2006, Bioorganic & Medicinal Chemistry Letters.

Fluorinated 2,6-Xylenesulfonyl Group: A Protective Group for Amines.

S. Yokoshima, Y. Nishiyama, Kenta Watanabe, 2023, Organic letters.

Total Synthesis of Lycopalhine A

T. Fukuyama, S. Yokoshima, Yuji Ochi, 2016, Synthesis.

Construction of the [7-5-5] Tricyclic Core of Daphniphyllum Alkaloids via a Cationic Cascade Reaction.

S. Yokoshima, Daisuke Nakajima, 2022, Organic letters.

Synthetic Studies Toward (+)‐Lysergic Acid: Construction of the Tetracyclic Ergoline Skeleton.

Tohru Inoue, T. Fukuyama, S. Yokoshima, 2009 .

Total Synthesis of Huperzine R.

T. Fukuyama, S. Yokoshima, Toshimune Nomura, 2018, Organic letters.

Synthesis of 2-Azabicyclo[3.3.1]nonanes: Lessons from Synthetic Studies of Macrocyclic Diamine Alkaloids

S. Yokoshima, 2021 .

Total Syntheses of Malettinins C and E.

S. Yokoshima, Nariyoshi Umekubo, 2023, Organic letters.

New photocleavable linker: α-thioacetophenone-type linker.

T. Iwatsubo, T. Tomita, T. Fukuyama, 2014, Bioorganic & medicinal chemistry letters.

Total synthesis of (-)-morphine.

T. Fukuyama, S. Yokoshima, H. Koizumi, 2010, Chemistry, an Asian journal.

Total Synthesis of (-)-Morphine.

M. Inoue, T. Fukuyama, S. Yokoshima, 2017, Chemistry.

Total synthesis of (-)-isoschizogamine.

Yusuke Miura, T. Fukuyama, S. Yokoshima, 2012, Journal of the American Chemical Society.

Concise total synthesis of (+)-lyconadin A.

T. Fukuyama, S. Yokoshima, Aditya K. Unni, 2011, Journal of the American Chemical Society.

Synthesis of eudistomin C and E: improved preparation of the indole unit.

T. Miyazaki, H. Tokuyama, T. Fukuyama, 2008, Organic letters.

Deep learning driven de novo drug design based on gastric proton pump structures

H. Shigematsu, S. Yokoshima, K. Abe, 2023, Communications biology.