Anuradha Gupta

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Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFβR1 Inhibitor as an Immuno-oncology Agent.

J. Fargnoli, S. Sheriff, A. Mathur, 2020, ACS medicinal chemistry letters.

Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132).

Steven A. Spronk, K. Behnia, J. Barrish, 2022, Journal of medicinal chemistry.

Facile Access to 1,4-Disubstituted Pyrrolo[1,2-a]pyrazines from α-Aminoacetonitriles

A. Mathur, N. Meanwell, A. Gupta, 2020, Synthesis.

Separation and preparative purification of l ‐ and d ‐valine ester: Diastereomeric conjugates of atazanavir using a combination of 2‐propanol and acetonitrile in reversed‐phase high‐performance liquid chromatography

Murugaiah A. M. Subbaiah, A. Mathur, M. Shyamsundar, 2020 .

Methyl-2,2-difluoro-2-(fluorosulfonyl) acetate (MDFA)/copper (I) iodide mediated and tetrabutylammonium iodide promoted trifluoromethylation of 1-aryl-4-iodo-1,2,3-triazoles

A. Mathur, Anuradha Gupta, R. Nimje, 2020 .

Identification and Preclinical Pharmacology of ((1 R,3 S)-1-Amino-3-(( S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials.

Michael G. Yang, K. McIntyre, D. Shen, 2019, Journal of medicinal chemistry.

Photoluminescence and Electroluminescence of Eu Doped Y2O3

D. P. Bisen, N. Brahme, Anuradha Gupta, 2015 .

Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.

K. McIntyre, Sidney Pitt, G. Schieven, 2017, Journal of medicinal chemistry.

Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P1 Receptor Modulator.

Michael G. Yang, K. McIntyre, D. Shen, 2016, Journal of medicinal chemistry.

Synthesis of C-2 Methylene O- and C-Glycosides and Sugar Derived α-Methylene-δ-valerolactones from C-2-Acetoxymethyl Glycals☆

Y. D. Vankar, Anuradha Gupta, Y. Vankar, 2000 .

Evolution of a Scale-Up Synthesis to a Potent GluN2B Inhibitor and Its Prodrug

Michael A. Galella, A. Mathur, M. Dabros, 2018, Organic Process Research & Development.

Development of a Scalable Synthesis for the Potent Kinase Inhibitor BMS-986236; 1-(5-(4-(3-Hydroxy-3-methylbutyl)-1H-1,2,3-triazol-1-yl)-4-(isopropylamino)pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile

A. Mathur, A. Gupta, P. Carter, 2019, Organic Process Research & Development.

Solvent-specific, DAST-mediated intramolecular Friedel-Crafts reaction: access to dibenzoxepine-fused spirooxindoles.

A. Mathur, Jianqing Li, Anuradha Gupta, 2021, Organic & biomolecular chemistry.

Syntheses of new spirocarbocyclic nucleoside analogs using iminonitroso Diels-Alder reactions.

Anuradha Gupta, D. Mendel, Marvin J Miller, 2009, Organic letters.

Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3.

B. Beno, A. Mathur, Chunjian Liu, 2022, Journal of medicinal chemistry.

CHLOROTRIMETHYLSILANE CATALYSED ACYLATION OF ALCOHOLS

Y. D. Vankar, Anuradha Gupta, R. Kumareswaran, 1997 .

Zeolite (H-ZSM 5) catalysed regio and stereoselective reduction of 2,3-epoxy alcohols to 1,2-diols and vinylic epoxides to homoallylic alcohols with sodium cyanoborohydride

Y. D. Vankar, Anuradha Gupta, 1999 .

An Easy Route to 2‐Amino‐β‐C‐glycosides by Conjugate Addition to 2‐Nitroglycals.

Y. D. Vankar, R. Schmidt, Anuradha Gupta, 2002 .

Development of a Scalable Synthesis of the Small Molecule TGFβR1 Inhibitor BMS-986260

David K. Leahy, Martin D. Eastgate, A. Mathur, 2020 .

Synthesis of (S,S)-isodityrosine by Dötz benzannulation.

S. Sen, Anuradha Gupta, M. Harmata, 2005, The Journal of organic chemistry.

Stability of (chloromethyl)platinum(II) complexes

M. Hampden‐Smith, A. Mcalees, R. McCrindle, 1991 .

Zeolite (H-ZSM 5)-catalysed reduction of conjugated nitroalkenes with sodium cyanoborohydride

Y. D. Vankar, Anuradha Gupta, A. Haque, 1996 .

Process Optimization for the Large-Scale Preparation of (2S,3aR,7aS)-tert-Butyl Hexahydro-2,5-methanopyrrolo[3,2-c]pyridine-1(4H)-carboxylate, an Intermediate for Nicotinic Acetylcholine Receptor Agonists

A. Mathur, I. Mcdonald, R. Olson, 2018, Organic Process Research & Development.

Trimethylsilylnitrate-chromium trioxide and trimethylsilylnitrate-DMSO: Novel reagent systems for one step conversion of olefins into α-nitro ketones and cyclic ethers into lactones

Y. D. Vankar, Anuradha Gupta, M. Reddy, 1999 .

A Short and Scalable Synthesis of Orthogonally Protected Bis(aminomethyl)malonic Acid: Access to Bioactive Macrocyclic Peptides

A. Mathur, Anuradha Gupta, M. Vetrichelvan, 2017 .

Synthesis of Cyclobutane-Fused Tetracyclic Scaffolds via Visible-Light Photocatalysis for Building Molecular Complexity.

Antonio Ramirez, A. Mathur, N. Meanwell, 2020, Journal of the American Chemical Society.

Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.

Shana L. Posy, A. Mathur, J. Guay, 2022, Journal of medicinal chemistry.

Dependence of field switched ordered arrays of dinuclear mixed-valence complexes on the distance between the redox centers and the size of the counterions.

Anuradha Gupta, Thomas P Fehlner, C. Lent, 2005, Journal of the American Chemical Society.

STABILITY IN SOLUTION OF (CHLOROMETHYL)PALLADIUM(II) COMPLEXES : X-RAY STRUCTURES OF TRANS-BIS(TRIPHENYLPHOSPHINE)CHLORO(CHLOROMETHYL)PALLADIUM(II) AN D -PLATINUM(II) AND COMPARISON OF THE RELATIVE STABILITIES OF ANALOGOUS PAL LADIUM AND PLATINUM CHLOROMETHYL COMPLEXES CONTAINING PHOSPHINE LIGANDS

M. Jennings, A. Mcalees, R. McCrindle, 1995 .

Low temperature polarized absorption spectra for Ni2+ in trigonal Ni2CdCl6 · 12H2O single crystals

A. Banerjee, Anuradha Gupta, R. Mukherjee, 1988 .

Thermoluminescence and Mechanoluminescence of Eu Doped Y2O3 Nanophosphors

D. P. Bisen, S. Dhoble, N. Brahme, 2012 .

Electroluminescence and photoluminescence of rare earth (Eu,Tb) doped Y2O3 nanophosphor

D. P. Bisen, N. Brahme, Anuradha Gupta, 2014 .

Crystallization-Induced Dynamic Resolution toward the Synthesis of (S)-7-Amino-5H,7H-dibenzo[b,d]-azepin-6-one: An Important Scaffold for γ-Secretase Inhibitors

A. Mathur, Anuradha Gupta, Richard Rampulla, 2016 .

Chlorotrimethylsilane and Sodium Iodide: An Expedient Combination for the Chemo/Regioselective Dehalogenation of Benzothiazole and Thiazole Derivatives

A. Mathur, Anuradha Gupta, M. Vetrichelvan, 2023, ChemistrySelect.

Synthesis of Differentially Protected Azatryptophan Analogs via Pd2(dba)3/XPhos Catalyzed Negishi Coupling of N-Ts Azaindole Halides with Zinc Derivative from Fmoc-protected tert-Butyl (R)-2-amino-3-iodopropanoate.

A. Mathur, C. Cavallaro, A. Roy, 2020, The Journal of organic chemistry.

Identification and optimization of small molecule antagonists of vasoactive intestinal peptide receptor-1 (VIPR1).

David S. Nirschl, David S Nirschl, G. Trainor, 2012, Bioorganic & medicinal chemistry letters.

Applications of 2, 2, 2 trifluoroethanol as a versatile co-solvent in supercritical fluid chromatography for purification of unstable boronate esters, enhancing throughput, reducing epimerization, and for additive free purifications.

A. Mathur, A. Gupta, Siddheshwar K Chauthe, 2018, Journal of chromatography. A.

Practical Synthesis of (3aR, 9bR)-8-Fluoro-7-(perfluoropropan-2-yl)-9b-(phenylsulfonyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole: An Advanced Intermediate to Access the RORγt Inverse Agonist BMT-362265

Amol G. Dikundwar, A. Mathur, A. Gupta, 2021, Organic Process Research & Development.

Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms.

J. Tokarski, G. Trainor, A. Mathur, 2015, ACS medicinal chemistry letters.

Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide.

S. Mandlekar, A. Mathur, Abhisek Banerjee, 2017, Journal of medicinal chemistry.

Identification of potent tricyclic prodrug S1P1 receptor modulators.

K. McIntyre, D. Shen, A. Mathur, 2017, MedChemComm.

Discovery of (S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain.

Alan G. E. Wilson, G. Shankar, J. Macor, 2022, Journal of medicinal chemistry.

Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt ‒ Identification of a Potent, Selective Series with Biologic-Like In Vivo Efficacy.

K. McIntyre, D. Shuster, J. Macor, 2019, Journal of medicinal chemistry.

Novel synergistic combination of Cu/S co-doped TiO2 nanoparticles incorporated as photoanode in dye sensitized solar cell

K. Sahu, V. Murty, Anuradha Gupta, 2020 .

Development of a Rapid Scale-Up Synthesis of (S)-N-(8-((2-Amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide, a Potent Adaptor-Associated Kinase 1 Inhibitor

J. Macor, A. Mathur, Jianqing Li, 2022, Organic Process Research & Development.

Metallaphotoredox Decarboxylative Arylation of Natural Amino Acids via an Elusive Mechanistic Pathway

A. Mathur, N. Meanwell, Darpandeep Aulakh, 2022, ACS Catalysis.

Solid-phase synthesis of JBIR-126 (Tambromycin), JBIR-35 and their analogs

A. Mathur, A. Roy, Anuradha Gupta, 2021 .

Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition.

B. Beno, N. Meanwell, M. Krystal, 2021, Bioorganic & medicinal chemistry letters.

The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.

A. Mathur, N. Meanwell, Zeyu Lin, 2022, Journal of medicinal chemistry.

A chiral route to the synthesis of (2S,3aR,7aS)-tertbutyl hexahydro-2,5-methanopyrrolo[3,2-c]pyridine1(4H)-carboxylate, an intermediate for nicotinic acetylcholine receptors agonists

A. Mathur, Jianqing Li, Anuradha Gupta, 2022, Social Science Research Network.

Vibrational dynamics of Zr67Ni33 amorphous alloy

N. Saxena, K. Jain, Anuradha Gupta, 1997 .

A. Mathur, A. Gupta, Siddheshwar K Chauthe, 2018, Journal of chromatography. A.

Concise synthesis of chiral pyrazolo[4,3‐ f ] [1,4]oxazepines and pyrazolo[4,3‐ f ] [1,4]thiazepines bearing pyrazole unit

A. Mathur, Anuradha Gupta, R. Rampulla, 2020 .

Tunable Synthesis of Pyrazolo Oxepines, Pyrazolo Thiophenes and 1H‐Indazoles Using Alkylation, Aldol Condensation and Thermal Rearrangement

A. Mathur, Anuradha Gupta, M. Pavan, 2024, ChemistrySelect.

Discovery of BMS-986308: A Renal Outer Medullary Potassium Channel Inhibitor for the Treatment of Heart Failure.

A. Mathur, E. Priestley, J. M. Richter, 2024, Journal of medicinal chemistry.