C. Spek

发表

Infectious diseases and fibrotic disorders : Potential novel targets

T. van der Poll, K. Borensztajn, T. Poll, 2014 .

Cardiovascular , Pulmonary and Renal Pathology Protease-Activated Receptor-2 Induces Myofibroblast Differentiation and Tissue Factor Up-Regulation during Bleomycin-Induced Lung Injury Potential Role in Pulmonary Fibrosis

M. D. den Bakker, M. Peppelenbosch, K. Borensztajn, 2010 .

Alveolar epithelial TET2 is not involved in the development of bleomycin‐induced pulmonary fibrosis

T. van der Poll, B. Scicluna, J. Duitman, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

CCAAT/enhancer-binding protein δ facilitates bacterial dissemination during pneumococcal pneumonia in a platelet-activating factor receptor-dependent manner

T. van der Poll, K. Borensztajn, J. Duitman, 2012, Proceedings of the National Academy of Sciences.

CCAAT-enhancer binding protein delta (C/EBPδ) protects against Klebsiella pneumoniae-induced pulmonary infection: potential role for macrophage migration.

T. van der Poll, J. Duitman, S. Florquin, 2012, The Journal of infectious diseases.

Protease activated receptor-1 regulates macrophage-mediated cellular senescence: a risk for idiopathic pulmonary fibrosis

T. van der Poll, K. Borensztajn, F. Rezaee, 2015, Oncotarget.

Myeloid DNA methyltransferase3b deficiency aggravates pulmonary fibrosis by enhancing profibrotic macrophage activation

T. van der Poll, J. Duitman, C. Spek, 2022, Respiratory Research.

Pharmacological Targeting of Protease-Activated Receptor 2 Affords Protection from Bleomycin-Induced Pulmonary Fibrosis

T. van der Poll, K. Borensztajn, B. Crestani, 2015, Molecular medicine.

Protease-Activated Receptor 2 Facilitates Bacterial Dissemination in Pneumococcal Pneumonia

T. van der Poll, M. Hollenberg, K. Borensztajn, 2018, The Journal of infectious diseases.

Toll-like receptor mRNA levels in alveolar macrophages after inhalation of endotoxin

T. van der Poll, P. Bresser, T. Poll, 2006, European Respiratory Journal.

Functional consequences of prolactin signalling in endothelial cells: a potential link with angiogenesis in pathophysiology?

A. Griffioen, K. Borensztajn, P. Nowak‐Sliwinska, 2012, Journal of cellular and molecular medicine.

Detrimental role for CCAAT/enhancer binding protein δ in blood-borne brain infection

J. Duitman, M. Brouwer, D. van de Beek, 2016, BMC Infectious Diseases.

CCAAT/enhancer-binding protein δ (C/EBPδ) aggravates inflammation and bacterial dissemination during pneumococcal meningitis

J. Duitman, M. Brouwer, D. van de Beek, 2015, Journal of Neuroinflammation.

CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy

K. Borensztajn, J. Duitman, S. Florquin, 2014 .

CCAAT/enhancer‐binding protein delta (C/EBPδ) plays a minor role in renal host defense against uropathogenic Escherichia coli

J. Duitman, S. Florquin, J. Leemans, 2013, Transplant infectious disease : an official journal of the Transplantation Society.

CCAAT/enhancer-binding protein δ: multifaceted regulator in respiratory disease.

T. van der Poll, Yan Ye, Hongwei Gao, 2013, The American journal of pathology.

Pharmacological PAR‐1 inhibition reduces blood glucose levels but does not improve kidney function in experimental type 2 diabetic nephropathy

J. Duitman, S. Florquin, C. Spek, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

CCAAT/enhancer binding protein delta (C/EBPδ) deficiency does not affect bleomycin-induced pulmonary fibrosis

Y. Castier, A. Cazes, K. Borensztajn, 2018, Journal of clinical and translational research.

Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inﬂammation

P. Reitsma, M. Bijlsma, C. Spek, 2007 .

Protease‐activated receptor‐1 impedes prostate and intestinal tumor progression in mice: comment

M. Bijlsma, C. Spek, C. Tekin, 2018, Journal of thrombosis and haemostasis : JTH.

Negative results > CCAAT / enhancer binding protein delta ( C / EBPδ ) deficiency does not affect bleomycin-induced pulmonary fibrosis

Y. Castier, K. Borensztajn, Aurélie, 2018 .

C/EBPδ Suppresses Motility-Associated Gene Signatures and Reduces PDAC Cell Migration

J. Duitman, V. Thijssen, M. Bijlsma, 2022, Cells.

Cathepsin S Contributes to Lung Inflammation in Acute Respiratory Distress Syndrome.

K. Borensztajn, D. McAuley, L. Holsinger, 2022, American journal of respiratory and critical care medicine.

Immune Checkpoints as Promising Targets for the Treatment of Idiopathic Pulmonary Fibrosis?

J. Duitman, T. van den Ende, C. Spek, 2019, Journal of clinical medicine.

C-reactive protein elicits white blood cell activation in humans.

J. Kastelein, F. Akdim, E. Stroes, 2009, The American journal of medicine.

Macrophage C/EBPδ Drives Gemcitabine, but Not 5-FU or Paclitaxel, Resistance of Pancreatic Cancer Cells in a Deoxycytidine-Dependent Manner

J. Duitman, C. Spek, H. Aberson, 2022, Biomedicines.

Protease-activated receptor-4 deficiency does not protect against bleomycin-induced pulmonary fibrosis in mice

K. Borensztajn, J. Duitman, C. Spek, 2012, European Respiratory Journal.

Gene Expression Profiles in Murine Influenza Pneumonia

T. van der Poll, M. Dessing, K. F. van der Sluijs, 2008, Journal of Innate Immunity.

Tissue factor haploinsufficiency during endotoxin induced coagulation and inflammation in mice

P. Reitsma, H. Versteeg, C. Spek, 2004, Journal of thrombosis and haemostasis : JTH.

Protease‐activated receptor 2 suppresses lymphangiogenesis and subsequent lymph node metastasis in a murine pancreatic cancer model

D. Richel, C. Spek, C. V. van Noesel, 2014, The Journal of pathology.

Active site inhibited factor VIIa attenuates myocardial ischemia/reperfusion injury in mice

C. Spek, R. van Oerle, K. Hamulýak, 2009, Journal of thrombosis and haemostasis : JTH.

Protease‐activated receptor‐2 induces migration of pancreatic cancer cells in an extracellular ATP‐dependent manner

D. Richel, K. Queiroz, C. Spek, 2013, Journal of thrombosis and haemostasis : JTH.

Nuclear Receptors Nur77, Nurr1, and NOR-1 Expressed in Atherosclerotic Lesion Macrophages Reduce Lipid Loading and Inflammatory Responses

T. van der Poll, J. Seppen, C. D. de Vries, 2006, Arteriosclerosis, thrombosis, and vascular biology.

Potential importance of protease activated receptor (PAR)-1 expression in the tumor stroma of non-small-cell lung cancer

H. Horlings, K. Borensztajn, C. Majoor, 2017, BMC Cancer.

Targeting coagulation factor receptors – protease‐activated receptors in idiopathic pulmonary fibrosis

K. Borensztajn, C. Spek, C. Spek, 2017, Journal of thrombosis and haemostasis : JTH.

Antiinflammatory effects of salmeterol after inhalation of lipopolysaccharide by healthy volunteers.

T. van der Poll, R. Lutter, P. Bresser, 2005, American journal of respiratory and critical care medicine.

Hypoxia induces a hedgehog response mediated by HIF‐1α

M. Peppelenbosch, C. Spek, M. Bijlsma, 2009, Journal of cellular and molecular medicine.

4 Nuclear Receptors Nur 77 , Nurr 1 and NOR-1 Expressed in Atherosclerotic Lesion Macrophages Reduce Lipid Loading and Inflammatory Responses

J. Seppen, H. Pannekoek, C. Spek, 2009 .

The Dual Role of C/EBPδ in Cancer.

J. Duitman, C. Spek, Leonie Hartl, 2023, Critical reviews in oncology/hematology.

Non-Tumor CCAAT/Enhancer-Binding Protein Delta Potentiates Tumor Cell Extravasation and Pancreatic Cancer Metastasis Formation

J. Duitman, J. Roelofs, M. Bijlsma, 2021, Biomolecules.

CCAAT/Enhancer-Binding Protein Delta (C/EBPδ): A Previously Unrecognized Tumor Suppressor that Limits the Oncogenic Potential of Pancreatic Ductal Adenocarcinoma Cells

G. Hooijer, M. Peppelenbosch, M. Besselink, 2020, Cancers.

Action and clinical significance of CCAAT/enhancer-binding protein delta in hepatocellular carcinoma

M. Li, M. Peppelenbosch, J. Kwekkeboom, 2018, Carcinogenesis.

Is idiopathic pulmonary fibrosis a cancer-like disease? Transcriptome analysis to fuel the debate

J. Duitman, C. Spek, 2019, ERJ Open Research.

High endogenous activated protein C levels attenuates bleomycin‐induced pulmonary fibrosis

T. van der Poll, B. Isermann, K. Borensztajn, 2016, Journal of cellular and molecular medicine.

Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis

T. van der Poll, K. Borensztajn, B. Crestani, 2015, Journal of cellular and molecular medicine.

C/EBP-Family Redundancy Determines Patient Survival and Lymph Node Involvement in PDAC

J. Duitman, J. Roelofs, M. Bijlsma, 2023, International journal of molecular sciences.

Leukotriene Synthesis Is Required for Hedgehog‐Dependent Neurite Projection in Neuralized Embryoid Bodies but Not for Motor Neuron Differentiation

M. Peppelenbosch, M. Bijlsma, C. Spek, 2008, Stem cells.

Ethyl pyruvate exerts combined anti-inflammatory and anticoagulant effects on human monocytic cells

T. van der Poll, C. van ′t Veer, M. Tanck, 2006, Thrombosis and Haemostasis.

CEBPD Potentiates the Macrophage Inflammatory Response but CEBPD Knock-Out Macrophages Fail to Identify CEBPD-Dependent Pro-Inflammatory Transcriptional Programs

A. D. de Vos, J. Duitman, C. Spek, 2021, Cells.

Potential novel targets: Protease-activated receptors in idiopathic pulmonary fibrosis

M. Brink, K. Borensztajn, T. Poll, 2015 .

Potential importance of protease activated receptor (PAR)-1 expression in the tumor stroma of non-small-cell lung cancer

H. Horlings, K. Borensztajn, C. Majoor, 2017, BMC Cancer.

Preclinical Assessment of ADAM9-Responsive Mesoporous Silica Nanoparticles for the Treatment of Pancreatic Cancer

A. Kros, M. Bijlsma, C. Spek, 2023, International journal of molecular sciences.

CCAAT/enhancer-binding protein δ (C/EBPδ) aggravates inflammation and bacterial dissemination during pneumococcal meningitis

J. Duitman, M. Brouwer, D. van de Beek, 2015, Journal of Neuroinflammation.

A mechanism for thrombin‐dependent lung metastasis in patients with osteosarcoma

M. Peppelenbosch, K. Borensztajn, C. Spek, 2009, British journal of haematology.

Local activation of the tissue factor-factor VIIa pathway in patients with pneumonia and the effect of inhibition of this pathway in murine pneumococcal pneumonia*

T. van der Poll, P. Reitsma, C. Spek, 2006, Critical care medicine.

Increased Mortality during Bleomycin-induced Pulmonary Fibrosis due to Low Endogenous Activated Protein C Levels.

T. van der Poll, K. Borensztajn, J. H. von der Thüsen, 2015, American journal of respiratory and critical care medicine.

Effects of IC14, an anti-CD14 antibody, on coagulation and fibrinolysis during low-grade endotoxemia in humans.

T. van der Poll, P. Reitsma, S. Deventer, 2003, The Journal of infectious diseases.

Experimental melanoma metastasis in lungs of mice with congenital coagulation disorders

P. Reitsma, H. Versteeg, C. Spek, 2008, Journal of cellular and molecular medicine.

Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement.

C. V. van Noorden, D. Richel, C. Esmon, 2009, Blood.

mTOR inhibitor treatment of pancreatic cancer in a patient With Peutz-Jeghers syndrome.

D. Richel, C. Spek, C. V. van Noesel, 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Protease-activated receptor-1 deficiency protects against streptozotocin-induced diabetic nephropathy in mice

C. Spek, J. Duitman, S. Florquin, 2016, Scientific Reports.

Protease-Activated Receptors, Apoptosis and Tumor Growth

K. Borensztajn, C. Spek, C. Spek, 2007, Pathophysiology of Haemostasis and Thrombosis.

Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation.

P. Reitsma, C. Spek, H. ten Cate, 2007, Blood.

Plasmin reduces fibronectin deposition by mesangial cells in a protease-activated receptor-1 independent manner

C. Spek, J. Duitman, C. Spek, 2017, Biochemistry and biophysics reports.

Inhibition of the tissue factor/factor VIIa pathway does not influence the inflammatory or antibacterial response to abdominal sepsis induced by Escherichia coli in mice.

T. van der Poll, P. Reitsma, C. Spek, 2004, The Journal of infectious diseases.

Potential novel targets: Protease-activated receptors in idiopathic pulmonary

K. Borensztajn, T. Poll, C. Spek, 2015 .

CCAAT/enhancer-binding protein δ facilitates bacterial dissemination during pneumococcal pneumonia in a platelet-activating factor receptor-dependent manner

T. van der Poll, K. Borensztajn, J. Duitman, 2012, Proceedings of the National Academy of Sciences.

CCAAT/enhancer‐binding protein delta (C/EBPδ) plays a minor role in renal host defense against uropathogenic Escherichia coli

J. Duitman, S. Florquin, J. Leemans, 2013, Transplant infectious disease : an official journal of the Transplantation Society.

CCAAT-enhancer binding protein delta (C/EBPδ) protects against Klebsiella pneumoniae-induced pulmonary infection: potential role for macrophage migration.

T. van der Poll, J. Duitman, S. Florquin, 2012, The Journal of infectious diseases.

Potential novel targets: Protease-activated receptors in idiopathic pulmonary fibrosis

K. Borensztajn, T. Poll, F. Rezaee, 2015 .

CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy

K. Borensztajn, J. Duitman, S. Florquin, 2014, Laboratory Investigation.

Treatment with an Anti-CD14 Monoclonal Antibody Delays and Inhibits Lipopolysaccharide-Induced Gene Expression in Humans in Vivo

P. Reitsma, J. Schouten, C. Mcelgunn, 2003, Journal of Clinical Immunology.

Pharmacological Targeting of Protease-Activated Receptor 2 Affords Protection from Bleomycin-Induced Pulmonary Fibrosis

T. van der Poll, K. Borensztajn, B. Crestani, 2015, Molecular medicine.

Infectious diseases and fibrotic disorders : Potential novel targets

M. Peppelenbosch, K. Borensztajn, S. Florquin, 2014 .

Protease‐activated receptor‐1 contributes to renal injury and interstitial fibrosis during chronic obstructive nephropathy

C. Spek, J. Duitman, S. Florquin, 2018, Journal of cellular and molecular medicine.

3 Chapter 3 Protease activated receptor 2 in diabetic nephropathy : a double edged sword .

C. Spek, S. Florquin, C. Spek, 2018 .

Hypoxia induces a hedgehog response mediated by HIF‐1α

M. Peppelenbosch, M. Bijlsma, C. Spek, 2009, Journal of cellular and molecular medicine.

Protease‐activated receptor 1 drives and maintains ductal cell fates in the premalignant pancreas and ductal adenocarcinoma

C. Spek, B. Scicluna, M. Bijlsma, 2021, Molecular oncology.

Tissue Factor-Dependent Chemokine Production Aggravates Experimental Colitis

A. T. Te Velde, H. Versteeg, C. Spek, 2011, Molecular medicine.

The coagulation factor Xa/protease activated receptor-2 axis in the progression of liver fibrosis: a multifaceted paradigm

M. Peppelenbosch, K. Borensztajn, C. Spek, 2009, Journal of cellular and molecular medicine.

Protease activated receptor-1 regulates macrophage-mediated cellular senescence: a risk for idiopathic pulmonary fibrosis

K. Borensztajn, F. Rezaee, Cong Lin, 2015, Oncotarget.