Guoxiang Shen

发表

Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis.

A. Kong, Changjiang Xu, T. Khor, 2008, Biochemical pharmacology.

Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.

A. Kong, Jung-Hwan Kim, M. Jain, 2005, Journal of biochemistry and molecular biology.

Differential Expression and Stability of Endogenous Nuclear Factor E 2-related Factor 2 ( Nrf 2 ) by Natural Chemopreventive Compounds in HepG 2 Human Hepatoma Cells

A. Kong, Jung-Hwan Kim, M. Jain, 2005 .

Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2

A. Kong, Jung-Hwan Kim, Jianjie Ma, 2006, Molecular Cancer Therapeutics.

Butylated hydroxyanisole regulates ARE‐mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells

A. Kong, A. Kong, Jung-Hwan Kim, 2006, Molecular carcinogenesis.

In vivo pharmacokinetics, activation of MAPK signaling and induction of phase II/III drug metabolizing enzymes/transporters by cancer chemopreventive compound BHA in the mice

A. Kong, R. Hu, S. Nair, 2006, Archives of pharmacal research.

Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters.

A. Kong, Guoxiang Shen, 2009, Biopharmaceutics & drug disposition.

Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice.

A. Kong, R. Hu, S. Nair, 2007, Toxicology letters.

FDA Approval Summary: Daratumumab for Treatment of Multiple Myeloma After One Prior Therapy

K. Goldberg, Amy McKee, R. Pazdur, 2017, The oncologist.

Comparison of (−)-Epigallocatechin-3-Gallate Elicited Liver and Small Intestine Gene Expression Profiles Between C57BL/6J Mice and C57BL/6J/Nrf2 (−/−) Mice

A. Kong, R. Hu, S. Nair, 2005, Pharmaceutical Research.

Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.

A. Conney, A. Kong, Changjiang Xu, 2006, Cancer research.

Toxicogenomics of resveratrol in rat liver.

A. Kong, Bok-Ryang Kim, R. Hu, 2005, Life sciences.

Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane.

A. Kong, Bok-Ryang Kim, R. Hu, 2003, Cancer research.

Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism

A. Kong, Jung-Hwan Kim, T. Khor, 2008, Molecular Cancer Therapeutics.

Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse.

A. Kong, Chi-Tang Ho, R. Hu, 2007, Cancer research.

Regulation of Nrf2 Transactivation Domain Activity THE DIFFERENTIAL EFFECTS OF MITOGEN-ACTIVATED PROTEIN KINASE CASCADES AND SYNERGISTIC STIMULATORY EFFECT OF Raf AND CREB-BINDING PROTEIN*

Jiahuai Han, M. Gallo, A. Kong, 2004 .

Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals.

A. Kong, S. Nair, V. Hebbar, 2004, Free radical biology & medicine.

Synergistic Effects of a Combination of Dietary Factors Sulforaphane and (−) Epigallocatechin-3-gallate in HT-29 AP-1 Human Colon Carcinoma Cells

S. Nair, A. Kong, V. Hebbar, 2008, Pharmaceutical Research.

Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis.

Michael A. Galella, S. Spergel, K. McIntyre, 2019, ACS medicinal chemistry letters.

Mouse Min / + Apc Dibenzoylmethane Alone and in Combination in Natural Dietary Compounds Sulforaphane and Chemoprevention of Familial Adenomatous Polyposis by Updated

A. Kong, Chi-Tang Ho, R. Hu, 2007 .

Regulation of Nrf2, NF-kappaB, and AP-1 signaling pathways by chemopreventive agents.

A. Kong, R. Hu, W. Jeong, 2005, Antioxidants & redox signaling.

Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors.

David S. Nirschl, David S Nirschl, Sidney Pitt, 2014, Bioorganic & medicinal chemistry letters.

Pharmacokinetics and safety of subcutaneous pasireotide and intramuscular pasireotide long-acting release in Chinese male healthy volunteers: a phase I, single-center, open-label, randomized study.

Xia Chen, Ji Jiang, P. Hu, 2014, Clinical therapeutics.

FDA Approval Summary: Entrectinib for the Treatment of NTRK gene Fusion Solid Tumors

Martha Donoghue, P. Keegan, R. Pazdur, 2020, Clinical Cancer Research.

Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily.

J. Fargnoli, J. Tokarski, G. Trainor, 2009, Journal of medicinal chemistry.

Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells.

A. Kong, R. Hu, V. Hebbar, 2003, Carcinogenesis.

Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable.

A. Kong, K. Chada, R. Hu, 2006, Carcinogenesis.

Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.

A. Kong, R. Hu, M. Jain, 2006, Cancer letters.

Pharmacokinetics and Pharmacodynamics of Broccoli Sprouts on the Suppression of Prostate Cancer in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Mice: Implication of Induction of Nrf2, HO-1 and Apoptosis and the Suppression of Akt-dependent Kinase Pathway

Ki Han Kwon, A. Kong, Y. Keum, 2009, Pharmaceutical Research.

Regulation of Nrf2 Transactivation Domain Activity

Jiahuai Han, M. Gallo, A. Kong, 2004, Journal of Biological Chemistry.

Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice.

A. Kong, A. Conney, R. Hu, 2006, Cancer research.

Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice

K. Chada, R. Hu, S. Nair, 2006, Biopharmaceutics & drug disposition.

Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.

A. Kong, C. Gélinas, Changjiang Xu, 2005, Oncogene.

p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1

A. Kong, V. Hebbar, Changjiang Xu, 2006, Cancer Chemotherapy and Pharmacology.

Suppression of NF-κB and NF-κB-regulated gene expression by sulforaphane and PEITC through IκBα, IKK pathway in human prostate cancer PC-3 cells

A. Kong, C. Gélinas, Changjiang Xu, 2005, Oncogene.

Pharmacogenomics of Phenolic Antioxidant Butylated Hydroxyanisole (BHA) in the Small Intestine and Liver of Nrf2 Knockout and C57BL/6J Mice

A. Kong, R. Hu, S. Nair, 2006, Pharmaceutical Research.

Regulation of Nrf2, NF-κB, and AP-1 Signaling Pathways by Chemopreventive Agents

A. Kong, R. Hu, W. Jeong, 2005 .

Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray.

A. Kong, R. Hu, M. Jain, 2006, Life sciences.

Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors.

K. McIntyre, Sidney Pitt, G. Schieven, 2017, Bioorganic & medicinal chemistry letters.

ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.

S. Nair, A. Kong, Jung-Hwan Kim, 2006, Carcinogenesis.

Modulation of nuclear factor E2-related factor 2–mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin

A. Kong, R. Hu, S. Nair, 2006, Molecular Cancer Therapeutics.

Regulation of Nrf2 transactivation domain activity by p160 RAC3/SRC3 and other nuclear co-regulators.

A. Kong, A. Zhang, M. Jain, 2006, Journal of biochemistry and molecular biology.

Inhibitory Effect of Ketoconazole on the Pharmacokinetics of a Multireceptor Tyrosine Kinase Inhibitor BMS‐690514 in Healthy Participants: Assessing the Mechanism of the Interaction With Physiologically‐Based Pharmacokinetic Simulations

V. Roongta, Zheng Yang, E. Masson, 2013, Journal of clinical pharmacology.

Pharmacokinetics of dietary cancer chemopreventive compound dibenzoylmethane in rats and the impact of nanoemulsion and genetic knockout of Nrf2 on its disposition

A. Kong, T. Heimbach, Qingrong Huang, 2011, Biopharmaceutics & drug disposition.

Development and validation of an HPLC method for the determination of dibenzoylmethane in rat plasma and its application to the pharmacokinetic study.

A. Kong, Guoxiang Shen, Jin-Liern Hong, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Development of a Carbon-14 Labeling Approach to Support Disposition Studies with a Pegylated Biologic

A. D. Rodrigues, P. Morin, S. Emanuel, 2012, Drug Metabolism and Disposition.

Development and validation of an LC-MS-MS method for the simultaneous determination of sulforaphane and its metabolites in rat plasma and its application in pharmacokinetic studies.

A. Kong, A. Nomeir, T. Khor, 2011, Journal of Chromatographic Science.

Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters.

A. Kong, Guoxiang Shen, 2009, Biopharmaceutics & drug disposition.

J. Fargnoli, J. Tokarski, G. Trainor, 2009, Journal of medicinal chemistry.

Pharmacokinetics of dietary cancer chemopreventive compound dibenzoylmethane in rats and the impact of nanoemulsion and genetic knockout of Nrf2 on its disposition

A. Kong, T. Heimbach, Qingrong Huang, 2011, Biopharmaceutics & drug disposition.