Usama M. Ammar

发表

Design, synthesis, anticancer evaluation and molecular docking of new V600EBRAF inhibitors derived from pyridopyrazinone

K. M. Amin, el-Badry Om, D. A. Rahman, 2016 .

Structural optimization of imidazothiazole derivatives affords a new promising series as B-Raf V600E inhibitors; synthesis, in vitro assay and in silico screening.

C. Oh, Mohammed S. Abdel-Maksoud, Usama M. Ammar, 2020, Bioorganic chemistry.

Modification of imidazothiazole derivatives gives promising activity in B-Raf kinase enzyme inhibition; synthesis, in vitro studies and molecular docking.

H. Choi, C. Oh, Mohammed S. Abdel-Maksoud, 2020, Bioorganic & medicinal chemistry letters.

Discovery of New Imidazo[2,1-b]thiazole Derivatives as Potent Pan-RAF Inhibitors with Promising In Vitro and In Vivo Anti-melanoma Activity.

Young Jik Kwon, Kyung-Tae Lee, K. Lee, 2021, Journal of medicinal chemistry.

Anticancer profile of newly synthesized BRAF inhibitors possess 5-(pyrimidin-4-yl)imidazo[2,1-b]thiazole scaffold.

C. Oh, Mohammed S. Abdel-Maksoud, Usama M. Ammar, 2019, Bioorganic & medicinal chemistry.

Scaffold Repurposing Reveals New Nanomolar Phosphodiesterase Type 5 (PDE5) Inhibitors Based on Pyridopyrazinone Scaffold: Investigation of In Vitro and In Silico Properties

M. El-Maghrabey, Doaa E Abdel Rahman, Mohamed A. El Hamd, 2022, Pharmaceutics.

Design, synthesis, in vitro determination and molecular docking studies of 4-(1-(tert-butyl)-3-phenyl-1H-pyrazol-4-yl) pyridine derivatives with terminal sulfonamide derivatives in LPS-induced RAW264.7 macrophage cells

Seyed-Omar Zaraei, Misook Ji, C. Oh, 2021, Medicinal Chemistry Research.

Design, synthesis, and anticancer activity of imidazo[2,1-b]oxazole-based RAF kinase inhibitors.

Kyung-Tae Lee, M. El-Gamal, C. Oh, 2019, Bioorganic chemistry.

Scaffold Repurposing of In-House Small Molecule Candidates Leads to Discovery of First-in-Class CDK-1/HER-2 Dual Inhibitors: In Vitro and In Silico Screening

E. Roh, Kyeong Lee, Usama M. Ammar, 2021, Molecules.

Synthesis and In Vitro Biological Evaluation of New Pyrido[2,3‐ b ]pyrazinone‐Based Cytotoxic Agents and Molecular Docking as BRAF Inhibitors

Usama M. Ammar, K. Amin, O. El-Badry, 2019, ChemistrySelect.

Recent advances of RAF (rapidly accelerated fibrosarcoma) inhibitors as anti-cancer agents.

C. Oh, Mohammed S. Abdel-Maksoud, Usama M. Ammar, 2018, European journal of medicinal chemistry.

Structural optimization of 4-(imidazol-5-yl)pyridine derivatives affords broad-spectrum anticancer agents with selective B-RAFV600E/p38α kinase inhibitory activity: Synthesis, in vitro assays and in silico study.

Jun‐Seok Lee, M. El-Gamal, Seyed-Omar Zaraei, 2022, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Design, synthesis, biological evaluation, and docking studies of novel (imidazol-5-yl)pyrimidine-based derivatives as dual BRAFV600E/p38α inhibitors.

M. El-Gamal, Seyed-Omar Zaraei, C. Oh, 2021, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of novel imidazole derivatives possessing terminal sulphonamides as potential BRAFV600Einhibitors.

C. Oh, Mohammed S. Abdel-Maksoud, Usama M. Ammar, 2020, Bioorganic chemistry.

Design and synthesis of novel pyrrolo[2,3-b]pyridine derivatives targeting V600EBRAF.

C. Oh, Mohammed S. Abdel-Maksoud, K. Yoo, 2020, Bioorganic & medicinal chemistry.

Design, synthesis and anti-inflammatory activity of imidazol-5-yl pyridine derivatives as p38α/MAPK14 inhibitor.

Kyung-Tae Lee, Anna Lee, C. Oh, 2020, Bioorganic & medicinal chemistry.

2-(3-Bromophenyl)-8-fluoroquinazoline-4-carboxylic Acid as a Novel and Selective Aurora A Kinase Inhibitory Lead with Apoptosis Properties: Design, Synthesis, In Vitro and In Silico Biological Evaluation

E. Roh, S. Ibrahim, Usama M. Ammar, 2022, Life.

Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells.

Tamer M. Ibrahim, Seyed-Omar Zaraei, T. Das, 2023, European journal of medicinal chemistry.

Design and Synthesis of Novel Aminoindazole-pyrrolo[2,3-b]pyridine Inhibitors of IKKα That Selectively Perturb Cellular Non-Canonical NF-κB Signalling

S. Mackay, Usama M. Ammar, C. Suckling, 2024, Molecules.