Lifeng Zhao

发表

SKLB316, a novel small-molecule inhibitor of cell-cycle progression, induces G2/M phase arrest and apoptosis in vitro and inhibits tumor growth in vivo.

Yuquan Wei, Q. Lei, Yong Xia, 2014, Cancer letters.

Synthesis and evaluation of novel thiazole‐based derivatives as selective inhibitors of DNA‐binding domain of the androgen receptor

J. Yu, Lifeng Zhao, Ruixue Xu, 2018, Chemical biology & drug design.

Development of selective mono or dual PROTAC degrader probe of CDK isoforms.

Jijun Cheng, Yongmei Xie, Lifeng Zhao, 2019, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of deuterated nintedanib for improving pharmacokinetic properties.

Lifeng Zhao, Lingling Peng, Ruixue Xu, 2015, Journal of labelled compounds & radiopharmaceuticals.

Discovery of SK-575 as a Highly Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of PARP1 for Treating Cancers.

Lifeng Zhao, Yong Chen, Jie Yang, 2020, Journal of medicinal chemistry.

Discovery of indol-6-yl-pyrrolo[2,3-c]pyridin-7-one derivatives as bromodomain-containing protein 4 (BRD4) inhibitors for the treatment of kidney fibrosis.

Lidan Zhang, Liang Ma, Lifeng Zhao, 2022, European journal of medicinal chemistry.

A convenient method for the Ru(0)-catalyzed regioselective deuteration of N-alkyl-substituted anilines

Lifeng Zhao, Ruixue Xu, Yuanwei Chen, 2014 .

Novel thiohydantoin analogues bearing the 1-hydroxyl-2,2,2-trifluoro-1-ethyl moiety as androgen receptor inhibitors for the potential treatment of castration resistant prostate cancer

Lifeng Zhao, Fan Lei, J. Yu, 2017 .

Discovery of novel polycyclic spiro-fused carbocyclicoxindole-based anticancer agents.

Lidan Zhang, Lifeng Zhao, Xia Zhang, 2017, European journal of medicinal chemistry.

A Simple and Cost‐Effective Method for the Regioselective Deuteration of Phenols

Yongmei Xie, Lifeng Zhao, Ruixue Xu, 2015 .

Design, synthesis and biological evaluation of novel C3-functionalized oxindoles as potential Pim-1 kinase inhibitors

Lidan Zhang, Lifeng Zhao, Xiaoyan Wang, 2015 .

Gelatin Particle-Stabilized High-Internal Phase Emulsions for Use in Oral Delivery Systems: Protection Effect and in Vitro Digestion Study.

To Ngai, Lifeng Zhao, X. Gou, 2017, Journal of agricultural and food chemistry.

Design, Synthesis, and Biological Evaluation of Dimorpholine Substituted Thienopyrimidines as Potential Class I PI3K/mTOR Dual Inhibitors.

Lifeng Zhao, Guoyi Yan, Yufang Deng, 2017, Journal of medicinal chemistry.

Cryptotanshinone induces melanoma cancer cells apoptosis via ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion.

Tinghong Ye, Yongxia Zhu, Luoting Yu, 2016, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Design, synthesis and biological evaluation of novel 1-methyl-3-oxo-2,3,5,6,7,8-hexahydroisoquinolins as potential EZH2 inhibitors

Lidan Zhang, Xuejiao Song, Ningyu Wang, 2015 .

Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis

Yuquan Wei, Sheng-yong Yang, Q. Lei, 2017, Cell Death & Disease.

Discovery of 4-phenyl-2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as potent and orally active PI3K/mTOR dual inhibitors.

Rui Li, Lifeng Zhao, Jie Yang, 2019, European journal of medicinal chemistry.

Discovery of a novel class of pyridine derivatives that selectively inhibits mutant isocitrate dehydrogenase 2

Yinglan Zhao, Lifeng Zhao, Mingxing Hu, 2018, Chemical biology & drug design.

Design and Synthesis of Fibroblast Growth Factor Receptor (FGFR) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Cancer.

Ningyu Wang, Luoting Yu, Lifeng Zhao, 2022, Journal of medicinal chemistry.

Novel Dual BET and PLK1 Inhibitor WNY0824 Exerts Potent Antitumor Effects in CRPC by Inhibiting Transcription Factor Function and Inducing Mitotic Abnormality

Xuejiao Song, Ningyu Wang, Ying Xu, 2020, Molecular Cancer Therapeutics.

A dual enhanced anti-bacterial strategy based on high chlorin e6-loaded polyethyleneimine functionalized graphene

Z. Yin, Kunping Liu, Jiangxia Wang, 2020, RSC advances.

Inhibition of FGFR signaling by PD173074 improves antitumor immunity and impairs breast cancer metastasis

Yuquan Wei, Yong Xia, Tinghong Ye, 2014, Breast Cancer Research and Treatment.

A novel VEGFR inhibitor ZLF-095 with potent antitumor activity and low toxicity

Q. Lei, Lidan Zhang, Xuejiao Song, 2023, Heliyon.

Nifuroxazide exerts potent anti-tumor and anti-metastasis activity in melanoma

Yuquan Wei, Q. Lei, Lidan Zhang, 2016, Scientific Reports.

Correction: Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis

Yuquan Wei, Sheng-yong Yang, Q. Lei, 2019, Cell Death and Disease.

Design, synthesis and biological evaluation of indazole derivatives as selective covalent inhibitors of FGFR4 in wild-type and gatekeeper mutants.

Ningyu Wang, Lifeng Zhao, Zhihao Liu, 2023, European journal of medicinal chemistry.

Novel small molecules as apoptosis inducers: synthesis, preliminary structure-activity relationships, and in vitro biological evaluation.

Yuquan Wei, Sheng-yong Yang, Lidan Zhang, 2013, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of deuterated Vismodegib for improving pharmacokinetic properties.

Lifeng Zhao, Yufang Deng, Yuanwei Chen, 2018, Bioorganic & medicinal chemistry letters.

Synthesis and characterization of a photoresponsive doxorubicin/combretastatin A4 hybrid prodrug.

Lifeng Zhao, X. Gou, Wei Liu, 2019, Bioorganic & medicinal chemistry letters.