S. Fustero

发表

Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001-2011).

Hong Liu, Jiang Wang, C. del Pozo, 2014, Chemical reviews.

Synthesis of polyfluoroalkyl sp2-iminosugar glycolipids and evaluation of their immunomodulatory properties towards anti-tumor, anti-leishmanial and anti-inflammatory therapies.

F. Gamarro, C. Ortiz Mellet, J. G. García Fernández, 2019, European journal of medicinal chemistry.

Gold-catalyzed tandem hydroamination/formal aza-Diels-Alder reaction of homopropargyl amino esters: a combined computational and experimental mechanistic study.

C. del Pozo, María Sánchez-Roselló, S. Fustero, 2015, Chemistry.

Tailor-Made Amino Acids and Fluorinated Motifs as Prominent Traits in the Modern Pharmaceuticals.

N. Meanwell, Haibo Mei, Jianlin Han, 2020, Chemistry.

The Self‐Disproportionation of Enantiomers ( SDE ): Fluorine as an SDE ‐Phoric Substituent

K. Klika, H. Moriwaki, Jianlin Han, 2021 .

Ring-opening metathesis of some strained bicyclic systems; stereocontrolled access to diolefinated saturated heterocycles with multiple stereogenic centers

L. Kiss, S. Fustero, Melinda Nonn, 2018, Beilstein journal of organic chemistry.

1,7-octadiene-assisted tandem multicomponent cross-enyne metathesis (CEYM)-Diels-Alder reactions: a useful alternative to Mori's conditions.

C. del Pozo, Paula Bello, S. Fustero, 2012, Chemistry.

An Insight into Substrate‐Dependent Fluorination of some Highly Substituted Alicyclic Scaffolds

M. Haukka, F. Fülöp, R. Sillanpää, 2017 .

Diversity-Oriented Synthesis of Highly Functionalized Alicycles across Dipolar Cycloaddition/Metathesis Reaction

L. Kiss, S. Fustero, Melinda Nonn, 2021, Synlett.

Intramolecular Nitrone Cycloaddition of α-(Trifluoromethyl)styrenes. Role of the CF3 Group in the Regioselectivity.

C. del Pozo, Marcos Escolano, María Sánchez-Roselló, 2017, The Journal of organic chemistry.

Synthesis of Nonracemic α‐Trifluoromethyl α‐Amino Acids from Sulfinimines of Trifluoropyruvate

S. V. Meille, A. Volonterio, M. Zanda, 2001 .

Chiral Brønsted Acid-Catalyzed Asymmetric Allyl(propargyl)boration Reaction of ortho-Alkynyl Benzaldehydes: Synthetic Applications and Factors Governing the Enantioselectivity

Matthew N. Grayson, K. Houk, S. Fustero, 2016 .

Recent Advances on the Halo- and Cyano-Trifluoromethylation of Alkenes and Alkynes

M. Sodeoka, Jianlin Han, V. Soloshonok, 2021, Molecules.

8-Iodonaphthalene-1-carbaldehyde: A Versatile Building Block for Diversity-Oriented Synthesis.

S. Fustero, N. Mateu, Raquel Román, 2016, Organic letters.

1,4-Benzodiazepine N-nitrosoamidines: useful intermediates in the synthesis of tricyclic benzodiazepines.

C. del Pozo, S. Fustero, Javier González, 2006, Molecules.

Organocatalytic enantioselective synthesis of trifluoromethyl-containing tetralin derivatives by sequential (hetero)Michael reaction–intramolecular nitrone cycloaddition

P. Merino, J. Torres, María Sánchez-Roselló, 2017 .

Asymmetric Synthesis of Monofluorinated 1-Amino-1,2-dihydronaphthalene and 1,3-Amino Alcohol Derivatives.

G. Haufe, S. Fustero, Rubén Lázaro, 2016, Organic letters.

Asymmetric Allylation/RCM-Mediated Synthesis of Fluorinated Benzo-Fused Bicyclic Homoallylic Amines As Dihydronaphthalene Derivatives.

S. Fustero, A. Simón, Raquel Román, 2016, The Journal of organic chemistry.

Diastereodivergent Synthesis of Fluorinated Cyclic β(3)-Amino Acid Derivatives.

C. del Pozo, María Sánchez-Roselló, S. Fustero, 2015, Organic letters.

Asymmetric Synthesis of Fluorinated Isoindolinones through Palladium-Catalyzed Carbonylative Amination of Enantioenriched Benzylic Carbamates.

S. Fustero, Raquel Román, Pablo Barrio, 2015, Chemistry.

Gold-catalyzed intramolecular hydroamination of o-alkynylbenzyl carbamates: a route to chiral fluorinated isoindoline and isoquinoline derivatives.

M. Maestro, S. Fustero, Pablo Barrio, 2013, Organic letters.

Asymmetric synthesis of quaternary α-amino acid derivatives and their fluorinated analogues

María Sánchez-Roselló, C. Pozo, Leyre Marzo, 2011, Amino Acids.

Chiral monofluorobenzyl carbanions: synthesis of enantiopure β-fluorinated β-phenylethylamines.

C. del Pozo, S. Fustero, I. Alonso, 2011, Chemistry.

A new strategy for the synthesis of fluorinated 3,4-dihydropyrimidinones

C. Pozo, J. L. Aceña, S. Fustero, 2009 .

Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors.

A. Volonterio, Francesca Olimpieri, M. Zanda, 2009, Bioorganic & medicinal chemistry letters.

Recent advances in the synthesis of functionalised monofluorinated compounds.

S. Fustero, Raquel Román, Pablo Barrio, 2018, Chemical communications.

Synthesis of fluorinated amino acid derivatives through late-stage deoxyfluorinations

F. Fülöp, L. Kiss, S. Fustero, 2018, Tetrahedron.

Selective Synthesis of New Fluorinated Alicyclic β‐Amino Ester Stereoisomers

F. Fülöp, L. Kiss, S. Fustero, 2011 .

Asymmetric synthesis of polycyclic 3-fluoroalkylproline derivatives by intramolecular azomethine ylide cycloaddition

P. Merino, C. del Pozo, S. Fustero, 2019, Organic Chemistry Frontiers.

C−C versus C−N Annulation Reactions of 2‐Alkyl‐2‐oxazolines and 2‐Alkyl‐2‐thiazolines: A Simple Synthesis of Novel 3‐Aminoindene, Phthalimidine, Pyrrolidine, and Piperidine Derivatives

S. Fustero, E. Aguilar, M. D. Díaz, 2001 .

A novel heterocyclic sulfonamide: N-benzyl-5-[N-benzyl-N-(tert-butyloxycarbonyl)amino]-N-(tert-butyloxycarbonyl)-1,3,4-thiadiazole-2-sulfonamide.

S. Fustero, J. Pedregosa, J. Server-Carrió, 2000, Acta crystallographica. Section C, Crystal structure communications.

Fluorine-Containing Drugs Approved by the FDA in 2018.

M. Medio‐Simón, Haibo Mei, Jianlin Han, 2019, Chemistry.

Pauson–Khand reaction of fluorinated compounds

M. Medio‐Simón, J. Escorihuela, S. Fustero, 2020, Beilstein journal of organic chemistry.

Biochemical quantitation of the eIF5A hypusination in Arabidopsis thaliana uncovers ABA-dependent regulation

J. Carbonell, A. Granell, J. Rambla, 2014, Front. Plant Sci..

A practical entry to β-aryl-β-alkyl amino alcohols: application to the synthesis of a potent BACE1 inhibitor.

Ó. Delgado, Michiel Van Gool, S. Fustero, 2012, Organic & biomolecular chemistry.

Fluorination of some highly functionalized cycloalkanes: chemoselectivity and substrate dependence

M. Haukka, F. Fülöp, L. Kiss, 2017, Beilstein journal of organic chemistry.

A novel and selective fluoride opening of aziridines by XtalFluor-E. synthesis of fluorinated diamino acid derivatives.

M. Haukka, F. Fülöp, L. Kiss, 2015, Organic letters.

Dual Role of Vinyl Sulfonamides as N -Nucleophiles and Michael Acceptors in the Enantioselective Synthesis of Bicyclic δ-Sultams

Marcos Escolano, María Sánchez-Roselló, C. Pozo, 2018, Advanced Synthesis & Catalysis.

Experiments demonstrating the creation of elements via pulsed electric field in water and deuterated water: application to the production of fluorine

S. Fustero, G. Ross, Daniel M Sedgwick, 2022, 2202.03744.

Enantioselective Synthesis of Fluorinated α-Amino Acids and Derivatives in Combination with Ring-Closing Metathesis: Intramolecular π-Stacking Interactions as a Source of Stereocontrol

A. Volonterio, M. Zanda, G. Fronza, 2001 .

Chemical Aspects of Human and Environmental Overload with Fluorine

Haibo Mei, H. Moriwaki, Jianlin Han, 2021, Chemical reviews.

Benzodiazines: recent synthetic advances.

G. S. Surya Prakash, T. Mathew, S. Fustero, 2017, Chemical Society reviews.

An efficient synthesis of uracil derivatives from 2-alkyl-Δ2-oxazolines and nitriles

S. Fustero, S. Mérida, J. F. Sanz-Cervera, 2008 .

Synthesis of a new fluorinated oxazolidinone and its reactivity as a chiral auxiliary in Aldol reactions

Paula Bello, S. Fustero, N. Mateu, 2007 .

Asymmetric synthesis of fluorinated cyclic beta-amino acid derivatives through cross metathesis.

C. del Pozo, María Sánchez-Roselló, J. L. Aceña, 2006, Organic letters.

New fluorinated 1,3-vinylogous amidines as versatile intermediates: synthesis of fluorinated pyrimidin-2(1H)-ones

Benjamin H. Brodsky, María Sánchez-Roselló, J. L. Aceña, 2006 .

A versatile synthesis of fluorinated uracils in solution and on solid-phase.

S. Fustero, C. Ramírez de Arellano, J. F. Sanz-Cervera, 2004, Organic letters.

Recent progress in the application of fluorinated chiral sulfinimine reagents

Haibo Mei, Jianlin Han, V. Soloshonok, 2018, Journal of Fluorine Chemistry.

Asymmetric Vinylogous Mannich‐Type Addition of α,α‐Dicyanoalkenes to α‐Fluoroalkyl Sulfinyl Imines

Jianlin Han, V. Soloshonok, J. Torres, 2018 .

Base-dependent stereodivergent intramolecular aza-Michael reaction: asymmetric synthesis of 1,3-disubstituted isoindolines.

S. Fustero, Elsa Rodríguez, N. Mateu, 2013, Chemistry.

Asymmetric allylation/ring closing metathesis: one-pot synthesis of benzo-fused cyclic homoallylic amines. Application to the formal synthesis of Sertraline derivatives.

S. Fustero, Elsa Rodríguez, N. Mateu, 2013, Organic letters.

Highly stereoselective tandem aza-Michael addition-enolate protonation to form partially modified retropeptide mimetics incorporating a trifluoroalanine surrogate.

A. Volonterio, M. Zanda, S. Fustero, 2003, Angewandte Chemie.

The role of fluorine in the stereoselective tandem aza-Michael addition to acrylamide acceptors: an experimental and theoretical mechanistic study.

A. Volonterio, M. Zanda, S. Fustero, 2007, Chemistry.

Highly enantioselective synthesis of fluorinated gamma-amino alcohols through proline-catalyzed cross-Mannich reaction.

María Sánchez-Roselló, S. Fustero, J. F. Sanz-Cervera, 2005, Organic letters.

Stereocontrolled solid-phase synthesis of fluorinated partially-modified retropeptides via tandem aza-Michael/enolate-protonation

A. Volonterio, M. Zanda, S. Fustero, 2003 .

Highly Stereoselective Tandem Aza‐Michael Addition—Enolate Protonation to Form Partially Modified Retropeptide Mimetics Incorporating a Trifluoroalanine Surrogate.

A. Volonterio, M. Zanda, S. Fustero, 2003 .

Substrate-dependent fluorinations of highly functionalized cycloalkanes

F. Fülöp, R. Sillanpää, L. Kiss, 2016 .

Olefin metathesis reactions with fluorinated substrates, catalysts, and solvents.

G. Haufe, S. Fustero, Pablo Barrio, 2015, Chemical reviews.

Concise preparation of 2,2-difluorohomopropargyl carbonyl derivatives. Application to the synthesis of 4,4-difluoroisoquinolinone congeners.

G. Hammond, C. Pozo, S. Fustero, 2008, The Journal of organic chemistry.

Synthesis of 2-Oxo-1,2,3,6-tetrahydropyridines from Ketimines and Dialkyl Maleates

V. Gotor, S. Fustero, J. Barluenga, 1975 .

Synthesis of new fluorinated Tebufenpyrad analogs with acaricidal activity through regioselective pyrazole formation.

S. Fustero, J. F. Sanz-Cervera, Raquel Román, 2008, The Journal of organic chemistry.

Tandem asymmetric Michael reaction-intramolecular Michael addition. An easy entry to chiral fluorinated 1,4-dihydropyridines.

C. del Pozo, María Sánchez-Roselló, S. Fustero, 2010, Organic letters.

Stereoselective access to fluorinated and non-fluorinated quaternary piperidines: synthesis of pipecolic acid and iminosugar derivatives.

J. L. Aceña, S. Fustero, Javier Miró, 2012, Chemistry.

A simple regiospecific synthesis of substituted pyridines from 2-aza-1,3-dienes

J. Joglar, V. Gotor, S. Fustero, 1988 .

2-Aza 1,3-dienes: a new and simple method for the synthesis of functionalized pyridine derivatives

S. Fustero, J. Barluenga, R. Carlón, 1991 .

Synthesis of 4(1H)-pyridones by carbonylation of 2-Aza-1,3-Dienes.

S. Fustero, J. Barluenga, R. Carlón, 1990 .

Fluorinated Pyrazoles and Indazoles

Ó. Delgado, S. Fustero, Raquel Román, 2014 .

A new and general synthesis of N-substituted fluorinated β-iminosulfoxides

S. Fustero, A. Asensio, A. Navarro, 1997 .

Recent Advances in the Synthesis of Pyrazoles. A Review

S. Fustero, J. F. Sanz-Cervera, Antonio Simón-Fuentes, 2009 .

Improved regioselectivity in pyrazole formation through the use of fluorinated alcohols as solvents: synthesis and biological activity of fluorinated tebufenpyrad analogs.

S. Fustero, M. Murguía, A. C. Cuñat, 2008, The Journal of organic chemistry.

Two Practical and Efficient Approaches to Fluorinated and Nonfluorinated Chiral beta-Imino Sulfoxides.

A. Volonterio, M. Zanda, S. Fustero, 1998, The Journal of organic chemistry.

Diels−Alder Reactions of 2-Azabutadienes with Aldehydes: Ab Initio and Density Functional Theoretical Study of the Reaction Mechanism, Regioselectivity, Acid Catalysis, and Stereoselectivity†

Javier Gonzalez, J. Joglar, Jesús Joglar, 1997 .

An AM1 study on π-facial selectivity in Diels-Alder reactions of 2-aza-1, 3-dienes with azodienophiles

S. Fustero, J. Barluenga, T. Sordo, 1994 .

Electronically Neutral 2-Aza-1,3-dienes: Are They Useful Intermediates in Organic Synthesis?

J. Joglar, S. Fustero, J. Barluenga, 1990 .

New perspectives of carbo- and hetero-l,3-dienes in organic synthesis

S. Fustero, J. Barluenga, M. Tomás, 1990 .

1,3-Amino alcohols from 4-amino-1-aza dienes. Diastereo- and enantioselective approach to the four diastereoisomers of the N-terminal amino acid component of nikkomycins B and Bx

S. Fustero, J. Barluenga, E. Aguilar, 1993 .

Synthesis and diastereofacial selectivity in Diels-Alder reactions of halogenated 2-aza-1,3-dienes

S. Fustero, J. Barluenga, E. Pérez-Carreño, 1991 .

Tandem cycloaddition–rearrangement of 2-aza-1,3-dienes. A simple and efficient synthesis of 1H-1,4-diazepine-7(6H)-thiones

S. Fustero, J. Barluenga, F. L. Ortiz, 1991 .

Unactivated 2.Aza.1,3-dienes: Halogenation and face selectivity in diels-alder reactions

S. Fustero, J. Barluenga, F. González, 1990 .

New approaches to the synthesis of organofluorine nitrogenated derivatives

María Sánchez-Roselló, S. Fustero, J. F. Sanz-Cervera, 2004 .

Solution-, solid-phase, and fluorous synthesis of beta,beta-difluorinated cyclic quaternary alpha-amino acid derivatives: a comparative study.

C. del Pozo, María Sánchez-Roselló, S. Fustero, 2008, Chemistry.

Synthesis and Reactivity of a-Halogenated, C-Protected -Enamino Acids

B. Fernández-Gutiérrez, S. Fustero, J. F. Sanz-Cervera, 2004 .

An efficient synthesis of new fluorinated uracil derivatives.

S. Fustero, A. Asensio, J. F. Sanz-Cervera, 2003, Chemical communications.

Asymmetric allylation/Pauson-Khand reaction: a simple entry to polycyclic amines. Application to the synthesis of aminosteroid analogues.

A. Riera, S. Fustero, Nuria Aiguabella, 2014, Organic letters.

One-pot cross-enyne metathesis (CEYM)–Diels–Alder reaction of gem-difluoropropargylic alkynes

G. Haufe, C. del Pozo, Paula Bello, 2013, Beilstein journal of organic chemistry.

Asymmetric tandem reactions: New synthetic strategies

C. del Pozo, María Sánchez-Roselló, S. Fustero, 2010 .

Organocatalytic anti‐Selective Mannich Reactions with Fluorinated Aldimines: Synthesis of anti‐γ‐Fluoroalkyl‐γ‐amino Alcohols

J. L. Aceña, S. Fustero, J. F. Sanz-Cervera, 2009 .

Cross-metathesis reactions as an efficient tool in the synthesis of fluorinated cyclic beta-amino acids.

C. del Pozo, María Sánchez-Roselló, J. L. Aceña, 2009, The Journal of organic chemistry.

A new strategy for the synthesis of optically pure beta-fluoroalkyl beta-amino acid derivatives.

C. del Pozo, V. Marcos, J. Alemán, 2009, Organic letters.

Asymmetric synthesis of new beta,beta-difluorinated cyclic quaternary alpha-amino acid derivatives.

C. del Pozo, María Sánchez-Roselló, S. Fustero, 2006, Organic letters.

Stereoselective synthesis of 1,3-amino alcohols and 1,3-amino ketones

S. Fustero, J. Barluenga, E. Aguilar, 1992 .

An Improved Diastereoselective Synthesis of 1,3-Amino Alcohols by Reduction of 1,3-Amino Ketone Derivatives

S. Fustero, J. Barluenga, E. Aguilar, 1990 .

Preparation and reactivity of 2‐Aza‐1,3‐butadienes: A Diels‐Alder route to 5,6‐dihydro‐2H‐1,3‐oxazine derivatives

M. Romão, J. Joglar, V. Gotor, 1985 .

Synthesis of 3-substituted isoindolin-1-ones via a tandem desilylation, cross-coupling, hydroamidation sequence under aqueous phase-transfer conditions.

G. Olah, G. Prakash, S. Munoz, 2016, Organic & biomolecular chemistry.

From 2000 to mid-2010: a fruitful decade for the synthesis of pyrazoles.

María Sánchez-Roselló, S. Fustero, Pablo Barrio, 2011, Chemical reviews.

Asymmetric synthesis of indolines through intramolecular shifting of aromatic sulfinyl groups. Role of the pi,pi-stacking interactions in these unusual S(N)Ar processes.

A. Poveda, C. del Pozo, V. Marcos, 2009, Journal of the American Chemical Society.

Anionic-anionic asymmetric tandem reactions: one-pot synthesis of optically pure fluorinated indolines from 2-p-tolylsulfinyl alkylbenzenes.

C. del Pozo, V. Marcos, J. Alemán, 2008, Angewandte Chemie.

Enantioselective organocatalytic intramolecular aza-Michael reaction: a concise synthesis of (+)-sedamine, (+)-allosedamine, and (+)-coniine.

C. Pozo, S. Fustero, S. Catalán, 2007, Organic letters.

Diastereoselective intramolecular additions of allyl- and propargylsilanes to iminium ions: synthesis of cyclic and bicyclic quaternary amino acids.

J. L. Aceña, S. Fustero, N. Mateu, 2010, Organic letters.

Synthesis of Fluorinated and Nonfluorinated Tebufenpyrad Analogues for the Study of Anti-angiogenesis MOA

Saba Husain, M. Alvim-Gaston, S. Fustero, 2014 .

Vinyl Fluorides: Competent Olefinic Counterparts in the Intramolecular Pauson-Khand Reaction.

M. Medio‐Simón, S. Fustero, N. Mateu, 2019, Organic letters.

Fluorine‐Containing Functionalized Cyclopentene Scaffolds Through Ring Contraction and Deoxofluorination of Various Substituted Cyclohexenes

M. Haukka, F. Fülöp, L. Kiss, 2018 .

Recent Advances in the Synthesis of Pyrazoles

S. Fustero, J. F. Sanz-Cervera, Antonio Simón-Fuentes, 2009 .

Microwave-assisted organocatalytic enantioselective intramolecular aza-Michael reaction with α,β-unsaturated ketones.

C. del Pozo, María Sánchez-Roselló, S. Fustero, 2011, Chemistry.

Asymmetric intramolecular aza-Michael reaction in desymmetrization processes. Total synthesis of hippodamine and epi-hippodamine.

C. del Pozo, María Sánchez-Roselló, S. Fustero, 2015, Organic letters.

Organocatalytic approach to benzofused nitrogen-containing heterocycles: enantioselective total synthesis of (+)-angustureine.

C. del Pozo, María Sánchez-Roselló, S. Fustero, 2008, Chemistry.

Novel approach for asymmetric synthesis of fluorinated beta-amino sulfones and allylic amines.

S. Fustero, J. G. Soler, A. Bartolomé, 2003, Organic letters.

Gold catalyzed stereoselective tandem hydroamination-formal aza-Diels-Alder reaction of propargylic amino esters.

M. Maestro, C. del Pozo, Paula Bello, 2013, Chemical communications.

A Decade of Advance in the Asymmetric Vinylogous Mannich Reaction

C. Pozo, S. Fustero, M. S. Roselló, 2016 .

An Approach to 2,4-Substituted Pyrazolo[1,5-a]pyridines and Pyrazolo[1,5-a]azepines by Ring-Closing Metathesis

M. Maestro, J. L. Aceña, S. Fustero, 2013 .

Chemodiscrimination of Olefin Bonds Through Cross-Metathesis Reactions - Synthesis of Functionalized β-Lactam and β-Amino Acid Derivatives

F. Fülöp, L. Kiss, S. Fustero, 2019, European Journal of Organic Chemistry.

Microwave-assisted tandem cross metathesis intramolecular Aza-Michael reaction: an easy entry to cyclic beta-amino carbonyl derivatives.

C. del Pozo, María Sánchez-Roselló, S. Fustero, 2007, Journal of the American Chemical Society.

Synthesis of N-Aryl-substituted 2-Aminoalkyl Ketones and 1,3-Alkanediamines

V. Gotor, S. Fustero, J. Barluenga, 1986 .

Organocatalytic enantioselective synthesis of quinolizidine alkaloids (+)-myrtine, (−)-lupinine, and (+)-epiepiquinamide

María Sánchez-Roselló, C. Pozo, S. Fustero, 2011 .

Synthesis and Reactivity of New β-Enamino Acid Derivatives: A Simple and General Approach to β-Enamino Esters and Thioesters

S. Fustero, V. Jofré, R. Carlón, 1998 .

A new and expeditious strategy for the synthesis of β-amino acids from Δ2-oxazolines

S. Fustero, E. Aguilar, M. D. Díaz, 2001 .

Diastereoselective synthesis of .gamma.-amino alcohols with three chiral centers by reduction of .beta.-amino ketones and derivatives

S. Fustero, J. Barluenga, B. Olano, 1985 .

Regio- and diastereoselective fluorination of alicyclic β-amino acids.

F. Fülöp, L. Kiss, S. Fustero, 2011, Organic & biomolecular chemistry.

N‐(Diphenylmethylene)benzenesulfonamide and N‐(Diphenylmethylene)‐4‐methylbenzenesulfonamide

S. Fustero, J. F. Sanz-Cervera, Antonio Simón-Fuentes, 2008 .

New Strategies for the Synthesis of Fluorinated Vinylogous Amidines and beta-Enamino Ketones.

S. Fustero, M. García de la Torre, B. Pina, 1999, The Journal of organic chemistry.

N-Substituted β-Enamino Acid Derivatives: A New Approach to Fluorinated β-Enamino Esters

S. Fustero, Antonio Simón-Fuentes, B. Pina, 1997 .

Synthesis and C-alkylation of C-protected β-enamino acid derivatives from oxa- thia- and imidazolines

S. Fustero, E. Aguilar, A. Asensio, 1999 .

Diastereoselective synthesis of fluorinated, seven-membered beta-amino acid derivatives via ring-closing metathesis.

María Sánchez-Roselló, S. Fustero, C. Ramírez de Arellano, 2003, Organic letters.

1,3-Amino Alcohols from 4-Amino-1-aza Dienes. Diastereo- and Enantioselective Approach to the Four Diastereoisomers of the N- Terminal Amino Acid Component of Nikkomycins B and BX.

S. Fustero, J. Barluenga, E. Aguilar, 1994 .

Asymmetric Vinylogous Mukaiyama‐Mannich Reactions of Heterocyclic Siloxy Dienes with Ellman's Fluorinated Aldimines

M. Medio‐Simón, Haibo Mei, Jianlin Han, 2019, Advanced Synthesis & Catalysis.

Novel strategy for the synthesis of fluorinated -amino acid derivatives from ? 2-oxazolines

S. Fustero, A. Asensio, C. R. D. Arellano, 2001 .

Synthesis of Fluorinated and Non‐Fluorinated Bicyclic Amidines through Ring‐Closing Metathesis

S. Fustero, A. C. Cuñat, S. Flores, 2011 .

Diels–Alder cycloaddition reaction of unactivated 2-aza-1,3-dienes with dialkyl azodicarboxylates and heterocumulenes

V. Gotor, S. Fustero, J. Barluenga, 1986 .

Synthesis of 1,3-amino alcohols from 2-aza-1,3-dienes by reduction of 5,6-dihydro-2H-1,3-oxazines

J. Joglar, S. Fustero, J. Barluenga, 1991 .

Microwave-Assisted Tandem Cross Metathesis Intramolecular Aza-Michael Reaction: An Easy Entry to Cyclic β-Amino Carbonyl Derivatives.

C. Pozo, S. Fustero, Diego Jiménez, 2008 .

Stereoselective Synthesis of 1,3-Amino Alcohols and 1,3-Amino Ketones.

S. Fustero, J. Barluenga, E. Aguilar, 1992 .

An Improved Diastereoselective Synthesis of 1,3-Amino Alcohols by Reduction of 1,3-Amino Ketone Derivatives.

S. Fustero, J. Barluenga, E. Aguilar, 1991 .

Diastereoselective Synthesis of γ-Amino Alcohols with Three Chiral Centers by Reduction of β-Amino Ketones and Derivatives.

S. Fustero, J. Barluenga, B. Olano, 1986 .

Fluorous TBAF: a convenient and selective reagent for fluoride-mediated deprotections.

J. L. Aceña, S. Fustero, J. F. Sanz-Cervera, 2009, The Journal of organic chemistry.

Diastereoselective synthesis of 2-phenyl-3-(trifluoromethyl)piperazines as building blocks for drug discovery.

Ó. Delgado, Michiel Van Gool, María Sánchez-Roselló, 2014, The Journal of organic chemistry.

A New Tandem Cross Metathesis–Intramolecular Aza-Michael Reaction for the Synthesis of α,α-Difluorinated Lactams

María Sánchez-Roselló, C. Pozo, S. Fustero, 2012 .

Asymmetric Michael Addition in Synthesis of β-Substituted GABA Derivatives

Jianlin Han, V. Soloshonok, J. Escorihuela, 2022, Molecules.

Diastereoselectivity of the Addition of Propargylic Magnesium Reagents to Fluorinated Aromatic Sulfinyl Imines

M. Medio‐Simón, J. Escorihuela, S. Fustero, 2021, Organic letters.

Asymmetric Synthesis of Fluorinated Monoterpenic Alkaloid Derivatives from Chiral Fluoroalkyl Aldimines via the Pauson‐Khand Reaction

A. Riera, M. Medio‐Simón, Jianlin Han, 2020 .

Solution versus fluorous versus solid-phase synthesis of 2,5-disubstituted 1,3-azoles. Preliminary antibacterial activity studies.

M. Cynamon, S. Fustero, M. Murguía, 2009, The Journal of organic chemistry.

Chemistry of detrifluoroacetylatively in situ generated fluoro-enolates.

Haibo Mei, Jianlin Han, V. Soloshonok, 2019, Organic & biomolecular chemistry.

Recent Developments in the Chiral Brønsted Acid-catalyzed Allylboration Reaction with Polyfunctionalized Substrates.

S. Fustero, Elsa Rodríguez, Pablo Barrio, 2016, Chemical record.

Relay Catalysis: Enantioselective Synthesis of Cyclic Benzo‐Fused Homoallylic Alcohols by Chiral Brønsted Acid‐Catalyzed Allylboration/Ring Closing Metathesis

S. Fustero, Elsa Rodríguez, Rubén Lázaro, 2013 .

Tandem Organocatalytic Cycloaromatization/ Intramolecular Friedel-Crafts Alkylation Sequence for the Synthesis of Indolizinones and Pyrrolo-azepinone Derivatives.

C. del Pozo, María Sánchez-Roselló, S. Fustero, 2019, The Journal of organic chemistry.

γ-Silylboronates in the chiral Brønsted acid-catalysed allylboration of aldehydes.

T. Akiyama, S. Fustero, Elsa Rodríguez, 2015, Chemical communications.

Enantioselective Palladium-Catalyzed Oxidative β,β-Fluoroarylation of α,β-Unsaturated Carbonyl Derivatives.

C. del Pozo, F. Toste, S. Fustero, 2016, Angewandte Chemie.

Addition of Nucleophiles to Fluorinated Michael Acceptors

Andreas Lerchen, G. Haufe, S. Fustero, 2016 .

Olefin‐Bond Chemodifferentiation through Cross‐Metathesis Reactions: A Stereocontrolled Approach to Functionalized β2,3‐Amino Acid Derivatives

M. Haukka, F. Fülöp, L. Kiss, 2017 .

Fluorinated Imines in Tandem and Cycloaddition Reactions

J. Escorihuela, S. Fustero, 2023, Chemical record.

Asymmetric Synthesis of Indolines Through Intramolecular Shifting of Aromatic Sulfinyl Groups. Role of the π,π-Stacking Interactions in these Unusual SNAr Processes.

A. Poveda, C. Pozo, V. Marcos, 2009 .

Gold-Catalyzed Povarov-Type Reaction of Fluorinated Imino Esters and Furans.

C. del Pozo, María Sánchez-Roselló, S. Fustero, 2016, The Journal of organic chemistry.

Homoallylic o-halobenzylamines: asymmetric diversity-oriented synthesis of benzo-fused cyclic amines

C. Finamore, S. Fustero, Rubén Lázaro, 2017, Structural Chemistry.

A new and mild synthesis of β-amino acids from masked β-enamino acid derivatives

S. Fustero, E. Aguilar, M. D. Díaz, 1999 .

The Fluoro-Pauson-Khand Reaction in the Synthesis of Enantioenriched Nitrogenated Bicycles Bearing a Quaternary C-F Stereogenic Center.

M. Medio‐Simón, S. Fustero, N. Mateu, 2019, Organic letters.

Synthesis and application of β-substituted Pauson-Khand adducts: trifluoromethyl as a removable steering group.

A. Riera, C. del Pozo, S. Fustero, 2013, Angewandte Chemie.

Nitrogen-Containing OrganofluorineDerivatives: An Overview

María Sánchez-Roselló, J. L. Aceña, S. Fustero, 2009 .

Cross-Metathesis Reactions as an Efficient Tool in the Synthesis of Fluorinated Cyclic β-Amino Acids.

María Sánchez-Roselló, C. Pozo, J. L. Aceña, 2009 .

STEREOSELECTIVE MANNICH-TYPE REACTION OF AN ACYCLIC KETIMINE WITH A SUBSTITUTED CHLOROTITANIUM ENOLATE : EFFICIENT APPROACH TO D-ERYTHRO-ALPHA -TRIFLU OROMETHYL-BETA -HYDROXYASPARTIC UNITS

A. Volonterio, M. Zanda, S. Fustero, 1999 .

Mild and regiospecific reduction of masked 1,3-dicarbonyl derivatives to monocarbonyl compounds and primary and secondary amines

S. Fustero, J. Barluenga, E. Aguilar, 1988 .

Reaction of Diimines with Carbonyl Compounds. Synthesis of Dihydropyrimidines

V. Gotor, S. Fustero, J. Barluenga, 1979 .

Synthesis of Diimines and Dihydropyrimidines

V. Gotor, S. Fustero, J. Barluenga, 1974 .

New cathepsin inhibitors to explore the fluorophilic properties of the S2 pocket of cathepsin B: design, synthesis, and biological evaluation.

J. Bajorath, M. Gütschow, F. Cañada, 2011, Chemistry.

Recent Developments and Applications of the Chiral Bronsted Acid Catalyzed Allylboration of Carbonyl Compounds

Matthew N. Grayson, S. Fustero, Pablo Barrio, 2018 .

A metal-free and regioselective approach to (Z)-β-fluorovinyl sulfones and their chemoselective hydrogenation to β-fluoroalkyl sulfones

S. Fustero, Raquel Román, Pablo Barrio, 2018 .

First Fluorous Synthesis of Fluorinated Uracils

C. Pozo, J. L. Aceña, S. Fustero, 2006 .

Intramolecular Hydroamination of Difluoropropargyl Amides: Regioselective Synthesis of Fluorinated β- and γ-Lactams‖

G. Hammond, Paula Bello, C. Pozo, 2007 .

Tandem gold self-relay catalysis for the synthesis of 2,3-dihydropyridin-4(1 H)-ones: combination of σ and π Lewis acid properties of gold salts.

C. del Pozo, María Sánchez-Roselló, S. Fustero, 2014, Chemistry.

Microwave-assisted tandem organocatalytic peptide-coupling intramolecular aza-Michael reaction: α,β-unsaturated N-acyl pyrazoles as Michael acceptors.

C. del Pozo, María Sánchez-Roselló, S. Fustero, 2014, Chemistry.

Role of the gem-difluoro moiety in the tandem ring-closing metathesis-olefin isomerization: regioselective preparation of unsaturated lactams.

C. del Pozo, María Sánchez-Roselló, J. L. Aceña, 2006, The Journal of organic chemistry.

First Highly Diastereoselective Synthesis of syn α-Methyl β-Fluoroalkyl β-Amino Esters

A. Arellano, S. Fustero, A. Simón, 1999 .

Asymmetric Tandem Reactions: New Strategies and Applications

S. Fustero, Pablo Barrio, Silvia Catalan‐Munoz, 2013 .

A new method for the regioselective synthesis of β-enamino acid derivatives

S. Fustero, R. Carlón, M. D. Díaz, 1993 .

A concise, asymmetric synthesis of tetramic acid derivatives.

S. Fustero, C. Ramírez de Arellano, M. García de la Torre, 2002, Organic letters.

An exceptionally simple and unexpected' one-pot synthesis of new 4,6-diazasemibullvalenes

X. Solans, S. Fustero, J. Barluenga, 1990 .

Tandem cross enyne metathesis (CEYM)–intramolecular Diels–Alder reaction (IMDAR). An easy entry to linear bicyclic scaffolds

C. del Pozo, María Sánchez-Roselló, S. Fustero, 2015, Beilstein journal of organic chemistry.

N-sulfinyl amines as a nitrogen source in the asymmetric intramolecular aza-Michael reaction: total synthesis of (-)-pinidinol.

Pablo Barrio, C. del Pozo, María Sánchez-Roselló, 2010, Chemistry.

Differential reactivity of fluorinated homopropargylic amino esters vs gold(I) salts. The role of the nitrogen protecting group

María Sánchez-Roselló, C. Pozo, S. Fustero, 2015 .

Stereoselective Syntheses of Allylic Amines Through Reduction of 1-Azadiene Intermediates

J. Joglar, F. Palacios, S. Fustero, 2000 .

Synthetic and biological applications of fluorous reagents as phase tags.

J. L. Aceña, S. Fustero, S. Catalán, 2012, Topics in current chemistry.

Synthesis of fluorinated allylic amines: Reaction of 2-(trimethylsilyl)ethyl sulfones and sulfoxides with fluorinated imines

C. Pozo, S. Fustero, A. C. Cuñat, 2007 .

Selective transformation of norbornadiene into novel functionalized azaheterocycles and β-amino esters with stereo- and regiocontrol.

L. Kiss, S. Fustero, Zsanett Benke, 2021, Chemistry, an Asian journal.

A Selective Synthesis of Fluorinated Cispentacin Derivatives

F. Fülöp, R. Sillanpää, L. Kiss, 2014 .

Efficient regio- and stereoselective access to novel fluorinated β-aminocyclohexanecarboxylates

F. Fülöp, R. Sillanpää, L. Kiss, 2013, Beilstein journal of organic chemistry.

A Stereocontrolled Protocol to Highly Functionalized Fluorinated Scaffolds through a Fluoride Opening of Oxiranes

F. Fülöp, L. Kiss, S. Fustero, 2016, Molecules.

Chemoselective, Substrate-directed Fluorination of Functionalized Cyclopentane β-Amino Acids.

M. Haukka, F. Fülöp, R. Sillanpää, 2016, Chemistry, an Asian journal.

Recent Developments in the Synthesis of Fluorinated -Amino Acids

J. L. Aceña, S. Fustero, Antonio Simón-Fuentes, 2010 .

Synthesis and reactivity of β-amino-α,β-unsaturated oxa- and thiazolines

S. Fustero, J. Barluenga, E. Aguilar, 1992 .

A Novel and Selective Fluoride Opening of Aziridines by XtalFluor‐E. Synthesis of Fluorinated Diamino Acid Derivatives.

M. Haukka, L. Kiss, S. Fustero, 2015 .

Synthesis of Fluorinated β-AminoAcids

K. Mikami, V. Soloshonok, María Sánchez-Roselló, 2011 .

Asymmetric Methods for Carbon‐Fluorine Bond Formation

J. Escorihuela, L. Kiss, S. Fustero, 2021, European Journal of Organic Chemistry.

Fluorine-containing drugs approved by the FDA in 2019

Haibo Mei, H. Moriwaki, Jianlin Han, 2020 .

Intramolecular rhodium-catalysed [2 + 2 + 2] cycloaddition of linear chiral N-bridged triynes: straightforward access to fused tetrahydroisoquinoline core.

M. Medio‐Simón, J. Escorihuela, S. Fustero, 2022, Organic & biomolecular chemistry.

Pentafluoroethylation of Carbonyl Compounds by HFC-125 via the Encapsulation of the K Cation with Glymes.

H. Mimura, N. Shibata, S. Fustero, 2021, The Journal of organic chemistry.

Asymmetric Synthesis of New ,-Difluorinated Cyclic Quaternary a-Amino Acid Derivatives

María Sánchez-Roselló, C. Pozo, S. Fustero, 2006 .

A De Novo Synthetic Route to 1,2,3,4-Tetrahydroisoquinoline Derivatives

F. Fülöp, L. Kiss, S. Fustero, 2018, Synlett.

The Ruthenium‐Catalyzed Domino Cross Enyne Metathesis/Ring‐Closing Metathesis in the Synthesis of Enantioenriched Nitrogen‐Containing Heterocycles

M. Medio‐Simón, Jianlin Han, V. Soloshonok, 2020, European Journal of Organic Chemistry.

Fluorinated Chaperone-β-Cyclodextrin Formulations for β-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease.

K. Higaki, E. Nanba, J. M. Benito, 2017, Journal of medicinal chemistry.

Synthesis and biological evaluation of new bicyclic fluorinated uracils through ring-closing metathesis.

J. L. Aceña, S. Fustero, J. F. Sanz-Cervera, 2006, The Journal of organic chemistry.

Chelation- and nonchelation-controlled reductions of .beta.-dicarbonyl compounds to 1,3-diols with three chiral centers

S. Fustero, J. Barluenga, B. Olano, 1987 .

Nucleic acid recognition and antiviral activity of 1,4-substituted terphenyl compounds mimicking all faces of the HIV-1 Rev protein positively-charged α-helix

L. Bedoya, J. Alcamí, S. Fustero, 2020, Scientific Reports.

Chelation- and Nonchelation-Controlled Reductions of β-Dicarbonyl Compounds to 1,3-Diols with Three Chiral Centers.

S. Fustero, J. Barluenga, B. Olano, 1987 .

Silylation of 2-aza-1,3-dienes. The first example of a thermally stable N-trimethyl-silyldivinylamine

J. Joglar, V. Gotor, S. Fustero, 1986 .

Silylation of 2-Aza-l,-3-dienes. The First Example of a Thermally Stable N-Trimethylsilyldivinylamine.

J. Joglar, V. Gotor, S. Fustero, 1986 .

Biorelevant fluorine-containing N-heterocycles

S. Fustero, A. A. Trabanco, Raquel Román, 2019, Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals.

Design, synthesis, and biological evaluation of novel fluorinated ethanolamines.

Ó. Delgado, G. Tresadern, M. Gütschow, 2011, Chemistry.

Tiratricol Neutralizes Bacterial Endotoxins and Reduces Lipopolysaccharide‐Induced TNF‐α Production in the Cell

E. Pérez-Payá, F. Albericio, J. L. Aceña, 2008, Chemical biology & drug design.

Copper-Catalyzed Regioselective Synthesis of (E)-β-Fluorovinyl Sulfones

S. Fustero, N. Mateu, Raquel Román, 2019, Molecules.

Regio-specific synthesis of new 1-(tert-butyl)-1H-pyrazolecarboxamide derivatives

S. Fustero, M. Murguía, C. R. D. Arellano, 2017 .

Diastereoselective Synthesis of Enantioenriched Trifluoromethylated Ethylenediamines and Isoindolines Containing Two Stereogenic Carbon Centers by Nucleophilic Trifluoromethylation Using HFC-23.

N. Shibata, S. Fustero, Takuya Saito, 2020, The Journal of organic chemistry.

Reduction of 5,6-dihydro-2H-1,3-oxazines. A simple approach to 1,3-aminoalcohols from 2-aza-1,3-dienes

J. Joglar, S. Fustero, J. Barluenga, 1989 .

Reduction of 5,6-Dihydro-2H-1,3-oxazines (III). A Simple Approach to 1,3-Amino Alcohols (IV), (V) from 2-Aza-1,3-dienes (I).

J. Joglar, S. Fustero, J. Barluenga, 1989 .

Diels-alder reaction of unactivated 2-aza-1,3-dienes with diethyl ketomalonate: A carbon dioxide equivalent

S. Fustero, J. Barluenga, F. González, 1989 .

Solution and fluorous phase synthesis of β,β-difluorinated 1-amino-1-cyclopentane carboxylic acid derivatives

María Sánchez-Roselló, C. Pozo, S. Fustero, 2008 .

Fluorine in Medicinal Chemistry and Chemical Biology. Edited by Iwao Ojima.

S. Fustero, 2009 .

Synthesis of 2-Oxo-2,5-dihydropyrroles; A Structural Reassignment

F. Palacios, V. Gotor, S. Fustero, 1981 .

A Versatile Approach to CF3 -Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors.

Ó. Delgado, Michiel Van Gool, G. Tresadern, 2015, Chemistry.

An Efficient and Simple Entry to N-Substituted beta-Enamino Acid Derivatives from 2-Alkyl-2-oxazolines and 2-Alkyl-2-thiazolines.

Marta G. de La Torre, S. Fustero, D. Diaz, 1996, The Journal of organic chemistry.

Frontispiece: Fluorine‐Containing Drugs Approved by the FDA in 2018

M. Medio‐Simón, Haibo Mei, Jianlin Han, 2019, Chemistry – A European Journal.

Frontispiece: Tailor‐Made Amino Acids and Fluorinated Motifs as Prominent Traits in Modern Pharmaceuticals

N. Meanwell, Haibo Mei, Jianlin Han, 2020 .

An enantio- and diastereoselective synthesis of fluorinated β-aminoalkyl-oxepine derivatives through mannich and ring-closing metathesis reactions

S. Fustero, J. F. Sanz-Cervera, F. Mojarrad, 2006 .

An Enantio‐ and Diastereoselective Synthesis of Fluorinated β‐Aminoalkyloxepin Derivatives Through Mannich and Ring‐Closing Metathesis Reactions.

S. Fustero, J. F. Sanz-Cervera, F. Mojarrad, 2007 .

Synthesis, growth and characterization of new 1,3,4 -thiadiazole-5-(n-substituted)-sulfonamides cristals

S. Fustero, J. Pedregosa, M. Arellano, 2006 .

Application of Metathesis Protocols to the Stereocontrolled Synthesis of Some Functionalized β-Amino Esters and Azaheterocycles.

L. Kiss, S. Fustero, Melinda Nonn, 2023, Chemical record.

Asymmetric Synthesis of Monofluorinated 1-Amino-1,2-dihydronaphthalene and 1,3-Amino Alcohol Derivatives.

G. Haufe, S. Fustero, Rubén Lázaro, 2016, Organic letters.

A Versatile Approach to CF3 -Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors.

Ó. Delgado, Michiel Van Gool, G. Tresadern, 2015, Chemistry.

Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001-2011).

Hong Liu, Jiang Wang, C. del Pozo, 2014, Chemical reviews.

A new strategy for the synthesis of fluorinated 3,4-dihydropyrimidinones

C. Pozo, J. L. Aceña, S. Fustero, 2009 .

Lewis Acid-Catalyzed Cyclization of 3-Amino-2-alkenimines. Synthesis of Quinolines

V. Gotor, S. Fustero, J. Barluenga, 1987 .

A Versatile Approach to CF3‐Containing 2‐Pyrrolidones by Tandem Michael Addition—Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors.

Ó. Delgado, G. Tresadern, L. Pérez-Benito, 2016 .

A practical entry to β-aryl-β-alkyl amino alcohols: application to the synthesis of a potent BACE1 inhibitor.

Ó. Delgado, Michiel Van Gool, S. Fustero, 2012, Organic & biomolecular chemistry.

Intramolecular Michael reaction of tert-butylsulfinyl ketimines: asymmetric synthesis of 3-substituted indanones.

M. Maestro, S. Fustero, A. Asensio, 2011, Organic letters.

Tandem nucleophilic addition-intramolecular aza-Michael reaction: facile synthesis of chiral fluorinated isoindolines.

Pablo Barrio, María Sánchez-Roselló, Santos Fustero, 2010, Organic letters.

Improved regioselectivity in pyrazole formation through the use of fluorinated alcohols as solvents: synthesis and biological activity of fluorinated tebufenpyrad analogs.

S. Fustero, M. Murguía, J. F. Sanz-Cervera, 2008, The Journal of organic chemistry.

Synthesis and application of β-substituted Pauson-Khand adducts: trifluoromethyl as a removable steering group.

A. Riera, C. del Pozo, S. Fustero, 2013, Angewandte Chemie.

Regioselectivity in intermolecular Pauson-Khand reactions of dissymmetric fluorinated alkynes.

Jean‐Claude Kizirian, A. Riera, Paula Bello, 2010, Organic letters.

A New Method for the Synthesis of Pyridines

V. Gotor, S. Fustero, J. Barluenga, 1975 .

Microwave-assisted organocatalytic enantioselective intramolecular aza-Michael reaction with α,β-unsaturated ketones.

C. del Pozo, María Sánchez-Roselló, S. Fustero, 2011, Chemistry.

Tandem gold self-relay catalysis for the synthesis of 2,3-dihydropyridin-4(1 H)-ones: combination of σ and π Lewis acid properties of gold salts.

C. del Pozo, María Sánchez-Roselló, S. Fustero, 2014, Chemistry.

An efficient entry to optically active anti- and syn-beta-amino-alpha-trifluoromethyl alcohols.

S. Fustero, A. Asensio, J. F. Sanz-Cervera, 2008, Organic Letters.

An Efficient Entry to Optically Active anti‐ and syn‐β‐Amino‐α‐trifluoromethyl Alcohols.

S. Fustero, A. Asensio, J. F. Sanz-Cervera, 2008 .

Nucleic acid recognition and antiviral activity of 1,4-substituted terphenyl compounds mimicking all faces of the HIV-1 Rev protein positively-charged α-helix

L. Bedoya, J. Alcamí, S. Fustero, 2020, Scientific Reports.