Jung-Chen Su

发表

RFX-1-dependent activation of SHP-1 inhibits STAT3 signaling in hepatocellular carcinoma cells.

Kuen-Feng Chen, Ping-Hui Tseng, Chun-Yu Liu, 2014, Carcinogenesis.

Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells

Kuen-Feng Chen, Chun-Yu Liu, C. Shiau, 2013, Breast Cancer Research.

Copper-obatoclax derivative complexes mediate DNA cleavage and exhibit anti-cancer effects in hepatocellular carcinoma.

Kuen-Feng Chen, Ping-Hui Tseng, C. Shiau, 2015, Chemico-biological interactions.

Synthesis and biological activity of obatoclax derivatives as novel and potent SHP-1 agonists.

Kuen-Feng Chen, Pei-Jer Chen, Chun-Yu Liu, 2012, European journal of medicinal chemistry.

RFX1–dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells

Kuen-Feng Chen, Ping-Hui Tseng, Chun-Yu Liu, 2014, Oncotarget.

Novel imidazopyridine suppresses STAT3 activation by targeting SHP-1

C. Shiau, Szu-Hsien Wu, Jung-Chen Su, 2018, Journal of enzyme inhibition and medicinal chemistry.

Cancer Therapy : Preclinical STAT 3 Mediates Regorafenib-Induced Apoptosis in Hepatocellular Carcinoma

Kuen-Feng Chen, C. Shiau, Yong-Shi Li, 2014 .

Design and Synthesis of Malonamide Derivatives as Antibiotics against Methicillin-Resistant Staphylococcus aureus

C. Shiau, Jung-Chen Su, Chang-Shi Chen, 2017, Molecules.

Naphtho[1,2-b]furan-4,5-dione induces apoptosis of oral squamous cell carcinoma: involvement of EGF receptor/PI3K/Akt signaling pathway.

Yeh-long Chen, C. Chien, Long-Sen Chang, 2010, European journal of pharmacology.

Naphtho[1,2-b]furan-4,5-dione disrupts Janus kinase-2 and induces apoptosis in breast cancer MDA-MB-231 cells.

Yeh-long Chen, C. Chien, Long-Sen Chang, 2010, Toxicology in vitro : an international journal published in association with BIBRA.

Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation.

Yeh-long Chen, C. Chien, Long-Sen Chang, 2010, Toxicology in vitro : an international journal published in association with BIBRA.

Naphtho[1,2-b]furan-4,5-dione inactivates EGFR and PI3K/Akt signaling pathways in human lung adenocarcinoma A549 cells.

Yeh-long Chen, C. Chien, Long-Sen Chang, 2010, Life sciences.

Development of erlotinib derivatives as CIP2A-ablating agents independent of EGFR activity.

Kuen-Feng Chen, Chun-Yu Liu, C. Shiau, 2012, Bioorganic & medicinal chemistry.

SC-2001 Overcomes STAT3-mediated Sorafenib Resistance through RFX-1/SHP-1 Activation in Hepatocellular Carcinoma

Kuen-Feng Chen, Ping-Hui Tseng, Chun-Yu Liu, 2014, Neoplasia.

Novel indoloquinoline derivative, IQDMA, induces G(2)/M phase arrest and apoptosis in A549 cells through JNK/p38 MAPK signaling activation.

C. Chien, Chih-Ming Lu, Shinne‐ren Lin, 2009, Life sciences.

In vitro and in vivo activity of a novel sorafenib derivative SC5005 against MRSA.

C. Shiau, Jung-Chen Su, Chang-Shi Chen, 2016, The Journal of antimicrobial chemotherapy.

Two novel SHP-1 agonists, SC-43 and SC-78, are more potent than regorafenib in suppressing the in vitro stemness of human colorectal cancer cells

C. Shiau, Yeu Su, T. Chao, 2018, Cell Death Discovery.

The tyrosine kinase inhibitor nintedanib activates SHP-1 and induces apoptosis in triple-negative breast cancer cells

Wen-Chun Tsai, Chun-Teng Huang, Pei-Yi Chu, 2017, Experimental &Molecular Medicine.

Disrupting VEGF-A paracrine and autocrine loops by targeting SHP-1 suppresses triple negative breast cancer metastasis

Pei-Yi Chu, Kuen-Feng Chen, Chun-Yu Liu, 2016, Scientific Reports.

Down-regulation of the JAK2/PI3K-mediated signaling activation is involved in Taiwan cobra cardiotoxin III-induced apoptosis of human breast MDA-MB-231 cancer cells.

C. Chien, Long-Sen Chang, Shinne‐ren Lin, 2010, Toxicon : official journal of the International Society on Toxinology.

Tamoxifen induces apoptosis through cancerous inhibitor of protein phosphatase 2A–dependent phospho-Akt inactivation in estrogen receptor–negative human breast cancer cells

Kuen-Feng Chen, Chun-Yu Liu, C. Shiau, 2014, Breast Cancer Research.

Use of a MCL-1 inhibitor alone to de-bulk melanoma and in combination to kill melanoma initiating cells

S. Robinson, C. Shiau, N. Mukherjee, 2016, Oncotarget.

Sequential combination of docetaxel with a SHP-1 agonist enhanced suppression of p-STAT3 signaling and apoptosis in triple negative breast cancer cells

Kuen-Feng Chen, Chun-Yu Liu, C. Shiau, 2017, Journal of Molecular Medicine.

Alteration of SHP-1/p-STAT3 Signaling: A Potential Target for Anticancer Therapy

Kuen-Feng Chen, Chun-Yu Liu, C. Shiau, 2017, International journal of molecular sciences.

Novel indoloquinoline derivative, IQDMA, inhibits STAT5 signaling associated with apoptosis in K562 cells

C. Chien, Long-Sen Chang, Shinne‐ren Lin, 2008, Journal of biochemical and molecular toxicology.

Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells

Kuen-Feng Chen, Chun-Yu Liu, C. Shiau, 2014, Breast Cancer Research and Treatment.

Sorafenib analogue SC‐60 induces apoptosis through the SHP‐1/STAT3 pathway and enhances docetaxel cytotoxicity in triple‐negative breast cancer cells

Kuen-Feng Chen, Chun-Yu Liu, C. Shiau, 2017, Molecular oncology.

Concomitant inactivation of the epidermal growth factor receptor, phosphatidylinositol 3‐kinase/Akt and Janus tyrosine kinase 2/signal transducer and activator of transcription 3 signalling pathways in cardiotoxin III‐treated A549 cells

C. Chien, Shinne‐ren Lin, Jung-Chen Su, 2010, Clinical and experimental pharmacology & physiology.

STAT3 Mediates Regorafenib-Induced Apoptosis in Hepatocellular Carcinoma

Kuen-Feng Chen, C. Shiau, Yong-Shi Li, 2014, Clinical Cancer Research.

A novel obatoclax derivative, SC-2001, induces apoptosis in hepatocellular carcinoma cells through SHP-1-dependent STAT3 inactivation.

Kuen-Feng Chen, Chun-Yu Liu, C. Shiau, 2012, Cancer letters.