Yanfang Zhao

发表

Design, synthesis and biological evaluation of novel thieno[3,2-d]pyrimidine derivatives possessing diaryl semicarbazone scaffolds as potent antitumor agents.

Jian Wang, P. Gong, Zijian Liu, 2014, European journal of medicinal chemistry.

Synthesis and in vitro antitumor activity of novel diaryl urea derivatives

X. Zhai, Danhua Ge, P. Gong, 2013 .

Design, synthesis and biological evaluation of novel 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 4-oxo-3,4-dihydrophthalazine-1-carboxamide moieties as c-Met kinase inhibitors.

Jinxing Hu, P. Gong, Zijian Liu, 2014, Bioorganic & medicinal chemistry.

Synthesis and Antitumor Activity of Sorafenib Analogs Containing a Tetrazole Moiety

Yanfang Zhao, Ye Tian, Simiao Yu, 2018, Chemical Research in Chinese Universities.

A novel small‐molecule activator of procaspase‐3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer xenografts

Ping Gong, Jingyu Yang, Yi Li, 2014, Molecular oncology.

Design, synthesis, and structure-activity relationships of novel benzothiazole derivatives bearing the ortho-hydroxy N-carbamoylhydrazone moiety as potent antitumor agents.

P. Gong, Lihui Wang, Yanfang Zhao, 2014, European journal of medicinal chemistry.

Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents.

Wei Li, Lei Cui, Yanfang Zhao, 2018, European journal of medicinal chemistry.

Design, synthesis and antitumor activity of novel indolin-2-one derivatives containing 4-thiazolidinone moiety

N. Xu, P. Gong, Zijian Liu, 2015, Chemical Research in Chinese Universities.

The interaction of 4-thiazolidinone derivatives containing indolin-2-one moiety with P-glycoprotein studied using K562 cell lines.

J. Tao, Jian Wang, P. Gong, 2015, European journal of medicinal chemistry.

Synthesis and Anticancer Activity of Indolin‐2‐one Derivatives Bearing the 4‐Thiazolidinone Moiety

Y. Liu, P. Gong, Wufu Zhu, 2012, Archiv der Pharmazie.

Design, synthesis and biological evaluation of novel 4-thiazolidinones containing indolin-2-one moiety as potential antitumor agent.

Ning Zhang, P. Gong, Yanfang Zhao, 2011, European journal of medicinal chemistry.

Multigram-scale synthesis of GSK 2,256,294, an inhibitor of soluble epoxide hydrolase in clinical evaluation

Yanfang Zhao, Siyu Fu, Ye Tian, 2022, Chemical Papers.

Evaluation of the Efficacy of Novel Oxazolidinone Analogues against Nontuberculous Mycobacteria In Vitro.

Yanfang Zhao, Liping Tang, Weiguo Zhao, 2015, Japanese journal of infectious diseases.

Discovery of 4-piperazinyl-2-aminopyrimidine derivatives as dual inhibitors of JAK2 and FLT3.

Yanfang Zhao, Yingxiu Li, Yajing Liu, 2019, European journal of medicinal chemistry.

Discovery of selective EGFR modulator to inhibit L858R/T790M double mutants bearing a N-9-Diphenyl-9H-purin-2-amine scaffold.

Jinxing Hu, P. Gong, Yanfang Zhao, 2018, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of new series of benzamide derivatives containing urea moiety as sEH inhibitors

Yanping Sun, Xiaolu Su, Yanfang Zhao, 2022, Bioorganic & Medicinal Chemistry Letters.

Synthesis and Antibacterial Activity of Novel Oxazolidinone Analogs Containing Substituted Thiazole/Fused-Bicyclic Groups

X. Zhai, P. Gong, Yanfang Zhao, 2006 .

Design, synthesis and biological evaluation of new Axl kinase inhibitors containing 1,3,4-oxadiazole acetamide moiety as novel linker.

P. Gong, Yanfang Zhao, Xiaofan Li, 2019, European journal of medicinal chemistry.

Novel methyl indolinone-6-carboxylates containing an indole moiety as angiokinase inhibitors.

Haotian Zhang, P. Gong, Yanfang Zhao, 2017, European journal of medicinal chemistry.

Recent Advances in Metal‐Catalyzed Decarboxylative Reactions of Vinyl Benzoxazinanones

Jialu Liu, Yanfang Zhao, Siyu Fu, 2021, Advanced Synthesis & Catalysis.

Ligand-based optimization to identify novel 2-aminobenzo[d]thiazole derivatives as potent sEH inhibitors with anti-inflammatory effects.

Yanping Sun, P. Gong, Yanfang Zhao, 2020, European journal of medicinal chemistry.

Discovery of novel diaryl urea derivatives bearing a triazole moiety as potential antitumor agents.

Haotian Zhang, P. Gong, Shasha Wu, 2016, European journal of medicinal chemistry.

Fibroblast activation protein α activatable theranostic pro-photosensitizer for accurate tumor imaging and highly-specific photodynamic therapy

Yanfang Zhao, Guihong Chai, Xiaoyu Xu, 2022, Theranostics.

Synthesis and Biological Evaluation of Novel 6‐Hydrazinyl‐2,4‐bismorpholino pyrimidine and 1,3,5‐Triazine Derivatives as Potential Antitumor Agents

P. Gong, Wufu Zhu, Yanfang Zhao, 2012, Archiv der Pharmazie.

Based on 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474), design, synthesis and biological evaluation of novel PI3Kα selective inhibitors.

Yu Wang, Yanfang Zhao, Yajing Liu, 2022, Bioorganic chemistry.

Palladium-catalyzed three-component tandem reaction of sulfonyl hydrazones, aryl iodides and allenes: highly stereoselective synthesis of (Z)-α-hydroxymethyl allylic sulfones

P. Gong, Yanfang Zhao, Mingze Qin, 2017 .

Design, synthesis and structure-activity relationship of oxazolidinone derivatives containing novel S4 ligand as FXa inhibitors.

P. Gong, Shasha Wu, Yanfang Zhao, 2015, European journal of medicinal chemistry.

The Application of Tandem Aza‐Wittig Reaction to Synthesize Artemisinin–Guanidine Hybrids and Their Anti‐Tumor Activity

X. Zhai, P. Li, P. Gong, 2011, Archiv der Pharmazie.

One-pot synthesis of N-fused 1,2,4-triazoles and related heterocycles via I2/TBHP-mediated oxidative C N bond formation

L. Ding, Yanfang Zhao, Yachuang Wu, 2018, Tetrahedron Letters.

Synthesis and anti-hepatitis B virus evaluation of novel ethyl 6-hydroxyquinoline-3-carboxylates in vitro.

X. Zhai, P. Gong, Yanfang Zhao, 2008, Bioorganic & medicinal chemistry.

Synthesis and in vitro anti-hepatitis B virus activities of some ethyl 6-bromo-5-hydroxy-1H-indole-3-carboxylates.

P. Gong, Yanfang Zhao, H. Chai, 2006, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 1H-benzimidazol-5-ols as potent HBV inhibitors.

P. Gong, Yanfang Zhao, Dong Chen, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and In‐Vitro Anti‐Hepatitis‐B Virus Activity of 6H‐[1]Benzothiopyrano[4,3‐b] quinolin‐10‐ols

P. Gong, Yanfang Zhao, Zebiao Li, 2009, Archiv der Pharmazie.

Synthesis and Anti‐HBV Activities Evaluation of New Ethyl 8‐Imidazolylmethyl‐7‐hydroxyquinoline‐3‐carboxylate Derivatives in vitro

X. Zhai, P. Gong, Yanfang Zhao, 2008, Archiv der Pharmazie.

Synthesis and antitumor activities of novel 1,4-disubstituted phthalazine derivatives.

P. Gong, Yanfang Zhao, Dong Chen, 2010, European journal of medicinal chemistry.

Palladium‐Catalyzed Three‐Component Tandem Reaction for One‐pot Highly Stereoselective Synthesis of (Z)‐α‐Hydroxymethyl Allylic Sulfones

P. Gong, Yanfang Zhao, Mingze Qin, 2018 .

Synthesis and biological evaluation of novel 2-(2-arylmethylene)hydrazinyl-4-aminoquinazoline derivatives as potent antitumor agents.

X. Zhai, Nan Jiang, P. Gong, 2012, European journal of medicinal chemistry.

Highly Stereoselective Synthesis of Imidazolidines through the Palladium(0)‐Catalyzed Three‐Component Reaction of 2,3‐Allenylamines, Organic Halides, and Imines

Jinxing Hu, P. Gong, Yanfang Zhao, 2017 .

Design, synthesis and biological evaluation of novel thieno[3,2-d]pyrimidine and quinazoline derivatives as potent antitumor agents.

P. Gong, Yanfang Zhao, Yuhong Dong, 2019, Bioorganic chemistry.

Palladium-catalyzed three-component tandem cyclization of buta-2,3-dien-1-ol, aryl iodides, and imines: an efficient protocol for the synthesis of oxazolidine derivatives

P. Gong, Yanfang Zhao, Yajing Liu, 2017 .

A novel and unusual method for C N bond formation between benzene ring and various amines

Yanfang Zhao, Yunlei Hou, Sicong Xu, 2021, Tetrahedron Letters.

Design, synthesis and structure-activity relationships of novel 4-phenoxyquinoline derivatives containing pyridazinone moiety as potential antitumor agents.

P. Gong, Yanfang Zhao, Huimin Liao, 2014, European journal of medicinal chemistry.

Copper(II)-mediated formation of oxazole-4-carbonitrile from acetophenone and coordinated cyanide anion via a radical coupling

P. Gong, Yanfang Zhao, Mingze Qin, 2017 .

Discovery andw biological evaluation of novel 6,7-disubstituted-4-(2-fluorophenoxy)quinoline derivatives possessing 1,2,3-triazole-4-carboxamide moiety as c-Met kinase inhibitors.

M. Cheng, P. Gong, Rui-Juan Li, 2014, Bioorganic & medicinal chemistry.

Synthesis and anti-tumor activity of 2-amino-3-cyano-6-(1H-indol-3-yl)-4-phenylpyridine derivatives in vitro.

Yucheng Gu, P. Gong, Yanfang Zhao, 2011, European journal of medicinal chemistry.

Synthesis and antitumor activities of novel 4-morpholinothieno[3,2-d]pyrimidine derivatives

P. Gong, Yanfang Zhao, Junjie Ma, 2014, Chemical Research in Chinese Universities.

Design and synthesis of biaryloxazolidinone derivatives containing a rhodanine or thiohydantoin moiety as novel antibacterial agents against Gram-positive bacteria.

H. Lei, Yanfang Zhao, Yachuang Wu, 2019, Bioorganic & medicinal chemistry letters.

Discovery of novel 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 5-(aminomethylene)pyrimidine-2,4,6-trione moiety as c-Met kinase inhibitors.

M. Cheng, P. Gong, Qidong Tang, 2014, Bioorganic & medicinal chemistry.

Design, synthesis, and structure-activity relationships of novel 6,7-disubstituted-4-phenoxyquinoline derivatives as potential antitumor agents.

P. Gong, Qidong Tang, Yanfang Zhao, 2013, European journal of medicinal chemistry.

Discovery of novel 4-(2-fluorophenoxy)quinoline derivatives bearing 4-oxo-1,4-dihydrocinnoline-3-carboxamide moiety as c-Met kinase inhibitors.

P. Gong, Yanfang Zhao, Yali Gao, 2013, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of novel pteridinone derivatives possessing a hydrazone moiety as potent PLK1 inhibitors.

Yanfang Zhao, Yajing Liu, Liangyu Zhu, 2020, Bioorganic & medicinal chemistry letters.

Design, synthesis and antitumor activity of novel artemisinin derivatives using hybrid approach.

X. Zhai, Wufu Zhu, Yanfang Zhao, 2011, Chemical & pharmaceutical bulletin.

Design, synthesis and biological evaluation of novel 2,4-diaminopyrimidine derivatives as potent antitumor agents

P. Gong, Yanfang Zhao, Gang Hu, 2019, New Journal of Chemistry.

Synthesis and antibacterial activity of oxazolidinone derivatives containing nitro heteroaromatic moiety

Lei Cui, Yanfang Zhao, Yachuang Wu, 2018, Chemical Research in Chinese Universities.

Design and synthesis of biaryloxazolidinone derivatives containing amide or acrylamide moiety as novel antibacterial agents against Gram-positive bacteria.

H. Lei, Yanfang Zhao, Yachuang Wu, 2019, Bioorganic & medicinal chemistry letters.

Optimization of biaryloxazolidinone as promising antibacterial agents against antibiotic-susceptible and antibiotic-resistant gram-positive bacteria.

Yanfang Zhao, Yingxiu Li, Yajing Liu, 2019, European journal of medicinal chemistry.

Synthesis and in vitro-Anti-hepatitis B Virus Activities of Several Ethyl 5-Hydroxy-1H-indole-3-carboxylates1

P. Gong, Yanfang Zhao, H. Chai, 2006 .

Synthesis and in vitro anti-hepatitis B virus activities of some ethyl 5-hydroxy-1H-indole-3-carboxylates.

P. Gong, Yanfang Zhao, H. Chai, 2006, Bioorganic & medicinal chemistry.

Discovery of a novel class anti-proliferative agents and potential inhibitors of EGFR tyrosine kinases based on 4-anilinotetrahydropyrido[4,3-d]pyrimidine scaffold: Design, synthesis and biological evaluations.

Yong Zhang, P. Gong, Meng-Yue Zhao, 2015, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of thieno[3,2-d]pyrimidine derivatives containing aroyl hydrazone or aryl hydrazide moieties for PI3K and mTOR dual inhibition.

Yanfang Zhao, Siyu Fu, Ye Tian, 2020, Bioorganic chemistry.

Design, synthesis and biological activity of novel 2,3,4,5-tetra-substituted thiophene derivatives as PI3Kα inhibitors with potent antitumor activity.

Ming Sun, Juan Xie, Yanfang Zhao, 2020, European journal of medicinal chemistry.

A rapid and sensitive LC-MS/MS method for evaluation of the absolute oral bioavailability of a novel c-Met tyrosine kinase inhibitor QBH-196 in rats.

Jin Sun, Zhonggui He, Chunnuan Wu, 2015, Biomedical chromatography : BMC.

Design, Synthesis, and Biological Evaluation of 4‐Phenoxyquinoline Derivatives Containing Benzo[d]thiazole‐2‐yl Urea as c‐Met Kinase Inhibitors

P. Gong, Zijian Liu, Yu Wang, 2016, Archiv der Pharmazie.

2-Aminopyrimidine derivatives as selective dual inhibitors of JAK2 and FLT3 for the treatment of acute myeloid leukemia.

Yanfang Zhao, Yajing Liu, Chen Wang, 2023, Bioorganic chemistry.

Novel hydrazone moiety-bearing aminopyrimidines as selective inhibitors of epidermal growth factor receptor T790M mutant.

T. Wang, H. Xie, Zonghui Ma, 2015, European journal of medicinal chemistry.

Targeting procaspase-3 with WF-208, a novel PAC-1 derivative, causes selective cancer cell apoptosis

Chunfu Wu, Li-hui Wang, Jingyu Yang, 2015, Journal of cellular and molecular medicine.

Design, synthesis and biological evaluation of novel c-Met/HDAC dual inhibitors.

P. Gong, Yanfang Zhao, Mingze Qin, 2020, Bioorganic & medicinal chemistry letters.

Discovery of [1,2,4]Triazolo[4,3- a]pyridines as Potent Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction.

H. Xie, Haotian Zhang, P. Gong, 2019, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of novel dihydropteridone derivatives possessing oxadiazoles moiety as potent inhibitors of PLK1.

Xinzi He, Yanfang Zhao, Yajing Liu, 2023, European journal of medicinal chemistry.

Discovery of 4-Arylindolines Containing a Thiazole Moiety as Potential Antitumor Agents Inhibiting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction.

Li-hui Wang, Haotian Zhang, Yanfang Zhao, 2021, Journal of medicinal chemistry.

Discovery of the programmed cell death-1/programmed cell death-ligand 1 interaction inhibitors bearing an indoline scaffold.

H. Xie, Haotian Zhang, Yanfang Zhao, 2019, European journal of medicinal chemistry.

Facile synthesis of 3-amino-5-aryl-1,2,4-oxadiazoles via PIDA-mediated intramolecular oxidative cyclization

Di Wu, P. Gong, Yanfang Zhao, 2016 .

Facile Synthesis of 3‐Amino‐5‐aryl‐1,2,4‐oxadiazoles via PIDA‐Mediated Intramolecular Oxidative Cyclization.

Di Wu, P. Gong, Yanfang Zhao, 2016 .

Designing, synthesis and antibacterial evaluation of novel oxazolidinone derivatives nitrogen-containing fused heterocyclic moiety.

Yanfang Zhao, Yachuang Wu, Xiudong Ding, 2020, Bioorganic & medicinal chemistry letters.

An Update on the Structure of Oxazolidinone Analogs and a Comparison with Linezolid in Terms of In Vitro and Intracellular Efficacy against Clinically Relevant Bacterial Species.

P. Gong, Yanfang Zhao, Di Wang, 2017, Japanese journal of infectious diseases.

Promising in vitro and in vivo inhibition of multidrug-resistant Helicobacter pylori by linezolid and novel oxazolidinone analogues.

Yanfang Zhao, Jingdong Shi, Ying Jiang, 2016, Journal of global antimicrobial resistance.

In vitro and intracellular activity of 4-substituted piperazinyl phenyl oxazolidinone analogues against Mycobacterium tuberculosis.

H. Lei, P. Gong, Zijian Liu, 2014, The Journal of antimicrobial chemotherapy.

Design, synthesis and 3D-QSAR analysis of novel 2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine derivatives as potential antitumor agents.

X. Zhai, Hongyu Zhou, Di Wu, 2012, European journal of medicinal chemistry.

Synthesis, and docking studies of phenylpyrimidine-carboxamide derivatives bearing 1H-pyrrolo[2,3-b]pyridine moiety as c-Met inhibitors.

Shan Xu, Qidong Tang, Pengwu Zheng, 2016, Bioorganic & medicinal chemistry.

Discovery and rational design of 2-aminopyrimidine-based derivatives targeting Janus kinase 2 (JAK2) and FMS-like tyrosine kinase 3 (FLT3).

P. Gong, Yanfang Zhao, Yingxiu Li, 2020, Bioorganic chemistry.

Design, synthesis, and biological evaluation of 4-phenoxyquinoline derivatives as potent c-Met kinase inhibitor.

P. Gong, Yanfang Zhao, Yingxiu Li, 2019, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of novel thieno[3,2-d]pyrimidine derivatives containing diaryl urea moiety as potent antitumor agents.

P. Gong, Dazhuang Zuo, Zijian Liu, 2014, European journal of medicinal chemistry.

Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety.

Yanfang Zhao, Mingze Qin, Xiudong Ding, 2019, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of novel 2,4-bismorpholinothieno[3,2-d]pyrimidine and 2-morpholinothieno[3,2-d]pyrimidinone derivatives as potent antitumor agents.

Yanfang Zhao, Yufei Han, Tianyu Ye, 2020, Bioorganic chemistry.

Discovery of novel 7,7-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidines as ATR inhibitors based on structure-based drug design.

Yanfang Zhao, Dexiao Yang, Hao Yue, 2022, European journal of medicinal chemistry.

MZH29 is a novel potent inhibitor that overcomes drug resistance FLT3 mutations in acute myeloid leukemia

Benhong Xu, W. Ge, P. Gong, 2017, Leukemia.

Medicinal chemistry strategies targeting NLRP3 inflammasome pathway: A recent update from 2019 to mid-2023.

Yanfang Zhao, Xinzi He, Zechen Wang, 2023, European journal of medicinal chemistry.

Structure-based drug design, synthesis, and biological evaluation of novel 1,3,5-triazine or pyrimidine derivatives containing benzoyl hydrazine moiety as PI3Kα selective inhibitors.

Yanfang Zhao, Siyu Fu, Jiuyu Liu, 2023, Bioorganic chemistry.

Design and Synthesis of 1,3,5-Triazines or Pyrimidines Containing Dithiocarbamate Moiety as PI3Kα Selective Inhibitors.

Yanfang Zhao, Yajing Liu, Siyu Fu, 2023, ACS medicinal chemistry letters.

Discovery of a novel series of hDHODH inhibitors with anti-pulmonary fibrotic activities.

Yuyang Jiang, Yanfang Zhao, Guowei Gong, 2019, Bioorganic chemistry.

Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumor agents with selective inhibition of gefitinib-resistant H1975 cancer cells

P. Gong, Yanfang Zhao, Ye Tian, 2017 .

Design, synthesis and biological evaluation of novel pteridinone derivatives as potent dual inhibitors of PLK1 and BRD4

P. Gong, Yanfang Zhao, Yajing Liu, 2020 .

Design, Synthesis and Biological Evaluation of Novel 4‐Thiazolidinones Containing Indolin‐2‐one Moiety as Potential Antitumor Agent.

P. Gong, Yanfang Zhao, Guogang Zhang, 2011 .

Discovery andw biological evaluation of novel 6,7-disubstituted-4-(2-fluorophenoxy)quinoline derivatives possessing 1,2,3-triazole-4-carboxamide moiety as c-Met kinase inhibitors.

Rui-Juan Li, Yanfang Zhao, Huimin Liao, 2014, Bioorganic & medicinal chemistry.

Palladium-catalyzed three-component tandem reaction of sulfonyl hydrazones, aryl iodides and allenes: highly stereoselective synthesis of (Z)-α-hydroxymethyl allylic sulfones

P. Gong, Yanfang Zhao, Mingze Qin, 2017 .

Synthesis and anti-tumor activity of 2-amino-3-cyano-6-(1H-indol-3-yl)-4-phenylpyridine derivatives in vitro.

Yucheng Gu, P. Gong, Yanfang Zhao, 2011, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of novel substituted benzamide derivatives bearing a 1,2,3-triazole moiety as potent human dihydroorotate dehydrogenase inhibitors.

P. Gong, Yanfang Zhao, L. Cai, 2018, Bioorganic chemistry.

Design, synthesis and antitumor activity of novel 6,7-dimethoxyquinazoline derivatives containing diaryl urea moiety

Zijian Liu, Shasha Wu, Yanfang Zhao, 2015, Chemical Research in Chinese Universities.