M. Lanning

发表

Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signaling.

Alexander D. MacKerell, J. Yap, S. Fletcher, 2013, Organic & biomolecular chemistry.

Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules.

J. Yap, S. Fletcher, M. Lanning, 2017, Journal of medicinal chemistry.

Structure-based design of N-substituted 1-hydroxy-4-sulfamoyl-2-naphthoates as selective inhibitors of the Mcl-1 oncoprotein.

Alexander D. MacKerell, P. Wilder, J. Yap, 2016, European journal of medicinal chemistry.

Structural Modifications of (Z)-3-(2-aminoethyl)-5-(4- ethoxybenzylidene)thiazolidine-2,4-dione that Improve Selectivity for the Inhibition of Melanoma Cells Containing Active ERK Signaling

J. Yap, S. Fletcher, P. Shapiro, 2014 .

Small-Molecule Inhibitors of the Mcl-1 Oncoprotein

S. Fletcher, M. Lanning, Lijia Chen, 2014 .

Chromatography-free entry to substituted salicylonitriles: Mitsunobu-triggered domino reactions of salicylaldoximes.

S. Fletcher, M. Lanning, Ellis Whiting, 2015, The Journal of organic chemistry.

Perturbation of the c-Myc-Max protein-protein interaction via synthetic α-helix mimetics.

E. Prochownik, Huabo Wang, N. Cosford, 2015, Journal of medicinal chemistry.

Azodicarbonyl dimorpholide (ADDM): an effective, versatile, and water-soluble Mitsunobu reagent

S. Fletcher, M. Lanning, 2013 .

BRD4 Structure-Activity Relationships of Dual PLK1 Kinase/BRD4 Bromodomain Inhibitor BI-2536.

J. Strovel, M. Yoshioka, J. Yap, 2015, ACS medicinal chemistry letters.

Multi-Facial, Non-Peptidic α-Helix Mimetics

S. Fletcher, M. Lanning, 2015, Biology.

Structural Re‐engineering of the α‐Helix Mimetic JY‐1‐106 into Small Molecules: Disruption of the Mcl‐1–Bak‐BH3 Protein–Protein Interaction with 2,6‐Di‐Substituted Nicotinates

P. Wilder, J. Yap, S. Fletcher, 2016, ChemMedChem.

Towards more drug-like proteomimetics: two-faced, synthetic α-helix mimetics based on a purine scaffold.

P. Wilder, J. Yap, S. Fletcher, 2015, Organic & biomolecular chemistry.

Recapitulating the α-helix: nonpeptidic, low-molecular-weight ligands for the modulation of helix-mediated protein-protein interactions.

S. Fletcher, M. Lanning, 2013, Future medicinal chemistry.

Amphipathic α-helix mimetics based on a 1,2-diphenylacetylene scaffold.

Alexander D. MacKerell, P. Wilder, J. Yap, 2013, Organic letters.

Recapitulating the a-helix: nonpeptidic, low-molecular-weight ligands for the modulation of helix-mediated protein-protein

S. Fletcher, M. Lanning, 2013 .

Rationally Designed Polypharmacology: α‐Helix Mimetics as Dual Inhibitors of the Oncoproteins Mcl‐1 and HDM2

A. MacKerell, P. Wilder, S. Fletcher, 2020, ChemMedChem.