X. Wan

发表

A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling.

Wei Zhang, Niu Huang, Li Li, 2013, Journal of medicinal chemistry.

Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes.

A. Burlingame, J. Taunton, K. Gajiwala, 2017, Journal of the American Chemical Society.

Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking.

J. Irwin, B. Shoichet, J. Taunton, 2019, Journal of the American Chemical Society.

Reversible lysine-targeted probes reveal residence time-based kinase selectivity

A. Burlingame, J. Taunton, J. Lapek, 2022, Nature Chemical Biology.

More than just a GPCR ligand: structure-based discovery of thioridazine derivatives as Pim-1 kinase inhibitors

Niu Huang, Li Li, Wei Zhang, 2014 .

Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors

Yurii S. Moroz, J. Irwin, B. Shoichet, 2022, bioRxiv.

Reversible lysine-targeted probes reveal residence time-based kinase selectivity

A. Burlingame, J. Taunton, J. Lapek, 2022, Nature Chemical Biology.

Molecular Determinants of Enterovirus 71 Viral Entry

Wenhui Li, Zhenglun Liang, Xinliang Shen, 2012, The Journal of Biological Chemistry.

Ab Initio Modeling and Experimental Assessment of Janus Kinase 2 (JAK2) Kinase-Pseudokinase Complex Structure

Xiaobo Wan, Yue Ma, Niu Huang, 2013, PLoS Comput. Biol..

Phosphorylation of Mutationally Introduced Tyrosine in the Activation Loop of HER2 Confers Gain-of-Function Activity

Yibo Gao, She Chen, Lin Li, 2015, PloS one.

Structure-based discovery of inhibitors of the SARS-CoV-2 Nsp14 N7-methyltransferase

Yurii S. Moroz, J. Irwin, B. Shoichet, 2023, bioRxiv.

Structure and Specificity of the Bacterial Cysteine Methyltransferase Effector NleE Suggests a Novel Substrate in Human DNA Repair Pathway

J. Chen, She Chen, Xiaojun Ding, 2014, PLoS pathogens.

Structural mechanism of ubiquitin and NEDD8 deamidation catalyzed by bacterial effectors that induce macrophage-specific apoptosis

Ting Li, F. Shao, X. Wan, 2012, Proceedings of the National Academy of Sciences.

A structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family

Yue Xu, F. Shao, Qiuhe Lu, 2014, eLife.

Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90.

A. Burlingame, J. Taunton, A. Cuesta, 2020, Journal of the American Chemical Society.

Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking.

J. Irwin, B. Shoichet, J. Taunton, 2019, Journal of the American Chemical Society.

Large library docking for novel SARS‐CoV‐2 main protease non‐covalent and covalent inhibitors

Yurii S. Moroz, J. Irwin, B. Shoichet, 2023, Protein science : a publication of the Protein Society.

Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes.

A. Burlingame, J. Taunton, K. Gajiwala, 2017, Journal of the American Chemical Society.

Redesigning and Optimizing UCSF DOCK3.7 on Sunway TaihuLight

B. Schmidt, Guangwen Yang, Weiguo Liu, 2022, IEEE Transactions on Parallel and Distributed Systems.