H. Onishi

发表

Combining celecoxib with sorafenib synergistically inhibits hepatocellular carcinoma cells in vitro.

Masayo Umebayashi, T. Morisaki, Mitsuo Katano, 2013, Anticancer research.

Semi‐quantitative evaluation of CD44+/CD24− tumor cell distribution in breast cancer tissue using a newly developed fluorescence immunohistochemical staining method

Masao Tanaka, M. Kubo, M. Kai, 2011, Cancer science.

Surface-bound TGF-beta1 on effusion-derived exosomes participates in maintenance of number and suppressive function of regulatory T-cells in malignant effusions.

T. Morisaki, S. Nagai, H. Onishi, 2010, Anticancer research.

Patched 1-interacting Peptide Represses Fibrosis in Pancreatic Cancer to Augment the Effectiveness of Immunotherapy

Masafumi Nakamura, K. Ohuchida, A. Fujimura, 2019, Journal of immunotherapy.

Cancer immunotherapy using NKG2D and DNAM-1 systems.

T. Morisaki, H. Onishi, M. Katano, 2012, Anticancer research.

Efficacy of Intranodal Neoantigen Peptide-pulsed Dendritic Cell Vaccine Monotherapy in Patients With Advanced Solid Tumors: A Retrospective Analysis

Yusuke Nakamura, K. Kiyotani, A. Takeuchi, 2021, AntiCancer Research.

Combining cetuximab with killer lymphocytes synergistically inhibits human cholangiocarcinoma cells in vitro.

Masayo Umebayashi, T. Morisaki, Akifumi Kiyota, 2012, Anticancer research.

Liprin-α4 as a New Therapeutic Target for SCLC as an Upstream Mediator of HIF1α

Masayo Umebayashi, T. Morisaki, Katsuya Nakamura, 2019, AntiCancer Research.

CD24 suppresses malignant phenotype by downregulation of SHH transcription through STAT1 inhibition in breast cancer cells.

Masafumi Nakamura, Y. Oda, Masao Tanaka, 2016, Cancer letters.

Hedgehog signaling pathway mediates the progression of non‐invasive breast cancer to invasive breast cancer

Masao Tanaka, M. Kubo, M. Kai, 2011, Cancer science.

NFκB and TGFβ contribute to the expression of PTPN3 in activated human lymphocytes.

Masafumi Nakamura, A. Fujimura, Shu Ichimiya, 2020, Cellular immunology.

Interferon-γ suppresses transforming growth factor-β-induced invasion of gastric carcinoma cells through cross-talk of Smad pathway in a three-dimensional culture model

Masao Tanaka, T. Morisaki, Katsuya Nakamura, 2003, Oncogene.

Lymph Nodes as Anti-Tumor Immunotherapeutic Tools: Intranodal-Tumor-Specific Antigen-Pulsed Dendritic Cell Vaccine Immunotherapy

M. Kubo, T. Morisaki, Y. Nakamura, 2022, Cancers.

New Approach to Complete Video-assisted Thoracoscopic Lobectomy in T2 and T3 Non-Small Cell Lung Cancer.

S. Yunotani, Katsuya Nakamura, Masato Kato, 2015, Anticancer research.

Preoperative chemoradiotherapy using cisplatin plus S-1 can induce downstaging in patients with locally advanced (stage III) non-small-cell lung cancer.

Jun-ichi Motoshita, Masato Kato, N. Tsuruta, 2012, Anticancer research.

Hypoxia activates the hedgehog signaling pathway in a ligand‐independent manner by upregulation of Smo transcription in pancreatic cancer

M. Kai, Seiichi Odate, H. Onishi, 2011, Cancer science.

NKG2D-directed cytokine-activated killer lymphocyte therapy combined with gemcitabine for patients with chemoresistant metastatic solid tumors.

Masayo Umebayashi, T. Hirano, T. Morisaki, 2014, Anticancer research.

Gamma-secretase complexes regulate the responses of human pancreatic ductal adenocarcinoma cells to taxanes.

Masao Tanaka, T. Akiyoshi, K. Yamaguchi, 2010, Anticancer research.

An epithelial cell adhesion molecule- and CD3-bispecific antibody plus activated T-cells can eradicate chemoresistant cancer stem-like pancreatic carcinoma cells in vitro.

Masayo Umebayashi, T. Morisaki, Akifumi Kiyota, 2014, Anticancer research.

The Novel Selective Pan-TRK Inhibitor ONO-7579 Exhibits Antitumor Efficacy Against Human Gallbladder Cancer In Vitro.

Y. Oda, H. Onishi, M. Kawamoto, 2018, Anticancer research.

Masafumi Nakamura, Y. Oda, H. Sumimoto, 2017, Oncotarget.

Hypoxia and pancreatic ductal adenocarcinoma.

H. Onishi, A. Yamasaki, Kosuke Yanai, 2020, Cancer letters.

CD24 Modulates Chemosensitivity of MCF-7 Breast Cancer Cells.

A. Fujimura, H. Onishi, M. Kawamoto, 2017, Anticancer research.

NOTCH4 is a potential therapeutic target for triple-negative breast cancer.

Y. Oda, Masao Tanaka, M. Kubo, 2014, Anticancer research.

Hedgehog signaling pathway as a new therapeutic target in pancreatic cancer.

H. Onishi, M. Katano, 2014, World journal of gastroenterology.

ERAP2 is a novel target involved in autophagy and activation of pancreatic stellate cells via UPR signaling pathway.

Masafumi Nakamura, K. Ohuchida, Y. Oda, 2021, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

Immunotherapy approaches targeting regulatory T-cells.

T. Morisaki, H. Onishi, M. Katano, 2012, Anticancer research.

VEGFR2 is selectively expressed by FOXP3high CD4+ Treg

T. Morisaki, K. Nakano, H. Onishi, 2009, European journal of immunology.

The Hedgehog inhibitor suppresses the function of monocyte-derived dendritic cells from patients with advanced cancer under hypoxia.

Masayo Umebayashi, T. Morisaki, Akifumi Kiyota, 2013, Biochemical and biophysical research communications.

Nuclear expression of Y‐box binding protein‐1 is associated with poor prognosis in patients with pancreatic cancer and its knockdown inhibits tumor growth and metastasis in mice tumor models

Y. Oda, Masao Tanaka, S. Obika, 2016, International journal of cancer.

Intranodal Administration of Neoantigen Peptide-loaded Dendritic Cell Vaccine Elicits Epitope-specific T Cell Responses and Clinical Effects in a Patient with Chemorefractory Ovarian Cancer with Malignant Ascites

Yusuke Nakamura, K. Kiyotani, M. Kubo, 2020, Immunological investigations.

Streptococcal preparation OK-432: a new maturation factor of monocyte-derived dendritic cells for clinical use

E. Baba, Masao Tanaka, T. Morisaki, 2003, Cancer Immunology, Immunotherapy.

Oestrogen receptor-α contributes to the regulation of the hedgehog signalling pathway in ERα-positive gastric cancer

H. Onishi, M. Katano, M. Tanaka, 2010, British Journal of Cancer.

Three-dimensional two-layer collagen matrix gel culture model for evaluating complex biological functions of monocyte-derived dendritic cells.

E. Baba, Masao Tanaka, M. Kubo, 2004, Journal of immunological methods.

Hedgehog signaling regulates PDL-1 expression in cancer cells to induce anti-tumor activity by activated lymphocytes.

A. Fujimura, Masayo Umebayashi, T. Morisaki, 2016, Cellular immunology.

Hedgehog signaling pathway is a potential therapeutic target for gallbladder cancer

Y. Oda, Masao Tanaka, K. Nakano, 2014, Cancer science.

The Hedgehog inhibitor cyclopamine impairs the benefits of immunotherapy with activated T and NK lymphocytes derived from patients with advanced cancer

Masayo Umebayashi, T. Morisaki, Akifumi Kiyota, 2013, Cancer Immunology, Immunotherapy.

Long-term survival of a patient with recurrent gallbladder carcinoma, treated with chemotherapy, immunotherapy, and surgery: a case report

Masafumi Nakamura, H. Saitsu, T. Morisaki, 2018, Surgical Case Reports.

Stage IV gastric cancer successfully treated by multidisciplinary therapy including chemotherapy, immunotherapy, and surgery: a case report

Masafumi Nakamura, Jun-ichi Motoshita, T. Morisaki, 2017, Surgical Case Reports.

NKG 2 D-directed Cytokine-activated Killer Lymphocyte Therapy Combined with Gemcitabine for Patients with Chemoresistant Metastatic Solid Tumors

Masayo Umebayashi, T. Hirano, T. Morisaki, 2014 .

Combinatorial cytotoxicity of gemcitabine and cytokine-activated killer cells in hepatocellular carcinoma via the NKG2D-MICA/B system.

Masayo Umebayashi, T. Morisaki, Akifumi Kiyota, 2011, Anticancer research.

Dendritic cell-based combined immunotherapy with autologous tumor-pulsed dendritic cell vaccine and activated T cells for cancer patients: rationale, current progress, and perspectives

E. Baba, Masao Tanaka, M. Kubo, 2003, Human Cell.

A new method for rapid cytotoxic T-lymphocyte induction using a multiple cytokine cocktail.

Masayo Umebayashi, T. Morisaki, Akifumi Kiyota, 2012, Anticancer research.

Inclusive estimation of complex antigen presentation functions of monocyte-derived dendritic cells differentiated under normoxia and hypoxia conditions

Masao Tanaka, T. Morisaki, H. Onishi, 2012, Cancer Immunology, Immunotherapy.

Monocyte-derived dendritic cells that capture dead tumor cells secrete IL-12 and TNF-α through IL-12/TNF-α/NF-κB autocrine loop

E. Baba, Masao Tanaka, T. Morisaki, 2004, Cancer Immunology, Immunotherapy.

Dysfunctional and short-lived subsets in monocyte-derived dendritic cells from patients with advanced cancer.

E. Baba, Masao Tanaka, T. Morisaki, 2002, Clinical immunology.

Intratumoral FOXP3+VEGFR2+ regulatory T cells are predictive markers for recurrence and survival in patients with colorectal cancer.

Masao Tanaka, T. Morisaki, H. Onishi, 2013, Clinical immunology.

Intratumoral FOXP 3 + VEGFR 2 + regulatory T cells are predictive markers for recurrence and survival in patients with colorectal cancer

Masao Tanaka, T. Morisaki, H. Onishi, 2012 .

Combined Gemcitabine and Metronidazole Is a Promising Therapeutic Strategy for Cancer Stem-like Cholangiocarcinoma.

Masafumi Nakamura, Masayo Umebayashi, T. Morisaki, 2018, Anticancer research.

PTPN3 is a potential target for a new cancer immunotherapy that has a dual effect of T cell activation and direct cancer inhibition in lung neuroendocrine tumor

Masafumi Nakamura, A. Fujimura, Masayo Umebayashi, 2021, Translational oncology.

Catumaxomab with Activated T-cells Efficiently Lyses Chemoresistant EpCAM-positive Triple-negative Breast Cancer Cell Lines

Masafumi Nakamura, M. Kubo, Masayo Umebayashi, 2018, AntiCancer Research.

PTPN3 expressed in activated T lymphocytes is a candidate for a non-antibody-type immune checkpoint inhibitor

A. Fujimura, Masayo Umebayashi, T. Morisaki, 2019, Cancer Immunology, Immunotherapy.

Hypoxia but not normoxia promotes Smoothened transcription through upregulation of RBPJ and Mastermind-like 3 in pancreatic cancer.

H. Onishi, M. Katano, M. Kawamoto, 2016, Cancer letters.

Katsuya Nakamura, Masato Kato, A. Uchiyama, 2013, Anticancer research.

TrkB/BDNF signaling pathway is a potential therapeutic target for pulmonary large cell neuroendocrine carcinoma.

Masao Tanaka, Katsuya Nakamura, Masato Kato, 2013, Lung cancer.

Induction of cytotoxic T lymphocytes by CEA peptide-pulsed γδ T-cells isolated from patients with advanced cancer.

T. Morisaki, H. Onishi, M. Katano, 2011, Anticancer research.

Combination therapy with tumor cell-pulsed dendritic cells and activated lymphocytes for patients with disseminated carcinomas.

Masafumi Nakamura, H. Nakashima, T. Morisaki, 2005, Anticancer research.

Effects of periodontal pathogen-induced intestinal dysbiosis on transplant immunity in an allogenic skin graft model

Masafumi Nakamura, K. Kaku, Y. Okabe, 2023, Scientific Reports.

Protein-bound Polysaccharide-K Inhibits Hedgehog Signaling Through Down-regulation of MAML3 and RBPJ Transcription Under Hypoxia, Suppressing the Malignant Phenotype in Pancreatic Cancer.

A. Fujimura, H. Onishi, M. Katano, 2016, Anticancer research.

Brain-derived neurotrophic factor/tropomyosin-related kinase B signaling pathway contributes to the aggressive behavior of lung squamous cell carcinoma

Masafumi Nakamura, Y. Oda, Jun-ichi Motoshita, 2017, Laboratory Investigation.

Hedgehog Gli3 activator signal augments tumorigenicity of colorectal cancer via upregulation of adherence‐related genes

Yoshinao Oda, Y. Oda, K. Nakano, 2013, Cancer science.

Exosomes secreted from monocyte-derived dendritic cells support in vitro naive CD4+ T cell survival through NF-(kappa)B activation.

Masafumi Nakamura, E. Baba, Masao Tanaka, 2004, Cellular immunology.

Inhibition of Wnt signaling pathway decreases chemotherapy-resistant side-population colon cancer cells.

Haruo Tanaka, Masao Tanaka, Masafumi Nakamura, 2010, Anticancer research.

Evaluation of a dysfunctional and short-lived subset of monocyte-derived dendritic cells from cancer patients.

E. Baba, Masao Tanaka, T. Morisaki, 2005, Anticancer research.

A LARGE QUANTITY OF CD3− /CD19− /CD16− LYMPHOCYTES IN MALIGNANT PLEURAL EFFUSION FROM A PATIENT WITH RECURRENT CHOLANGIO CELL CARCINOMA

Masao Tanaka, T. Morisaki, F. Doi, 2002, Immunological investigations.

Dual blockade of phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer.

R. Wakabayashi, R. Mibu, K. Nakano, 2011, Cancer letters.

Protein-bound polysaccharide decreases invasiveness and proliferation in pancreatic cancer by inhibition of hedgehog signaling and HIF-1α pathways under hypoxia.

T. Morisaki, Seiichi Odate, H. Onishi, 2013, Cancer letters.

Hedgehog signaling pathway as a therapeutic target in various types of cancer

Mitsuo Katano, H. Onishi, M. Katano, 2011, Cancer science.

Lipopolysaccharide (LPS) increases the invasive ability of pancreatic cancer cells through the TLR4/MyD88 signaling pathway

Masafumi Nakamura, N. Sato, Masao Tanaka, 2009, Journal of surgical oncology.

C4orf47 contributes to the dormancy of pancreatic cancer under hypoxic conditions

Masafumi Nakamura, Y. Oda, Shu Ichimiya, 2023, Journal of Cancer.

Intratumoral CD8+ T/FOXP3+ cell ratio is a predictive marker for survival in patients with colorectal cancer

Masao Tanaka, T. Morisaki, Y. Kitaura, 2010, Cancer Immunology, Immunotherapy.

Hypoxic Conditions Promote Gemcitabine Sensitivity in a Pancreatic Cancer Stem Cell Line.

Masayo Umebayashi, T. Morisaki, H. Onishi, 2016, Anticancer research.

RBPJ and MAML3: Potential Therapeutic Targets for Small Cell Lung Cancer

H. Ogata, Masayo Umebayashi, T. Morisaki, 2018, AntiCancer Research.

Long-term vaccine therapy with autologous whole tumor cell-pulsed dendritic cells for a patient with recurrent rectal carcinoma.

E. Baba, T. Morisaki, H. Onishi, 2011, Anticancer research.

Hedgehog Inhibition Upregulates TRK Expression to Antagonize Tumor Suppression in Small Cell Lung Cancer Cells.

T. Morisaki, Katsuya Nakamura, S. Nagai, 2017, Anticancer research.

Reoxygenation from chronic hypoxia promotes metastatic processes in pancreatic cancer through the Hedgehog signaling

Masao Tanaka, K. Nakano, H. Onishi, 2014, Cancer science.

TrkB/BDNF Signaling Could Be a New Therapeutic Target for Pancreatic Cancer

A. Fujimura, Masayo Umebayashi, T. Morisaki, 2021, AntiCancer Research.

Regulatory T Cells

T. Morisaki, H. Onishi, M. Katano, 2016 .

Pancreatic Juice Exosomal MicroRNAs as Biomarkers for Detection of Pancreatic Ductal Adenocarcinoma

T. Ohtsuka, Masafumi Nakamura, M. Goggins, 2019, Annals of Surgical Oncology.

Objective response with lapatinib in patients with meningitis carcinomatosa derived from HER2/HER1-negative breast cancer

K. Yokohata, T. Morisaki, H. Onishi, 2011, International Journal of Clinical Oncology.

Masafumi Nakamura, Y. Oda, Katsuya Nakamura, 2022, AntiCancer Research.

GLI2 but not GLI1/GLI3 plays a central role in the induction of malignant phenotype of gallbladder cancer

Masafumi Nakamura, Y. Oda, A. Fujimura, 2021, Oncology reports.

Hedgehog inhibitor decreases chemosensitivity to 5‐fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer

M. Kai, H. Onishi, M. Katano, 2012, Cancer science.

Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh

Masao Tanaka, M. Kubo, T. Morisaki, 2010, Cancer Immunology, Immunotherapy.

Short-term and low-dose prednisolone administration reduces aromatase inhibitor-induced arthralgia in patients with breast cancer.

Masao Tanaka, M. Kubo, K. Yokohata, 2012, Anticancer research.

Contribution of pre-existing neoantigen-specific T cells to a durable complete response after tumor-pulsed dendritic cell vaccine plus nivolumab therapy in a patient with metastatic salivary duct carcinoma

Yusuke Nakamura, Masafumi Nakamura, M. Masuda, 2021, Immunological investigations.

Monocyte-derived dendritic cells that capture dead tumor cells secrete IL-12 and TNF-alpha through IL-12/TNF-alpha/NF-kappaB autocrine loop.

E. Baba, Masao Tanaka, T. Morisaki, 2004, Cancer immunology, immunotherapy : CII.

Prognostic significance of urine N1, N12-diacetylspermine in patients with non-small cell lung cancer.

Jun-ichi Motoshita, N. Tsuruta, H. Onishi, 2014, Anticancer research.

C4orf47 Contributes to the Induction of Stem-like Properties in Gallbladder Cancer Under Hypoxia

H. Onishi, Shinji Morisaki, Shogo Masuda, 2023, AntiCancer Research.

Future prospect of gallbladder therapy using Hedgehog signaling inhibitor.

H. Onishi, 2017, Chinese clinical oncology.

Asymptomatic adenocarcinoma arising from a gastric duplication cyst: A case report

Masafumi Nakamura, Hirofumi Yamamoto, R. Terasaka, 2016, International journal of surgery case reports.

PTPN3 Could Βe a Therapeutic Target of Pancreatic Cancer

A. Fujimura, Katsuya Nakamura, S. Nagai, 2022, AntiCancer Research.

Liprin-α4 as a Possible New Therapeutic Target for Pancreatic Cancer.

A. Fujimura, S. Nagai, H. Onishi, 2017, Anticancer research.

Transforming Growth Factor &bgr;1 Contributes to the Invasiveness of Pancreatic Ductal Adenocarcinoma Cells Through the Regulation of CD24 Expression

Masao Tanaka, Y. Kitaura, K. Nakano, 2011, Pancreas.

MAML3 Contributes to Induction of Malignant Phenotype of Gallbladder Cancer Through Morphogenesis Signalling Under Hypoxia

Masafumi Nakamura, Y. Oda, Shu Ichimiya, 2023, AntiCancer Research.

Combined immunotherapy with intracavital injection of activated lymphocytes, monocyte-derived dendritic cells and low-dose OK-432 in patients with malignant effusion.

E. Baba, M. Kubo, T. Morisaki, 2003, Anticancer research.

1664PLiprin-α4 could be a potential therapeutic target for pancreatic cancer

H. Onishi, M. Kawamoto, A. Yamasaki, 2017 .

Inhibition of PTPN3 Expressed in Activated Lymphocytes Enhances the Antitumor Effects of Anti-PD-1 Therapy in Head and Neck Cancer, Especially in Hypoxic Environments

A. Fujimura, Masayo Umebayashi, N. Komune, 2024, Journal of immunotherapy.

Combination of adoptive immunotherapy with Herceptin for patients with HER2-expressing breast cancer.

E. Baba, M. Kubo, T. Morisaki, 2003, Anticancer research.