L. Bloem

发表

Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model

D. Clawson, Eileen L. Considine, M. Uhlik, 2012, Investigational New Drugs.

Complete Inhibition of Anisomycin and UV Radiation but Not Cytokine Induced JNK and p38 Activation by an Aryl-substituted Dihydropyrrolopyrazole Quinoline and Mixed Lineage Kinase 7 Small Interfering RNA*

R. Campbell, Xiaohong Yu, C. Vlahos, 2005, Journal of Biological Chemistry.

Decreased p38 MAPK activity in end-stage failing human myocardium: p38 MAPK alpha is the predominant isoform expressed in human heart.

G. Sandusky, C. Vlahos, M. Esterman, 2001, Journal of molecular and cellular cardiology.

The serum angiotensinogen concentration and variants of the angiotensinogen gene in white and black children.

A. Manatunga, J. Pratt, D. Tewksbury, 1995, The Journal of clinical investigation.

Protein kinase C βII activation induces angiotensin converting enzyme expression in neonatal rat cardiomyocytes

P. Iversen, C. Vlahos, Lan Yu, 2003 .

Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling.

J. Dixon, C. Vlahos, W. Matter, 2001, Biochemical and biophysical research communications.

Parathyroid hormone (hPTH 1–38) stimulates the expression of UBP41, an ubiquitin‐specific protease, in bone

J. Onyia, S. R. Patanjali, J. P. Sluka, 2002, Journal of cellular biochemistry.

Characterization of LY3023414, a Novel PI3K/mTOR Dual Inhibitor Eliciting Transient Target Modulation to Impede Tumor Growth

P. Iversen, V. Wacheck, M. Mader, 2016, Molecular Cancer Therapeutics.

Spironolactone increases integrin β3 gene expression in kidney and heart muscle cells

J. Pratt, L. Bloem, T. Chun, 2002, Molecular and Cellular Endocrinology.

The fall in creatine levels and creatine kinase isozyme changes in the failing heart are reversible: complex post-transcriptional regulation of the components of the CK system.

J. Ingwall, M. Spindler, R. Gill, 2005, Journal of molecular and cellular cardiology.

ADAMTS-1: A cellular disintegrin and metalloprotease with thrombospondin motifs is a target for parathyroid hormone in bone.

K. Thirunavukkarasu, J. Onyia, J. Hock, 2000, Endocrinology.

Isolation of cDNA clones coding for human tissue factor: primary structure of the protein and cDNA.

K. Williams, A. Guha, W. Konigsberg, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Dynamic regulation of RGS2 in bone: potential new insights into parathyroid hormone signaling mechanisms.

K. Thirunavukkarasu, J. Onyia, J. Hock, 2000, Endocrinology.

Use of polymerase chain reaction to screen phage libraries.

L. Bloem, L. Yu, 1996, Methods in molecular biology.

Genetic variants in the epithelial sodium channel in relation to aldosterone and potassium excretion and risk for hypertension.

W. Ambrosius, J. Rebhun, P. Snyder, 1999, Hypertension.

Serum stimulation of quiescent human fibroblasts induces the synthesis of tissue factor mRNA followed by the appearance of tissue factor antigen and procoagulant activity

W. Konigsberg, L. Bloem, R. Bach, 1989, Journal of cellular physiology.

Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase.

R. Beavis, M. Donoghue, X. Wang, 2001, Journal of molecular and cellular cardiology.

Transgenic mice with cardiac-specific over-expression of MLK7 have increased mortality when exposed to chronic beta-adrenergic stimulation.

P. Iversen, Xiaohong Yu, J. Lorenz, 2004, Journal of molecular and cellular cardiology.

Racial differences in aldosterone excretion: a longitudinal study in children.

A. Manatunga, L. Bloem, J. H. Pratt, 1993, The Journal of clinical endocrinology and metabolism.

Analysis of the promoter sequence and the transcription initiation site of the mouse 5-HT1C serotonin receptor gene.

L. S. Bye, L. Bloem, J. Liu, 1993, Brain research. Molecular brain research.

A Novel, Selective Inhibitor of Fibroblast Growth Factor Receptors That Shows a Potent Broad Spectrum of Antitumor Activity in Several Tumor Xenograft Models

Hong-Yu Li, Daohong Chen, Sheng-Bin Peng, 2011, Molecular Cancer Therapeutics.

Functional Analysis of a Mutation Occurring between the Two In-frame AUG Codons of Human Angiotensinogen*

T. Nakajima, J. Lalouel, J. Pratt, 1999, The Journal of Biological Chemistry.

Potent Broad-spectrum of Anti-tumor Activity in Several Tumor Xenograft Models

Daohong Chen, Sheng-Bin Peng, Hong‐yu Li, 2011 .

Racial difference in the relationship of an angiotensin I-converting enzyme gene polymorphism to serum angiotensin I-converting enzyme activity.

A. Manatunga, L. Bloem, J. H. Pratt, 1996, Hypertension.

Aldosterone inhibits inducible nitric oxide synthase in neonatal rat cardiomyocytes.

J. Pratt, L. Bloem, T. Chun, 2003, Endocrinology.

The mouse 5-HT1C receptor contains eight hydrophobic domains and is X-linked.

H. Lester, N. Davidson, C. Kozak, 1991, Brain research. Molecular brain research.

Identification of a splice variant of the rat and human mineralocorticoid receptor genes

Chunlu Guo, L. Bloem, J. Pratt, 1995, The Journal of Steroid Biochemistry and Molecular Biology.

Association of the angiotensinogen gene to serum angiotensinogen in blacks and whites.

W. Ambrosius, T. Foroud, J. Pratt, 1997, Hypertension.

Structure—Function Studies of the Eighth Hydrophobic Domain of a Serotonin Receptor

J. Hurley, Lei Yu, L. Bloem, 1999, Journal of neurochemistry.

Relation of race and a polymorphism in the angiotensin I-converting enzyme gene to enzyme levels

A. Manatunga, L. Bloem, J. H. Pratt, 1993 .

Effect of C-terminal truncations on MLK7 catalytic activity and JNK activation.

Xiaohong Yu, L. Bloem, 2003, Biochemical and biophysical research communications.

A Novel, Selective Inhibitor of Fibroblast Growth Factor Receptors That Shows a Potent Broad Spectrum of Antitumor Activity in Several Tumor Xenograft Models

Daohong Chen, Sheng-Bin Peng, Hong‐yu Li, 2011, Molecular Cancer Therapeutics.

Capture of drug targets from live cells using a multipurpose immuno-chemo-proteomics tool.

R. Higgs, J. Hale, Tabetha M. Bonacci, 2009, Journal of proteome research.

Discovery and characterization of LY2784544, a small-molecule tyrosine kinase inhibitor of JAK2V617F

P. Iversen, R. Walgren, B. Zhao, 2013, Blood Cancer Journal.