H. Saito

发表

Contribution of BCR–ABL‐independent activation of ERK1/2 to acquired imatinib resistance in K562 chronic myeloid leukemia cells

N. Araki, T. Kawaguchi, Takeru Nambu, 2010, Cancer science.

Edoxaban Exerts Antioxidant Effects Through FXa Inhibition and Direct Radical-Scavenging Activity

H. Jono, M. Mukoyama, T. Irie, 2019, International journal of molecular sciences.

Co-administration of irinotecan decreases the plasma concentration of an active metabolite of amrubicin, amrubicinol in rats

J. Sasaki, A. Hamada, H. Saito, 2010, Cancer Chemotherapy and Pharmacology.

Relationship between clinicopathological characteristics and CYLD expression in patients with cholesteatoma

R. Minoda, H. Jono, T. Miwa, 2020, PloS one.

Effects of oral administration of S-1 on the pharmacokinetics of SN-38 , irinotecan active metabolite ...

A. Hamada, H. Saito, Kensuke Tazoe, 2019 .

Effects of Oral Administration of S-1 on the Pharmacokinetics of SN-38, Irinotecan Active Metabolite, in Patients With Advanced Colorectal Cancer

A. Hamada, H. Saito, Koji Yokoo, 2009, Therapeutic drug monitoring.

Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: pharmacological and toxicological implications.

H. Saito, 2010, Pharmacology & therapeutics.

Altered Pharmacokinetics of Cationic Drugs Caused by Down-Regulation of Renal Rat Organic Cation Transporter 2 (Slc22a2) and Rat Multidrug and Toxin Extrusion 1 (Slc47a1) in Ischemia/Reperfusion-Induced Acute Kidney Injury

K. Tomita, H. Nonoguchi, K. Inui, 2008, Drug Metabolism and Disposition.

(Slc22a2) and rMATE1 (Slc47a1) in ischemia/reperfusion-induced acute kidney injury

K. Tomita, H. Nonoguchi, K. Inui, 2008 .

Pharmacokinetic Impact of SLCO1A2 Polymorphisms on Imatinib Disposition in Patients With Chronic Myeloid Leukemia

T. Shuto, H. Kai, T. Kawaguchi, 2011, Clinical pharmacology and therapeutics.

Prospective evaluation of pharmacokinetically guided dosing of carboplatin in Japanese patients with cancer

M. Kondo, Y. Hasegawa, Y. Ando, 2010, Cancer science.

transporter SLCO1B3 and the efflux transporter AB

C. Hirayama, T. Kawaguchi, A. Hamada, 2011 .

Association of Genetic Polymorphisms in the Influx Transporter SLCO1B3 and the Efflux Transporter ABCB1 With Imatinib Pharmacokinetics in Patients With Chronic Myeloid Leukemia

C. Hirayama, T. Kawaguchi, A. Hamada, 2011, Therapeutic drug monitoring.

Involvement of Up-Regulation of Hepatic Breast Cancer Resistance Protein in Decreased Plasma Concentration of 7-Ethyl-10-hydroxycamptothecin (SN-38) by Coadministration of S-1 in Rats

T. Imai, Hiroshi Watanabe, T. Matsuzaki, 2007, Drug Metabolism and Disposition.

Development and evaluation of a vancomycin dosing nomogram to achieve the target area under the concentration-time curve. A retrospective study.

H. Jono, H. Saito, Yuki Narita, 2019, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events

Minoru Yoshida, A. Hamada, H. Saito, 2012, Clinical and Experimental Nephrology.

Phase I and Pharmacokinetic Study of Erlotinib Administered in Combination With Amrubicin in Patients With Previously Treated, Advanced Non–small Cell Lung Cancer

K. Katono, N. Masuda, A. Hamada, 2015, American journal of clinical oncology.

Relationship between an effective dose of imatinib, body surface area, and trough drug levels in patients with chronic myeloid leukemia

H. Mitsuya, C. Hirayama, Hiroshi Watanabe, 2009, International journal of hematology.

Interaction of Imatinib Mesilate with Human P-Glycoprotein

Hiroshi Watanabe, A. Hamada, H. Saito, 2003, Journal of Pharmacology and Experimental Therapeutics.

Pharmacokinetics of Amrubicin and Its Active Metabolite Amrubicinol in Lung Cancer Patients

I. Okamoto, J. Sasaki, M. Matsumoto, 2006, Therapeutic drug monitoring.

Population Pharmacokinetics and Adverse Events of Erlotinib in Japanese Patients with Non-small-cell Lung Cancer: Impact of Genetic Polymorphisms in Metabolizing Enzymes and Transporters.

J. Sasaki, T. Isobe, K. Kashiwabara, 2018, Biological & pharmaceutical bulletin.

Implementing Effective Exercise and Cognitive Training Interventions in the Community for the Prevention of Dementia

Takehide Kimura, H. Naoi, H. Saito, 2019, An Official Journal of the Japan Primary Care Association.

Toxico-Pathological Role of Hepatic Sulfotransferase (SULT) 1A1 in Acute Kidney Injuries

H. Saito, 2020 .

Alleviation of cisplatin-induced acute kidney injury using phytochemical polyphenols is accompanied by reduced accumulation of indoxyl sulfate in rats

K. Tomita, Y. Kohda, A. Hamada, 2011, Clinical and Experimental Nephrology.

Hepatic sulfotransferase as a nephropreventing target by suppression of the uremic toxin indoxyl sulfate accumulation in ischemic acute kidney injury.

H. Jono, Yuko Yamamoto, H. Saito, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Involvement of Pharmacists in Self-injection Treatment with Interferon for Patients with Multiple Sclerosis

M. Uchino, S. Yamashita, T. Hirahara, 2010 .

Role of P-glycoprotein in accumulation and cytotoxicity of amrubicin and amrubicinol in MDR1 gene-transfected LLC-PK1 cells and human A549 lung adenocarcinoma cells.

J. Sasaki, Hiroshi Watanabe, A. Hamada, 2008, Biochemical pharmacology.

Indoxyl Sulfate as a Mediator Involved in Dysregulation of Pulmonary Aquaporin-5 in Acute Lung Injury Caused by Acute Kidney Injury

H. Jono, Yuko Yamamoto, H. Saito, 2016, International journal of molecular sciences.

Association of SLCO1B3 polymorphism with intracellular accumulation of imatinib in leukocytes in patients with chronic myeloid leukemia.

H. Mitsuya, T. Kawaguchi, Takeru Nambu, 2011, Biological & pharmaceutical bulletin.

Enhanced renal accumulation of cisplatin via renal organic cation transporter deteriorates acute kidney injury in hypomagnesemic rats

T. Matsuzaki, A. Hamada, H. Saito, 2009, Clinical and Experimental Nephrology.

Regulation of Renal Organic Ion Transporters in Cisplatin-Induced Acute Kidney Injury and Uremia in Rats

T. Morisaki, T. Matsuzaki, A. Hamada, 2008, Pharmaceutical Research.

Phase I and pharmacokinetic study of amrubicin, a synthetic 9-aminoanthracycline, in patients with refractory or relapsed lung cancer

I. Okamoto, J. Sasaki, A. Hamada, 2006, Cancer Chemotherapy and Pharmacology.

P-glycoprotein mediates efflux transport of darunavir in human intestinal Caco-2 and ABCB1 gene-transfected renal LLC-PK1 cell lines.

Arun K. Ghosh, H. Mitsuya, Y. Koh, 2009, Biological & pharmaceutical bulletin.

Constitutive Overexpression of P-glycoprotein, Rather than Breast Cancer Resistance Protein or Organic Cation Transporter 1, Contributes to Acquisition of Imatinib-Resistance in K562 Cells

C. Hirayama, Hiroshi Watanabe, T. Kawaguchi, 2008, Pharmaceutical Research.

Evaluation of the Drug Information Content of Package Inserts with a View to Achieving Optimal Use of Drugs (for antibiotics)

A. Hamada, H. Saito, I. Ogata, 2004 .

Clinical evaluation of an authorized medical equipment based on high performance liquid chromatography for measurement of serum voriconazole concentration

H. Jono, S. Uchino, H. Saito, 2021, Journal of pharmaceutical health care and sciences.

Acute and chronic metabolic acidosis interferes with aquaporin-2 translocation in the rat kidney collecting ducts

K. Tomita, H. Nonoguchi, Y. Nakayama, 2009, Hypertension Research.

Effect of Administration Duration of Low Dose Methotrexate on Development of Acute Kidney Injury in Rats

H. Jono, H. Saito, Xiao Li, 2016 .

Study on Clinical Implications of Serum Mycophenolate Trough Concentration Measurements in Liver Transplant Patients

Y. Ando, K. Asonuma, Y. Inomata, 2010 .

Distinct interaction of nilotinib and imatinib with P-Glycoprotein in intracellular accumulation and cytotoxicity in CML Cell Line K562 cells.

T. Kawaguchi, A. Hamada, H. Saito, 2014, Biological & pharmaceutical bulletin.

Role of P-glycoprotein in the efflux of raltegravir from human intestinal cells and CD4+ T-cells as an interaction target for anti-HIV agents.

H. Jono, T. Shinohara, K. Tsuchiya, 2013, Biochemical and biophysical research communications.

Meclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury by suppressing indoxyl sulfate production and restoring renal organic anion transporters

H. Jono, Yuko Yamamoto, H. Saito, 2014, Drug design, development and therapy.

Evaluation of percutaneous absorption of midazolam by terpenes.

M. Nakano, A. Hamada, H. Saito, 2003, Drug metabolism and pharmacokinetics.

A novel step‐down infusion method of barbiturate therapy: Its safety and effectiveness for intracranial pressure control

M. Morioka, H. Jono, K. Orito, 2021, Pharmacology research & perspectives.

Comparative Study of Constipation Exacerbation by Potassium Binders Using a Loperamide-Induced Constipation Model

H. Jono, T. Irie, H. Saito, 2020, International journal of molecular sciences.

Uremic Toxins and Organ Failure

H. Saito, Takaaki, 2020 .

Vasopressin regulates the renin-angiotensin-aldosterone system via V1a receptors in macula densa cells.

K. Tomita, H. Nonoguchi, A. Tanoue, 2008, American journal of physiology. Renal physiology.

Downregulation of organic anion transporters in rat kidney under ischemia/reperfusion-induced qacute renal failure

K. Tomita, H. Nonoguchi, Y. Kohda, 2007 .

High-performance liquid chromatographic assay for the determination of nilotinib in human plasma.

T. Kawaguchi, Takeru Nambu, A. Hamada, 2011, Biological & pharmaceutical bulletin.

Successful treatment of Wernicke encephalopathy in terminally ill cancer patients: Report of 3 cases and review of the literature

C. Kawanishi, K. Noda, H. Saito, 2004, Supportive Care in Cancer.

Association of ABCB1 polymorphisms with erlotinib pharmacokinetics and toxicity in Japanese patients with non-small-cell lung cancer.

J. Sasaki, T. Isobe, K. Kashiwabara, 2012, Pharmacogenomics.

Performance of Area under the Concentration-Time Curve Estimations of Vancomycin with Limited Sampling by a Newly Developed Web Application

Kazuaki Matsumoto, K. Shoji, H. Saito, 2021, Pharmaceutical Research.

Model‐informed precision dosing of teicoplanin for the rapid achievement of the target area under the concentration‐time curve: A simulation study

H. Jono, H. Saito, Toshimi Kimura, 2023, Clinical and translational science.

A reduced linezolid dosage maintains favorable efficacy with minimal hematologic toxicity in a methicillin-resistant Staphylococcus aureus-infected patient with renal insufficiency

T. Kawaguchi, H. Mizuta, T. Okada, 2013, Scandinavian journal of infectious diseases.

Carbamazepine–imatinib interaction in a child with chronic myeloid leukemia

F. Endo, H. Jono, H. Saito, 2014, Pediatrics international : official journal of the Japan Pediatric Society.

Ribosomal protein S6 promotes stem‐like characters in glioma cells

N. Shinojima, A. Mukasa, H. Jono, 2020, Cancer science.

Doxycycline attenuates cisplatin-induced acute kidney injury through pleiotropic effects.

H. Jono, M. Mukoyama, Y. Izumi, 2018, American journal of physiology. Renal physiology.

A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

Arun K. Ghosh, H. Mitsuya, H. Jono, 2017, eLife.

Relationship between Serum Bortezomib Concentration and Emergence of Diarrhea in Patients with Multiple Myeloma and/or AL Amyloidosis

Y. Okuno, M. Matsuoka, H. Jono, 2021, Cancers.

Glioma Cells Acquire Stem-like Characters by Extrinsic Ribosome Stimuli

N. Shinojima, A. Mukasa, H. Jono, 2021, Cells.

Genetic polymorphisms in metabolic and cellular transport pathway of methotrexate impact clinical outcome of methotrexate monotherapy in Japanese patients with rheumatoid arthritis.

S. Mori, A. Hamada, H. Saito, 2012, Drug metabolism and pharmacokinetics.

Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder.

S. Higuchi, S. Ohdo, T. Jodoi, 2005, American journal of physiology. Regulatory, integrative and comparative physiology.

Lowered Risk of Nephrotoxicity through Intervention against the Combined Use of Vancomycin and Tazobactam/Piperacillin: A Retrospective Cohort Study

H. Jono, H. Saito, H. Nakata, 2021, Microbiology spectrum.

A case of recovery from aphasia following dose reduction of cefepime by bayesian prediction-based therapeutic drug monitoring.

H. Jono, H. Saito, Toshikazu Miyakawa, 2020, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

Effects of Atrial Natriuretic Peptide on Bicarbonate Transport in Long- and Short-Looped Medullary Thick Ascending Limbs of Rats

K. Tomita, H. Nonoguchi, Y. Izumi, 2013, PloS one.

Downregulation of the V2 vasopressin receptor in dehydration: mechanisms and role of renal prostaglandin synthesis.

K. Tomita, H. Nonoguchi, Y. Izumi, 2007, American journal of physiology. Renal physiology.

Loss of Tumor Suppressor CYLD Expression Triggers Cisplatin Resistance in Oral Squamous Cell Carcinoma

H. Jono, S. Shinriki, H. Nakayama, 2019, International journal of molecular sciences.

Assessment of adverse reactions and pharmacokinetics of ribavirin in combination with interferon alpha-2b in patients with chronic hepatitis C.

A. Hamada, H. Saito, S. Fujiyama, 2004, Drug metabolism and pharmacokinetics.

Toxico-pharmacological perspective of the Nrf2-Keap1 defense system against oxidative stress in kidney diseases.

H. Saito, 2013, Biochemical pharmacology.

Downregulation of organic anion transporters in rat kidney under ischemia/reperfusion-induced acute [corrected] renal failure.

K. Tomita, H. Nonoguchi, Y. Kohda, 2007, Kidney international.

Nephropreventive Effect of Shikonin on Murine LPS-induced Septic Acute Kidney Injury via Nrf2 Activation with Antioxidative Responses

H. Jono, Yuko Yamamoto, H. Saito, 2016 .

Suppressed Hepatic Production of Indoxyl Sulfate Attenuates Cisplatin-Induced Acute Kidney Injury in Sulfotransferase 1a1-Deficient Mice

H. Jono, H. Saito, Yuki Narita, 2021, International journal of molecular sciences.

Development of Vancomycin Dose Individualization Strategy by Bayesian Prediction in Patients Receiving Continuous Renal Replacement Therapy

H. Jono, H. Kamohara, H. Saito, 2020, Pharmaceutical Research.

Model-Informed Precision Dosing of Vancomycin in Adult Patients Undergoing Hemodialysis

H. Jono, H. Saito, Kazutaka Oda, 2023, Antimicrobial agents and chemotherapy.

Population Pharmacokinetics and AUC-Guided Dosing of Tobramycin in the Treatment of Infections Caused by Glucose-Nonfermenting Gram-Negative Bacteria.

H. Jono, H. Saito, Yumi Hashiguchi, 2023, Clinical therapeutics.

Comparative Inter-lot Quality Investigation on Nafamostat Mesilate Preparations for Injection between Original Product and Generics

H. Saito, Y. Honda, 2005 .

Efficacy of a Novel Prophylactic Barbiturate Therapy for Severe Traumatic Brain Injuries: Step-down Infusion of a Barbiturate with Normothermia

M. Hirohata, T. Kawano, M. Morioka, 2021, Neurologia medico-chirurgica.

The relationship between treatment time of gemcitabine and development of hematologic toxicity in cancer patients.

Minoru Yoshida, A. Hamada, H. Saito, 2011, Biological & pharmaceutical bulletin.

Pharmacokinetic Changes of Irinotecan by Intestinal Alkalinization in an Advanced Colorectal Cancer Patient

A. Hamada, H. Saito, Koji Yokoo, 2005, Therapeutic drug monitoring.

Effect of S‐1 on pharmacokinetics of irinotecan in a patient with colorectal cancer

Hiroshi Watanabe, A. Hamada, H. Saito, 2006, Clinical pharmacology and therapeutics.

Spouse caregivers of terminally-ill cancer patients as cancer patients: A pilot study in a palliative care unit

C. Kawanishi, H. Saito, Hideki Onishi, 2005, Palliative and Supportive Care.

Conversion disorder with convulsion and motor deficit mimicking the adverse effects of high-dose Ara-C treatment in a posttransplant acute myeloid leukemia patient: A case report and review of the literature

H. Saito, Tomoki Yamada, Hideki Onishi, 2004, Palliative & Supportive Care.

Bayesian prediction-based individualized dosing of anti-methicillin-resistant Staphylococcus aureus treatment: Recent advancements and prospects in therapeutic drug monitoring.

H. Jono, H. Saito, Kazutaka Oda, 2023, Pharmacology & therapeutics.

Reduced nephrotoxicity in vancomycin therapeutic drug monitoring guided by area under the concentration-time curve against a trough 15-20 μg/mL concentration.

H. Jono, H. Saito, K. Nosaka, 2020, International journal of antimicrobial agents.

Suppression of Indoxyl Sulfate Accumulation Reduces Renal Fibrosis in Sulfotransferase 1a1-Deficient Mice

H. Jono, M. Mukoyama, Y. Izumi, 2023, International journal of molecular sciences.

Involvement of Indoxyl Sulfate in Renal and Central Nervous System Toxicities During Cisplatin-induced Acute Renal Failure

Hiroshi Watanabe, T. Morisaki, T. Matsuzaki, 2007, Pharmaceutical Research.

Continuous high-dose infusion of doripenem in a pneumonia patient infected by carbapenem-resistant Pseudomonas aeruginosa: a case report

H. Jono, H. Kamohara, H. Saito, 2019, Journal of Pharmaceutical Health Care and Sciences.

A Case Study on Pharmacokinetics of Methotrexate(MTX)in Serum and CSF in a Patient with Pancytopenia Following Intraventricular Administration of MTX

M. Uchino, J. Fujii, H. Saito, 2008 .