Virna Borowski

发表

A highly selective, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor has potent activity in vitro and in vivo

Angel R. Fuentes-Pesquera, P. Connolly, Shenlin Huang, 2009, Angiogenesis.

Engineering of a Novel Anti-CD40L Domain Antibody for Treatment of Autoimmune Diseases

A. Yamniuk, S. Grant, J. Bryson, 2014, The Journal of Immunology.

Identification and Preclinical Pharmacology of ((1 R,3 S)-1-Amino-3-(( S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials.

Michael G. Yang, K. McIntyre, D. Shen, 2019, Journal of medicinal chemistry.

Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1).

Michael A. Galella, K. McIntyre, D. Shen, 2016, Journal of medicinal chemistry.

Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P1 Receptor Modulator.

Michael G. Yang, K. McIntyre, D. Shen, 2016, Journal of medicinal chemistry.

Anticancer drug delivery systems: multi-loaded N4-acyl poly(ethylene glycol) prodrugs of ara-C. II. Efficacy in ascites and solid tumors.

M. Royzen, Virna Borowski, M. Mehlig, 2002, Journal of controlled release : official journal of the Controlled Release Society.

Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists.

Michael A. Galella, D. Shuster, D. Shen, 2019, ACS medicinal chemistry letters.

Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitor

A. Calcagno, S. Ambudkar, S. Emanuel, 2006, Molecular Cancer Therapeutics.

Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist.

D. Shuster, J. Macor, C. Weigelt, 2020, ACS medicinal chemistry letters.

Engineering an arginine catabolizing bioconjugate: Biochemical and pharmacological characterization of PEGylated derivatives of arginine deiminase from Mycoplasma arthritidis.

T. Palm, Lisa Y Hwang, Yue Zhang, 2006, Bioconjugate chemistry.

Tailoring structure-function and pharmacokinetic properties of single-chain Fv proteins by site-specific PEGylation.

D. Filpula, H. Janjua, David Filpula, 2003, Protein engineering.

Structure-function engineering of interferon-beta-1b for improving stability, solubility, potency, immunogenicity, and pharmacokinetic properties by site-selective mono-PEGylation.

Hong Zhao, Jun Liu, T. Palm, 2006, Bioconjugate chemistry.

Antitumor activity of poly(ethylene glycol)-camptothecin conjugate: the inhibition of tumor growth in vivo.

Yang Wang, S. Dharap, T. Minko, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Delivery of G3139 using releasable PEG-linkers: impact on pharmacokinetic profile and anti-tumor efficacy.

G. Borchard, C. Stein, L. Benimetskaya, 2007, Journal of controlled release : official journal of the Controlled Release Society.

Cellular and in Vivo Activity of JNJ-28871063, A Nonquinazoline Pan-ErbB Kinase Inhibitor That Crosses the Blood-Brain Barrier and Displays Efficacy against Intracranial Tumors

Mary Adams, Niranjan Pandey, Terry V Hughes, 2008, Molecular Pharmacology.

Substituted Diaryl Ether Compounds as Retinoic Acid-Related Orphan Receptor-γt (RORγt) Agonists.

Zhuyin Li, C. Weigelt, B. Fink, 2021, Bioorganic & medicinal chemistry letters.

Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORγt) agonists.

Zhuyin Li, C. Weigelt, B. Fink, 2020, Bioorganic & medicinal chemistry letters.

Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt ‒ Identification of a Potent, Selective Series with Biologic-Like In Vivo Efficacy.

K. McIntyre, D. Shuster, J. Macor, 2019, Journal of medicinal chemistry.

Dual Inhibition of Interleukin-23 and Interleukin-17 Offers Superior Efficacy in Mouse Models of Autoimmunity

Noah T. Ditto, M. Struthers, K. McIntyre, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.

Michael A. Galella, D. Shen, J. Barrish, 2018, Bioorganic & medicinal chemistry letters.

Diseases Antibody for Treatment of Autoimmune Engineering of a Novel Anti-CD 40 L Domain

A. Yamniuk, S. Grant, J. Bryson, 2014 .

Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORγt) agonists.

C. Weigelt, B. Fink, T. Huynh, 2020, Bioorganic & medicinal chemistry letters.