Hiroyuki Nakamura

发表

Activation of cytosolic phospholipase A2alpha by epidermal growth factor (EGF) and phorbol ester in HeLa cells: different effects of inhibitors for EGF receptor, protein kinase C, Src, and C-Raf.

Y. Matsuzawa, Y. Kiuchi, Kaori Toyomura, 2009, Journal of pharmacological sciences.

Cytotoxicity induced by inhibition of thioredoxin reductases via multiple signaling pathways: Role of cytosolic phospholipase A2α‐dependent and ‐independent release of arachidonic acid

Y. Matsuzawa, Hiroyuki Nakamura, H. Fujino, 2009, Journal of cellular physiology.

Tankyrase Regulates Neurite Outgrowth through Poly(ADP-ribosyl)ation-Dependent Activation of β-Catenin Signaling

Hiroyuki Nakamura, T. Murayama, R. Kizu, 2022, International journal of molecular sciences.

Down-regulation of ceramide kinase via proteasome and lysosome pathways in PC12 cells by serum withdrawal: Its protection by nerve growth factor and role in exocytosis.

Hiroyuki Nakamura, T. Murayama, T. Kohama, 2020, Biochimica et biophysica acta. Molecular cell research.

Ser515 phosphorylation-independent regulation of cytosolic phospholipase A2alpha (cPLA2alpha) by calmodulin-dependent protein kinase: possible interaction with catalytic domain A of cPLA2alpha.

A. Suganami, Y. Tamura, Hiroyuki Nakamura, 2008, Cellular signalling.

Antifibrotic effects of cyclosporine A on TGF‐β1–treated lung fibroblasts and lungs from bleomycin‐treated mice: role of hypoxia‐inducible factor‐1α

I. Yoshino, Y. Kasuya, K. Tatsumi, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Effects of Hsp 90 inhibitors , geldanamycin and its analog , on ceramide metabolism and cytotoxicity in PC 12 cells

Y. Okuma, Takeshi Saito, M. Kaneko, 2012 .

Effects of Hsp90 inhibitors, geldanamycin and its analog, on ceramide metabolism and cytotoxicity in PC12 cells.

Takeshi Saito, Y. Okuma, M. Kaneko, 2012, The Journal of toxicological sciences.

Modulation of the activity of cytosolic phospholipase A2α (cPLA2α) by cellular sphingolipids and inhibition of cPLA2α by sphingomyelin[S]

K. Hanada, A. Suganami, Y. Tamura, 2010, Journal of Lipid Research.

Ceramide-1-phosphate activates cytosolic phospholipase A2alpha directly and by PKC pathway.

Hiroyuki Nakamura, T. Murayama, T. Hirabayashi, 2006, Biochemical pharmacology.

Vanadate-induced activation of cytosolic phospholipase A2alpha in L929 cells: Roles of tyrosine kinase, protein kinase C, and extracellular signal-regulated kinase.

Takeshi Saito, Hiroyuki Nakamura, H. Fujino, 2007, Biochemical pharmacology.

Decrease of guanylyl cyclase β1 subunit and nitric oxide (NO)-induced relaxation in mouse rectum with colitis and its reproduction on long-term NO treatment

Kenjiro Matsumoto, Hiroyuki Nakamura, H. Fujino, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Quercetin-induced PC12 cell death accompanied by caspase-mediated DNA fragmentation.

Takeshi Saito, M. Kashiwayanagi, Hiroyuki Nakamura, 2007, Biological & pharmaceutical bulletin.

Activation of ceramidase and ceramide kinase by vanadate via a tyrosine kinase-mediated pathway.

Takeshi Saito, Y. Okuma, M. Kaneko, 2010, Journal of pharmacological sciences.

Accumulation of sphingomyelin in Niemann‐Pick disease type C cells disrupts Rab9‐dependent vesicular trafficking of cholesterol

Hiroyuki Nakamura, T. Murayama, N. Hashimoto, 2019, Journal of cellular physiology.

L-Cysteine/D,L-homocysteine-regulated ileum motility via system L and B°(,+) transporter: Modification by inhibitors of hydrogen sulfide synthesis and dietary treatments.

Kenjiro Matsumoto, Hiroyuki Nakamura, H. Fujino, 2015, European journal of pharmacology.

Beneficial effects of primidone in Niemann-Pick disease type C (NPC)-model cells and mice: Reduction of unesterified cholesterol levels in cells and extension of lifespan in mice.

Hiroyuki Nakamura, T. Murayama, Takuya Honda, 2021, European journal of pharmacology.

Inhibition of the SET8 Pathway Ameliorates Lung Fibrosis Even Through Fibroblast Dedifferentiation

M. Hatano, Y. Kasuya, K. Tatsumi, 2020, Frontiers in Molecular Biosciences.

Effects of ceramide, ceramidase inhibition and expression of ceramide kinase on cytosolic phospholipase A2alpha; additional role of ceramide-1-phosphate in phosphorylation and Ca2+ signaling.

Hiroyuki Nakamura, H. Fujino, T. Murayama, 2009, Cellular signalling.

Contrary effects of sphingosine-1-phosphate on expression of α-smooth muscle actin in transforming growth factor β1-stimulated lung fibroblasts.

Y. Matsuzawa, Hiroyuki Nakamura, H. Fujino, 2012, European journal of pharmacology.

Involvement of p38 MAP kinase-mediated cytochrome c release on sphingosine-1-phosphate (S1P)- and N-monomethyl-S1P-induced cell death of PC12 cells.

A. Nishida, Hiroyuki Nakamura, T. Murayama, 2005, Biochemical pharmacology.

Effects of Glycerophospholipids on Ceramide Kinase Activity: Cardiolipin-Affected Cellular Formation of Ceramide-1-phosphate.

Hiroyuki Nakamura, T. Murayama, Wataru Matsuzaki, 2016, Biological & pharmaceutical bulletin.

Inhibitory effects of ceramide kinase on Rac1 activation, lamellipodium formation, cell migration, and metastasis of A549 lung cancer cells.

K. Yamagata, H. Hatakeyama, Satoshi Tomizawa, 2020, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Lactosylceramide‐Induced Phosphorylation Signaling to Group IVA Phospholipase A2 via Reactive Oxygen Species in Tumor Necrosis Factor‐α‐Treated Cells

Satoshi Tomizawa, Hiroyuki Nakamura, T. Murayama, 2017, Journal of cellular biochemistry.

Tyrosine-phosphorylation and activation of glucosylceramide synthase by v-Src: Its role in survival of HeLa cells against ceramide.

K. Yamagata, Hiroyuki Nakamura, T. Murayama, 2020, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Arachidonic acid metabolism via cytosolic phospholipase A2α induces cytotoxicity in niemann–pick disease type C cells

I. Matsumoto, Hiroyuki Nakamura, H. Fujino, 2012, Journal of cellular physiology.

Effects of synthetic sphingosine-1-phosphate analogs on cytosolic phospholipase A2alpha-independent release of arachidonic acid and cell toxicity in L929 fibrosarcoma cells: the structure-activity relationship.

A. Nishida, Y. Muramatsu, Hiroyuki Nakamura, 2009, Journal of pharmacological sciences.

Sphingomyelin Regulates the Activity of Secretory Phospholipase A2 in the Plasma Membrane

Hiroyuki Nakamura, T. Murayama, N. Hashimoto, 2015, Journal of cellular biochemistry.

Reversible activation of secretory phospholipase A2 by sulfhydryl reagents.

Takeshi Saito, Y. Nomura, Y. Okuma, 2005, Archives of biochemistry and biophysics.

Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells.

J. Regan, Hiroyuki Nakamura, H. Fujino, 2015, European journal of pharmacology.

Ceramide kinase knockout ameliorates multiple sclerosis-like behaviors and demyelination in cuprizone-treated mice.

Hiroyuki Nakamura, T. Murayama, Takuya Honda, 2022, Life sciences.

Up-regulation of cytosolic phospholipase A2alpha expression by N,N-diethyldithiocarbamate in PC12 cells; involvement of reactive oxygen species and nitric oxide.

Takeshi Saito, Hiroyuki Nakamura, H. Fujino, 2006, Toxicology and applied pharmacology.

Release of arachidonic acid by 2-arachidonoyl glycerol and HU210 in PC12 cells; roles of Src, phospholipase C and cytosolic phospholipase A(2)alpha.

Takeshi Saito, Y. Okuma, N. Yamaguchi, 2008, European journal of pharmacology.

Trafficking of Acetyl‐C16‐Ceramide‐NBD with Long‐Term Stability and No Cytotoxicity into the Golgi Complex

N. Yamaguchi, A. Nishida, Hiroyuki Nakamura, 2015, Traffic.

Role of sphingolipids in arachidonic acid metabolism.

Hiroyuki Nakamura, T. Murayama, 2014, Journal of pharmacological sciences.

Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine.

Hiroyuki Nakamura, T. Murayama, Akiyoshi Someya, 2004, European journal of pharmacology.

Hydrogen peroxide-induced arachidonic acid release in L929 cells; roles of Src, protein kinase C and cytosolic phospholipase A2α

Hiroyuki Nakamura, H. Fujino, T. Murayama, 2006 .

Regulation of alkaline ceramidase activity by the c-Src-mediated pathway.

N. Yamaguchi, Kaori Toyomura, Hiroyuki Nakamura, 2014, Archives of biochemistry and biophysics.

C2-di-ethyl-ceramide-1-phosphate as an inhibitor of group IVA cytosolic phospholipase A2.

A. Nishida, Hiroyuki Nakamura, T. Murayama, 2012, European journal of pharmacology.

Decrease of guanylyl cyclase β1 subunit and nitric oxide (NO)-induced relaxation in mouse rectum with colitis and its reproduction on long-term NO treatment

Kenjiro Matsumoto, Hiroyuki Nakamura, H. Fujino, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

N-butyldeoxynojirimycin (miglustat) ameliorates pulmonary fibrosis through inhibition of nuclear translocation of Smad2/3.

I. Yoshino, Y. Kasuya, K. Tatsumi, 2023, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Hydrogen sulfide-mediated regulation of contractility in the mouse ileum with electrical stimulation: roles of L-cysteine, cystathionine β-synthase, and K+ channels.

Hiroyuki Nakamura, H. Fujino, T. Murayama, 2014, European journal of pharmacology.

Identification and characterization of diacylglycerol kinase ζ as a novel enzyme producing ceramide-1-phosphate.

Hiroyuki Nakamura, T. Murayama, T. Kohama, 2023, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Phosphorylation and inhibition of ceramide kinase by protein kinase C-β: Their changes by serine residue mutations.

Hiroyuki Nakamura, T. Murayama, Hitomi Ashikawa, 2019, Cellular signalling.

Cholesterol-dependent increases in glucosylceramide synthase activity in Niemann-Pick disease type C model cells: Abnormal trafficking of endogenously formed ceramide metabolites by inhibition of the enzyme

I. Matsumoto, Hiroyuki Nakamura, T. Murayama, 2016, Neuropharmacology.

Knockout of Ceramide Kinase Aggravates Pathological and Lethal Responses in Mice with Experimental Colitis.

Hiroyuki Nakamura, T. Murayama, Satomi Suzuki, 2018, Biological & pharmaceutical bulletin.

Translocation and activation of sphingosine kinase 1 by ceramide‐1‐phosphate

K. Yamagata, Hiroyuki Nakamura, T. Murayama, 2018, Journal of cellular biochemistry.

Role of cytosolic phospholipase A(2)α in cell rounding and cytotoxicity induced by ceramide-1-phosphate via ceramide kinase.

Hiroyuki Nakamura, T. Murayama, Tomohiko Makiyama, 2011, Archives of biochemistry and biophysics.

Newly synthetic ceramide-1-phosphate analogs; their uptake, intracellular localization, and roles as an inhibitor of cytosolic phospholipase A(2)α and inducer of cell toxicity.

A. Nishida, Hiroyuki Nakamura, T. Murayama, 2010, Biochemical pharmacology.

Effects of synthetic sphingosine-1-phosphate analogs on arachidonic acid metabolism and cell death.

A. Nishida, Hiroyuki Nakamura, T. Murayama, 2004, Biochemical pharmacology.

Eicosanoids Derived From Arachidonic Acid and Their Family Prostaglandins and Cyclooxygenase in Psychiatric Disorders

K. Yui, Hiroyuki Nakamura, N. Ohara, 2015, Current neuropharmacology.

Cellular density‐dependent increases in HIF‐1α compete with c‐Myc to down‐regulate human EP4 receptor promoter activity through Sp‐1‐binding region

J. Regan, K. Yamagata, Hiroyuki Nakamura, 2018, Pharmacology research & perspectives.

Lactosylceramide Interacts with and Activates Cytosolic Phospholipase A2α*

Hiroyuki Nakamura, T. Murayama, Tomohiko Makiyama, 2013, The Journal of Biological Chemistry.

Py3-FITC: a new fluorescent probe for live cell imaging of collagen-rich tissues and ionocytes

M. Itoh, T. Nemoto, Takamasa Mizoguchi, 2021, Open Biology.

Release of arachidonic acid induced by tumor necrosis factor-alpha in the presence of caspase inhibition: evidence for a cytosolic phospholipase A2alpha-independent pathway.

Y. Okuma, C. Azuma, M. Kaneko, 2008, Biochemical pharmacology.

Miglustat, a glucosylceramide synthase inhibitor, mitigates liver fibrosis through TGF-β/Smad pathway suppression in hepatic stellate cells.

T. Kanda, S. Nakamoto, R. Muroyama, 2022, Biochemical and biophysical research communications.

Development of a new doubly-labeled fluorescent ceramide probe for monitoring the metabolism of sphingolipids in living cells.

K. Yamagata, A. Nishida, N. Suzuki, 2018, Bioorganic & medicinal chemistry letters.