H. Fujino

发表

Activation of cytosolic phospholipase A2alpha by epidermal growth factor (EGF) and phorbol ester in HeLa cells: different effects of inhibitors for EGF receptor, protein kinase C, Src, and C-Raf.

Y. Matsuzawa, Y. Kiuchi, Kaori Toyomura, 2009, Journal of pharmacological sciences.

Cytotoxicity induced by inhibition of thioredoxin reductases via multiple signaling pathways: Role of cytosolic phospholipase A2α‐dependent and ‐independent release of arachidonic acid

Y. Matsuzawa, Hiroyuki Nakamura, H. Fujino, 2009, Journal of cellular physiology.

Bee venom phospholipase A2-induced phasic contractions in mouse rectum: independent roles of eicosanoid and gap junction proteins and their loss in experimental colitis.

Hiromi Sato, Kenjiro Matsumoto, H. Fujino, 2013, European journal of pharmacology.

Inhibitory effects of clinical reagents having anti-oxidative activity on transforming growth factor-β1-induced expression of α-smooth muscle actin in human fetal lung fibroblasts.

Y. Matsuzawa, H. Fujino, T. Murayama, 2011, The Journal of toxicological sciences.

Effect of wild grape on the signaling of histamine H1 receptor gene expression responsible for the pathogenesis of allergic rhinitis.

N. Takeda, H. Mizuguchi, Y. Kitamura, 2018, The journal of medical investigation : JMI.

Nitrosonifedipine, a Photodegradation Product of Nifedipine, Suppresses Pharmacologically Induced Aortic Aneurysm Formation

M. Yoshizumi, T. Tamaki, K. Tsuchiya, 2018, Pharmacology.

Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity.

S. Kishi, K. Aihara, T. Tamaki, 2020, Kidney international.

Vanadate-induced activation of cytosolic phospholipase A2alpha in L929 cells: Roles of tyrosine kinase, protein kinase C, and extracellular signal-regulated kinase.

Takeshi Saito, Hiroyuki Nakamura, H. Fujino, 2007, Biochemical pharmacology.

Decrease of guanylyl cyclase β1 subunit and nitric oxide (NO)-induced relaxation in mouse rectum with colitis and its reproduction on long-term NO treatment

Kenjiro Matsumoto, Hiroyuki Nakamura, H. Fujino, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

PGE1 and E3 show lower efficacies than E2 to β‐catenin‐mediated activity as biased ligands of EP4 prostanoid receptors

J. Regan, A. Suganami, Y. Tamura, 2017, FEBS letters.

Prostaglandin E2 Induced Functional Expression of Early Growth Response Factor-1 by EP4, but Not EP2, Prostanoid Receptors via the Phosphatidylinositol 3-Kinase and Extracellular Signal-regulated Kinases*

J. Regan, Wei Xu, H. Fujino, 2003, The Journal of Biological Chemistry.

Indomethacin decreases arachidonic acid uptake in HCA-7 human colon cancer cells.

Kaori Toyomura, H. Fujino, T. Murayama, 2008, Journal of pharmacological sciences.

Anti-cancer Effects of MW-03, a Novel Indole Compound, by Inducing 15-Hydroxyprostaglandin Dehydrogenase and Cellular Growth Inhibition in the LS174T Human Colon Cancer Cell Line.

J. Regan, N. Yamaguchi, T. Arai, 2017, Biological and Pharmaceutical Bulletin.

L-Cysteine/D,L-homocysteine-regulated ileum motility via system L and B°(,+) transporter: Modification by inhibitors of hydrogen sulfide synthesis and dietary treatments.

Kenjiro Matsumoto, Hiroyuki Nakamura, H. Fujino, 2015, European journal of pharmacology.

The Gαs‐protein‐mediated pathway may be steadily stimulated by prostanoid EP2 receptors, but not by EP4 receptors

J. Regan, H. Fujino, Keijo Fukushima, 2022, FEBS open bio.

15-Keto-PGE2 acts as a biased/partial agonist to terminate PGE2-evoked signaling

J. Regan, A. Suganami, Y. Tamura, 2020, The Journal of Biological Chemistry.

EP4 Prostanoid Receptor Coupling to a Pertussis Toxin-Sensitive Inhibitory G Protein

J. Regan, H. Fujino, 2006, Molecular Pharmacology.

[Novel anti-cancer effects of indomethacin: exploring the cyclooxygenase-inhibition-independent effects].

H. Fujino, T. Murayama, 2011, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Prostanoid receptors and phosphatidylinositol 3-kinase: a pathway to cancer?

J. Regan, H. Fujino, 2003, Trends in pharmacological sciences.

Development of a mugineic acid family phytosiderophore analog as an iron fertilizer

Takanori Kobayashi, Y. Murata, N. Nishizawa, 2021, Nature Communications.

Renoprotective effects of a factor Xa inhibitor: fusion of basic research and a database analysis

T. Tamaki, K. Tsuchiya, K. Ishizawa, 2018, Scientific Reports.

Prostaglandin F2α amplifies tumor necrosis factor-α promoter activity by the FPB prostanoid receptor

J. Regan, H. Fujino, 2004 .

Effects of ceramide, ceramidase inhibition and expression of ceramide kinase on cytosolic phospholipase A2alpha; additional role of ceramide-1-phosphate in phosphorylation and Ca2+ signaling.

Hiroyuki Nakamura, H. Fujino, T. Murayama, 2009, Cellular signalling.

Stimulatory roles of muscarinic acetylcholine receptors on T cell antigen receptor/CD3 complex-mediated interleukin-2 production in human peripheral blood lymphocytes.

Y. Kitamura, T. Yada, T. Uehara, 1997, Molecular pharmacology.

Contrary effects of sphingosine-1-phosphate on expression of α-smooth muscle actin in transforming growth factor β1-stimulated lung fibroblasts.

Y. Matsuzawa, Hiroyuki Nakamura, H. Fujino, 2012, European journal of pharmacology.

PARP14 regulates EP4 receptor expression in human colon cancer HCA-7 cells

H. Fujino, Masato Mashimo, T. Fujii, 2022, Biochemical and Biophysical Research Communications.

Arachidonic acid metabolism via cytosolic phospholipase A2α induces cytotoxicity in niemann–pick disease type C cells

I. Matsumoto, Hiroyuki Nakamura, H. Fujino, 2012, Journal of cellular physiology.

Effects of synthetic sphingosine-1-phosphate analogs on cytosolic phospholipase A2alpha-independent release of arachidonic acid and cell toxicity in L929 fibrosarcoma cells: the structure-activity relationship.

A. Nishida, Y. Muramatsu, Hiroyuki Nakamura, 2009, Journal of pharmacological sciences.

THE ROLE OF THE TRANSACTIVATION DOMAIN IN C-MYC MEDIATED CELL CYCLE PROGRESSION AND TRANSFORMATION

David N. Boone, S. Hanks, S. Hiebert, 2008 .

Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells.

J. Regan, Hiroyuki Nakamura, H. Fujino, 2015, European journal of pharmacology.

Cellular Conditioning and Activation of β-Catenin Signaling by the FPB Prostanoid Receptor*

J. Regan, D. Srinivasan, H. Fujino, 2002, The Journal of Biological Chemistry.

Delayed reversal of shape change in cells expressing FP(B) prostanoid receptors. Possible role of receptor resensitization.

J. Regan, K. L. Pierce, D. Srinivasan, 2000, The Journal of biological chemistry.

Up-regulation of cytosolic phospholipase A2alpha expression by N,N-diethyldithiocarbamate in PC12 cells; involvement of reactive oxygen species and nitric oxide.

Takeshi Saito, Hiroyuki Nakamura, H. Fujino, 2006, Toxicology and applied pharmacology.

Release of arachidonic acid by 2-arachidonoyl glycerol and HU210 in PC12 cells; roles of Src, phospholipase C and cytosolic phospholipase A(2)alpha.

Takeshi Saito, Y. Okuma, N. Yamaguchi, 2008, European journal of pharmacology.

Prostaglandin F2α stimulation of cyclooxygenase-2 promoter activity by the FPB prostanoid receptor

J. Regan, H. Fujino, 2003 .

Prostaglandin F(2alpha) stimulation of cyclooxygenase-2 promoter activity by the FP(B) prostanoid receptor.

J. Regan, H. Fujino, 2003, European journal of pharmacology.

Identification and characterisation of the anti‐allergic compound from lotus root

N. Takeda, H. Mizuguchi, Y. Kitamura, 2020 .

Identification of pyrogallol from Awa-tea as an anti-allergic compound that suppresses nasal symptoms and IL-9 gene expression.

N. Takeda, O. Kaminuma, H. Mizuguchi, 2020, The journal of medical investigation : JMI.

Indomethacin decreases EP2 prostanoid receptor expression in colon cancer cells.

J. Regan, H. Fujino, T. Murayama, 2007, Biochemical and biophysical research communications.

Differential Regulation of Phosphorylation of the cAMP Response Element-Binding Protein after Activation of EP2 and EP4 Prostanoid Receptors by Prostaglandin E2

J. Regan, H. Fujino, Sambhitab Salvi, 2005, Molecular Pharmacology.

Assessment of constitutive activity in E-type prostanoid receptors.

J. Regan, H. Fujino, T. Murayama, 2010, Methods in enzymology.

Human EP3(I) prostanoid receptor induces VEGF and VEGF receptor-1 mRNA expression.

J. Regan, D. Israel, H. Fujino, 2008, Biochemical and biophysical research communications.

Induction of cyclooxygenase-2 expression by prostaglandin E2 stimulation of the prostanoid EP4 receptor via coupling to Gαi and transactivation of the epidermal growth factor receptor in HCA-7 human colon cancer cells.

J. Regan, Kenji Yoshida, H. Fujino, 2013, European journal of pharmacology.

Phosphorylation of Glycogen Synthase Kinase-3 and Stimulation of T-cell Factor Signaling following Activation of EP2 and EP4 Prostanoid Receptors by Prostaglandin E2 *

J. Regan, H. Fujino, K. West, 2002, The Journal of Biological Chemistry.

Human DP and EP2 prostanoid receptors take on distinct forms depending on the diverse binding of different ligands

J. Regan, A. Suganami, Y. Tamura, 2016, The FEBS journal.

A novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells.

J. Regan, T. Arai, H. Fujino, 2014, Archives of biochemistry and biophysics.

Indomethacin antagonizes EP(2) prostanoid receptor activation in LS174T human colon cancer cells.

H. Fujino, T. Murayama, Sho Otake, 2012, European journal of pharmacology.

Prostaglandin E2 Selectively Antagonizes Prostaglandin F2α-stimulated T-cell Factor/β-Catenin Signaling Pathway by the FPB Prostanoid Receptor*

J. Regan, H. Fujino, G. Vielhauer, 2004, Journal of Biological Chemistry.

Differential Regulation of Prostaglandin F2αReceptor Isoforms by Protein Kinase C

J. Regan, K. L. Pierce, D. Srinivasan, 2000 .

Hydrogen peroxide-induced arachidonic acid release in L929 cells; roles of Src, protein kinase C and cytosolic phospholipase A2α

Hiroyuki Nakamura, H. Fujino, T. Murayama, 2006 .

Decrease of guanylyl cyclase β1 subunit and nitric oxide (NO)-induced relaxation in mouse rectum with colitis and its reproduction on long-term NO treatment

Kenjiro Matsumoto, Hiroyuki Nakamura, H. Fujino, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway.

T. Tamaki, K. Tsuchiya, K. Ishizawa, 2019, Toxicology letters.

Identification of prophylactic drugs for oxaliplatin-induced peripheral neuropathy using big data.

T. Shimazoe, Naoto Okada, Daisuke Kobayashi, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Fibroblast-specific ERK5 deficiency changes tumor vasculature and exacerbates tumor progression in a mouse model

K. Tsuneyama, K. Tsuchiya, K. Ishizawa, 2020, Naunyn-Schmiedeberg's Archives of Pharmacology.

Dysfunction of neurogenic VIP-mediated relaxation in mouse distal colon with dextran sulfate sodium-induced colitis.

Takeshi Saito, Kenjiro Matsumoto, H. Fujino, 2012, Pharmacological research.

Neurogenic contraction of mouse rectum via the cyclooxygenase pathway: Changes of PGE2-induced contraction with dextran sulfate sodium-induced colitis.

Kenjiro Matsumoto, H. Fujino, T. Murayama, 2010, Pharmacological research.

Why PGD2 has different functions from PGE2

H. Fujino, 2020, BioEssays : news and reviews in molecular, cellular and developmental biology.

Effect of Royal Jelly and Brazilian Green Propolis on the Signaling for Histamine H1 Receptor and Interleukin-9 Gene Expressions Responsible for the Pathogenesis of the Allergic Rhinitis.

N. Takeda, H. Mizuguchi, Y. Kitamura, 2018, Biological & pharmaceutical bulletin.

Nicotine-induced neurogenic relaxation in the mouse colon: changes with dextran sodium sulfate-induced colitis.

H. Fujino, T. Murayama, S. Horie, 2009, Journal of pharmacological sciences.

Roles of Muscarinic Receptors m1 and m2 on Interleukin 2 Production in Human Peripheral Blood Lymphocytes and Human Leukemic T Cell Line Jurkat Cells

H. Fujino, 1997 .

Irinotecan-induced neutropenia is reduced by oral alkalization drugs: analysis using retrospective chart reviews and the spontaneous reporting database

T. Tamaki, Naoto Okada, K. Ishizawa, 2018, Supportive Care in Cancer.

Hydrogen sulfide-mediated regulation of contractility in the mouse ileum with electrical stimulation: roles of L-cysteine, cystathionine β-synthase, and K+ channels.

Hiroyuki Nakamura, H. Fujino, T. Murayama, 2014, European journal of pharmacology.

The Roles of EP4 Prostanoid Receptors in Cancer Malignancy Signaling.

H. Fujino, 2016, Biological & pharmaceutical bulletin.

Prostaglandin E₂ regulates cellular migration via induction of vascular endothelial growth factor receptor-1 in HCA-7 human colon cancer cells.

J. Regan, Kaori Toyomura, H. Fujino, 2011, Biochemical pharmacology.

Differential internalization of the prostaglandin f(2alpha) receptor isoforms: role of protein kinase C and clathrin.

J. Regan, D. Srinivasan, H. Fujino, 2002, The Journal of pharmacology and experimental therapeutics.

Differential regulation of prostaglandin F(2alpha) receptor isoforms by protein kinase C.

J. Regan, K. L. Pierce, D. Srinivasan, 2000, Molecular pharmacology.

Characterization of Immune Checkpoint Inhibitor–Induced Myasthenia Gravis Using the US Food and Drug Administration Adverse Event Reporting System

Naoto Okada, K. Ishizawa, H. Yanagawa, 2022, Journal of clinical pharmacology.

Indomethacin induces cellular morphological change and migration via epithelial-mesenchymal transition in A549 human lung cancer cells: a novel cyclooxygenase-inhibition-independent effect.

H. Fujino, T. Murayama, T. Kawashima, 2011, Biochemical pharmacology.

Down-regulation of the expression of cyclooxygenase-2 and prostaglandin E2 by interleukin-4 is mediated via a reduction in the expression of prostanoid EP4 receptors in HCA-7 human colon cancer cells.

J. Regan, H. Fujino, Masato Mashimo, 2022, European journal of pharmacology.

Activation of FP Prostanoid Receptor Isoforms Leads to Rho-mediated Changes in Cell Morphology and in the Cell Cytoskeleton*

J. Regan, K. L. Pierce, D. Srinivasan, 1999, The Journal of Biological Chemistry.

Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor.

J. Regan, H. Fujino, G. Vielhauer, 2004, Archives of biochemistry and biophysics.

Delayed Reversal of Shape Change in Cells Expressing FPB Prostanoid Receptors

J. Regan, K. L. Pierce, D. Srinivasan, 2000, Journal of Biological Chemistry.

FP Prostanoid Receptor-Mediated Induction of the Expression of Early Growth Response Factor-1 by Activation of a Ras/Raf/Mitogen-Activated Protein Kinase Signaling Cascade

Qin M. Chen, J. Regan, W. Xu, 2008, Molecular Pharmacology.

Short chain fatty acid butyrate uptake reduces expressions of prostanoid EP4 receptors and their mediation of cyclooxygenase‐2 induction in HCA‐7 human colon cancer cells

J. Regan, H. Fujino, T. Murayama, 2019, European journal of pharmacology.

Xanthine Oxidase Inhibition by Febuxostat in Macrophages Suppresses Angiotensin II-Induced Aortic Fibrosis

K. Tsuchiya, K. Ishizawa, H. Fujino, 2018, American journal of hypertension.

Individual resolvin E family members work distinctly and in a coordinated manner in the resolution of inflammation.

H. Fukuda, H. Fujino, Koichi Fujiwara, 2023, Prostaglandins & other lipid mediators.

FP Prostanoid Receptor Activation of a T-cell Factor/β-Catenin Signaling Pathway*

J. Regan, H. Fujino, 2001, The Journal of Biological Chemistry.

Cellular density‐dependent increases in HIF‐1α compete with c‐Myc to down‐regulate human EP4 receptor promoter activity through Sp‐1‐binding region

J. Regan, K. Yamagata, Hiroyuki Nakamura, 2018, Pharmacology research & perspectives.

Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest

M. Kano, T. Tamaki, K. Tsuchiya, 2017, Scientific Reports.

Human EP2 prostanoid receptors exhibit more constraints to mutations than human DP prostanoid receptors

H. Fujino, T. Murayama, Junno Tanimoto, 2015, FEBS letters.

Extracellular signal regulated protein kinase and c-jun N-terminal kinase are involved in ml muscarinic receptor-enhanced interleukin-2 production pathway in Jurkat cells.

H. Ariga, T. Uehara, Y. Nomura, 2000, Biological and Pharmaceutical Bulletin.

Decrease in uptake of arachidonic acid by indomethacin in LS174T human colon cancer cells; a novel cyclooxygenase-2-inhibition-independent effect.

H. Fujino, T. Murayama, T. Kawashima, 2010, Archives of biochemistry and biophysics.

Differential regulation of Ca(2+)-dependent Cl- currents by FP prostanoid receptor isoforms in Xenopus oocytes.

J. Regan, K. L. Pierce, H. Fujino, 2002, Biochemical Pharmacology.

Cellular density-dependent down-regulation of EP4 prostanoid receptors via the up-regulation of hypoxia-inducible factor-1α in HCA-7 human colon cancer cells

J. Regan, Kenji Yoshida, H. Fujino, 2014, Pharmacology research & perspectives.

Pemafibrate inhibited renal dysfunction and fibrosis in a mouse model of adenine-induced chronic kidney disease.

K. Tsuchiya, K. Shinomiya, H. Fujino, 2023, Life sciences.

Expression of the ubiquitin ligase HRD1 in neural stem/progenitor cells of the adult mouse brain.

Y. Nomura, H. Hamana, Y. Okuma, 2011, Journal of pharmacological sciences.