T. Stout

发表

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.

Hieu T. Do, Meenhard Herlyn, David M. Wilson, 2006, Cancer research.

Two imidazole alkaloids from a sponge

J. Clardy, P. Scheuer, T. Stout, 1990 .

Studies on the solution- and solid-state structure of patellin 2

J. Clardy, M. Foster, C. Ireland, 1990 .

D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.

R. Stroud, J. Finer-Moore, R. Nissen, 1998 .

The design, synthesis, and biological evaluation of PIM kinase inhibitors.

Wei Xu, J. Nuss, Wentao Zhang, 2012, Bioorganic & medicinal chemistry letters.

Neoadjuvant letrozole plus taselisib versus letrozole plus placebo in postmenopausal women with oestrogen receptor-positive, HER2-negative, early-stage breast cancer (LORELEI): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.

M. Piccart, J. Baselga, A. Ballestrero, 2019, The Lancet. Oncology.

Discovery of XL413, a potent and selective CDC7 inhibitor.

Wei Xu, Charles R. Holst, J. Nuss, 2012, Bioorganic & medicinal chemistry letters.

Total Synthesis of the Macrolide Antibiotic Cytovaricin.

J. Clardy, Davidr . Evans, S. Kaldor, 1990 .

Growth‐rate model predicts in vivo tumor response from in vitro data

T. Wilson, M. Hafner, B. Alicke, 2022, CPT: pharmacometrics & systems pharmacology.

The three-dimensional structure of neohalicholactone, an unusual fatty acid metabolite from the marine sponge halichondria okadai kadota

J. Clardy, H. Niwa, T. Stout, 1991 .

Transannular Diels-Alder route to systems related to dynemicin A

S. Schreiber, J. Clardy, F. Schoenen, 1990 .

Structures of active and latent PAI-1: a possible stabilizing role for chloride ions.

D. J. Matthews, T. Stout, D. Buckley, 2000, Biochemistry.

The structure and biological activity of cercosporamide from Cercosporidium henningsii

G. A. Gray, S. Strobel, J. Clardy, 1991 .

Comparison of PIK3CA Mutation Prevalence in Breast Cancer Across Predicted Ancestry Populations

E. Sokol, K. Hutchinson, J. Newberg, 2022, JCO precision oncology.

Salinamides A and B: anti-inflammatory depsipeptides from a marine streptomycete

J. Clardy, C. Ireland, P. Jensen, 1994 .

D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.

R. Stroud, J. Finer-Moore, R. Nissen, 1998, Biochemistry.

Vinylogous polypeptides: an alternative peptide backbone

S. Schreiber, J. Clardy, N. Anthony, 1992 .

Octalactins A and B, cytotoxic eight membered ring lactones from a marine bacterium Streptomyces sp.

J. Clardy, W. Fenical, T. Stout, 1991 .

Emeniveol; A new pollen growth inhibitor from the fungus, Emericella nivea

J. Clardy, F. Sugawara, T. Hamasaki, 1992 .

Salinamides A and B: anti-inflammatory depsipeptides from a marine streptomycete

J. Clardy, C. Ireland, P. Jensen, 1994 .

The baconipyrones: novel polypropionates from the pulmonate Siphonaria baconi

J. Clardy, D. Faulkner, T. Stout, 1989 .

The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition.

R. Stroud, T. Stout, 1996, Structure.

Novel sesquiterpenoids from the fairy ring fungus, Marasmiusoreades

J. Clardy, W. Ayer, T. Stout, 1989 .

Novel Sesquiterpenoids from the Fairy Ring Fungus, Marasmius oreades

J. Clardy, W. Ayer, T. Stout, 1989 .

Phase II Study of Taselisib (GDC-0032) in Combination with Fulvestrant in Patients with HER2-Negative, Hormone Receptor–Positive Advanced Breast Cancer

L. Pusztai, J. Baselga, T. Wilson, 2018, Clinical Cancer Research.

The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors.

Wei Xu, Wei Cheng, F. Yakes, 2012, Bioorganic & medicinal chemistry letters.

Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1*

P. Mak, Rui-Hong Chen, J. Lougheed, 2004, Journal of Biological Chemistry.

Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis.

R. Stroud, D. Santi, U. Schellenberger, 1998, Biochemistry.

Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition.

R. Stroud, D. Santi, S. Ghelli, 1999, Journal of medicinal chemistry.

The additivity of substrate fragments in enzyme-ligand binding.

R M Stroud, R. Stroud, T J Stout, 1998, Structure.

Multiple PIK3CA mutation clonality correlates with outcomes in taselisib + fulvestrant-treated ER+/HER2–, PIK3CA-mutated breast cancers

E. Sokol, T. Wilson, K. Hutchinson, 2023, Genome Medicine.

APLASMOMYCIN C : STRUCTURAL STUDIES OF A MARINE ANTIBIOTIC

J. Clardy, T. Stout, I. C. Pathirana, 1991 .

Aplasmomycin C: Structural Studies of a Marine Antibiotic.

J. Clardy, W. Fenical, T. Stout, 1991 .

An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q.

R. Stroud, T. Stout, E. Rutenber, 1996, Biochemistry.

DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12.

Jon Clardy, J. Luengo, L. Rozamus, 1994 .

Ohioensins : novel benzonaphthoxanthenones from Polytrichum ohioense

J. Clardy, T. Stout, J. Cassady, 1993 .

Ohioensin-A: a novel benzonaphthoxanthenone from Polytrichum ohioense

J. Clardy, T. Stout, J. Cassady, 1989 .