M. Schaber

发表

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.

Hieu T. Do, Meenhard Herlyn, David M. Wilson, 2006, Cancer research.

Synthesis and structure-activity relationships of imidazo[1,2-a]pyrimidin-5(1H)-ones as a novel series of beta isoform selective phosphatidylinositol 3-kinase inhibitors.

J. F. Mack, J. Luengo, Ramona N Plant, 2012, Bioorganic & medicinal chemistry letters.

by a Farnesyl : Protein Transferase Inhibitor Develop Mammary Carcinomas That Can Be Growth-inhibited B Transgenic Mice ras Mouse Mammary Tumor Virus-Ki-Updated

R. Diehl, A. Kral, J. Davide, 2000 .

Steady-state kinetic mechanism of Ras farnesyl:protein transferase.

J. Gibbs, E. Rands, D. Pompliano, 1992, Biochemistry.

Discovery of Novel AKT Inhibitors with Enhanced Anti-Tumor Effects in Combination with the MEK Inhibitor

Ming-Chih Crouthamel, Rakesh Kumar, S. Rabindran, 2014, PloS one.

Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protien transferase

J. Gibbs, D. Pompliano, K. Silverman, 1993, Applied Microbiology and Biotechnology.

Xenopus oocyte germinal-vesicle breakdown induced by [Val12]Ras is inhibited by a cytosol-localized Ras mutant.

E. Scolnick, I. Sigal, J. Gibbs, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase.

R. Dixon, S. Moores, V. Garsky, 1990, Journal of Biological Chemistry.

Signal peptide specificity in posttranslational processing of the plant protein phaseolin in Saccharomyces cerevisiae

K. Lea, M. Schaber, J. H. Cramer, 1987, Molecular and cellular biology.

An intrinsic ATPase activity of phospho-MEK-1 uncoupled from downstream ERK phosphorylation.

R. Copeland, E. May, R. Gontarek, 2007, Archives of biochemistry and biophysics.

Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: interactive binding between substrates and a preferred kinetic pathway.

J. Shafer, J. Gibbs, D. Pompliano, 1993, Biochemistry.

Cascades of Mammalian Caspase Activation in the YeastSaccharomyces cerevisiae *

S. Srinivasula, E. Alnemri, M. Bjornsti, 1999, The Journal of Biological Chemistry.

Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP.

P. Coleman, C. Buser, K. Rickert, 2008, Archives of biochemistry and biophysics.

Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP.

Youwei Yan, P. Coleman, Christopher D. Cox, 2006, Bioorganic & medicinal chemistry letters.

The fos gene product undergoes extensive post-translational modification in eukaryotic but not in prokaryotic cells.

T. Curran, R. Kramer, R. Crowl, 1986, Gene.

Expression of Preprosomatostatin in Foreign Cells: Secretion of Mature Somatostatin by Yeast (Saccharomyces Cerevisiae)

M. Schaber, R. Kramer, D. Shields, 1987 .

Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor.

R. Diehl, A. Kral, J. Davide, 2000, Cancer research.

Rational Design, Synthesis, and SAR of a Novel Thiazolopyrimidinone Series of Selective PI3K-beta Inhibitors.

J. F. Mack, J. Luengo, Ramona N Plant, 2012, ACS medicinal chemistry letters.

Regulated expression of a human interferon gene in yeast: control by phosphate concentration or temperature.

S. Hilliker, T. Dechiara, M. Schaber, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Structural homology among mammalian and Saccharomyces cerevisiae isoprenyl-protein transferases.

S. Moores, S. Powers, R. Diehl, 1991, The Journal of biological chemistry.

2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase.

T. Ciccarone, A. Kral, J. Davide, 1996, Journal of medicinal chemistry.

src-homology 2 (SH2) domain ligation as an allosteric regulator: modulation of phosphoinositide-specific phospholipase C gamma 1 structure and activity.

J. Gibbs, D. Pompliano, G. Edwards, 1995, Biochemical Journal.

The ras Oncogene Protein

R. Dixon, E. Scolnick, I. Sigal, 1989 .

[3a,4]-Dihydropyrazolo[1,5a]pyrimidines: Novel, Potent, and Selective Phosphatidylinositol-3-kinase β Inhibitors.

J. Luengo, Ramona N Plant, K. Erhard, 2013, ACS medicinal chemistry letters.

Synthesis and structure-activity relationships of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potent β isoform selective phosphatidylinositol 3-kinase inhibitors.

J. Luengo, Ramona N Plant, K. Erhard, 2012, Bioorganic & medicinal chemistry letters.

Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility.

W. F. Hoffman, Youwei Yan, L. Kuo, 2006, Bioorganic & medicinal chemistry letters.

Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.

G. Warren, R. Copeland, T. J. Lansing, 2008, Journal of medicinal chemistry.

Inhibition of a mitotic motor protein: where, how, and conformational consequences.

Lawrence C Kuo, Youwei Yan, L. Kuo, 2004, Journal of molecular biology.

Design and in vivo analysis of potent non-thiol inhibitors of farnesyl protein transferase.

N. Kohl, J. Gibbs, E. Rands, 1999, Journal of medicinal chemistry.

Purification of ras GTPase activating protein from bovine brain.

J B Gibbs, E. Scolnick, I. Sigal, 1988, Proceedings of the National Academy of Sciences of the United States of America.

HTLV-III gag protein is processed in yeast cells by the virus pol-protease.

E. Reddy, A. Skalka, F. Wong-Staal, 1986, Science.

Clavaric acid and steroidal analogues as Ras- and FPP-directed inhibitors of human farnesyl-protein transferase.

N. Kohl, J. Gibbs, S. Graham, 1998, Journal of medicinal chemistry.

Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction.

Neysa Nevins, D. Mcnulty, A. Gilmartin, 2014, Nature chemical biology.

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

A. Kral, J. Davide, N. Kohl, 1995, Nature Medicine.

Cloning of bovine GAP and its interaction with oncogenic ras p21

Irving S. Sigal, R. Dixon, E. Scolnick, 1988, Nature.

A C‐terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity.

R. Dixon, E. Scolnick, I. Sigal, 1989, The EMBO journal.

Selection of Potent Inhibitors of Farnesyl-protein Transferase from a Synthetic Tetrapeptide Combinatorial Library*

R. Cortese, J. Gibbs, A. Pessi, 1996, The Journal of Biological Chemistry.

Purification and Molecular Cloning of Bovine GAP

R. Dixon, E. Scolnick, I. Sigal, 1989 .

N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity.

J. Huff, J. Davide, N. Kohl, 1999, Journal of medicinal chemistry.

Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT)

J. Cuozzo, M. Clark, Paolo A. Centrella, 2015, ACS medicinal chemistry letters.

CAK1 Promotes Meiosis and Spore Formation in Saccharomyces cerevisiae in a CDC28-Independent Fashion

E. Winter, P. Kaldis, K. Schindler, 2002, Molecular and Cellular Biology.

Inhibition of the ras p21 GTPase-activating protein-stimulated GTPase activity of c-Ha-ras p21 by smg p21 having the same putative effector domain as ras p21s.

T. Sasaki, Y. Hata, J. Gibbs, 1990, The Journal of biological chemistry.

A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis

D. Troyer, M. Subler, J. Windle, 1998, Molecular and Cellular Biology.

Determination of Ras and GTPase-activating protein interactions by kinetic competition assay.

J. Gibbs, M. Schaber, 1995, Methods in enzymology.

Structure/function studies of the ras protein.

J B Gibbs, E. Scolnick, I. Sigal, 1988, Cold Spring Harbor symposia on quantitative biology.

Molecular Biology of GAP and its Interaction with Oncogenic ras p21

R. Dixon, E. Scolnick, I. Sigal, 1989 .

Sequence dependence of protein isoprenylation.

S. Moores, V. Garsky, M. Marshall, 1991, The Journal of biological chemistry.

Ras interaction with the GTPase‐activating protein (GAP)

E. Scolnick, V. Garsky, I. Sigal, 1989, Proteins.

Molecular cloning and regulated expression of the human c-myc gene in Escherichia coli and Saccharomyces cerevisiae: comparison of the protein products.

R. Kramer, C. Miyamoto, R. Chizzonite, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Tetrasubstituted pyridines as potent and selective AKT inhibitors: Reduced CYP450 and hERG inhibition of aminopyridines.

Sharad Verma, Kristin K. Brown, Anthony E Choudhry, 2010, Bioorganic & medicinal chemistry letters.

Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.

Youwei Yan, P. Coleman, Christopher D. Cox, 2008, Journal of medicinal chemistry.

Aminofurazans as potent inhibitors of AKT kinase.

D. Heerding, E. Minthorn, N. Concha, 2009, Bioorganic & medicinal chemistry letters.

Identification of guanine nucleotides bound to ras-encoded proteins in growing yeast cells.

E. Scolnick, I. Sigal, M. Marshall, 1987, The Journal of biological chemistry.

Conformational restriction of flexible ligands guided by the transferred noe experiment: potent macrocyclic inhibitors of farnesyltransferase.

J. Huff, M. Bogusky, S. Graham, 2001, Journal of the American Chemical Society.

Yeast vectors for production of interferon.

T. Dechiara, M. Schaber, R. Kramer, 1986, Methods in enzymology.

Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT)

Nicholas D. Adams, J. Cuozzo, M. Clark, 2015, ACS medicinal chemistry letters.

[59] Yeast vectors for production of interferon

T. Dechiara, M. Schaber, R. Kramer, 1986 .

Secretion of somatostatin by Saccharomyces cerevisiae. Correct processing of an alpha-factor-somatostatin hybrid.

M. Schaber, R. Kramer, D. Shields, 1986, The Journal of biological chemistry.

Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.

W. F. Hoffman, Youwei Yan, P. Coleman, 2006, Bioorganic & medicinal chemistry letters.